BDBM621900 (S)-N-((R or S)-(4- chloro-3- cyanophenyl)(4- (trifluoromethoxy) phenyl)methyl)-2- oxoimidazolidine-4- carboxamide::US11802122, Example 57A::US20230312528, Example 57B

SMILES N#Cc3cc([C@H](NC(=O)[C@@H]1CNC(=O)N1)c2ccc(OC(F)(F)F)cc2)ccc3Cl

InChI Key InChIKey=QEPBHTRFWCUOCU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 621900   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 621900BDBM621900(US20230312528, Example 57B | US11802122, Example 5...)
Affinity DataIC50: 2.40nMAssay Description:Compounds were tested on human NaV1.8 and NaV1.5 channels stably expressed in human embryo kidney (HEK) 293 cells. Sodium current measurements on Qub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 621900BDBM621900(US20230312528, Example 57B | US11802122, Example 5...)
Affinity DataIC50: 3.5nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent