BDBM612264 (S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy)-3-methylphenyl)-5-((3,3-difluoro-1-methylpiperidin-4-yl)oxy)-6-(methoxy-d3)quinazolin-4-amine::BDBM612287::US11723908, Example 37

SMILES COc1ccc2ncnc(Nc3ccc(Oc4cc5ncnn5cn4)c(C)c3)c2c1O[C@@H]1CCN(C)CC1(F)F

InChI Key InChIKey=PTKRHBXNNDLRPO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 612264   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 612264BDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 9.5nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 612264BDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 12nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 612264BDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 14nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Zanrong Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 612264BDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of phosphor wt-EGFR was determined by enzyme-linked immunosorbent assay (ELISA) in NCI H838 cells (ATCC, catalog number CRL-5844). Human P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Zanrong Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 612264BDBM612264((S)-N-(4-([1,2,4]-triazolo[1,5-c]pyrimidin-7-yloxy...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed