BDBM609973 US11708366, Example 82

SMILES c1cc(c(cc1N2C(=O)CCCC23CCN(CC3)c4cc(ncn4)OCC(F)(F)F)F)F

InChI Key InChIKey=AQDBIXQGLAUSIM-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 609973   

TargetLeukotriene C4 synthase(Human)
Novartis Pharma AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 609973BDBM609973(US11708366, Example 82)
Affinity DataIC50: 7.5nMAssay Description:Inhibition of LTC4S in human PBMC cells assessed as inhibition of calcium ionophore A23187 stimulated LTC4 release preincubated for 15 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Novartis Pharma AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 609973BDBM609973(US11708366, Example 82)
Affinity DataIC50: 14nMAssay Description:Inhibition of human LTC4S assessed as conversion of LTA4-Me to LTC4-Me using GSH as substrate preincubated for 15 mins followed by substrate addition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Novartis Pharma AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 609973BDBM609973(US11708366, Example 82)
Affinity DataIC50: 44nMAssay Description:Inhibition of LTC4S in human whole blood assessed as inhibition of calcium ionophore A23187 stimulated LTC4 release preincubated with compound for 4 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene C4 synthase(Human)
Novartis Pharma AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 609973BDBM609973(US11708366, Example 82)
Affinity DataIC50: 1.20E+4nMAssay Description:LTC4 synthase catalyzes the conversion of Leukotriene A4(LTA4) to Leukotriene C4 (LTC4) in the presence of reduced glutathione (GSH) as a co-substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)