BDBM606195 US11684616, Example 201

SMILES CC[C@H]1CCc2nnc(-c3cccc(n3)N3Cc4c(cc(nc4CNC)N(C)C(C)C)C3=O)n12

InChI Key InChIKey=QQXZJQAEELFYDV-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 606195   

LigandChemical structure of BindingDB Monomer ID 606195BDBM606195(US11684616, Example 201)
Affinity DataKi: <0.0500nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 606195BDBM606195(US11684616, Example 201)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of LDH-A (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase D2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 606195BDBM606195(US11684616, Example 201)
Affinity DataIC50: 5.43nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 606195BDBM606195(US11684616, Example 201)
Affinity DataIC50: 6.73nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetLymphocyte cytosolic protein 2(Human)
Pfizer Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 606195BDBM606195(US11684616, Example 201)
Affinity DataIC50: 37nMAssay Description:Inhibition of chymotrypsin-like activity of Proteasome subunit beta 5 (unknown origin) assessed as inhibition of beta-amyloid production by cell-base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed