BDBM606098 US11684616, Example 1

SMILES CC[C@@H](N)c1nc(cc2C(=O)N(Cc12)c1cccc(n1)-c1nnc2CC[C@H](C)n12)N1CCC[C@H]1C

InChI Key InChIKey=FOLSZCLZVLICGG-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 606098   

LigandChemical structure of BindingDB Monomer ID 606098BDBM606098(US11684616, Example 1)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of LDH-A (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 606098BDBM606098(US11684616, Example 1)
Affinity DataKi: <0.0500nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 606098BDBM606098(US11684616, Example 1)
Affinity DataKi: <0.0500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetLymphocyte cytosolic protein 2(Human)
Pfizer Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 606098BDBM606098(US11684616, Example 1)
Affinity DataIC50: 17nMAssay Description:Inhibition of postacid activity of 20s proteasome beta-1 subunit in HEK293 cells using Z-nLPnLD-Glo as substrate incubated for 2 hrs prior to substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetLymphocyte cytosolic protein 2(Human)
Pfizer Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 606098BDBM606098(US11684616, Example 1)
Affinity DataIC50: 17nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetRibosomal protein S6 kinase alpha-2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 606098BDBM606098(US11684616, Example 1)
Affinity DataIC50: 47nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase D2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 606098BDBM606098(US11684616, Example 1)
Affinity DataIC50: 155nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent