BDBM60438 US9067937, 28

SMILES CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O

InChI Key InChIKey=DKZYXHCYPUVGAF-UHFFFAOYSA-N

Data  8 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 60438   

LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataKd:  0.120nMAssay Description:Binding affinity to wild-type human partial length DYRK1A (H129 to S509 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Oncotherapy Science

US Patent
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 0.400nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2016
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataEC50:  5nMAssay Description:Inhibition of human DYRK1A transfected in HEK293T cells co-transfected with Renilla plasmid, pGL3-NFAT and NFATc1 assessed as derepression of NFAT-de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Oncotherapy Science

US Patent
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataKd:  15nMAssay Description:Binding affinity to wild-type human full length MELK (M1 to V651 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 40nMAssay Description:Inhibition of human P38alpha incubated for 30 mins in presence of ATP by ADP-GLO reagent based multimode microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 60nMAssay Description:Inhibition of human CK1alpha incubated for 30 mins in presence of ATP by ADP-GLO reagent based multimode microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 62nMAssay Description:Inhibition of human CK1epsilon transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K8 tracer by NanoBRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 66nMAssay Description:Inhibition of human CK1delta transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K10 tracer by NanoBRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine protein kinase YCK2(Candida albicans (strain SC5314 / ATCC MYA-2876) (...)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant Yck2 in Candida albicans incubated for 30 mins in presence of ATP by ADP-GLO reagent based multimode microplate reader anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine protein kinase YCK2(Candida albicans (strain SC5314 / ATCC MYA-2876) (...)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 660nMAssay Description:Inhibition of N-terminal NLuc fused YCK2 (S37 to N345 residues) in Candida albicans transfected in HEK293 cells using NanoBRET NanoGlo substrate incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60438BDBM60438(US9067937, 28)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human P38alpha transfected in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of K4 tracer by NanoBRET as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed