BDBM591138 2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)isoquinolin-3- yl)amino)-6-methyl-5,6-dihydro-4H- pyrazolo[1,5-d][1,4]diazepin-7(8H)- one::US11566003, Compound 230::US11566003, Compound 231

SMILES CN1CCc2cc(Nc3cc4cc(c(F)c(N)c4cn3)-c3cnccc3C)nn2CC1=O

InChI Key InChIKey=ZYHJSEQCEOTYCF-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 591138   

LigandChemical structure of BindingDB Monomer ID 591138BDBM591138(US11566003, Compound 230 | US11566003, Compound 23...)
Affinity DataKi:  0.128nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 591138BDBM591138(US11566003, Compound 230 | US11566003, Compound 23...)
Affinity DataKi:  0.150nMAssay Description:For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 591138BDBM591138(US11566003, Compound 230 | US11566003, Compound 23...)
Affinity DataKi:  0.150nMAssay Description:To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 591138BDBM591138(US11566003, Compound 230 | US11566003, Compound 23...)
Affinity DataEC50:  20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 591138BDBM591138(US11566003, Compound 230 | US11566003, Compound 23...)
Affinity DataIC50: 61nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed