BDBM585253 General Procedure for Preparation of 5′-(4-fluorophenyl)-3′-isopropyl-N-(4-(4-methylpiperazin-1-yl)phenyl)-1H,3′H-[2,4′-biimidazole]-4-carboxamide ::US11530197, Compound 112
SMILES CC(C)n1cnc(c1-c1nc(c[nH]1)C(=O)Nc1ccc(cc1)N1CCN(C)CC1)-c1ccc(F)cc1
InChI Key InChIKey=ZVDNXHUSIKGTSF-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 585253
Affinity DataKd: 4.30nMAssay Description:Binding affinity to human recombinant TNIK (1 to 367 residues) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human recombinant TNIK (1 to 367 residues) using RLGRDKYKTLRQI as substrate incubated for 40 mins in presence of Mg/ATP mix by scintill...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:ATP-competitive inhibition of human recombinant TNIK (1 to 367 residues) in presence of 64 uM ATP by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of human TNIKMore data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM RLGRDKYKTLRQIRQ, 10 mM Magnesium Acetate and [gamma-33P-ATP](specific activit...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:The required volume of the 50× stock of test compound was added to the assay before a reaction mix containing the enzyme and substrate was added. The...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:The required volume of the 50× stock of test compound was added to the assay before a reaction mix containing the enzyme and substrate was added. The...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:TNIK(h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM RLGRDKYKTLRQIRQ, 10 mM Magnesium Acetate and [gamma-33P-ATP](specific activity a...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
Insilico Medicine AI Ltd.
Curated by ChEMBL
Insilico Medicine AI Ltd.
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human PDGFR alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human YESMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human ALK4More data for this Ligand-Target Pair
Affinity DataIC50: 257nMAssay Description:ATP-competitive inhibition of human recombinant TNIK (1 to 367 residues) in presence of 2 mM ATP by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of human wild type partial length LCK (R207 to P509 residues) expressed in bacteria by Eurofins DiscoverX methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
Insilico Medicine AI Ltd.
Curated by ChEMBL
Insilico Medicine AI Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human wild type partial length VEGFR2 (R787 to P1253 residues) expressed in mammalian cells by Eurofins DiscoverX methodMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human CHRM1 by Eurofins DiscoverX methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ErbB4More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TNIKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Aurora BMore data for this Ligand-Target Pair