BDBM581508 (S*)-6-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-7- fluoro-2-(o-tolyl)-4-(1,1,1-trifluoropropan-2-yl)phthalazin-1(2H)-one::US11505536, Example 56

SMILES CCn1c(CO)nn(-c2cc3c(nn(-c4ccccc4C)c(=O)c3cc2F)[C@H](C)C(F)(F)F)c1=O

InChI Key InChIKey=ATPQLRLIRAXHDW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 581508   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581508BDBM581508(US11505536, Example 56 | (S*)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581508BDBM581508(US11505536, Example 56 | (S*)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 2.31nMAssay Description:The following assay is referred to herein as the DHODH Enzymatic Assay. To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent