BDBM569986 (+/−)-[2-(3,5-difluoro-4-{[3-(propan-2-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}anilino)-5-methyl-5,6-dihydro-4H-1,3-oxazin-5-yl]methanol::US11427578, Example 159

SMILES CC(C)c1c[nH]c2nccc(Oc3c(F)cc(NC4=NCC(C)(CO)CO4)cc3F)c12

InChI Key InChIKey=QIPJMCUGOIBQIS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 569986   

LigandChemical structure of BindingDB Monomer ID 569986BDBM569986((+/−)-[2-(3,5-difluoro-4-{[3-(propan-2-yl)-1...)
Affinity DataIC50: 1nMAssay Description:Displacement of Tracer222 from N-terminal GST-tagged/TEV-fused human full length wild type MAP4K1 expressed in baculovirus-infected Sf9 cells incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 569986BDBM569986((+/−)-[2-(3,5-difluoro-4-{[3-(propan-2-yl)-1...)
Affinity DataIC50: 460nMAssay Description:Inhibition of MAP4K1 in human Jurkat E6.1 cells expressing FLAG-tagged human SLP76 assessed as inhibition of SLP76 phosphorylation at Ser376 residue ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 569986BDBM569986((+/−)-[2-(3,5-difluoro-4-{[3-(propan-2-yl)-1...)
Affinity DataIC50: 2.00E+4nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into either a black low volume 384 well microtiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent