BDBM568705 (6S)-6-Methyl-5-[4-(pyridin-4-yl)-3-(trifluoromethyl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one::US11427553, Example 166

SMILES C[C@@H]1OC(=O)NN=C1c1ccc(-c2ccncc2)c(c1)C(F)(F)F

InChI Key InChIKey=KJJACMBDLFUVJV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 568705   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 568705BDBM568705((6S)-6-Methyl-5-[4-(pyridin-4-yl)-3-(trifluorometh...)
Affinity DataIC50: 42nMAssay Description:The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568705BDBM568705((6S)-6-Methyl-5-[4-(pyridin-4-yl)-3-(trifluorometh...)
Affinity DataIC50: 67nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568705BDBM568705((6S)-6-Methyl-5-[4-(pyridin-4-yl)-3-(trifluorometh...)
Affinity DataIC50: 69nMAssay Description:The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent