BDBM568564 5-[3-Fluoro-4-(morpholin-4-yl)phenyl]-3,6-dihydro-2H-1,3,4-oxadiazin-2-one::US11427553, Example 4

SMILES Fc1cc(ccc1N1CCOCC1)C1=NNC(=O)OC1

InChI Key InChIKey=DNLCENYRYRBODW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 568564   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 568564BDBM568564(5-[3-Fluoro-4-(morpholin-4-yl)phenyl]-3,6-dihydro-...)
Affinity DataIC50: 154nMAssay Description:The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568564BDBM568564(5-[3-Fluoro-4-(morpholin-4-yl)phenyl]-3,6-dihydro-...)
Affinity DataIC50: 180nMAssay Description:Effective concentration to measure the adherence of LFA-1 expressing JY8 cells to immobilized ICAM-1 in cell-based adhesion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568564BDBM568564(5-[3-Fluoro-4-(morpholin-4-yl)phenyl]-3,6-dihydro-...)
Affinity DataIC50: 203nMAssay Description:The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2022
Entry Details
US Patent