BDBM535533 (R)-N-(2-(4,4-Difluoropiperidin-1-yl)- 6-methylpyrimidin-4-yl)-4-((2- hydroxy-1-methylethyl)sulfonamido)- 2-(6-azaspiro[2.5]octan-6- yl)benzamide::US11236069, Example 5-1

SMILES C[C@H](CO)S(=O)(=O)Nc1ccc(C(=O)Nc2cc(C)nc(n2)N2CCC(F)(F)CC2)c(c1)N1CCC2(CC2)CC1

InChI Key InChIKey=OLCRYQGHHMGOJZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535533   

TargetKinesin-like protein KIF18A [1-467](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 535533BDBM535533((R)-N-(2-(4,4-Difluoropiperidin-1-yl)- 6-methylpyr...)
Affinity DataIC50: 62nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetKinesin-like protein KIF18A(Human)
Changchun Genescience Pharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 535533BDBM535533((R)-N-(2-(4,4-Difluoropiperidin-1-yl)- 6-methylpyr...)
Affinity DataIC50: 71nMAssay Description:Inhibition of BRAF (unknown origin)-mediated ERK phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed