BDBM534481 (S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-N-(3-(4-chlorophenyl)-3-hydroxypropyl)-2 -fluorobenzamide::WO2022086828, Example 217

SMILES Nc1nc2cc(ccn2n1)-c1cccc(C(=O)NCC[C@H](O)c2ccc(Cl)cc2)c1F

InChI Key InChIKey=WCZYJWNVPLJLFK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 534481   

LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 15nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 18nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetMixed lineage kinase domain-like protein(Human)
Bristol-Myers Squibb

WIPO
LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 18nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 70nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828

LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 1.50E+4nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 40 nM probe and 1 nM GST-tagged PIK3C5 in complex with PIK3R1 (Invitrogen #...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2022
Entry Details
WIPO WO2022086828