BDBM531230 US11208399, Example 6

SMILES Cc1cc(cc(O)c1-c1ccc(N[C@@H]2CCCN(CCO)C2)nn1)C(F)(F)F

InChI Key InChIKey=PMWMWOJQUHUPKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 531230   

TargetInterleukin-1 beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531230BDBM531230(US11208399, Example 6)
Affinity DataIC50: 0.900nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Novartis Biomedical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 531230BDBM531230(US11208399, Example 6)
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGF-induced phosphorylation of VEGFR2 by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Novartis Biomedical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 531230BDBM531230(US11208399, Example 6)
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at human recombinant 5HT2B receptor by cell-based systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Novartis Biomedical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 531230BDBM531230(US11208399, Example 6)
Affinity DataIC50: 9nMAssay Description:Agonist activity at human recombinant 5HT2B receptor by cell-based systemMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetTumor necrosis factor(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 531230BDBM531230(US11208399, Example 6)
Affinity DataIC50: 1.00E+5nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent