BDBM519663 US11142525, Example 64

SMILES CCCn1c(C)nnc1-c1cccc(n1)N1Cc2c(cc(nc2CNC)N(C)C(C)C)C1=O

InChI Key InChIKey=RYBKWTCRKGAJRM-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 519663   

LigandChemical structure of BindingDB Monomer ID 519663BDBM519663(US11142525, Example 64)
Affinity DataKi: <0.170nMAssay Description:HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay (MSA). The reactions were conducted in 50 μL volumes in 96-well pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 519663BDBM519663(US11142525, Example 64)
Affinity DataIC50: 0.170nMAssay Description:Inhibition of LDH-A (unknown origin) by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetLymphocyte cytosolic protein 2(Human)
Pfizer Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 519663BDBM519663(US11142525, Example 64)
Affinity DataIC50: 81nMAssay Description:Inhibition of human voltage-gated Na channel 1.7 by cell based patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed