BDBM519645 US11142525, Example 46::US11684616, Example 300

SMILES CCCn1cnnc1-c1cccc(n1)N1Cc2c(cc(nc2CNC)N(C)C)C1=O

InChI Key InChIKey=XVKPIWUWUZOHIR-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 519645   

LigandChemical structure of BindingDB Monomer ID 519645BDBM519645(US11142525, Example 46 | US11684616, Example 300)
Affinity DataKi:  0.140nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 519645BDBM519645(US11142525, Example 46 | US11684616, Example 300)
Affinity DataKi:  0.140nMAssay Description:HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay (MSA). The reactions were conducted in 50 μL volumes in 96-well pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 519645BDBM519645(US11142525, Example 46 | US11684616, Example 300)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human gamma-secretase by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetSerine/threonine-protein kinase D2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 519645BDBM519645(US11142525, Example 46 | US11684616, Example 300)
Affinity DataIC50: 1.93nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 519645BDBM519645(US11142525, Example 46 | US11684616, Example 300)
Affinity DataIC50: 6.26nMAssay Description:PRKD2 (PKD2) and RPS6KA2 (RSK3) kinase assays were performed with Km-levels of ATP at the Thermo Fisher Scientific, Inc. (Madison, Wis.), using their...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetLymphocyte cytosolic protein 2(Human)
Pfizer Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 519645BDBM519645(US11142525, Example 46 | US11684616, Example 300)
Affinity DataIC50: 121nMAssay Description:Inhibition of LRRK2 (unknown origin) autophosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed