BDBM50637125 CHEMBL5557761

SMILES Cn1cc-2c(n1)C(=O)N(c3c2cc(c(c3)Cl)F)c4cccnc4C5CC5

InChI Key InChIKey=LJPOSFHRBZRBMV-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50637125   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Suzhou Genhouse Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637125BDBM50637125(CHEMBL5557761)
Affinity DataIC50: 11nMAssay Description:Inhibition of MAT2A (unknown origin) assessed as release of inorganic phosphate using ATP/L-methionine incubated for 30 mins by colorimetric phosphat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
Suzhou Genhouse Bio

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637125BDBM50637125(CHEMBL5557761)
Affinity DataIC50: 74nMAssay Description:Inhibition of MAT2A in MTAP-knock out human HCT-116 cells assessed as reduction in PRMT5-mediated symmetrical demethylation of arginine (SDMA) measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)