BDBM50605545 CHEMBL5182175

SMILES COc1ccc(NC(=O)N2CCc3c(C2)sc(NC(=O)c2cnn(C)c2)c3C#N)cc1

InChI Key InChIKey=WVYHDFDOBCBKGI-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50605545   

TargetSignal transducer and activator of transcription 3(Human)
Kunming Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605545BDBM50605545(CHEMBL5182175)
Affinity DataKd:  58nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kunming Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605545BDBM50605545(CHEMBL5182175)
Affinity DataKd:  460nMAssay Description:Binding affinity to His-tagged STAT3 (127 to 722 residues) (unknown origin) incubated for 30 mins by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Kunming Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605545BDBM50605545(CHEMBL5182175)
Affinity DataKd:  960nMAssay Description:Binding affinity to His-tagged STAT3-SH2 domain (586 to 685 residues) (unknown origin) incubated for 30 mins by MST assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605545BDBM50605545(CHEMBL5182175)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605545BDBM50605545(CHEMBL5182175)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605545BDBM50605545(CHEMBL5182175)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50605545BDBM50605545(CHEMBL5182175)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed