BDBM50601781 CHEMBL5197101

SMILES CCC1=Cc2ccc(cc2NC1=O)CN3CCN(CC3)c4ccc(nc4)C(=O)NC

InChI Key InChIKey=CEIZJAXIHJZKRG-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50601781   

TargetPoly [ADP-ribose] polymerase 1(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601781BDBM50601781(CHEMBL5197101)
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601781BDBM50601781(CHEMBL5197101)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601781BDBM50601781(CHEMBL5197101)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601781BDBM50601781(CHEMBL5197101)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human microsomal 11beta-HSD2 assessed as inhibition of conversion of radiolabeled cortisone to radiolabeled cortisol by cell-based assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 50601781BDBM50601781(CHEMBL5197101)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed