BDBM50572160 CHEMBL1452107

SMILES Cc1ccc(CSc2ncn(n2)-c2ccccc2)cc1

InChI Key InChIKey=JAVBFNWBMPZICK-UHFFFAOYSA-N

Data  1 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50572160   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572160BDBM50572160(CHEMBL1452107)
Affinity DataEC50:  600nMAssay Description:Inhibition of human 15-LOX-2 expressed in HEK293T cells assessed as a reduction in 15-HETE production using arachidonic acid as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572160BDBM50572160(CHEMBL1452107)
Affinity DataKi:  2.50E+3nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572160BDBM50572160(CHEMBL1452107)
Affinity DataIC50: 3.10E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572160BDBM50572160(CHEMBL1452107)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed