BDBM50572159 CHEMBL1489870::US20240317691, Compound Inhibitor-545091

SMILES Clc1ccc(cc1)-c1nnc(o1)C1CCCCC1

InChI Key InChIKey=ASRSXDRAEGLYDZ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50572159   

TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572159BDBM50572159(CHEMBL1489870 | US20240317691, Compound Inhibitor-...)
Affinity DataKi:  900nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572159BDBM50572159(CHEMBL1489870 | US20240317691, Compound Inhibitor-...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572159BDBM50572159(CHEMBL1489870 | US20240317691, Compound Inhibitor-...)
Affinity DataIC50: 2.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50572159BDBM50572159(CHEMBL1489870 | US20240317691, Compound Inhibitor-...)
Affinity DataIC50: 2.60E+3nMAssay Description:The full IC50 experiments were done with at least five different inhibitor concentrations. All reaction mixtures were 2 mL in volume and constantly s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent