BDBM50545281 CHEMBL4635100

SMILES Fc1cccc(COc2ccc(Nc3ncnc4cc5OCCN(C(=O)\C=C\CN6CCCC6)c5cc34)cc2Cl)c1

InChI Key InChIKey=ZZCPVBCYUULJEG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50545281   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545281BDBM50545281(CHEMBL4635100)
Affinity DataIC50: 4nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545281BDBM50545281(CHEMBL4635100)
Affinity DataIC50: 4nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cells by whole cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545281BDBM50545281(CHEMBL4635100)
Affinity DataIC50: 7nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545281BDBM50545281(CHEMBL4635100)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50545281BDBM50545281(CHEMBL4635100)
Affinity DataIC50: 121nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed