BDBM50532384 CHEMBL4560508

SMILES c1ccc(cc1)S(=O)(=O)N[C@@H]2Cc3ccc(cc3)NC(=O)CCN4CCN(CCC(=O)Nc5ccc(cc5)C[C@H](NC2=O)C(=O)NCc6ccc(cc6)CN)CC4

InChI Key InChIKey=AFXLLOQEGPNGRX-UHFFFAOYSA-N

Data  14 KI

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50532384   

TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  0.540nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  0.540nMAssay Description:Binding affinity to human plasmin assessed as slow binding constant in presence of Mes-DArg-Phe-Arg-AMC after 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  0.560nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPlasminogen(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  0.560nMAssay Description:Inhibition of human plasmin using Mes-DSer(Bzl)-Phe-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrypsin(Pig)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  1.54E+3nMAssay Description:Inhibition of porcine trypsin using Mes-DArg-Gly-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTrypsin(Pig)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  1.54E+3nMAssay Description:Inhibition of porcine trypsin using Mes-DArg-Gly-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  3.69E+4nMAssay Description:Inhibition of bovine thrombin using Tos-Gly-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Bovine)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  3.69E+4nMAssay Description:Inhibition of bovine thrombin using Tos-Gly-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  4.87E+4nMAssay Description:Inhibition of human plasma kallikrein using Mes-DArg-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi:  4.87E+4nMAssay Description:Inhibition of human plasma kallikrein using Mes-DArg-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human f10a using Mes-DArg-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human activated Protein C using Mes-DArg-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human f10a using Mes-DArg-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Philipps University Marburg

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50532384BDBM50532384(CHEMBL4560508)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human activated Protein C using Mes-DArg-Pro-Arg-AMC as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed