BDBM50505845 CHEMBL4566193

SMILES Cn1ncc-2c1OCCCCCN1\C(Nc3ccccc13)=N\C(=O)c1cc(F)nc-2c1

InChI Key InChIKey=XUHCGNIUATXAJQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50505845   

TargetEpidermal growth factor receptor [1-745,751-1210,T790M,C797S](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 50505845BDBM50505845(CHEMBL4566193 | US12522615, Example I-037)
Affinity DataIC50: 0.200nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 50505845BDBM50505845(CHEMBL4566193 | US12522615, Example I-037)
Affinity DataIC50: 0.300nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor [695-1022,T790M,C797S,L858R](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 50505845BDBM50505845(CHEMBL4566193 | US12522615, Example I-037)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 50505845BDBM50505845(CHEMBL4566193 | US12522615, Example I-037)
Affinity DataIC50: 13nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent

TargetEpidermal growth factor receptor(Mouse)
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505845BDBM50505845(CHEMBL4566193 | US12522615, Example I-037)
Affinity DataIC50: 270nMAssay Description:Inhibition of wild type EGFR in mouse BAF3 cells assessed as reduction in cell proliferation incubated for 72 hrs by Celltiter-Glo luminescent cell v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 50505845BDBM50505845(CHEMBL4566193 | US12522615, Example I-037)
Affinity DataIC50: 1.00E+5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2026
Entry Details US Patent