BDBM50436423 CHEMBL2397014

SMILES COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1

InChI Key InChIKey=XXHHOTZUJIXPJX-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50436423   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2019
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant wild type LRRK2 using biotin-LRRKtide as substrate preincubated for 15 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataEC50:  4nMAssay Description:Inhibition of LRRK2 G2019S mutant-induced neuronal toxicity in human cortical neuronsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human LRRK2 measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human LRRK2 G2019S mutant measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Charles River Discovery Research Services

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 7nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 52nMAssay Description:Activity at human PPARalpha receptor by cell based transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMitogen-activated protein kinase 15(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436423BDBM50436423(CHEMBL2397014)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed