BDBM50243255 1-(3-(methylcarbamoyl)-5-phenylthiophen-2-yl)urea::CHEMBL488238

SMILES CNC(=O)c1cc(sc1NC(N)=O)-c1ccccc1

InChI Key InChIKey=XUMVGDNPUZOUSZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50243255   

TargetSerine/threonine-protein kinase Chk1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243255BDBM50243255(1-(3-(methylcarbamoyl)-5-phenylthiophen-2-yl)urea ...)
Affinity DataIC50: 890nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Toray Industries, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50243255BDBM50243255(1-(3-(methylcarbamoyl)-5-phenylthiophen-2-yl)urea ...)
Affinity DataIC50: 920nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed