BDBM501120 7-((6- ((dimethylamino)- methyl)-5- (tetrahydro- 2H-4-pyran-4- yl)pyridin-2- yl)amino)-4-(7- fluoroimidazo [1,2-a]pyridin- 3-yl)isoindolin- 1-one::US11021481, Compound I-792::US11078201, Compound I-792::US11548890, Compound I-792

SMILES CN(C)Cc1nc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cc(F)ccn23)ccc1C1CCOCC1

InChI Key InChIKey=DRNGJPGUKLOJKE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 501120   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 2.90nMAssay Description:Activity at human PPARalpha receptor by cell based transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataEC50:  16nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataEC50:  43nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 260nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 304nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMisshapen-like kinase 1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 350nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetTyrosine-protein kinase SYK(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at human PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetTyrosine-protein kinase JAK1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at human PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at human PPARgamma assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetTyrosine-protein kinase Fyn(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Activity at human PPARalpha receptor by cell based transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetTyrosine-protein kinase Lyn(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetTyrosine-protein kinase Lck(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at human PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARalpha assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 501120BDBM501120(US11021481, Compound I-792 | 7-((6- ((dimethylamin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at mouse PPARdelta assessed as receptor activation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed