BDBM50086572 CHEMBL434237::NB-506 Analogue

SMILES OCC(CO)NN1C(=O)c2c(C1=O)c1c3ccc(O)cc3n([C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c1c1[nH]c3cc(O)ccc3c21

InChI Key InChIKey=QMVPQBFHUJZJCS-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50086572   

TargetDNA topoisomerase 1(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086572BDBM50086572(NB-506 Analogue | CHEMBL434237)
Affinity DataEC50:  300nMAssay Description:Inhibitory effect on topoisomerase-1 mediated DNA cleavage using supercoiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C (PKC)(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086572BDBM50086572(NB-506 Analogue | CHEMBL434237)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibitory effect on protein kinase C using histone II-As as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha/2-beta(Human)
Banyu Tsukuba Research Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50086572BDBM50086572(NB-506 Analogue | CHEMBL434237)
Affinity DataEC50: >5.00E+4nMAssay Description:Tested for inhibitory effect on topoisomerase-2 mediated DNA cleavage using super coiled pBR322 plasmid DNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed