BDBM485871 US10946019, Example 19

SMILES OC(=O)c1ccc(Nc2nc(nc(c2CC=C)C(F)(F)F)-c2ccc(Cl)cc2)cc1

InChI Key InChIKey=PMBGOHCPTCZWKQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 485871   

TargetRetinoic acid receptor RXR-alpha(Human)
TBA

US Patent
LigandChemical structure of BindingDB Monomer ID 485871BDBM485871(US10946019, Example 19)
Affinity DataEC50:  1.00E+4nMAssay Description:The in vitro transactivation assay determined the capacity of the compounds of the invention to activate the Nurr1:RXR heterodimers. Naive SHSY-5Y ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 485871BDBM485871(US10946019, Example 19)
Affinity DataEC50:  1.00E+4nMAssay Description:Activation of Nurr1-RXRalpha (unknown origin) heterodimer transfected in HEK293 cells co-transfected with pcDNA3 incubated for 16 hrs by Dual-Glo luc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed