BDBM475151 US10849982, Compd # 63

SMILES O=C1CCC(C(=O)N1)c1ccccc1

InChI Key InChIKey=KAKZYGLQCHMNGS-UHFFFAOYSA-N

Data  3 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 475151   

TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 475151BDBM475151(US10849982, Compd # 63)
Affinity DataKd:  430nMAssay Description:Displacement of [3H]-N-methyl-scopolamine from human muscarinic M3 receptor after 6 hrs by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 475151BDBM475151(US10849982, Compd # 63)
Affinity DataIC50: 600nMAssay Description:Antagonist activity at CGRP receptor assessed as inhibition of CGRP-stimulated cAMP production by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 475151BDBM475151(US10849982, Compd # 63)
Affinity DataIC50: 2.19E+3nMAssay Description:Inhibition of CRBN (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein cereblon(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 475151BDBM475151(US10849982, Compd # 63)
Affinity DataIC50: 2.20E+3nMAssay Description:Displacement of [3H]-N-methyl-scopolamine from human muscarinic M3 receptor after 6 hrs by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetZinc finger protein Aiolos(Homo sapiens)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 475151BDBM475151(US10849982, Compd # 63)
Affinity DataEC50: >1.00E+4nMAssay Description:Induction of ePL tagged Aiolos degradation in human DF15 cells incubated for 4 hrs by luminescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
TargetDNA damage-binding protein 1/Protein cereblon(Human)
C4 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 475151BDBM475151(US10849982, Compd # 63)
Affinity DataKd:  3.00E+4nMAssay Description:Measuring compound ligand binding to CRBN-DDB1 was carried out using an established sensitive and quantitative in vitro fluorescence polarization (FP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent