BDBM4539 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimethoxyquinazoline::N-(2,4-dichloro-5-methoxyphenyl)-6,7-dimethoxyquinazolin-4-amine::quinazoline deriv. 3b

SMILES COc1cc(Nc2ncnc3cc(OC)c(OC)cc23)c(Cl)cc1Cl

InChI Key InChIKey=PRWLJVUZPGQTGF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 4539   

LigandChemical structure of BindingDB Monomer ID 4539BDBM4539(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimeth...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant RIPK2 (1 to 317 residues) expressed in Sf21 insect cells using MBP as substrate preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Univ. Lille

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4539BDBM4539(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimeth...)
Affinity DataIC50: 61nMAssay Description:Inhibition of recombinant EGFR (unknown origin) using PGT as substrate preincubated for 10 mins followed by substrate addition and measured after 1 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 4539BDBM4539(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimeth...)
Affinity DataIC50: 106nMAssay Description:Inhibition of human NOD1 expressed in HEK-Blue hNOD1 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of NF-kappaB tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth-Ayerst Research

LigandChemical structure of BindingDB Monomer ID 4539BDBM4539(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimeth...)
Affinity DataIC50: 390nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 4539BDBM4539(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NOD2 expressed in HEK-Blue hNOD2 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of NF-kappaB tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 4539BDBM4539(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6,7-dimeth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NOD2 expressed in HEK-Blue hNOD2 cells coexpressing NF-kappaB-inducible SEAP reporter gene assessed as inhibition of TNF-alpha in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed