BDBM453058 US10711036, Compound 116

SMILES CC(C)[C@H](NC(=O)c1ccc(Br)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)CF

InChI Key InChIKey=QZOFLKQMJMFUCU-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 453058   

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 453058BDBM453058(US10711036, Compound 116)
Affinity DataKi:  10nMAssay Description:Binding affinity to full length C-terminal His-tagged wild-type MALT1 catalytic domain (329 to 566 residues) (unknown origin) extracted from Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 453058BDBM453058(US10711036, Compound 116)
Affinity DataKi:  10nMAssay Description:For exemplary compounds of the disclosure, Ki for inhibition of MALT1 was measured (Table E11). A concentration of 100 nM MALT1 was used for the assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2021
Entry Details
US Patent

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 453058BDBM453058(US10711036, Compound 116)
Affinity DataIC50: 10nMAssay Description:Inhibition of MALT1 (340 to 789 residues) (unknown origin) using Ac-LRSR-AMC as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed