BDBM436829 5-((S)-7-amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-fluoro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 517a
SMILES Cn1nccc1C(=O)N1CC2(CCCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(-c5ccc(F)c6sc(N)c(C#N)c56)c(Cl)cc34)C2)C1
InChI Key InChIKey=IIVOFBAPEBNFQG-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 436829
Affinity DataKd: 0.0270nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
Affinity DataKd: 0.180nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences
US Patent
Treeline Biosciences
US Patent
Affinity DataIC50: 2.60nMAssay Description:Table B1: KRas G12V: Compounds were pre-dispensed via Echo liquid handling (acoustic, touch-free) to generate assay ready plates (ARP). More precisel...More data for this Ligand-Target Pair