BDBM423132 US10500194, Example 21

SMILES CCC(=O)N[C@@H](Cc1nc2ccc(cc2s1)C(C)C)C(=O)N[C@H](CNC(=O)C(=C)CN(C)C)C1CCCCC1

InChI Key InChIKey=HNIUOJXOXQUOMN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 423132   

TargetDCN1-like protein 1(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 423132BDBM423132(US10500194, Example 21)
Affinity DataKi: <1nMAssay Description:Agonist activity at human KOR assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins by cell based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetDCN1-like protein 1(Human)
Henan University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 423132BDBM423132(US10500194, Example 21)
Affinity DataIC50: 150nMAssay Description:The Fluorescence Polarization (FP) competitive binding assays were performed to accurately determine the binding affinities of our DCN1 inhibitors. A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2020
Entry Details
US Patent