BDBM376919 US10329300, Example 13::US11696917, Example 13::US9920060, 13

SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C

InChI Key InChIKey=JCCIICHPRAAMGK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 376919   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 376919BDBM376919(US9920060, 13 | US10329300, Example 13 | US1169691...)
Affinity DataIC50: 13nMAssay Description:For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 376919BDBM376919(US9920060, 13 | US10329300, Example 13 | US1169691...)
Affinity DataIC50: 13nMAssay Description:For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 376919BDBM376919(US9920060, 13 | US10329300, Example 13 | US1169691...)
Affinity DataIC50: 13nMAssay Description:For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 376919BDBM376919(US9920060, 13 | US10329300, Example 13 | US1169691...)
Affinity DataIC50: 16nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cells by whole cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 376919BDBM376919(US9920060, 13 | US10329300, Example 13 | US1169691...)
Affinity DataIC50: 65nMAssay Description:Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed