BDBM368126 3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-aminoethyl)sulfonyl)-2-(2H-tetrazol-5-yl)benzenesulfonamide::US10227331, Example 313

SMILES NCCS(=O)(=O)c1ccc(-c2cccc3sc(N)nc23)c(-c2nn[nH]n2)c1S(N)(=O)=O

InChI Key InChIKey=YUKOXBMPBHMICW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368126   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368126BDBM368126(3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-aminoethyl)s...)
Affinity DataIC50: 0.155nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368126BDBM368126(3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-aminoethyl)s...)
Affinity DataIC50: 0.160nMAssay Description:Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368126BDBM368126(3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-aminoethyl)s...)
Affinity DataIC50: 0.232nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368126BDBM368126(3-(2-aminobenzo[d]thiazol-4-yl)-6-((2-aminoethyl)s...)
Affinity DataIC50: 0.257nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent