BDBM368041 4′-(piperidin-4-yl)-4-(piperidin-4-ylsulfonyl)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 228

SMILES NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1)S(=O)(=O)C1CCNCC1

InChI Key InChIKey=MMQDOCFJJIBSMW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368041   

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368041BDBM368041(US10227331, Example 228 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 0.314nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368041BDBM368041(US10227331, Example 228 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 0.521nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368041BDBM368041(US10227331, Example 228 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 0.985nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368041BDBM368041(US10227331, Example 228 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 0.990nMAssay Description:Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed