BDBM368039 4′-(piperidin-4-yl)-4-(piperidin-4-ylthio)-2-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 226

SMILES NS(=O)(=O)c1c(SC2CCNCC2)ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nnn[nH]1

InChI Key InChIKey=KTLKWWIZCBHJBC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368039   

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck & Co.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 368039BDBM368039(US10227331, Example 226 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck & Co.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 368039BDBM368039(US10227331, Example 226 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 15.1nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368039BDBM368039(US10227331, Example 226 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 35.7nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 368039BDBM368039(US10227331, Example 226 | 4′-(piperidin-4-yl...)
Affinity DataIC50: 48.5nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent