BDBM367819 4-(Azetidin-3-ylsulfonyl)-4′-piperidin-4-yl)-2-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-3-sulfonamide::US10227331, Example 6

SMILES NS(=O)(=O)c1c(ccc(-c2ccc(cc2)C2CCNCC2)c1-c1nn[nH]n1)S(=O)(=O)C1CNC1

InChI Key InChIKey=DZZOFVHNQASPFO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 367819   

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 367819BDBM367819(US10227331, Example 6 | 4-(Azetidin-3-ylsulfonyl)-...)
Affinity DataIC50: 0.195nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 367819BDBM367819(US10227331, Example 6 | 4-(Azetidin-3-ylsulfonyl)-...)
Affinity DataIC50: 0.212nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 367819BDBM367819(US10227331, Example 6 | 4-(Azetidin-3-ylsulfonyl)-...)
Affinity DataIC50: 0.307nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 367819BDBM367819(US10227331, Example 6 | 4-(Azetidin-3-ylsulfonyl)-...)
Affinity DataIC50: 0.310nMAssay Description:Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed