BDBM337760 1-[3-Methyl-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3-[2-methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid::US9751843, 153

SMILES Cc1cc(ccc1N1CCOC1=O)-n1cc(C(O)=O)c(=O)n(Cc2cccc(c2C)C(F)(F)F)c1=O

InChI Key InChIKey=PLJAWCYYGGSYJK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 337760   

TargetChymase(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 337760BDBM337760(1-[3-Methyl-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3...)
Affinity DataIC50: 38nMAssay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

TargetChymase(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 337760BDBM337760(1-[3-Methyl-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl]-3...)
Affinity DataIC50: 98nMAssay Description:Inhibition of human recombinant chymase using Abz-HPFHL-Lys(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed