BDBM310628 US10150762, Example 2/13

SMILES CN(C1CCC1)C(=O)c1nc(sc1-c1ccc(c(Cl)c1Cl)C(O)(C(F)(F)F)C(F)(F)F)C(=O)NCC(C)(C)O

InChI Key InChIKey=OAGAIQVHCFYVBR-UHFFFAOYSA-N

Data  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 310628   

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 310628BDBM310628(US10150762, Example 2/13)
Affinity DataKd:  0.400nMAssay Description:Inverse agonist activity at N-terminal his-tagged wild type human RORgammat LBD domain expressed in Escherichia coli assessed as dissociation constan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 310628BDBM310628(US10150762, Example 2/13)
Affinity DataKd:  0.430nMAssay Description:Project compounds were arranged in a pre-dosed mother plate (Greiner Bio-one) wherein compounds are serially diluted in 100% DMSO by 1:2 from a high ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 310628BDBM310628(US10150762, Example 2/13)
Affinity DataIC50: 9.40nMAssay Description:Inverse agonist activity at human RORgammat by mammalian 1-hybrid assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNuclear receptor ROR-gamma(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 310628BDBM310628(US10150762, Example 2/13)
Affinity DataIC50: 10nMAssay Description:Cells used in this assay were transiently co-transfected with three different plasmids, one expressing the GAL4-DNA binding domain (DBD)-RORγt f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent

TargetNuclear receptor ROR-beta(Human)
Phenex Pharmaceuticals AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 310628BDBM310628(US10150762, Example 2/13)
Affinity DataKd:  2.30E+3nMAssay Description:Inverse agonist activity at human RORbeta assessed as dissociation constant by thermofluor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed