BDBM50635713 Azd-9574::AZD9574::US20250346573, Compound AZD9574

SMILES CNC(=O)c1ccc(N2CCN(Cc3ccc4nc(C)c(=O)[nH]c4c3F)CC2)c(F)n1

InChI Key

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50635713   

TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataKd:  0.540nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 0.602nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 1.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 5nMAssay Description:Displacement of [125I]-glucagon-cex from human glucagon receptor by cell based assay in presence of 0.2% bovine serum albuminMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 5nMAssay Description:Inhibition of PARP1 (unknown origin) expressed in Escherichia coli BL21 incubated for 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataEC50:  153nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataEC50:  297nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Haihe Biopharma Co., Ltd

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 870nMAssay Description:Agonist activity at OX2R (unknown origin) expressed in CHO cells by cell based calcium assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 3.48E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
3/4/2026
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataEC50:  7.26E+3nMAssay Description:Agonist activity at FXR (unknown origin) expressed in human HepG2 cells co-transfected with human RXR assessed as luciferase activity incubated for 2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 9.30E+4nMAssay Description:Inhibition of TEL-fused ALK (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50635713BDBM50635713(Azd-9574 | AZD9574 | US20250346573, Compound AZD95...)
Affinity DataIC50: 6.72E+5nMAssay Description:Inhibition of GSK-3beta (unknown origin) assessed as decrease in tau phosphorylation by high content cell based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed