BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 760K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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15 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Ras inhibition via direct Ras binding--is there a path forward?EBI
Genentech
Synthesis and antitumor activity of new benzoheterocyclic derivatives of distamycin A.EBI
University of Ferrara
Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.EBI
University of Ferrara
 
Synthesis and evaluation of pyrazolo[3,4-b]quinoline ribofuranosides and their derivatives as inhibitors of oncogenic RasEBI
TBA
Peptide inhibitors targeting Ras and Ras-associated protein-protein interactions.EBI
Second Military Medical University
An Improved PDE6D Inhibitor Combines with Sildenafil To Inhibit KRAS Mutant Cancer Cell Growth.EBI
University of Luxembourg
A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives.EBI
China Pharmaceutical University
Targeting mutated GTPase KRAS in tumor therapies.EBI
Sun Yat-Sen University
Zinc enzymes in medicinal chemistry.EBI
Hefei University of Technology
Targeting KRAS mutant cancers by preventing signaling transduction in the MAPK pathway.EBI
Massachusetts College of Pharmacy and Health Sciences University
Fragment-to-Lead Medicinal Chemistry Publications in 2018.EBI
Frontier Medicines
C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice.EBI
Warner-Lambert
Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.EBI
Harbor Branch Oceanographic Institution
Benzothiophene derivative regulator, preparation method therefor and use thereofBDB
Shanghai Hansoh Biomedical
RET inhibitors, pharmaceutical compositions and uses thereofBDB
Sunshine Lake Pharma