BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 760K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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18 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.EBI
Columbia University
MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products.EBI
Dupont Pharmaceuticals
Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma.EBI
Knight Cancer Institute
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.EBI
The Scripps Research Institute
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.EBI
New York University Medical Center
A review: FDA-approved fluorine-containing small molecules from 2015 to 2022.EBI
Iran University of Medical Sciences
Kinase Inhibitors as Underexplored Antiviral Agents.EBI
Complutense University of Madrid
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.EBI
National Research Centre
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.EBI
TBA
Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor.EBI
Merck Research Laboratories
Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.EBI
Research Biomet. Glaxo Wellcome Medicines Research Centre
Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.EBI
Merck
Towards the development of chromone-based MEK1/2 modulators.EBI
University of Gothenburg
Fused thiophene derivatives as MEK inhibitors.EBI
Ucb Pharma
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.EBI
University of Auckland
Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAFEBI
Nanjing University
Therapeutic compounds and compositionsBDB
Exithera Pharmaceuticals