BindingDB

The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 3.2M data for 1.4M Compounds and 11.5K Targets. Of those, 1.6M data for 760K Compounds and 4.8K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

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16 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.EBI
Genentech
Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors.EBI
Ludwig-Maximilians-Universit£T M£Nchen
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.EBI
AbbVie
Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template.EBI
Medical University of Warsaw
Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma.EBI
Fudan University
From Hit Seeking to Magic Bullets: The Successful Union of Epigenetic and Fragment Based Drug Discovery (EPIDD + FBDD).EBI
University of S£O Paulo
Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.EBI
Glaxosmithkline
Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2.EBI
Peking University Shenzhen Graduate School
Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism.EBI
Sichuan University
Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications.EBI
China Pharmaceutical University
Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening.EBI
Chinese Academy of Sciences
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors.EBI
Chinese Academy of Sciences
Theoretical research in structure characteristics of different inhibitors and differences of binding modes with CBP bromodomain.EBI
Jilin University
Design and synthesis of a biaryl series as inhibitors for the bromodomains of CBP/P300.EBI
Wuxi Apptec
Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.EBI
Abbvie
A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors.EBI
Genentech