Compile Data Set for Download or QSAR
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TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025834BDBM50025834(CHEMBL3330880)
Affinity DataKd:  0.380nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50025847BDBM50025847(CHEMBL3330879)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to SUR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50118351BDBM50118351(6-chloro-3-(1-methylcyclobutyl)-amino-4H-thieno[3,...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50012957BDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50153520BDBM50153520(CHEMBL1272 | AGEE-623ZW | 2-Ethoxy-4-{[(S)-3-methy...)
Affinity DataKd:  50nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50139706BDBM50139706(3-(2,4-Dinitro-phenyl)-4-nitro-5-trifluoromethyl-1...)
Affinity DataEC50:  70nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50378565BDBM50378565(CHEMBL568795)
Affinity DataEC50:  80nMAssay Description:Activation of human recombinant SUR1/Kir6.2 channel expressed in HEK293 cells assessed as increase in ionic current by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50190500BDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataIC50: 81nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50153521BDBM50153521(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)
Affinity DataKd:  83nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614577BDBM50614577(CHEMBL5285443)
Affinity DataEC50:  100nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50153520BDBM50153520(CHEMBL1272 | AGEE-623ZW | 2-Ethoxy-4-{[(S)-3-methy...)
Affinity DataIC50: 106nMAssay Description:In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 50118349BDBM50118349((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50: 120nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50153522BDBM50153522(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)
Affinity DataKd:  134nMAssay Description:Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50190502BDBM50190502(6-bromo-3-(1-methylcyclopropyl)amino-4H-thieno[3,2...)
Affinity DataEC50:  160nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50153521BDBM50153521(2-Methoxy-4-{[(S)-3-methyl-1-(2-piperidin-1-yl-phe...)
Affinity DataIC50: 163nMAssay Description:In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50118348BDBM50118348((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50: 180nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50190500BDBM50190500(6-chloro-3-(1-methyl-1-phenylethyl)amino-4H-thieno...)
Affinity DataEC50:  180nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50118359BDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50118359BDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50119272BDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  196nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50119272BDBM50119272((7-Chloro-1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1...)
Affinity DataEC50:  200nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50118360BDBM50118360(tert-Butyl-(2-chloro-7,7-dioxo-4,7-dihydro-1,7lamb...)
Affinity DataIC50: 230nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614548BDBM50614548(CHEMBL5273275)
Affinity DataEC50:  250nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50130735BDBM50130735((7-chloro-1,1-dioxo-1,4-dihydro-benzo[1,2,4]thiadi...)
Affinity DataEC50:  250nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetATP-binding cassette sub-family C member 8(Human)
Universidade Federal De Santa Catarina

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50153522BDBM50153522(2-(2-Fluoro-ethoxy)-4-{[(S)-3-methyl-1-(2-piperidi...)
Affinity DataIC50: 281nMAssay Description:In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50118359BDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50: 286nMAssay Description:Displacement of [3H]glibenclamide from human Kir6.2/SUR1 expressed in HEK293 cells in presence of 2 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614570BDBM50614570(CHEMBL5267062)
Affinity DataEC50:  310nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50118359BDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataIC50: 320nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50118343BDBM50118343((2-Chloro-7,7-dioxo-4,7-dihydro-1,7lambda*6*-dithi...)
Affinity DataIC50: 340nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50119269BDBM50119269(Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-dihydro-1lambda...)
Affinity DataEC50:  356nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50119269BDBM50119269(Cyclobutyl-(7-fluoro-1,1-dioxo-1,4-dihydro-1lambda...)
Affinity DataEC50:  400nMAssay Description:Negative log EC50 for Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50118359BDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  450nMAssay Description:Activation of human Kir6.2/SUR1 channel outward current expressed in HEK293 cells at -70 mV holding potential by EPC9 patch-clamp amplifier based ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50118359BDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  450nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614547BDBM50614547(CHEMBL5273292)
Affinity DataEC50:  460nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50119274BDBM50119274(Cyclobutyl-(7-nitro-1,1-dioxo-1,4-dihydro-1lambda*...)
Affinity DataEC50:  530nMAssay Description:Inhibition of Beta-cell KATP channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50190501BDBM50190501(6-chloro-3-{[1-(trifluoromethyl)cyclopropyl]-amino...)
Affinity DataEC50:  530nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614559BDBM50614559(CHEMBL5291259)
Affinity DataEC50:  530nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50139709BDBM50139709(3-(2,4-Bis-trifluoromethyl-phenyl)-4-nitro-5-trifl...)
Affinity DataEC50:  540nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614565BDBM50614565(CHEMBL5291159)
Affinity DataEC50:  550nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614568BDBM50614568(CHEMBL5270996)
Affinity DataEC50:  560nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614571BDBM50614571(CHEMBL5270814)
Affinity DataEC50:  570nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50023475BDBM50023475(CHEMBL2111887)
Affinity DataIC50: 640nMAssay Description:Inhibition of [3H]glibenclamide binding to HEK293 cells co-expressing human Sulfonylurea receptor SUR1 and Inward rectifier K+ channel Kir6.2 at high...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614549BDBM50614549(CHEMBL5286136)
Affinity DataEC50:  660nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50139705BDBM50139705(4-Nitro-3-(4-nitro-phenyl)-5-trifluoromethyl-1H-py...)
Affinity DataEC50:  700nMAssay Description:Maximum activation of human KATP (SUR1/Kir6.2) channel expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614561BDBM50614561(CHEMBL5269505)
Affinity DataEC50:  710nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614560BDBM50614560(CHEMBL5280182)
Affinity DataEC50:  710nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50118359BDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  750nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614550BDBM50614550(CHEMBL5283421)
Affinity DataEC50:  780nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50190496BDBM50190496(6-chloro-3-(1-phenylcyclopropyl)amino-4H-thieno[3,...)
Affinity DataEC50:  810nMAssay Description:Repolarization of HEK293 cells expressing Kir6.2/SUR1 KATP channelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSulfonylurea receptor 1, Kir6.2(Human)
Vanderbilt University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614564BDBM50614564(CHEMBL5285592)
Affinity DataEC50:  880nMAssay Description:Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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