Compile Data Set for Download or QSAR
Report error Found 582 for UniProtKB: D2K2A8
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485492BDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of Hepatitis C virus NS3-4A protease genotype 1aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485492BDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of Hepatitis C virus NS3-4A protease genotype 1bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110121BDBM50110121(AcAsp-Glu-Dif-Glu-Cha-Fab | 3-[2-(2-{2-[2-(2-Acety...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110121BDBM50110121(AcAsp-Glu-Dif-Glu-Cha-Fab | 3-[2-(2-{2-[2-(2-Acety...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461540BDBM50461540(CHEMBL4226033)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573891BDBM50573891(Glecaprevir | A-1282576 | A-1282576.0 | A-12825760...)
Affinity DataKi:  0.0500nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485492BDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of Hepatitis C virus NS3-4A protease genotype 2aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485492BDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of Hepatitis C virus NS3-4A protease genotype 2bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461545BDBM50461545(CHEMBL4226876)
Affinity DataIC50: 0.190nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485492BDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573903BDBM50573903(CHEMBL4852970)
Affinity DataKi:  0.200nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50495950BDBM50495950(Danoprevir | R-05190591 | R05190591 | RO-5190591 |...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HCV NS3/4a protease using Ac-DE-Dap(QXL520)-EE-Abu-shi-[COO]AS-C(5-FAMsp)-NH2 as substrate after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458698BDBM50458698(CHEMBL4203709)
Affinity DataKi:  0.200nMAssay Description:Inhibition of wild type HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) using Ac-DE-Dap(QXL 520)-EE-Abu-psi-[COO]AS-C(5-FAMsp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461549BDBM50461549(CHEMBL4225009)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461552BDBM50461552(CHEMBL4228791)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461537BDBM50461537(CHEMBL4228440)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461556BDBM50461556(CHEMBL4225149)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461547BDBM50461547(CHEMBL4225051)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573887BDBM50573887(CHEMBL4879085)
Affinity DataKi:  0.300nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461555BDBM50461555(CHEMBL4225768)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461554BDBM50461554(CHEMBL4225514)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461539BDBM50461539(CHEMBL4229110)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461551BDBM50461551(CHEMBL4229052)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110117BDBM50110117(4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{3...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573891BDBM50573891(Glecaprevir | A-1282576 | A-1282576.0 | A-12825760...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HCV GT-3a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573886BDBM50573886(CHEMBL4848452)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110117BDBM50110117(4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{3...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573919BDBM50573919(CHEMBL4854503)
Affinity DataKi:  0.600nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573914BDBM50573914(CHEMBL4875061)
Affinity DataKi:  0.700nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573915BDBM50573915(CHEMBL4864092)
Affinity DataKi:  0.700nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461542BDBM50461542(CHEMBL4224705)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458698BDBM50458698(CHEMBL4203709)
Affinity DataKi:  0.800nMAssay Description:Inhibition of HCV genotype 1a NS3/4A protease R155K mutant expressed in Escherichia coli BL21(DE3) using Ac-DE-Dap(QXL 520)-EE-Abu-psi-[COO]AS-C(5-FA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461541BDBM50461541(CHEMBL4225301)
Affinity DataIC50: 0.820nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461564BDBM50461564(CHEMBL4228533)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573881BDBM50573881(CHEMBL4848772)
Affinity DataKi:  0.900nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573902BDBM50573902(CHEMBL4860811)
Affinity DataKi:  0.900nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573884BDBM50573884(CHEMBL4863541)
Affinity DataKi:  0.900nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50485492BDBM50485492(Grazoprevir | Grazoprevir monohydrate | MK-5172 | ...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of Hepatitis C virus NS3-4A protease genotype 3aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50287622BDBM50287622(CHEMBL4160876)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50287594BDBM50287594(Asunaprevir | BMS 650032 | BMS-650032)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50287594BDBM50287594(Asunaprevir | BMS 650032 | BMS-650032)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant full length HCV genotype 1a NS3/4A protease (1027 to 1711 residues) expressed in Escherichia coli strain BL21 (DE3) using R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573880BDBM50573880(CHEMBL4847539)
Affinity DataKi:  1.10nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573883BDBM50573883(CHEMBL4863232)
Affinity DataKi:  1.10nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50461562BDBM50461562(CHEMBL4227396)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal poly-His tagged recombinant HCV genotype 1a NS3/4A protease expressed in Escherichia coli BL21(DE3) pLysS using HCV-FRET pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573916BDBM50573916(CHEMBL4846475)
Affinity DataKi:  1.30nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573888BDBM50573888(CHEMBL4849669)
Affinity DataKi:  1.30nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573917BDBM50573917(CHEMBL4863621)
Affinity DataKi:  1.40nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573913BDBM50573913(CHEMBL4876997)
Affinity DataKi:  1.5nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50573890BDBM50573890(CHEMBL4856675)
Affinity DataKi:  1.5nMAssay Description:Inhibition of HCV GT-1a NS3/4a protease using Ac-DE-D(Edans)-EE-Abu-c-[COO]-AS-K(Dabcy1)-NH2 preincubated for 1 hr followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Children's Hospital Affiliated to Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110122BDBM50110122((S)-4-((S)-2-Acetylamino-3-carboxy-propionylamino)...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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