BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 1541461 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H66N8O8/c1-9-57-41-15-14-32-24-37(41)38(45(57)36-12-10-17-52-43(36)30(4)65-8)25-50(5,6)28-66-49(64)39-13-11-18-58(54-39)48(63)40(22-31-20-34(32)23-35(59)21-31)53-46(61)44(29(2)3)55(7)47(62)33-16-19-56(27-33)42(60)26-51/h10,12,14-15,17,20-21,23-24,29-30,33,39-40,44,54,59H,9,11,13,16,18-19,22,25-28,51H2,1-8H3,(H,53,61) LFTJRHMTGVMUQF-UHFFFAOYSA-N 750606 US20250195521, Example A1 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750606&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159542736 519649200 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541462 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O7/c1-8-53-40-12-11-30-22-35(40)36(42(53)37-25-49-16-14-32(37)26-60-7)23-47(4,5)27-61-46(59)38-10-9-17-54(51-38)45(58)39(20-29-18-33(30)21-34(55)19-29)50-43(56)41(28(2)3)52(6)44(57)31-13-15-48-24-31/h11-12,14,16,18-19,21-22,25,28,31,38-39,41,48,51,55H,8-10,13,15,17,20,23-24,26-27H2,1-7H3,(H,50,56) HHRQGUIULJRDMP-UHFFFAOYSA-N 750607 US20250195521, Example A10 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750607&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156351482 519649201 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541463 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-10-55-41-16-15-32-25-37(41)38(44(55)36-13-11-18-50-42(36)30(4)62-9)26-49(5,6)28-63-48(61)39-14-12-19-56(52-39)47(60)40(23-31-21-34(32)24-35(57)22-31)51-45(58)43(29(2)3)54(8)46(59)33-17-20-53(7)27-33/h11,13,15-16,18,21-22,24-25,29-30,33,39-40,43,52,57H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,51,58) OMGVHORHGHWUNJ-UHFFFAOYSA-N 750608 US20250195521, Example A100 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750608&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346866 519649202 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541464 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OC1CN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O8/c1-9-53-40-13-12-30-21-35(40)36(42(53)37-23-48-15-14-31(37)26-60-8)22-47(4,5)27-61-45(58)38-11-10-16-54(50-38)44(57)39(19-29-17-32(30)20-33(55)18-29)49-43(56)41(28(2)3)52(7)46(59)62-34-24-51(6)25-34/h12-15,17-18,20-21,23,28,34,38-39,41,50,55H,9-11,16,19,22,24-27H2,1-8H3,(H,49,56) JXAVAEMSDCMUCT-UHFFFAOYSA-N 750609 US20250195521, Example A101 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750609 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750609&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346880 519649203 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541465 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N1COCC1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H54N6O8/c1-7-48-37-11-10-28-19-32(37)33(40(48)34-21-45-13-12-29(34)22-56-6)20-44(4,5)24-58-43(55)35-9-8-14-50(47-35)42(54)36(17-27-15-30(28)18-31(51)16-27)46-41(53)39(26(2)3)49-25-57-23-38(49)52/h10-13,15-16,18-19,21,26,35-36,39,47,51H,7-9,14,17,20,22-25H2,1-6H3,(H,46,53) FEWQOPBSFYDYFW-UHFFFAOYSA-N 750610 US20250195521, Example A102 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750610 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750610&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347694 519649204 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541466 CO[C@@H](C)c1ncccc1-c1c2c3cc(ccc3n1C)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H53N7O6S/c1-23(2)36(46(7)25(4)49)38(50)44-31-19-34-43-32(21-55-34)26-14-15-33-28(18-26)29(37(47(33)8)27-12-10-16-42-35(27)24(3)53-9)20-41(5,6)22-54-40(52)30-13-11-17-48(45-30)39(31)51/h10,12,14-16,18,21,23-24,30-31,36,45H,11,13,17,19-20,22H2,1-9H3,(H,44,50) SOCFNTVASQPRDU-UHFFFAOYSA-N 750611 US20250195521, Example A103 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750611 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750611&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160889663 519649205 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541467 CO[C@@H](C)c1ncccc1-c1c2c3cc(ccc3n1C)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O7/c1-25(2)39(48(7)27(4)51)41(53)46-36-20-28-18-30(21-31(52)19-28)29-14-15-37-33(22-29)34(40(49(37)8)32-12-10-16-45-38(32)26(3)56-9)23-44(5,6)24-57-43(55)35-13-11-17-50(47-35)42(36)54/h10,12,14-16,18-19,21-22,25-26,35-36,39,47,52H,11,13,17,20,23-24H2,1-9H3,(H,46,53) DMANJOXRZUYVJG-UHFFFAOYSA-N 750612 US20250195521, Example A104 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750612&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346854 519649206 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541468 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H66N8O7/c1-9-57-41-18-17-34-25-37(41)38(45(57)36-15-11-20-52-43(36)31(4)64-8)26-50(5,6)29-65-49(63)39-16-12-21-58(54-39)48(62)40(24-32-13-10-14-33(34)23-32)53-46(60)44(30(2)3)55(7)47(61)35-19-22-56(28-35)42(59)27-51/h10-11,13-15,17-18,20,23,25,30-31,35,39-40,44,54H,9,12,16,19,21-22,24,26-29,51H2,1-8H3,(H,53,60) RANHISRRZCPCMK-UHFFFAOYSA-N 750613 US20250195521, Example A105 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750613 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750613&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347460 519649207 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541469 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O7S/c1-9-55-37-15-14-29-20-32(37)33(42(55)31-12-10-17-49-40(31)28(4)62-8)22-47(5,6)26-63-46(61)34-13-11-18-56(52-34)45(60)35(21-38-50-36(29)25-64-38)51-43(58)41(27(2)3)53(7)44(59)30-16-19-54(24-30)39(57)23-48/h10,12,14-15,17,20,25,27-28,30,34-35,41,52H,9,11,13,16,18-19,21-24,26,48H2,1-8H3,(H,51,58) UJUGNDPMZXQKRW-UHFFFAOYSA-N 750614 US20250195521, Example A106 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750614&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161111845 519649208 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541470 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O6/c1-10-55-41-19-18-34-26-37(41)38(44(55)36-16-12-21-50-42(36)31(4)61-9)27-49(5,6)29-62-48(60)39-17-13-22-56(52-39)47(59)40(25-32-14-11-15-33(34)24-32)51-45(57)43(30(2)3)54(8)46(58)35-20-23-53(7)28-35/h11-12,14-16,18-19,21,24,26,30-31,35,39-40,43,52H,10,13,17,20,22-23,25,27-29H2,1-9H3,(H,51,57) DWHWRHDFORZSCN-UHFFFAOYSA-N 750615 US20250195521, Example A107 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750615&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347706 519649209 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541471 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O6S/c1-10-53-37-16-15-29-21-32(37)33(41(53)31-13-11-18-47-39(31)28(4)59-9)23-46(5,6)26-60-45(58)34-14-12-19-54(50-34)44(57)35(22-38-48-36(29)25-61-38)49-42(55)40(27(2)3)52(8)43(56)30-17-20-51(7)24-30/h11,13,15-16,18,21,25,27-28,30,34-35,40,50H,10,12,14,17,19-20,22-24,26H2,1-9H3,(H,49,55) AFFYNHDEQKZFPW-UHFFFAOYSA-N 750616 US20250195521, Example A108 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750616&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157096264 519649210 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541472 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(CCO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O7/c1-9-56-42-18-17-35-27-38(42)39(45(56)37-15-11-20-51-43(37)32(4)63-8)28-50(5,6)30-64-49(62)40-16-12-21-57(53-40)48(61)41(26-33-13-10-14-34(35)25-33)52-46(59)44(31(2)3)54(7)47(60)36-19-22-55(29-36)23-24-58/h10-11,13-15,17-18,20,25,27,31-32,36,40-41,44,53,58H,9,12,16,19,21-24,26,28-30H2,1-8H3,(H,52,59) ZIUYNIRSAZXEIL-UHFFFAOYSA-N 750617 US20250195521, Example A109 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750617&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348126 519649211 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541473 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O9/c1-9-55-41-13-12-31-23-36(41)37(43(55)38-25-50-16-14-33(38)27-63-7)24-49(4,5)28-65-47(61)39-11-10-17-56(52-39)46(60)40(21-30-19-34(31)22-35(57)20-30)51-44(58)42(29(2)3)53(6)45(59)32-15-18-54(26-32)48(62)64-8/h12-14,16,19-20,22-23,25,29,32,39-40,42,52,57H,9-11,15,17-18,21,24,26-28H2,1-8H3,(H,51,58) IVZOHOFFDWRRAR-UHFFFAOYSA-N 750618 US20250195521, Example A11 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750618 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750618&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347954 519649212 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541474 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(CCO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-9-54-38-15-14-30-22-33(38)34(42(54)32-12-10-17-48-40(32)29(4)61-8)24-47(5,6)27-62-46(60)35-13-11-18-55(51-35)45(59)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)52(7)44(58)31-16-19-53(25-31)20-21-56/h10,12,14-15,17,22,26,28-29,31,35-36,41,51,56H,9,11,13,16,18-21,23-25,27H2,1-8H3,(H,50,57) CWJBHVICIYVWKO-UHFFFAOYSA-N 750619 US20250195521, Example A110 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750619&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157711396 519649213 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541475 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(CCO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O8/c1-9-56-42-15-14-33-26-38(42)39(45(56)37-12-10-17-51-43(37)31(4)64-8)27-50(5,6)29-65-49(63)40-13-11-18-57(53-40)48(62)41(24-32-22-35(33)25-36(59)23-32)52-46(60)44(30(2)3)54(7)47(61)34-16-19-55(28-34)20-21-58/h10,12,14-15,17,22-23,25-26,30-31,34,40-41,44,53,58-59H,9,11,13,16,18-21,24,27-29H2,1-8H3,(H,52,60) USECLSMLGXJWAO-UHFFFAOYSA-N 750620 US20250195521, Example A111 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750620 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750620&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347690 519649214 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541476 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C(C)(C)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H74N8O7/c1-13-61-44-22-21-37-29-40(44)41(47(61)39-19-15-24-55-45(39)34(4)68-12)30-53(5,6)32-69-51(66)42-20-16-25-62(57-42)50(65)43(28-35-17-14-18-36(37)27-35)56-48(63)46(33(2)3)59(11)49(64)38-23-26-60(31-38)52(67)54(7,8)58(9)10/h14-15,17-19,21-22,24,27,29,33-34,38,42-43,46,57H,13,16,20,23,25-26,28,30-32H2,1-12H3,(H,56,63) FIOHNBDRWSNGDM-UHFFFAOYSA-N 750621 US20250195521, Example A112 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750621&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346515 519649215 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541477 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C(C)(C)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H71N9O7S/c1-13-59-40-19-18-32-24-35(40)36(44(59)34-16-14-21-52-42(34)31(4)66-12)26-50(5,6)29-67-48(64)37-17-15-22-60(55-37)47(63)38(25-41-53-39(32)28-68-41)54-45(61)43(30(2)3)57(11)46(62)33-20-23-58(27-33)49(65)51(7,8)56(9)10/h14,16,18-19,21,24,28,30-31,33,37-38,43,55H,13,15,17,20,22-23,25-27,29H2,1-12H3,(H,54,61) PLDSJPXANMPINF-UHFFFAOYSA-N 750622 US20250195521, Example A113 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750622 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750622&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160237111 519649216 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541478 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C(C)(C)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H74N8O8/c1-13-61-44-19-18-35-28-40(44)41(47(61)39-16-14-21-55-45(39)33(4)69-12)29-53(5,6)31-70-51(67)42-17-15-22-62(57-42)50(66)43(26-34-24-37(35)27-38(63)25-34)56-48(64)46(32(2)3)59(11)49(65)36-20-23-60(30-36)52(68)54(7,8)58(9)10/h14,16,18-19,21,24-25,27-28,32-33,36,42-43,46,57,63H,13,15,17,20,22-23,26,29-31H2,1-12H3,(H,56,64) PQFCCNDRLRTAGA-UHFFFAOYSA-N 750623 US20250195521, Example A114 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750623 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750623&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347048 519649217 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541479 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O8/c1-10-56-41-19-18-34-26-37(41)38(44(56)36-16-12-21-51-42(36)31(4)63-8)27-50(5,6)29-65-48(61)39-17-13-22-57(53-39)47(60)40(25-32-14-11-15-33(34)24-32)52-45(58)43(30(2)3)54(7)46(59)35-20-23-55(28-35)49(62)64-9/h11-12,14-16,18-19,21,24,26,30-31,35,39-40,43,53H,10,13,17,20,22-23,25,27-29H2,1-9H3,(H,52,58) HWYICWQWRMVPNO-UHFFFAOYSA-N 750624 US20250195521, Example A115 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750624 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750624&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346933 519649218 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541480 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O8S/c1-10-54-37-16-15-29-21-32(37)33(41(54)31-13-11-18-48-39(31)28(4)61-8)23-47(5,6)26-63-45(59)34-14-12-19-55(51-34)44(58)35(22-38-49-36(29)25-64-38)50-42(56)40(27(2)3)52(7)43(57)30-17-20-53(24-30)46(60)62-9/h11,13,15-16,18,21,25,27-28,30,34-35,40,51H,10,12,14,17,19-20,22-24,26H2,1-9H3,(H,50,56) PACGHYPYQDMPDO-UHFFFAOYSA-N 750625 US20250195521, Example A116 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750625 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750625&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160147441 519649219 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541481 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H69N7O9/c1-11-58-43-17-16-34-26-39(43)40(46(58)38-14-12-19-53-44(38)32(6)66-10)27-52(7,8)29-67-50(64)41-15-13-20-59(55-41)49(63)42(24-33-22-36(34)25-37(60)23-33)54-47(61)45(30(2)3)56(9)48(62)35-18-21-57(28-35)51(65)68-31(4)5/h12,14,16-17,19,22-23,25-26,30-32,35,41-42,45,55,60H,11,13,15,18,20-21,24,27-29H2,1-10H3,(H,54,61) DEQQQNMNEMLOLC-UHFFFAOYSA-N 750626 US20250195521, Example A117 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750626 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750626&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347718 519649220 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541482 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O6S/c1-9-52-36-15-14-28-20-31(36)32(40(52)30-12-10-17-47-38(30)27(4)58-8)22-45(5,6)25-59-44(57)33-13-11-19-53(50-33)43(56)34(21-37-48-35(28)24-60-37)49-41(54)39(26(2)3)51(7)42(55)29-16-18-46-23-29/h10,12,14-15,17,20,24,26-27,29,33-34,39,46,50H,9,11,13,16,18-19,21-23,25H2,1-8H3,(H,49,54) ZIAOMGQRXBJTKS-UHFFFAOYSA-N 750627 US20250195521, Example A118 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750627 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750627&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162126018 519649221 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541483 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O6/c1-9-54-40-18-17-33-25-36(40)37(43(54)35-15-11-20-50-41(35)30(4)60-8)26-48(5,6)28-61-47(59)38-16-12-22-55(52-38)46(58)39(24-31-13-10-14-32(33)23-31)51-44(56)42(29(2)3)53(7)45(57)34-19-21-49-27-34/h10-11,13-15,17-18,20,23,25,29-30,34,38-39,42,49,52H,9,12,16,19,21-22,24,26-28H2,1-8H3,(H,51,56) XVEHDTJRLJVFBZ-UHFFFAOYSA-N 750628 US20250195521, Example A119 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750628 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750628&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156335229 519649222 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541484 CCc1ncccc1-c1c2c3cc(ccc3n1CC)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H64N8O7/c1-8-38-35(12-10-17-51-38)44-37-25-49(5,6)28-64-48(63)39-13-11-18-57(53-39)47(62)40(22-30-20-33(23-34(58)21-30)31-14-15-41(36(37)24-31)56(44)9-2)52-45(60)43(29(3)4)54(7)46(61)32-16-19-55(27-32)42(59)26-50/h10,12,14-15,17,20-21,23-24,29,32,39-40,43,53,58H,8-9,11,13,16,18-19,22,25-28,50H2,1-7H3,(H,52,60) MPQPBVAUOUQNQT-UHFFFAOYSA-N 750629 US20250195521, Example A12 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750629 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750629&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160703407 519649223 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541485 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CNC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H68N8O8/c1-10-58-42-16-15-33-25-38(42)39(46(58)37-13-11-18-53-44(37)31(4)66-9)26-51(5,6)29-67-50(65)40-14-12-19-59(55-40)49(64)41(23-32-21-35(33)24-36(60)22-32)54-47(62)45(30(2)3)56(8)48(63)34-17-20-57(28-34)43(61)27-52-7/h11,13,15-16,18,21-22,24-25,30-31,34,40-41,45,52,55,60H,10,12,14,17,19-20,23,26-29H2,1-9H3,(H,54,62) WFEAUSNZCCUNJH-UHFFFAOYSA-N 750630 US20250195521, Example A120 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750630 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750630&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161487540 519649224 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541486 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@@H](O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O8/c1-9-53-40-15-14-30-24-36(40)37(43(53)35-12-10-16-49-41(35)28(4)61-8)25-48(5,6)26-62-47(60)38-13-11-17-54(51-38)46(59)39(20-29-18-31(30)21-33(55)19-29)50-44(57)42(27(2)3)52(7)45(58)32-22-34(56)23-32/h10,12,14-16,18-19,21,24,27-28,32,34,38-39,42,51,55-56H,9,11,13,17,20,22-23,25-26H2,1-8H3,(H,50,57) LVOOVEJGEUIQEN-UHFFFAOYSA-N 750631 US20250195521, Example A121 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750631 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750631&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346522 519649225 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541487 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCNCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-9-55-41-15-14-33-26-37(41)38(44(55)36-12-10-18-51-42(36)30(4)62-8)27-49(5,6)28-63-48(61)39-13-11-21-56(53-39)47(60)40(24-31-22-34(33)25-35(57)23-31)52-45(58)43(29(2)3)54(7)46(59)32-16-19-50-20-17-32/h10,12,14-15,18,22-23,25-26,29-30,32,39-40,43,50,53,57H,9,11,13,16-17,19-21,24,27-28H2,1-8H3,(H,52,58) ABBRIQIIQFEFPB-UHFFFAOYSA-N 750632 US20250195521, Example A122 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750632 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750632&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347686 519649226 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541488 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCN3CCOCC13)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O8/c1-9-57-42-15-14-33-26-38(42)39(46(57)37-12-10-17-52-44(37)31(4)64-8)27-51(5,6)29-66-50(63)40-13-11-18-58(54-40)49(62)41(24-32-22-34(33)25-35(59)23-32)53-47(60)45(30(2)3)55(7)48(61)36-16-19-56-20-21-65-28-43(36)56/h10,12,14-15,17,22-23,25-26,30-31,36,40-41,43,45,54,59H,9,11,13,16,18-21,24,27-29H2,1-8H3,(H,53,60) KTCVOAPVYWQDDU-UHFFFAOYSA-N 750633 US20250195521, Example A123 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750633 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750633&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348141 519649227 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541489 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-10-54-40-16-15-31-23-36(40)37(43(54)35-13-11-17-49-41(35)29(4)61-9)24-48(5,6)27-62-47(60)38-14-12-18-55(51-38)46(59)39(21-30-19-32(31)22-34(56)20-30)50-44(57)42(28(2)3)53(8)45(58)33-25-52(7)26-33/h11,13,15-17,19-20,22-23,28-29,33,38-39,42,51,56H,10,12,14,18,21,24-27H2,1-9H3,(H,50,57) MYSSDFGXHXOIOI-UHFFFAOYSA-N 750634 US20250195521, Example A124 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750634 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750634&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347715 519649228 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541490 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O7/c1-9-53-39-15-14-30-22-35(39)36(42(53)34-12-10-16-49-40(34)28(4)60-8)23-47(5,6)26-61-46(59)37-13-11-17-54(51-37)45(58)38(20-29-18-31(30)21-33(55)19-29)50-43(56)41(27(2)3)52(7)44(57)32-24-48-25-32/h10,12,14-16,18-19,21-22,27-28,32,37-38,41,48,51,55H,9,11,13,17,20,23-26H2,1-8H3,(H,50,56) OIMONTCHQPULIM-UHFFFAOYSA-N 750635 US20250195521, Example A125 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750635 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750635&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160003681 519649229 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541491 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)Cc1cc[nH]n1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H60N8O7/c1-9-55-40-15-14-31-24-36(40)37(44(55)35-12-10-17-49-42(35)29(4)62-8)26-48(5,6)27-63-47(61)38-13-11-19-56(53-38)46(60)39(22-30-20-32(31)23-34(57)21-30)51-45(59)43(28(2)3)54(7)41(58)25-33-16-18-50-52-33/h10,12,14-18,20-21,23-24,28-29,38-39,43,53,57H,9,11,13,19,22,25-27H2,1-8H3,(H,50,52)(H,51,59) XQLVUNGBPNGTJS-UHFFFAOYSA-N 750636 US20250195521, Example A126 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750636 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750636&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346525 519649230 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541492 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-10-55-41-16-15-32-25-37(41)38(44(55)36-13-11-18-51-42(36)30(5)62-9)26-49(6,7)27-63-48(61)39-14-12-20-56(53-39)47(60)40(23-31-21-33(32)24-34(57)22-31)52-45(58)43(28(2)3)54(8)46(59)35-17-19-50-29(35)4/h11,13,15-16,18,21-22,24-25,28-30,35,39-40,43,50,53,57H,10,12,14,17,19-20,23,26-27H2,1-9H3,(H,52,58) IYCYVNITARFJAI-UHFFFAOYSA-N 750637 US20250195521, Example A127 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750637 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750637&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346549 519649231 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541493 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CNC[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-10-55-41-16-15-32-23-36(41)37(44(55)35-13-11-17-51-42(35)30(5)62-9)24-49(6,7)27-63-48(61)39-14-12-18-56(53-39)47(60)40(21-31-19-33(32)22-34(57)20-31)52-45(58)43(28(2)3)54(8)46(59)38-26-50-25-29(38)4/h11,13,15-17,19-20,22-23,28-30,38-40,43,50,53,57H,10,12,14,18,21,24-27H2,1-9H3,(H,52,58) PYVHHWZKJRKTFD-UHFFFAOYSA-N 750638 US20250195521, Example A128 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750638 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750638&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160348037 519649232 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541494 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-9-54-40-15-14-31-24-36(40)37(43(54)35-12-10-17-50-41(35)29(4)61-8)25-48(5,6)27-62-47(60)38-13-11-19-55(52-38)46(59)39(22-30-20-33(31)23-34(56)21-30)51-44(57)42(28(2)3)53(7)45(58)32-16-18-49-26-32/h10,12,14-15,17,20-21,23-24,28-29,32,38-39,42,49,52,56H,9,11,13,16,18-19,22,25-27H2,1-8H3,(H,51,57) WPNIAWVWAWKIGS-UHFFFAOYSA-N 750639 US20250195521, Example A129 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750639 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750639&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161570174 519649233 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541495 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(S(=O)(=O)CC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O9S/c1-10-56-42-17-16-33-26-38(42)39(45(56)37-14-12-19-51-43(37)31(5)65-9)27-50(6,7)29-66-49(62)40-15-13-20-57(53-40)48(61)41(24-32-22-35(33)25-36(58)23-32)52-46(59)44(30(3)4)54(8)47(60)34-18-21-55(28-34)67(63,64)11-2/h12,14,16-17,19,22-23,25-26,30-31,34,40-41,44,53,58H,10-11,13,15,18,20-21,24,27-29H2,1-9H3,(H,52,59) MBCXKPUTHANPLV-UHFFFAOYSA-N 750640 US20250195521, Example A13 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750640 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750640&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158542692 519649234 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541496 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC3CCCCN3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H69N7O7/c1-9-58-44-18-17-34-27-40(44)41(47(58)39-15-12-19-53-45(39)32(4)65-8)28-52(5,6)30-66-51(64)42-16-13-21-59(55-42)50(63)43(24-33-22-35(34)26-38(60)23-33)54-48(61)46(31(2)3)56(7)49(62)36-25-37-14-10-11-20-57(37)29-36/h12,15,17-19,22-23,26-27,31-32,36-37,42-43,46,55,60H,9-11,13-14,16,20-21,24-25,28-30H2,1-8H3,(H,54,61) FMEQRSLJQAVDJH-UHFFFAOYSA-N 750641 US20250195521, Example A130 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750641 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750641&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347732 519649235 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541497 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCC[C@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-9-55-41-18-17-31-25-36(41)37(44(55)35-14-11-19-51-42(35)29(4)62-8)26-49(5,6)27-63-48(61)39-16-12-20-56(53-39)47(60)40(23-30-21-32(31)24-33(57)22-30)52-45(58)43(28(2)3)54(7)46(59)34-13-10-15-38(34)50/h11,14,17-19,21-22,24-25,28-29,34,38-40,43,53,57H,9-10,12-13,15-16,20,23,26-27,50H2,1-8H3,(H,52,58) YHNDEVYFEJKOER-UHFFFAOYSA-N 750642 US20250195521, Example A131 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750642 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750642&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347454 519649236 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541498 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(O)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-38-15-14-30-24-34(38)35(41(52)33-12-10-18-48-39(33)28(4)60-8)25-46(5,6)26-61-44(57)36-13-11-19-53(50-36)43(56)37(22-29-20-31(30)23-32(54)21-29)49-42(55)40(27(2)3)51(7)45(58)47(59)16-17-47/h10,12,14-15,18,20-21,23-24,27-28,36-37,40,50,54,59H,9,11,13,16-17,19,22,25-26H2,1-8H3,(H,49,55) FPZACKGWZKGUAH-UHFFFAOYSA-N 750643 US20250195521, Example A132 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750643 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750643&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347468 519649237 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541499 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC3CC1CN3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O7/c1-9-56-42-15-14-31-23-38(42)39(45(56)36-12-10-16-51-43(36)29(4)63-8)25-50(5,6)27-64-49(62)40-13-11-17-57(54-40)48(61)41(20-30-18-32(31)22-35(58)19-30)53-46(59)44(28(2)3)55(7)47(60)37-24-34-21-33(37)26-52-34/h10,12,14-16,18-19,22-23,28-29,33-34,37,40-41,44,52,54,58H,9,11,13,17,20-21,24-27H2,1-8H3,(H,53,59) XCWCZXXWHXGUCW-UHFFFAOYSA-N 750644 US20250195521, Example A133 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750644 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750644&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347671 519649238 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541500 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCN[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O7/c1-10-56-42-18-17-33-26-38(42)39(45(56)37-15-12-20-52-43(37)31(5)63-9)27-50(6,7)28-64-49(62)40-16-13-21-57(54-40)48(61)41(24-32-22-34(33)25-35(58)23-32)53-46(59)44(29(2)3)55(8)47(60)36-14-11-19-51-30(36)4/h12,15,17-18,20,22-23,25-26,29-31,36,40-41,44,51,54,58H,10-11,13-14,16,19,21,24,27-28H2,1-9H3,(H,53,59) LNGOYLCUDZQRSA-UHFFFAOYSA-N 750645 US20250195521, Example A134 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750645 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750645&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346504 519649239 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541501 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@@]3(C)CCCN3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H72N8O8/c1-10-61-44-17-16-35-28-40(44)41(47(61)39-14-11-20-55-45(39)33(4)69-9)29-53(5,6)31-70-51(67)42-15-12-22-62(58-42)50(66)43(26-34-24-37(35)27-38(63)25-34)57-48(64)46(32(2)3)59(8)49(65)36-18-23-60(30-36)52(68)54(7)19-13-21-56-54/h11,14,16-17,20,24-25,27-28,32-33,36,42-43,46,56,58,63H,10,12-13,15,18-19,21-23,26,29-31H2,1-9H3,(H,57,64) ZJPBMJGTGHYMCE-UHFFFAOYSA-N 750646 US20250195521, Example A135 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750646 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750646&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346513 519649240 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541502 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H58N8O6S/c1-11-50-34-17-16-27-20-29(34)30(38(50)28-14-12-18-44-36(28)26(4)56-10)22-43(5,6)24-57-41(54)31-15-13-19-51(47-31)40(53)32(21-35-45-33(27)23-58-35)46-39(52)37(25(2)3)49(9)42(55)48(7)8/h12,14,16-18,20,23,25-26,31-32,37,47H,11,13,15,19,21-22,24H2,1-10H3,(H,46,52) LPXACMPKJZRREZ-UHFFFAOYSA-N 750647 US20250195521, Example A136 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750647 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750647&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346493 519649241 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541503 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)NC)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H56N8O6S/c1-10-49-33-16-15-26-19-28(33)29(37(49)27-13-11-17-44-35(27)25(4)55-9)21-42(5,6)23-56-40(53)30-14-12-18-50(47-30)39(52)31(20-34-45-32(26)22-57-34)46-38(51)36(24(2)3)48(8)41(54)43-7/h11,13,15-17,19,22,24-25,30-31,36,47H,10,12,14,18,20-21,23H2,1-9H3,(H,43,54)(H,46,51) DDEFYJKRXAZXBB-UHFFFAOYSA-N 750648 US20250195521, Example A137 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750648 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750648&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346924 519649242 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541504 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OC)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H55N7O7S/c1-10-48-33-16-15-26-19-28(33)29(37(48)27-13-11-17-43-35(27)25(4)54-8)21-42(5,6)23-56-40(52)30-14-12-18-49(46-30)39(51)31(20-34-44-32(26)22-57-34)45-38(50)36(24(2)3)47(7)41(53)55-9/h11,13,15-17,19,22,24-25,30-31,36,46H,10,12,14,18,20-21,23H2,1-9H3,(H,45,50) GPLSHTGQXCIEGN-UHFFFAOYSA-N 750649 US20250195521, Example A138 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750649 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750649&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346921 519649243 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541505 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(CN)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-9-54-39-15-14-31-24-35(39)36(42(54)34-12-10-18-50-40(34)29(4)61-8)25-47(5,6)27-62-45(59)37-13-11-19-55(52-37)44(58)38(22-30-20-32(31)23-33(56)21-30)51-43(57)41(28(2)3)53(7)46(60)48(26-49)16-17-48/h10,12,14-15,18,20-21,23-24,28-29,37-38,41,52,56H,9,11,13,16-17,19,22,25-27,49H2,1-8H3,(H,51,57) UAHVXXNMMJRFPP-UHFFFAOYSA-N 750650 US20250195521, Example A139 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750650 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750650&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347674 519649244 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541506 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN3CC(O)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H68N8O9/c1-8-59-44-12-11-33-22-39(44)40(47(59)41-24-53-15-13-35(41)29-68-7)23-52(4,5)30-69-51(67)42-10-9-16-60(55-42)50(66)43(20-32-18-36(33)21-37(61)19-32)54-48(64)46(31(2)3)56(6)49(65)34-14-17-58(25-34)45(63)28-57-26-38(62)27-57/h11-13,15,18-19,21-22,24,31,34,38,42-43,46,55,61-62H,8-10,14,16-17,20,23,25-30H2,1-7H3,(H,54,64) SIWFUAPITBFOMG-UHFFFAOYSA-N 750651 US20250195521, Example A14 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750651 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750651&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157933089 519649245 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541507 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC13CNC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O7/c1-9-55-40-15-14-31-22-35(40)36(43(55)34-12-10-16-51-41(34)29(4)62-8)23-48(5,6)27-63-47(61)38-13-11-17-56(53-38)46(60)39(20-30-18-32(31)21-33(57)19-30)52-44(58)42(28(2)3)54(7)45(59)37-24-49(37)25-50-26-49/h10,12,14-16,18-19,21-22,28-29,37-39,42,50,53,57H,9,11,13,17,20,23-27H2,1-8H3,(H,52,58) DZLNUTZXGOBIEY-UHFFFAOYSA-N 750652 US20250195521, Example A140 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750652 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750652&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346909 519649246 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541508 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H57N7O6S/c1-8-50-36-18-17-29-21-31(36)32(40(50)30-15-11-19-45-38(30)26(2)56-7)23-44(4,5)25-57-43(55)33-16-12-20-51(48-33)42(54)34(22-37-46-35(29)24-58-37)47-41(53)39(49(6)27(3)52)28-13-9-10-14-28/h11,15,17-19,21,24,26,28,33-34,39,48H,8-10,12-14,16,20,22-23,25H2,1-7H3,(H,47,53) SMPHPBLESAPCQW-UHFFFAOYSA-N 750653 US20250195521, Example A141 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750653 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750653&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347461 519649247 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541509 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C(=C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H56N6O7/c1-10-50-38-16-15-30-23-34(38)35(41(50)33-13-11-17-46-39(33)27(4)57-9)24-45(6,7)25-58-44(56)36-14-12-18-51(48-36)43(55)37(21-29-19-31(30)22-32(53)20-29)47-42(54)40(26(2)3)49(8)28(5)52/h11,13,15-17,19-20,22-23,27,36-37,48,53H,10,12,14,18,21,24-25H2,1-9H3,(H,47,54) OOHSRGQMAWQPST-UHFFFAOYSA-N 750654 US20250195521, Example A142 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750654 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750654&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346918 519649248 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541510 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H61N7O7S/c1-10-52-36-16-15-29-21-31(36)32(40(52)30-13-11-18-47-38(30)28(5)58-9)23-46(6,7)25-60-45(57)33-14-12-19-53(50-33)43(55)34(22-37-48-35(29)24-61-37)49-42(54)39(26(2)3)51(8)44(56)41-27(4)17-20-59-41/h11,13,15-16,18,21,24,26-28,33-34,39,41,50H,10,12,14,17,19-20,22-23,25H2,1-9H3,(H,49,54) VYRVNHUWUACHDF-UHFFFAOYSA-N 750655 US20250195521, Example A143 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750655 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750655&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347052 519649249 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541511 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H]1[C@H](C)CCN1C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H56N6O7/c1-8-49-38-14-13-30-23-34(38)35(41(49)33-11-9-16-46-39(33)27(3)57-7)24-45(5,6)25-58-44(56)36-12-10-17-51(48-36)43(55)37(21-29-19-31(30)22-32(53)20-29)47-42(54)40-26(2)15-18-50(40)28(4)52/h9,11,13-14,16,19-20,22-23,26-27,36-37,40,48,53H,8,10,12,15,17-18,21,24-25H2,1-7H3,(H,47,54) OTRGMQWVUUUHKB-UHFFFAOYSA-N 750656 US20250195521, Example A144 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750656 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750656&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348134 519649250 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541512 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(cc(NC(C)=O)c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O7/c1-11-53-40-17-16-32-24-36(40)37(43(53)35-14-12-18-48-41(35)28(4)60-10)25-47(7,8)26-61-46(59)38-15-13-19-54(51-38)45(58)39(50-44(57)42(27(2)3)52(9)30(6)56)22-31-20-33(32)23-34(21-31)49-29(5)55/h12,14,16-18,20-21,23-24,27-28,38-39,42,51H,11,13,15,19,22,25-26H2,1-10H3,(H,49,55)(H,50,57) YOUQJLFSJYDSKJ-UHFFFAOYSA-N 750657 US20250195521, Example A145 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750657 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750657&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346993 519649251 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541513 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O7/c1-10-53-40-16-15-31-24-36(40)37(43(53)34-13-11-17-49-41(34)29(5)60-9)25-48(6,7)26-61-47(59)38-14-12-18-54(51-38)46(58)39(22-30-20-32(31)23-33(55)21-30)50-44(56)42(27(2)3)52(8)45(57)35-19-28(35)4/h11,13,15-17,20-21,23-24,27-29,35,38-39,42,51,55H,10,12,14,18-19,22,25-26H2,1-9H3,(H,50,56) IUKNWVGAPTWPBU-UHFFFAOYSA-N 750658 US20250195521, Example A146 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750658 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750658&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347471 519649252 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541514 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1C[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O7/c1-10-53-40-16-15-31-24-36(40)37(43(53)34-13-11-17-49-41(34)29(5)60-9)25-48(6,7)26-61-47(59)38-14-12-18-54(51-38)46(58)39(22-30-20-32(31)23-33(55)21-30)50-44(56)42(27(2)3)52(8)45(57)35-19-28(35)4/h11,13,15-17,20-21,23-24,27-29,35,38-39,42,51,55H,10,12,14,18-19,22,25-26H2,1-9H3,(H,50,56) IUKNWVGAPTWPBU-UHFFFAOYSA-N 750659 US20250195521, Example A147 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750659 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750659&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346941 519649253 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541515 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC13CCNC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O7/c1-9-56-41-15-14-32-24-36(41)37(44(56)35-12-10-17-52-42(35)30(4)63-8)25-49(5,6)28-64-48(62)39-13-11-19-57(54-39)47(61)40(22-31-20-33(32)23-34(58)21-31)53-45(59)43(29(2)3)55(7)46(60)38-26-50(38)16-18-51-27-50/h10,12,14-15,17,20-21,23-24,29-30,38-40,43,51,54,58H,9,11,13,16,18-19,22,25-28H2,1-8H3,(H,53,59) MKIBKWBYVPTSPI-UHFFFAOYSA-N 750660 US20250195521, Example A148 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750660 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750660&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348138 519649254 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541516 C=C[C@@H]1C[C@]1(N)C(=O)N(C)[C@H](C(=O)N[C@H]1Cc2cc(O)cc(c2)-c2ccc3c(c2)c(c(-c2cccnc2[C@H](C)OC)n3CC)CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C1=O)C(C)C InChI=1S/C49H63N7O7/c1-10-33-25-49(33,50)47(61)54(8)42(28(3)4)44(58)52-39-22-30-20-32(23-34(57)21-30)31-16-17-40-36(24-31)37(43(55(40)11-2)35-14-12-18-51-41(35)29(5)62-9)26-48(6,7)27-63-46(60)38-15-13-19-56(53-38)45(39)59/h10,12,14,16-18,20-21,23-24,28-29,33,38-39,42,53,57H,1,11,13,15,19,22,25-27,50H2,2-9H3,(H,52,58) GBNPHVPRCZQKBZ-UHFFFAOYSA-N 750661 US20250195521, Example A149 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750661 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750661&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156736514 519649255 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541517 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C(C)(C)N)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H68N8O8/c1-10-58-42-14-13-32-24-37(42)38(44(58)39-26-53-17-15-34(39)28-66-9)25-50(4,5)29-67-48(64)40-12-11-18-59(55-40)47(63)41(22-31-20-35(32)23-36(60)21-31)54-45(61)43(30(2)3)56(8)46(62)33-16-19-57(27-33)49(65)51(6,7)52/h13-15,17,20-21,23-24,26,30,33,40-41,43,55,60H,10-12,16,18-19,22,25,27-29,52H2,1-9H3,(H,54,61) IVVQETUKFSWTSO-UHFFFAOYSA-N 750662 US20250195521, Example A15 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750662 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750662&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347617 519649256 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541518 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(C(=O)O)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H60N6O9/c1-9-53-38-15-14-30-24-34(38)35(41(53)33-12-10-18-49-39(33)28(4)62-8)25-47(5,6)26-63-44(58)36-13-11-19-54(51-36)43(57)37(22-29-20-31(30)23-32(55)21-29)50-42(56)40(27(2)3)52(7)45(59)48(16-17-48)46(60)61/h10,12,14-15,18,20-21,23-24,27-28,36-37,40,51,55H,9,11,13,16-17,19,22,25-26H2,1-8H3,(H,50,56)(H,60,61) BOMUMROWCFWWBP-UHFFFAOYSA-N 750663 US20250195521, Example A150 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750663 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750663&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346544 519649257 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541519 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC13CCNCC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O7/c1-9-57-42-15-14-33-26-37(42)38(45(57)36-12-10-18-53-43(36)31(4)64-8)27-50(5,6)29-65-49(63)40-13-11-21-58(55-40)48(62)41(24-32-22-34(33)25-35(59)23-32)54-46(60)44(30(2)3)56(7)47(61)39-28-51(39)16-19-52-20-17-51/h10,12,14-15,18,22-23,25-26,30-31,39-41,44,52,55,59H,9,11,13,16-17,19-21,24,27-29H2,1-8H3,(H,54,60) NGWUSCOCEYRBHX-UHFFFAOYSA-N 750664 US20250195521, Example A151 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750664 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750664&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347431 519649258 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541520 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1nc(cs1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H55N7O6S/c1-10-48-34-16-15-27-19-30(34)31(37(48)29-13-11-17-43-35(29)25(4)54-9)21-42(6,7)23-55-41(53)32-14-12-18-49(46-32)40(52)33(20-28-22-56-39(27)44-28)45-38(51)36(24(2)3)47(8)26(5)50/h11,13,15-17,19,22,24-25,32-33,36,46H,10,12,14,18,20-21,23H2,1-9H3,(H,45,51) GFVMVZFCDZWCDJ-UHFFFAOYSA-N 750665 US20250195521, Example A152 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750665 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750665&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346901 519649259 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541521 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(cc3nc[nH]c13)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N8O6/c1-10-53-38-16-15-30-22-33(38)34(42(53)31-13-11-17-47-39(31)27(4)59-9)23-46(6,7)24-60-45(58)35-14-12-18-54(51-35)44(57)37(50-43(56)41(26(2)3)52(8)28(5)55)21-29-19-32(30)40-36(20-29)48-25-49-40/h11,13,15-17,19-20,22,25-27,35,37,41,51H,10,12,14,18,21,23-24H2,1-9H3,(H,48,49)(H,50,56) OQGBBFZUHXZMIM-UHFFFAOYSA-N 750666 US20250195521, Example A153 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750666 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750666&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346562 519649260 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541522 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(cc(S(C)(=O)=O)c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N6O8S/c1-11-51-39-17-16-31-24-35(39)36(42(51)34-14-12-18-47-40(34)28(4)59-9)25-46(6,7)26-60-45(56)37-15-13-19-52(49-37)44(55)38(48-43(54)41(27(2)3)50(8)29(5)53)22-30-20-32(31)23-33(21-30)61(10,57)58/h12,14,16-18,20-21,23-24,27-28,37-38,41,49H,11,13,15,19,22,25-26H2,1-10H3,(H,48,54) TXCFCASULKCAKE-UHFFFAOYSA-N 750667 US20250195521, Example A154 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750667 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750667&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346566 519649261 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541523 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C13CNCC1C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O7/c1-9-55-40-15-14-31-22-36(40)37(43(55)35-12-10-16-51-41(35)29(4)62-8)24-48(5,6)27-63-46(60)38-13-11-17-56(53-38)45(59)39(20-30-18-32(31)21-34(57)19-30)52-44(58)42(28(2)3)54(7)47(61)49-23-33(49)25-50-26-49/h10,12,14-16,18-19,21-22,28-29,33,38-39,42,50,53,57H,9,11,13,17,20,23-27H2,1-8H3,(H,52,58) OWUYMWUBWBGGGC-UHFFFAOYSA-N 750668 US20250195521, Example A155 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750668 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750668&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347697 519649262 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541524 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC13CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H62N6O7/c1-9-54-40-15-14-31-24-35(40)36(43(54)34-12-10-18-50-41(34)29(4)61-8)25-48(5,6)27-62-47(60)38-13-11-19-55(52-38)46(59)39(22-30-20-32(31)23-33(56)21-30)51-44(57)42(28(2)3)53(7)45(58)37-26-49(37)16-17-49/h10,12,14-15,18,20-21,23-24,28-29,37-39,42,52,56H,9,11,13,16-17,19,22,25-27H2,1-8H3,(H,51,57) YELZPEIGTZVBGB-UHFFFAOYSA-N 750669 US20250195521, Example A156 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750669 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750669&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161893762 519649263 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541525 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CC1(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H64N6O7/c1-11-54-40-17-16-31-24-35(40)36(43(54)34-14-12-18-50-41(34)29(4)61-10)25-48(5,6)27-62-47(60)38-15-13-19-55(52-38)46(59)39(22-30-20-32(31)23-33(56)21-30)51-44(57)42(28(2)3)53(9)45(58)37-26-49(37,7)8/h12,14,16-18,20-21,23-24,28-29,37-39,42,52,56H,11,13,15,19,22,25-27H2,1-10H3,(H,51,57) SLXZWBQWKRIZBB-UHFFFAOYSA-N 750670 US20250195521, Example A157 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750670&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347465 519649264 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541526 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC1(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H64N6O7/c1-11-54-40-17-16-31-24-35(40)36(43(54)34-14-12-18-50-41(34)29(4)61-10)25-48(5,6)27-62-47(60)38-15-13-19-55(52-38)46(59)39(22-30-20-32(31)23-33(56)21-30)51-44(57)42(28(2)3)53(9)45(58)37-26-49(37,7)8/h12,14,16-18,20-21,23-24,28-29,37-39,42,52,56H,11,13,15,19,22,25-27H2,1-10H3,(H,51,57) SLXZWBQWKRIZBB-UHFFFAOYSA-N 750671 US20250195521, Example A158 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750671 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750671&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347464 519649265 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541527 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(C#N)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H59N7O7/c1-9-54-39-15-14-31-24-35(39)36(42(54)34-12-10-18-50-40(34)29(4)61-8)25-47(5,6)27-62-45(59)37-13-11-19-55(52-37)44(58)38(22-30-20-32(31)23-33(56)21-30)51-43(57)41(28(2)3)53(7)46(60)48(26-49)16-17-48/h10,12,14-15,18,20-21,23-24,28-29,37-38,41,52,56H,9,11,13,16-17,19,22,25,27H2,1-8H3,(H,51,57) MDWCOXYFTHVBNH-UHFFFAOYSA-N 750672 US20250195521, Example A159 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750672&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346949 519649266 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541528 CCN1C[C@@H](C(=O)N(C)[C@H](C(=O)N[C@H]2Cc3cc(O)cc(c3)-c3ccc4c(c3)c(c(-c3cnccc3COC)n4CC)CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C2=O)C(C)C)CC1=O InChI=1S/C49H63N7O8/c1-9-54-26-34(23-42(54)58)46(60)53(7)43(29(3)4)45(59)51-40-20-30-18-33(21-35(57)19-30)31-13-14-41-36(22-31)37(44(55(41)10-2)38-25-50-16-15-32(38)27-63-8)24-49(5,6)28-64-48(62)39-12-11-17-56(52-39)47(40)61/h13-16,18-19,21-22,25,29,34,39-40,43,52,57H,9-12,17,20,23-24,26-28H2,1-8H3,(H,51,59) JFKRHSFWKCQCTH-UHFFFAOYSA-N 750673 US20250195521, Example A16 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750673&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348179 519649267 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541529 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1C[C@@H]1F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H59FN6O7/c1-9-53-39-15-14-29-22-33(39)35(42(53)32-12-10-16-49-40(32)27(4)60-8)24-47(5,6)25-61-46(59)37-13-11-17-54(51-37)45(58)38(20-28-18-30(29)21-31(55)19-28)50-43(56)41(26(2)3)52(7)44(57)34-23-36(34)48/h10,12,14-16,18-19,21-22,26-27,34,36-38,41,51,55H,9,11,13,17,20,23-25H2,1-8H3,(H,50,56) QFSKYAGTLYWOPB-UHFFFAOYSA-N 750674 US20250195521, Example A160 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750674&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347639 519649268 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541530 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@@H]1F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H59FN6O7/c1-9-53-39-15-14-29-22-33(39)35(42(53)32-12-10-16-49-40(32)27(4)60-8)24-47(5,6)25-61-46(59)37-13-11-17-54(51-37)45(58)38(20-28-18-30(29)21-31(55)19-28)50-43(56)41(26(2)3)52(7)44(57)34-23-36(34)48/h10,12,14-16,18-19,21-22,26-27,34,36-38,41,51,55H,9,11,13,17,20,23-25H2,1-8H3,(H,50,56) QFSKYAGTLYWOPB-UHFFFAOYSA-N 750675 US20250195521, Example A161 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750675&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346573 519649269 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541531 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@H]1F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H59FN6O7/c1-9-53-39-15-14-29-22-33(39)35(42(53)32-12-10-16-49-40(32)27(4)60-8)24-47(5,6)25-61-46(59)37-13-11-17-54(51-37)45(58)38(20-28-18-30(29)21-31(55)19-28)50-43(56)41(26(2)3)52(7)44(57)34-23-36(34)48/h10,12,14-16,18-19,21-22,26-27,34,36-38,41,51,55H,9,11,13,17,20,23-25H2,1-8H3,(H,50,56) QFSKYAGTLYWOPB-UHFFFAOYSA-N 750676 US20250195521, Example A162 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750676 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750676&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347750 519649270 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541532 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1[C@@H]3CNC[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O7/c1-9-55-40-15-14-30-22-34(40)35(44(55)33-12-10-16-51-42(33)28(4)62-8)23-49(5,6)26-63-48(61)38-13-11-17-56(53-38)46(59)39(20-29-18-31(30)21-32(57)19-29)52-45(58)43(27(2)3)54(7)47(60)41-36-24-50-25-37(36)41/h10,12,14-16,18-19,21-22,27-28,36-39,41,43,50,53,57H,9,11,13,17,20,23-26H2,1-8H3,(H,52,58) QKCFGQALSRPZTE-UHFFFAOYSA-N 750677 US20250195521, Example A163 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750677 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750677&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346893 519649271 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541533 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1[C@@H]3CNC[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O7/c1-9-55-40-15-14-30-22-34(40)35(44(55)33-12-10-16-51-42(33)28(4)62-8)23-49(5,6)26-63-48(61)38-13-11-17-56(53-38)46(59)39(20-29-18-31(30)21-32(57)19-29)52-45(58)43(27(2)3)54(7)47(60)41-36-24-50-25-37(36)41/h10,12,14-16,18-19,21-22,27-28,36-39,41,43,50,53,57H,9,11,13,17,20,23-26H2,1-8H3,(H,52,58) QKCFGQALSRPZTE-UHFFFAOYSA-N 750678 US20250195521, Example A164 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750678 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750678&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346893 519649272 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541534 CCn5c(c1cccnc1[C@@H](C)OC)c6CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C3(F)CC3)Cc4cc(O)cc(c4)c7ccc5c6c7 InChI=1S/C47H59FN6O7/c1-9-53-38-15-14-30-24-34(38)35(41(53)33-12-10-18-49-39(33)28(4)60-8)25-46(5,6)26-61-44(58)36-13-11-19-54(51-36)43(57)37(22-29-20-31(30)23-32(55)21-29)50-42(56)40(27(2)3)52(7)45(59)47(48)16-17-47/h10,12,14-15,18,20-21,23-24,27-28,36-37,40,51,55H,9,11,13,16-17,19,22,25-26H2,1-8H3,(H,50,56) FTGGWEANEIUZCD-UHFFFAOYSA-N 750679 US20250195521, Example A165 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750679&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 177372996 519649273 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541535 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC1(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H58F2N6O7/c1-9-54-38-15-14-29-22-33(38)34(41(54)32-12-10-16-50-39(32)27(4)61-8)23-46(5,6)25-62-45(60)36-13-11-17-55(52-36)44(59)37(20-28-18-30(29)21-31(56)19-28)51-42(57)40(26(2)3)53(7)43(58)35-24-47(35,48)49/h10,12,14-16,18-19,21-22,26-27,35-37,40,52,56H,9,11,13,17,20,23-25H2,1-8H3,(H,51,57) WYRUEVUDHHMAPI-UHFFFAOYSA-N 750680 US20250195521, Example A166 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750680&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347056 519649274 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541536 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CC1(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H58F2N6O7/c1-9-54-38-15-14-29-22-33(38)34(41(54)32-12-10-16-50-39(32)27(4)61-8)23-46(5,6)25-62-45(60)36-13-11-17-55(52-36)44(59)37(20-28-18-30(29)21-31(56)19-28)51-42(57)40(26(2)3)53(7)43(58)35-24-47(35,48)49/h10,12,14-16,18-19,21-22,26-27,35-37,40,52,56H,9,11,13,17,20,23-25H2,1-8H3,(H,51,57) WYRUEVUDHHMAPI-UHFFFAOYSA-N 750681 US20250195521, Example A167 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750681 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750681&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346542 519649275 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541537 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(N)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O7/c1-9-53-38-15-14-30-24-34(38)35(41(53)33-12-10-18-49-39(33)28(4)60-8)25-46(5,6)26-61-44(58)36-13-11-19-54(51-36)43(57)37(22-29-20-31(30)23-32(55)21-29)50-42(56)40(27(2)3)52(7)45(59)47(48)16-17-47/h10,12,14-15,18,20-21,23-24,27-28,36-37,40,51,55H,9,11,13,16-17,19,22,25-26,48H2,1-8H3,(H,50,56) GVKSSYHJUDFLIT-UHFFFAOYSA-N 750682 US20250195521, Example A168 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750682 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750682&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346946 519649276 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541538 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)O[C@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O8/c1-10-55-41-16-15-32-25-37(41)38(44(55)36-13-11-18-50-42(36)30(4)62-9)26-49(5,6)28-63-47(60)39-14-12-19-56(52-39)46(59)40(23-31-21-33(32)24-34(57)22-31)51-45(58)43(29(2)3)54(8)48(61)64-35-17-20-53(7)27-35/h11,13,15-16,18,21-22,24-25,29-30,35,39-40,43,52,57H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,51,58) JCWUHDRGBQRZEY-UHFFFAOYSA-N 750683 US20250195521, Example A169 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750683 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750683&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348152 519649277 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541539 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H61N7O8/c1-8-54-41-12-11-31-22-36(41)37(43(54)38-24-49-15-13-33(38)26-62-7)23-48(4,5)27-63-47(61)39-10-9-16-55(51-39)46(60)40(20-30-18-34(31)21-35(57)19-30)50-44(58)42(29(2)3)52(6)45(59)32-14-17-53(25-32)28-56/h11-13,15,18-19,21-22,24,28-29,32,39-40,42,51,57H,8-10,14,16-17,20,23,25-27H2,1-7H3,(H,50,58) XGFLWMKXPJGGGO-UHFFFAOYSA-N 750684 US20250195521, Example A17 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750684 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750684&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348007 519649278 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541540 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H66N8O7/c1-11-56-41-17-16-32-24-37(41)38(44(56)36-14-12-18-50-42(36)30(4)63-10)25-49(5,6)28-64-47(61)39-15-13-19-57(52-39)46(60)40(22-31-20-33(32)23-35(58)21-31)51-45(59)43(29(2)3)54(9)48(62)55-26-34(27-55)53(7)8/h12,14,16-18,20-21,23-24,29-30,34,39-40,43,52,58H,11,13,15,19,22,25-28H2,1-10H3,(H,51,59) NTPMFHGICLEVBL-UHFFFAOYSA-N 750685 US20250195521, Example A170 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750685 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750685&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347746 519649279 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541541 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H66N8O7/c1-11-56-41-17-16-32-24-37(41)38(44(56)36-14-12-18-50-42(36)30(4)63-10)25-49(5,6)28-64-47(61)39-15-13-19-57(52-39)46(60)40(22-31-20-33(32)23-35(58)21-31)51-45(59)43(29(2)3)54(9)48(62)55-26-34(27-55)53(7)8/h12,14,16-18,20-21,23-24,29-30,34,39-40,43,52,58H,11,13,15,19,22,25-28H2,1-10H3,(H,51,59) NTPMFHGICLEVBL-UHFFFAOYSA-N 750686 US20250195521, Example A171 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750686 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750686&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347746 519649280 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541542 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)(C)OC)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N6O8/c1-10-50-37-16-15-29-23-33(37)34(39(50)32-13-11-17-46-38(32)26(2)57-8)24-44(4,5)25-59-43(56)35-14-12-18-51(49-35)42(55)36(21-28-19-30(29)22-31(53)20-28)48-41(54)40(47-27(3)52)45(6,7)58-9/h11,13,15-17,19-20,22-23,26,35-36,40,49,53H,10,12,14,18,21,24-25H2,1-9H3,(H,47,52)(H,48,54) ZQDOFTWOJWNOHH-UHFFFAOYSA-N 750687 US20250195521, Example A172 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750687 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750687&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346572 519649281 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541543 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)O[C@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-10-53-37-16-15-29-21-32(37)33(41(53)31-13-11-18-47-39(31)28(4)59-9)23-46(5,6)26-60-44(57)34-14-12-19-54(50-34)43(56)35(22-38-48-36(29)25-62-38)49-42(55)40(27(2)3)52(8)45(58)61-30-17-20-51(7)24-30/h11,13,15-16,18,21,25,27-28,30,34-35,40,50H,10,12,14,17,19-20,22-24,26H2,1-9H3,(H,49,55) BDYBVQOUAMXESB-UHFFFAOYSA-N 750688 US20250195521, Example A173 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750688 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750688&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346919 519649282 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541544 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OC1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-39-17-14-30-24-35(39)36(42(52)34-12-10-18-48-40(34)28(4)59-8)25-47(5,6)26-60-45(57)37-13-11-19-53(50-37)44(56)38(22-29-20-31(30)23-32(54)21-29)49-43(55)41(27(2)3)51(7)46(58)61-33-15-16-33/h10,12,14,17-18,20-21,23-24,27-28,33,37-38,41,50,54H,9,11,13,15-16,19,22,25-26H2,1-8H3,(H,49,55) CXVABYAPPPEDLV-UHFFFAOYSA-N 750689 US20250195521, Example A174 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750689 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750689&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347790 519649283 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541545 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C3CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O7/c1-9-57-43-17-14-33-26-39(43)40(46(57)38-12-10-19-52-44(38)31(4)64-8)27-51(5,6)29-65-50(63)41-13-11-20-58(54-41)49(62)42(24-32-22-35(33)25-37(59)23-32)53-47(60)45(30(2)3)55(7)48(61)34-18-21-56(28-34)36-15-16-36/h10,12,14,17,19,22-23,25-26,30-31,34,36,41-42,45,54,59H,9,11,13,15-16,18,20-21,24,27-29H2,1-8H3,(H,53,60) KRUGOMZBCKWPQX-UHFFFAOYSA-N 750690 US20250195521, Example A175 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750690 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750690&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347926 519649284 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541546 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H]1CCCCCN1C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O7/c1-7-50-39-17-16-31-25-35(39)36(42(50)34-13-11-18-47-41(34)28(2)58-6)26-46(4,5)27-59-45(57)37-14-12-20-52(49-37)44(56)38(23-30-21-32(31)24-33(54)22-30)48-43(55)40-15-9-8-10-19-51(40)29(3)53/h11,13,16-18,21-22,24-25,28,37-38,40,49,54H,7-10,12,14-15,19-20,23,26-27H2,1-6H3,(H,48,55) QINMIQWVPMBQFB-UHFFFAOYSA-N 750691 US20250195521, Example A176 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750691 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750691&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347704 519649285 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541547 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)CCc1ccncc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H52N6O6/c1-6-50-39-13-12-31-25-35(39)36(42(50)34-9-7-17-47-41(34)28(2)56-5)26-45(3,4)27-57-44(55)37-10-8-20-51(49-37)43(54)38(23-30-21-32(31)24-33(52)22-30)48-40(53)14-11-29-15-18-46-19-16-29/h7,9,12-13,15-19,21-22,24-25,28,37-38,49,52H,6,8,10-11,14,20,23,26-27H2,1-5H3,(H,48,53) QCOJCNKIVBSSOG-UHFFFAOYSA-N 750692 US20250195521, Example A177 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750692 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750692&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348143 519649286 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541548 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)CC(C)c1ccncc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H54N6O6/c1-7-51-40-13-12-32-25-36(40)37(43(51)35-10-8-16-48-42(35)29(3)57-6)26-46(4,5)27-58-45(56)38-11-9-19-52(50-38)44(55)39(23-30-21-33(32)24-34(53)22-30)49-41(54)20-28(2)31-14-17-47-18-15-31/h8,10,12-18,21-22,24-25,28-29,38-39,50,53H,7,9,11,19-20,23,26-27H2,1-6H3,(H,49,54) XQHAWNPDLAXYCQ-UHFFFAOYSA-N 750693 US20250195521, Example A178 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750693 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750693&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347024 519649287 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541549 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C(C)Cc1ccncc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H54N6O6/c1-7-51-40-13-12-32-25-36(40)37(42(51)35-10-8-16-48-41(35)29(3)57-6)26-46(4,5)27-58-45(56)38-11-9-19-52(50-38)44(55)39(23-31-21-33(32)24-34(53)22-31)49-43(54)28(2)20-30-14-17-47-18-15-30/h8,10,12-18,21-22,24-25,28-29,38-39,50,53H,7,9,11,19-20,23,26-27H2,1-6H3,(H,49,54) XNRWFNICFYJTIT-UHFFFAOYSA-N 750694 US20250195521, Example A179 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750694 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750694&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347062 519649288 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541550 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-39-15-14-30-22-35(39)36(42(52)34-12-10-16-48-40(34)28(4)59-8)23-47(5,6)26-61-46(58)37-13-11-17-53(50-37)45(57)38(20-29-18-31(30)21-33(54)19-29)49-43(55)41(27(2)3)51(7)44(56)32-24-60-25-32/h10,12,14-16,18-19,21-22,27-28,32,37-38,41,50,54H,9,11,13,17,20,23-26H2,1-8H3,(H,49,55) YHTWZBFUUAKCAJ-UHFFFAOYSA-N 750695 US20250195521, Example A18 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750695 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750695&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158951628 519649289 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541551 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C13CCCC1C3(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H51F2N5O6/c1-6-50-35-14-13-27-22-31(35)32(38(50)30-10-8-16-47-37(30)25(2)56-5)23-42(3,4)24-57-40(54)33-11-9-17-51(49-33)39(53)34(20-26-18-28(27)21-29(52)19-26)48-41(55)43-15-7-12-36(43)44(43,45)46/h8,10,13-14,16,18-19,21-22,25,33-34,36,49,52H,6-7,9,11-12,15,17,20,23-24H2,1-5H3,(H,48,55) XVQAGWJDGKTECS-UHFFFAOYSA-N 750696 US20250195521, Example A180 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750696 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750696&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347476 519649290 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541552 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C1CCC3C1C3(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H51F2N5O6/c1-6-50-36-14-11-26-21-31(36)32(39(50)30-9-7-15-47-38(30)24(2)56-5)22-43(3,4)23-57-42(55)34-10-8-16-51(49-34)41(54)35(19-25-17-27(26)20-28(52)18-25)48-40(53)29-12-13-33-37(29)44(33,45)46/h7,9,11,14-15,17-18,20-21,24,29,33-35,37,49,52H,6,8,10,12-13,16,19,22-23H2,1-5H3,(H,48,53) DNQZJFOJRXEODN-UHFFFAOYSA-N 750697 US20250195521, Example A181 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750697 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750697&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346952 519649291 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541553 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H]1C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H51N5O6/c1-7-46-36-13-12-27-21-32(36)33(38(46)30-10-8-14-43-37(30)25(3)52-6)22-42(4,5)23-53-41(51)34-11-9-15-47(45-34)40(50)35(44-39(49)31-16-24(31)2)19-26-17-28(27)20-29(48)18-26/h8,10,12-14,17-18,20-21,24-25,31,34-35,45,48H,7,9,11,15-16,19,22-23H2,1-6H3,(H,44,49) HXRLRMAYJWPNLI-UHFFFAOYSA-N 750698 US20250195521, Example A182 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750698 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750698&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346575 519649292 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541554 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H]1C[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H51N5O6/c1-7-46-36-13-12-27-21-32(36)33(38(46)30-10-8-14-43-37(30)25(3)52-6)22-42(4,5)23-53-41(51)34-11-9-15-47(45-34)40(50)35(44-39(49)31-16-24(31)2)19-26-17-28(27)20-29(48)18-26/h8,10,12-14,17-18,20-21,24-25,31,34-35,45,48H,7,9,11,15-16,19,22-23H2,1-6H3,(H,44,49) HXRLRMAYJWPNLI-UHFFFAOYSA-N 750699 US20250195521, Example A183 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750699 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750699&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348155 519649293 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541555 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C(C1CC1)C1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H55N5O6/c1-6-49-38-16-15-30-23-34(38)35(41(49)33-9-7-17-46-40(33)26(2)55-5)24-45(3,4)25-56-44(54)36-10-8-18-50(48-36)43(53)37(21-27-19-31(30)22-32(51)20-27)47-42(52)39(28-11-12-28)29-13-14-29/h7,9,15-17,19-20,22-23,26,28-29,36-37,39,48,51H,6,8,10-14,18,21,24-25H2,1-5H3,(H,47,52) ILOFUONRPCSATR-UHFFFAOYSA-N 750700 US20250195521, Example A184 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750700 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750700&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347474 519649294 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541556 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H62N6O8/c1-9-56-43-20-19-35-27-39(43)40(46(56)38-17-13-21-52-44(38)32(4)63-8)28-51(5,6)30-65-49(61)41-18-14-22-57(54-41)48(60)42(25-34-23-36(35)26-37(58)24-34)53-47(59)45(31(2)3)55(7)50(62)64-29-33-15-11-10-12-16-33/h10-13,15-17,19-21,23-24,26-27,31-32,41-42,45,54,58H,9,14,18,22,25,28-30H2,1-8H3,(H,53,59) RFBORPSKDNOAQH-UHFFFAOYSA-N 750701 US20250195521, Example A185 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750701 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750701&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787090 519649295 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541557 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)CC#N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C39H46N6O7S/c1-6-44-34-12-11-26-21-30(34)31(36(44)29-9-7-14-41-35(29)24(2)51-5)22-39(3,4)23-52-38(48)32-10-8-15-45(42-32)37(47)33(43-53(49,50)16-13-40)19-25-17-27(26)20-28(46)18-25/h7,9,11-12,14,17-18,20-21,24,32-33,42-43,46H,6,8,10,15-16,19,22-23H2,1-5H3 UJJFULKMDVGIEZ-UHFFFAOYSA-N 750702 US20250195521, Example A186 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750702 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750702&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347481 519649296 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541558 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)CC1OCCC13CNC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O8S/c1-6-49-37-12-11-29-21-33(37)34(40(49)32-9-7-14-46-39(32)27(2)56-5)22-43(3,4)26-58-42(53)35-10-8-15-50(47-35)41(52)36(19-28-17-30(29)20-31(51)18-28)48-59(54,55)23-38-44(13-16-57-38)24-45-25-44/h7,9,11-12,14,17-18,20-21,27,35-36,38,45,47-48,51H,6,8,10,13,15-16,19,22-26H2,1-5H3 TVCMHXLCBLQDAJ-UHFFFAOYSA-N 750703 US20250195521, Example A187 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750703 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750703&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346534 519649297 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541559 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)CC1CCC3(CNC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N6O7S/c1-6-50-39-12-11-31-21-35(39)36(41(50)34-9-7-15-47-40(34)28(2)57-5)23-44(3,4)27-58-43(54)37-10-8-16-51(48-37)42(53)38(19-30-17-32(31)20-33(52)18-30)49-59(55,56)24-29-13-14-45(22-29)25-46-26-45/h7,9,11-12,15,17-18,20-21,28-29,37-38,46,48-49,52H,6,8,10,13-14,16,19,22-27H2,1-5H3 UNIVDCBASOBASY-UHFFFAOYSA-N 750704 US20250195521, Example A188 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750704 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750704&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346576 519649298 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541560 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)N1CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C40H50N6O7S/c1-6-45-35-13-12-27-22-31(35)32(37(45)30-10-7-14-41-36(30)25(2)52-5)23-40(3,4)24-53-39(49)33-11-8-17-46(42-33)38(48)34(43-54(50,51)44-15-9-16-44)20-26-18-28(27)21-29(47)19-26/h7,10,12-14,18-19,21-22,25,33-34,42-43,47H,6,8-9,11,15-17,20,23-24H2,1-5H3 VPNUYXXBNNYMKF-UHFFFAOYSA-N 750705 US20250195521, Example A189 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750705 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750705&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347013 519649299 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541561 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O7/c1-9-52-40-13-12-30-22-35(40)36(42(52)37-24-48-15-14-31(37)25-59-8)23-47(5,6)26-60-46(58)38-11-10-16-53(50-38)45(57)39(20-29-18-32(30)21-33(54)19-29)49-43(55)41(27(2)3)51(7)44(56)34-17-28(34)4/h12-15,18-19,21-22,24,27-28,34,38-39,41,50,54H,9-11,16-17,20,23,25-26H2,1-8H3,(H,49,55) VUKJKVQRMKWWQG-UHFFFAOYSA-N 750706 US20250195521, Example A19 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750706 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750706&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159522022 519649300 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541562 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)CCN(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H54N6O7S/c1-8-46-36-14-13-28-23-32(36)33(38(46)31-11-9-15-42-37(31)26(2)53-7)24-41(3,4)25-54-40(50)34-12-10-16-47(43-34)39(49)35(44-55(51,52)18-17-45(5)6)21-27-19-29(28)22-30(48)20-27/h9,11,13-15,19-20,22-23,26,34-35,43-44,48H,8,10,12,16-18,21,24-25H2,1-7H3 VQZFBDNDMAUHMI-UHFFFAOYSA-N 750707 US20250195521, Example A190 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750707 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750707&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348167 519649301 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541563 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)C1CS(=O)(=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C40H49N5O9S2/c1-6-44-35-12-11-26-19-31(35)32(37(44)30-9-7-13-41-36(30)24(2)53-5)20-40(3,4)23-54-39(48)33-10-8-14-45(42-33)38(47)34(17-25-15-27(26)18-28(46)16-25)43-56(51,52)29-21-55(49,50)22-29/h7,9,11-13,15-16,18-19,24,29,33-34,42-43,46H,6,8,10,14,17,20-23H2,1-5H3 LWCWJOJCQGROMZ-UHFFFAOYSA-N 750708 US20250195521, Example A191 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750708 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750708&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346571 519649302 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541564 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)c1cnc[nH]1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C40H47N7O7S/c1-6-46-34-12-11-26-19-30(34)31(37(46)29-9-7-13-42-36(29)24(2)53-5)20-40(3,4)22-54-39(50)32-10-8-14-47(44-32)38(49)33(17-25-15-27(26)18-28(48)16-25)45-55(51,52)35-21-41-23-43-35/h7,9,11-13,15-16,18-19,21,23-24,32-33,44-45,48H,6,8,10,14,17,20,22H2,1-5H3,(H,41,43) UQVCDQVVVRVCHH-UHFFFAOYSA-N 750709 US20250195521, Example A192 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750709 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750709&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348153 519649303 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541565 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)N1CCN(C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H55N7O7S/c1-7-48-37-13-12-29-24-33(37)34(39(48)32-10-8-14-43-38(32)27(2)55-6)25-42(3,4)26-56-41(52)35-11-9-15-49(44-35)40(51)36(22-28-20-30(29)23-31(50)21-28)45-57(53,54)47-18-16-46(5)17-19-47/h8,10,12-14,20-21,23-24,27,35-36,44-45,50H,7,9,11,15-19,22,25-26H2,1-6H3 ZTQRDUYJLMZXJM-UHFFFAOYSA-N 750710 US20250195521, Example A193 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750710&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348156 519649304 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541566 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H52N6O8S/c1-6-46-36-12-11-28-23-32(36)33(38(46)31-9-7-13-42-37(31)26(2)53-5)24-41(3,4)25-55-40(50)34-10-8-14-47(43-34)39(49)35(21-27-19-29(28)22-30(48)20-27)44-56(51,52)45-15-17-54-18-16-45/h7,9,11-13,19-20,22-23,26,34-35,43-44,48H,6,8,10,14-18,21,24-25H2,1-5H3 RLWFYCKUVKUVDS-UHFFFAOYSA-N 750711 US20250195521, Example A194 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750711 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750711&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347477 519649305 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541567 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)c1ccc(O)cc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H49N5O8S/c1-6-47-38-16-11-28-23-34(38)35(40(47)33-9-7-17-44-39(33)26(2)55-5)24-43(3,4)25-56-42(52)36-10-8-18-48(45-36)41(51)37(21-27-19-29(28)22-31(50)20-27)46-57(53,54)32-14-12-30(49)13-15-32/h7,9,11-17,19-20,22-23,26,36-37,45-46,49-50H,6,8,10,18,21,24-25H2,1-5H3 QBRWVUCFIZGPFN-UHFFFAOYSA-N 750712 US20250195521, Example A195 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750712&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347482 519649306 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541568 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)C1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C40H49N5O7S/c1-6-44-35-14-11-26-21-31(35)32(37(44)30-9-7-15-41-36(30)24(2)51-5)22-40(3,4)23-52-39(48)33-10-8-16-45(42-33)38(47)34(43-53(49,50)29-12-13-29)19-25-17-27(26)20-28(46)18-25/h7,9,11,14-15,17-18,20-21,24,29,33-34,42-43,46H,6,8,10,12-13,16,19,22-23H2,1-5H3 YKRVLVDDDFXLTB-UHFFFAOYSA-N 750713 US20250195521, Example A196 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750713 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750713&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347453 519649307 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541569 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)c1cn(C)c(C)n1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H51N7O7S/c1-8-48-36-14-13-28-21-32(36)33(39(48)31-11-9-15-43-38(31)25(2)55-7)22-42(4,5)24-56-41(52)34-12-10-16-49(45-34)40(51)35(19-27-17-29(28)20-30(50)18-27)46-57(53,54)37-23-47(6)26(3)44-37/h9,11,13-15,17-18,20-21,23,25,34-35,45-46,50H,8,10,12,16,19,22,24H2,1-7H3 CVZOXNNFCKGYOH-UHFFFAOYSA-N 750714 US20250195521, Example A197 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750714 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750714&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347475 519649308 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541570 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)c1ccc(OC)cc1OC)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H53N5O9S/c1-8-49-38-15-13-29-23-34(38)35(42(49)33-11-9-17-46-41(33)27(2)56-5)25-45(3,4)26-59-44(53)36-12-10-18-50(47-36)43(52)37(21-28-19-30(29)22-31(51)20-28)48-60(54,55)40-16-14-32(57-6)24-39(40)58-7/h9,11,13-17,19-20,22-24,27,36-37,47-48,51H,8,10,12,18,21,25-26H2,1-7H3 QGJNOUGVLOMBPO-UHFFFAOYSA-N 750715 US20250195521, Example A198 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750715&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347483 519649309 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541571 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H52N6O7/c1-6-47-36-12-11-28-23-32(36)33(38(47)31-9-7-13-43-37(31)26(2)53-5)24-42(3,4)25-55-40(51)34-10-8-14-48(45-34)39(50)35(21-27-19-29(28)22-30(49)20-27)44-41(52)46-15-17-54-18-16-46/h7,9,11-13,19-20,22-23,26,34-35,45,49H,6,8,10,14-18,21,24-25H2,1-5H3,(H,44,52) UBLUVARINZJNLU-UHFFFAOYSA-N 750716 US20250195521, Example A199 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750716&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346991 519649310 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541572 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN3CC[C@H](O)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H70N8O9/c1-8-60-45-12-11-34-24-40(45)41(48(60)42-26-54-16-13-36(42)30-69-7)25-53(4,5)31-70-52(68)43-10-9-17-61(56-43)51(67)44(22-33-20-37(34)23-39(63)21-33)55-49(65)47(32(2)3)57(6)50(66)35-14-19-59(27-35)46(64)29-58-18-15-38(62)28-58/h11-13,16,20-21,23-24,26,32,35,38,43-44,47,56,62-63H,8-10,14-15,17-19,22,25,27-31H2,1-7H3,(H,55,65) PUKNUUDOUPJXRX-UHFFFAOYSA-N 750717 US20250195521, Example A2 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750717&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347814 519649311 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541573 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O9/c1-8-55-41-12-11-31-22-36(41)37(44(55)38-24-50-15-13-33(38)27-64-7)23-49(4,5)28-65-48(63)39-10-9-16-56(52-39)47(62)40(20-30-18-34(31)21-35(58)19-30)51-45(60)43(29(2)3)53(6)46(61)32-14-17-54(25-32)42(59)26-57/h11-13,15,18-19,21-22,24,29,32,39-40,43,52,57-58H,8-10,14,16-17,20,23,25-28H2,1-7H3,(H,51,60) PTTOALWBZXNXRU-UHFFFAOYSA-N 750718 US20250195521, Example A20 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750718&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161060032 519649312 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541574 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NS(=O)(=O)CC1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H51N5O7S/c1-6-45-36-14-13-28-21-32(36)33(38(45)31-9-7-15-42-37(31)25(2)52-5)22-41(3,4)24-53-40(49)34-10-8-16-46(43-34)39(48)35(44-54(50,51)23-26-11-12-26)19-27-17-29(28)20-30(47)18-27/h7,9,13-15,17-18,20-21,25-26,34-35,43-44,47H,6,8,10-12,16,19,22-24H2,1-5H3 BEUCFSZNFCJQIC-UHFFFAOYSA-N 750719 US20250195521, Example A200 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750719&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346940 519649313 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541575 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CCc3ccccc3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C57H71N7O8/c1-9-63-48-21-20-39-31-44(48)45(52(63)43-17-13-24-58-50(43)36(4)71-8)32-57(5,6)34-72-56(70)46-18-14-25-64(60-46)55(69)47(29-38-27-41(39)30-42(65)28-38)59-53(67)51(35(2)3)61(7)54(68)40-23-26-62(33-40)49(66)22-19-37-15-11-10-12-16-37/h10-13,15-17,20-21,24,27-28,30-31,35-36,40,46-47,51,60,65H,9,14,18-19,22-23,25-26,29,32-34H2,1-8H3,(H,59,67) LQEHFLGXRVEEKU-UHFFFAOYSA-N 750720 US20250195521, Example A201 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750720&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787103 519649314 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541576 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC3CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H67N7O9/c1-9-58-43-17-14-33-26-39(43)40(46(58)38-12-10-19-53-44(38)31(4)66-8)27-52(5,6)29-67-50(64)41-13-11-20-59(55-41)49(63)42(24-32-22-35(33)25-36(60)23-32)54-47(61)45(30(2)3)56(7)48(62)34-18-21-57(28-34)51(65)68-37-15-16-37/h10,12,14,17,19,22-23,25-26,30-31,34,37,41-42,45,55,60H,9,11,13,15-16,18,20-21,24,27-29H2,1-8H3,(H,54,61) BQOOYEMOKQVTOA-UHFFFAOYSA-N 750721 US20250195521, Example A202 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750721&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348146 519649315 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541577 CCn1c(-c2ccccc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC3COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O9S/c1-9-56-41-17-16-31-21-36(41)37(44(56)35-14-11-10-13-34(35)30(4)63-8)23-50(5,6)28-65-48(61)38-15-12-19-57(53-38)47(60)39(22-42-51-40(31)27-67-42)52-45(58)43(29(2)3)54(7)46(59)32-18-20-55(24-32)49(62)66-33-25-64-26-33/h10-11,13-14,16-17,21,27,29-30,32-33,38-39,43,53H,9,12,15,18-20,22-26,28H2,1-8H3,(H,52,58) POVLBOYEWOOHDU-UHFFFAOYSA-N 750722 US20250195521, Example A203 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750722&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787030 519649316 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541578 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC3COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H67N7O10/c1-9-58-43-15-14-33-24-39(43)40(46(58)38-12-10-17-53-44(38)31(4)66-8)25-52(5,6)29-68-50(64)41-13-11-18-59(55-41)49(63)42(22-32-20-35(33)23-36(60)21-32)54-47(61)45(30(2)3)56(7)48(62)34-16-19-57(26-34)51(65)69-37-27-67-28-37/h10,12,14-15,17,20-21,23-24,30-31,34,37,41-42,45,55,60H,9,11,13,16,18-19,22,25-29H2,1-8H3,(H,54,61) PWMBOAVHRKWEOZ-UHFFFAOYSA-N 750723 US20250195521, Example A204 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750723&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347472 519649317 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541579 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-10-52-36-16-15-28-19-31(36)32(40(52)30-13-11-17-46-38(30)27(4)58-8)21-45(5,6)25-60-43(56)33-14-12-18-53(49-33)42(55)34(20-37-47-35(28)24-61-37)48-41(54)39(26(2)3)50(7)44(57)51-22-29(23-51)59-9/h11,13,15-17,19,24,26-27,29,33-34,39,49H,10,12,14,18,20-23,25H2,1-9H3,(H,48,54) PLMFWNXCVDDSEL-UHFFFAOYSA-N 750724 US20250195521, Example A205 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750724&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348148 519649318 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541580 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCN(C3COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O7/c1-9-57-43-18-17-35-25-39(43)40(46(57)38-15-11-20-52-44(38)32(4)63-8)26-51(5,6)30-65-50(62)41-16-12-21-58(54-41)49(61)42(24-33-13-10-14-34(35)23-33)53-47(59)45(31(2)3)55(7)48(60)36-19-22-56(27-36)37-28-64-29-37/h10-11,13-15,17-18,20,23,25,31-32,36-37,41-42,45,54H,9,12,16,19,21-22,24,26-30H2,1-8H3,(H,53,59) GLABAVHOSWLPAZ-UHFFFAOYSA-N 750725 US20250195521, Example A206 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750725&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787115 519649319 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541581 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H]1[C@H]3C[C@H]3CN1C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H54N6O7/c1-7-49-38-13-12-28-20-34(38)35(40(49)32-10-8-14-46-39(32)25(2)57-6)22-45(4,5)24-58-44(56)36-11-9-15-51(48-36)43(55)37(18-27-16-29(28)19-31(53)17-27)47-42(54)41-33-21-30(33)23-50(41)26(3)52/h8,10,12-14,16-17,19-20,25,30,33,36-37,41,48,53H,7,9,11,15,18,21-24H2,1-6H3,(H,47,54) VPMPFLBLPAMMFD-UHFFFAOYSA-N 750726 US20250195521, Example A207 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750726&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347495 519649320 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541582 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H]1[C@@H](C)CCN1C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H56N6O7/c1-8-49-38-14-13-30-23-34(38)35(41(49)33-11-9-16-46-39(33)27(3)57-7)24-45(5,6)25-58-44(56)36-12-10-17-51(48-36)43(55)37(21-29-19-31(30)22-32(53)20-29)47-42(54)40-26(2)15-18-50(40)28(4)52/h9,11,13-14,16,19-20,22-23,26-27,36-37,40,48,53H,8,10,12,15,17-18,21,24-25H2,1-7H3,(H,47,54) OTRGMQWVUUUHKB-UHFFFAOYSA-N 750727 US20250195521, Example A208 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750727&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346932 519649321 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541583 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)O[C@H]1CCOC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O9/c1-9-53-40-15-14-31-24-36(40)37(43(53)35-12-10-17-49-41(35)29(4)60-8)25-48(5,6)27-62-46(58)38-13-11-18-54(51-38)45(57)39(22-30-20-32(31)23-33(55)21-30)50-44(56)42(28(2)3)52(7)47(59)63-34-16-19-61-26-34/h10,12,14-15,17,20-21,23-24,28-29,34,38-39,42,51,55H,9,11,13,16,18-19,22,25-27H2,1-8H3,(H,50,56) QHYGPEAWSZBBLO-UHFFFAOYSA-N 750728 US20250195521, Example A209 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750728&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160421943 519649322 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541584 CCn1c(-c2cnccc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N6O7/c1-10-50-39-14-13-30-22-34(39)35(41(50)36-24-46-16-15-33(36)27(4)57-9)23-45(6,7)25-58-44(56)37-12-11-17-51(48-37)43(55)38(20-29-18-31(30)21-32(53)19-29)47-42(54)40(26(2)3)49(8)28(5)52/h13-16,18-19,21-22,24,26-27,37-38,40,48,53H,10-12,17,20,23,25H2,1-9H3,(H,47,54) HGRDKFKQMQWMFA-UHFFFAOYSA-N 750729 US20250195521, Example A21 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750729&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161375753 519649323 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541585 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)O[C@H]1CCOC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H59N7O8S/c1-9-51-36-15-14-28-20-31(36)32(40(51)30-12-10-17-46-38(30)27(4)57-8)22-45(5,6)25-59-43(55)33-13-11-18-52(49-33)42(54)34(21-37-47-35(28)24-61-37)48-41(53)39(26(2)3)50(7)44(56)60-29-16-19-58-23-29/h10,12,14-15,17,20,24,26-27,29,33-34,39,49H,9,11,13,16,18-19,21-23,25H2,1-8H3,(H,48,53) JOAKSDBKONUZLY-UHFFFAOYSA-N 750730 US20250195521, Example A210 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750730&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346964 519649324 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541586 CCOC(=O)N1CC[C@H](C(=O)N(C)[C@H](C(=O)N[C@H]2Cc3cc(O)cc(c3)-c3ccc4c(c3)c(c(-c3cccnc3[C@H](C)OC)n4CC)CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C2=O)C(C)C)C1 InChI=1S/C51H67N7O9/c1-10-57-42-17-16-33-26-38(42)39(45(57)37-14-12-19-52-43(37)31(5)65-9)27-51(6,7)29-67-49(63)40-15-13-20-58(54-40)48(62)41(24-32-22-35(33)25-36(59)23-32)53-46(60)44(30(3)4)55(8)47(61)34-18-21-56(28-34)50(64)66-11-2/h12,14,16-17,19,22-23,25-26,30-31,34,40-41,44,54,59H,10-11,13,15,18,20-21,24,27-29H2,1-9H3,(H,53,60) XHNBXPUUIOVUGF-UHFFFAOYSA-N 750731 US20250195521, Example A211 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750731&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347500 519649325 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541587 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCCC1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H55N7O6S/c1-8-48-34-16-15-27-20-29(34)30(39(48)28-12-9-17-44-37(28)26(4)55-7)22-43(5,6)24-56-42(54)31-13-10-19-50(47-31)41(53)32(21-35-45-33(27)23-57-35)46-40(52)38(25(2)3)49-18-11-14-36(49)51/h9,12,15-17,20,23,25-26,31-32,38,47H,8,10-11,13-14,18-19,21-22,24H2,1-7H3,(H,46,52) XTYPHDXLKPIXNA-UHFFFAOYSA-N 750732 US20250195521, Example A212 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750732&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348181 519649326 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541588 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCC3(CCN(C)C3)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O6S/c1-9-53-37-15-14-30-22-32(37)33(41(53)31-12-10-18-48-39(31)29(4)60-8)24-46(5,6)27-61-44(58)34-13-11-19-55(51-34)43(57)35(23-38-49-36(30)25-62-38)50-42(56)40(28(2)3)54-21-17-47(45(54)59)16-20-52(7)26-47/h10,12,14-15,18,22,25,28-29,34-35,40,51H,9,11,13,16-17,19-21,23-24,26-27H2,1-8H3,(H,50,56) FJPRYRMQODVNND-UHFFFAOYSA-N 750733 US20250195521, Example A213 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750733&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348110 519649327 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541589 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)(C)O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O8/c1-9-49-36-15-14-28-22-32(36)33(38(49)31-12-10-16-45-37(31)25(2)57-8)23-43(4,5)24-58-42(55)34-13-11-17-50(48-34)41(54)35(20-27-18-29(28)21-30(52)19-27)47-40(53)39(44(6,7)56)46-26(3)51/h10,12,14-16,18-19,21-22,25,34-35,39,48,52,56H,9,11,13,17,20,23-24H2,1-8H3,(H,46,51)(H,47,53) QQHNDOOYPBBCEF-UHFFFAOYSA-N 750734 US20250195521, Example A214 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750734&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348161 519649328 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541590 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CN(C(C)=O)C[C@H]1C(F)(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H62F3N7O8/c1-9-59-42-13-12-31-21-35(42)36(44(59)37-23-54-15-14-32(37)26-67-8)22-49(5,6)27-68-48(66)40-11-10-16-60(56-40)47(65)41(19-30-17-33(31)20-34(62)18-30)55-45(63)43(28(2)3)57(7)46(64)38-24-58(29(4)61)25-39(38)50(51,52)53/h12-15,17-18,20-21,23,28,38-41,43,56,62H,9-11,16,19,22,24-27H2,1-8H3,(H,55,63) OFDJFZQWPOITRU-UHFFFAOYSA-N 750735 US20250195521, Example A215 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750735&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159975820 519649329 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541591 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CNC[C@H]1C(F)(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H60F3N7O7/c1-8-57-40-12-11-29-20-33(40)34(42(57)35-22-52-14-13-30(35)25-64-7)21-47(4,5)26-65-46(63)38-10-9-15-58(55-38)45(62)39(18-28-16-31(29)19-32(59)17-28)54-43(60)41(27(2)3)56(6)44(61)36-23-53-24-37(36)48(49,50)51/h11-14,16-17,19-20,22,27,36-39,41,53,55,59H,8-10,15,18,21,23-26H2,1-7H3,(H,54,60) ZOXRDJSVTKFBBH-UHFFFAOYSA-N 750736 US20250195521, Example A216 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750736&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162180264 519649330 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541592 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1NC[C@@H]3C[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O7/c1-9-55-40-15-14-30-22-36(40)37(44(55)34-12-10-16-50-41(34)28(4)62-8)24-49(5,6)26-63-48(61)38-13-11-17-56(53-38)46(59)39(20-29-18-31(30)21-33(57)19-29)52-45(58)43(27(2)3)54(7)47(60)42-35-23-32(35)25-51-42/h10,12,14-16,18-19,21-22,27-28,32,35,38-39,42-43,51,53,57H,9,11,13,17,20,23-26H2,1-8H3,(H,52,58) YMEVQDMFHAAVII-UHFFFAOYSA-N 750737 US20250195521, Example A217 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750737&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346971 519649331 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541593 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O7/c1-9-53-40-18-17-32-25-36(40)37(43(53)35-15-11-19-49-41(35)29(4)60-8)26-48(5,6)27-61-47(59)38-16-12-20-54(51-38)46(58)39(23-30-21-33(32)24-34(55)22-30)50-44(56)42(28(2)3)52(7)45(57)31-13-10-14-31/h11,15,17-19,21-22,24-25,28-29,31,38-39,42,51,55H,9-10,12-14,16,20,23,26-27H2,1-8H3,(H,50,56) NKVBZJWQEHRHEX-UHFFFAOYSA-N 750738 US20250195521, Example A218 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750738 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750738&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346579 519649332 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541594 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H64N6O7/c1-9-54-41-19-18-33-26-37(41)38(44(54)36-16-12-20-50-42(36)30(4)61-8)27-49(5,6)28-62-48(60)39-17-13-21-55(52-39)47(59)40(24-31-22-34(33)25-35(56)23-31)51-45(57)43(29(2)3)53(7)46(58)32-14-10-11-15-32/h12,16,18-20,22-23,25-26,29-30,32,39-40,43,52,56H,9-11,13-15,17,21,24,27-28H2,1-8H3,(H,51,57) NBCJZXJYPWRGEE-UHFFFAOYSA-N 750739 US20250195521, Example A219 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750739&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346943 519649333 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541595 CCn1c(-c2cccnc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O8/c1-9-55-42-15-14-32-24-37(42)38(44(55)36-12-10-17-50-41(36)27-63-8)25-49(5,6)28-64-48(62)39-13-11-18-56(52-39)47(61)40(22-31-20-34(32)23-35(58)21-31)51-45(59)43(29(2)3)53(7)46(60)33-16-19-54(26-33)30(4)57/h10,12,14-15,17,20-21,23-24,29,33,39-40,43,52,58H,9,11,13,16,18-19,22,25-28H2,1-8H3,(H,51,59) HFUKKWMBGAPQCO-UHFFFAOYSA-N 750740 US20250195521, Example A22 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750740 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750740&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160053111 519649334 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541596 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCC3(CCN(S(C)(=O)=O)C3)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O8S2/c1-9-53-37-15-14-30-22-32(37)33(41(53)31-12-10-18-48-39(31)29(4)62-7)24-46(5,6)27-63-44(58)34-13-11-19-55(51-34)43(57)35(23-38-49-36(30)25-64-38)50-42(56)40(28(2)3)54-21-17-47(45(54)59)16-20-52(26-47)65(8,60)61/h10,12,14-15,18,22,25,28-29,34-35,40,51H,9,11,13,16-17,19-21,23-24,26-27H2,1-8H3,(H,50,56) JPTJWEBUDWLNNB-UHFFFAOYSA-N 750741 US20250195521, Example A220 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750741 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750741&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158987584 519649335 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541597 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCC3(CCN(C(=O)OC)C3)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N8O8S/c1-9-54-37-15-14-30-22-32(37)33(41(54)31-12-10-18-49-39(31)29(4)62-7)24-47(5,6)27-64-44(59)34-13-11-19-56(52-34)43(58)35(23-38-50-36(30)25-65-38)51-42(57)40(28(2)3)55-21-17-48(45(55)60)16-20-53(26-48)46(61)63-8/h10,12,14-15,18,22,25,28-29,34-35,40,52H,9,11,13,16-17,19-21,23-24,26-27H2,1-8H3,(H,51,57) ABKAFJKNKDISKM-UHFFFAOYSA-N 750742 cyclopropane-1-carboxamide::US20250195521, Example A221 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750742 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750742&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347077 519649336 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541598 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCC3(CN(C)C3)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O6S/c1-9-52-36-15-14-29-20-31(36)32(40(52)30-12-10-17-47-38(30)28(4)59-8)22-45(5,6)26-60-43(57)33-13-11-18-54(50-33)42(56)34(21-37-48-35(29)23-61-37)49-41(55)39(27(2)3)53-19-16-46(44(53)58)24-51(7)25-46/h10,12,14-15,17,20,23,27-28,33-34,39,50H,9,11,13,16,18-19,21-22,24-26H2,1-8H3,(H,49,55) KTBJEJQLCXESRV-UHFFFAOYSA-N 750743 US20250195521, Example A222 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750743 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750743&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346561 519649337 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541599 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O7/c1-10-53-40-16-15-31-24-36(40)37(43(53)34-13-11-17-49-41(34)29(5)60-9)25-48(6,7)26-61-47(59)38-14-12-18-54(51-38)46(58)39(22-30-20-32(31)23-33(55)21-30)50-44(56)42(27(2)3)52(8)45(57)35-19-28(35)4/h11,13,15-17,20-21,23-24,27-29,35,38-39,42,51,55H,10,12,14,18-19,22,25-26H2,1-9H3,(H,50,56) IUKNWVGAPTWPBU-UHFFFAOYSA-N 750744 US20250195521, Example A223 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750744 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750744&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346975 519649338 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541600 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O7/c1-9-52-39-17-16-31-24-35(39)36(42(52)34-12-10-18-48-40(34)28(4)59-8)25-47(5,6)26-60-46(58)37-13-11-19-53(50-37)45(57)38(22-29-20-32(31)23-33(54)21-29)49-43(55)41(27(2)3)51(7)44(56)30-14-15-30/h10,12,16-18,20-21,23-24,27-28,30,37-38,41,50,54H,9,11,13-15,19,22,25-26H2,1-8H3,(H,49,55) XRGUBOSOYBQIQB-UHFFFAOYSA-N 750745 US20250195521, Example A224 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750745 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750745&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347943 519649339 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541601 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C1CCC1C#N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H50N6O6/c1-6-48-37-14-12-27-21-33(37)34(39(48)32-9-7-15-45-38(32)25(2)54-5)22-43(3,4)24-55-42(53)35-10-8-16-49(47-35)41(52)36(19-26-17-29(27)20-30(50)18-26)46-40(51)31-13-11-28(31)23-44/h7,9,12,14-15,17-18,20-21,25,28,31,35-36,47,50H,6,8,10-11,13,16,19,22,24H2,1-5H3,(H,46,51) OMXVJVDJGZCUPX-UHFFFAOYSA-N 750746 US20250195521, Example A225 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750746 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750746&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346959 519649340 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541602 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCc3ccccc3N1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H65N7O7/c1-9-59-45-21-19-35-28-39(45)40(48(59)38-15-12-22-54-46(38)32(4)66-8)29-53(5,6)30-67-52(65)43-17-13-23-60(57-43)51(64)44(26-33-24-36(35)27-37(61)25-33)56-49(62)47(31(2)3)58(7)50(63)42-20-18-34-14-10-11-16-41(34)55-42/h10-12,14-16,19,21-22,24-25,27-28,31-32,42-44,47,55,57,61H,9,13,17-18,20,23,26,29-30H2,1-8H3,(H,56,62) HLRTZGJVKKXKLJ-UHFFFAOYSA-N 750747 US20250195521, Example A226 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750747&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346545 519649341 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541603 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1NCCC1C(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H69N7O7/c1-11-57-42-17-16-33-26-38(42)39(46(57)37-14-12-19-52-43(37)31(6)64-10)27-51(7,8)28-65-50(63)40-15-13-21-58(55-40)48(61)41(24-32-22-34(33)25-35(59)23-32)54-47(60)45(30(4)5)56(9)49(62)44-36(29(2)3)18-20-53-44/h12,14,16-17,19,22-23,25-26,29-31,36,40-41,44-45,53,55,59H,11,13,15,18,20-21,24,27-28H2,1-10H3,(H,54,60) UQUCMTVVQQTZPY-UHFFFAOYSA-N 750748 US20250195521, Example A227 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750748 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750748&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346954 519649342 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541604 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1NCCC13CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O7/c1-9-56-40-15-14-32-26-36(40)37(43(56)35-12-10-19-51-41(35)30(4)63-8)27-49(5,6)28-64-48(62)38-13-11-21-57(54-38)46(60)39(24-31-22-33(32)25-34(58)23-31)53-45(59)42(29(2)3)55(7)47(61)44-50(16-17-50)18-20-52-44/h10,12,14-15,19,22-23,25-26,29-30,38-39,42,44,52,54,58H,9,11,13,16-18,20-21,24,27-28H2,1-8H3,(H,53,59) FISKKCRWTBUCHY-UHFFFAOYSA-N 750749 US20250195521, Example A228 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750749 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750749&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346957 519649343 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541605 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CNCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O8/c1-9-54-39-15-14-31-24-35(39)36(43(54)34-12-10-16-50-41(34)29(4)61-8)25-48(5,6)27-63-47(60)37-13-11-18-55(52-37)45(58)38(22-30-20-32(31)23-33(56)21-30)51-44(57)42(28(2)3)53(7)46(59)40-26-49-17-19-62-40/h10,12,14-16,20-21,23-24,28-29,37-38,40,42,49,52,56H,9,11,13,17-19,22,25-27H2,1-8H3,(H,51,57) SLOMDQKDYWJYFE-UHFFFAOYSA-N 750750 US20250195521, Example A229 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750750&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346982 519649344 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541606 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(CCO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O8/c1-8-55-42-12-11-32-24-37(42)38(44(55)39-26-50-15-13-34(39)28-63-7)25-49(4,5)29-64-48(62)40-10-9-16-56(52-40)47(61)41(22-31-20-35(32)23-36(58)21-31)51-45(59)43(30(2)3)53(6)46(60)33-14-17-54(27-33)18-19-57/h11-13,15,20-21,23-24,26,30,33,40-41,43,52,57-58H,8-10,14,16-19,22,25,27-29H2,1-7H3,(H,51,59) OMFMXSNNOUSNNJ-UHFFFAOYSA-N 750751 US20250195521, Example A23 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750751&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347795 519649345 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541607 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCC(=O)N1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O8/c1-10-55-39-16-15-31-25-35(39)36(44(55)34-13-11-19-50-42(34)29(4)63-9)26-49(5,6)27-64-48(62)37-14-12-20-56(52-37)46(60)38(23-30-21-32(31)24-33(57)22-30)51-45(59)43(28(2)3)54(8)47(61)40-17-18-41(58)53(40)7/h11,13,15-16,19,21-22,24-25,28-29,37-38,40,43,52,57H,10,12,14,17-18,20,23,26-27H2,1-9H3,(H,51,59) VDHMEXBHHPULAT-UHFFFAOYSA-N 750752 US20250195521, Example A230 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750752&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347479 519649346 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541608 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CN[C@@H]3CCO[C@H]13)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O8/c1-9-56-41-15-14-31-24-35(41)36(44(56)34-12-10-17-51-42(34)29(4)63-8)25-50(5,6)27-65-49(62)39-13-11-18-57(54-39)48(61)40(22-30-20-32(31)23-33(58)21-30)53-46(59)43(28(2)3)55(7)47(60)37-26-52-38-16-19-64-45(37)38/h10,12,14-15,17,20-21,23-24,28-29,37-40,43,45,52,54,58H,9,11,13,16,18-19,22,25-27H2,1-8H3,(H,53,59) WVUZRFHSBGPJKT-UHFFFAOYSA-N 750753 US20250195521, Example A231 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750753&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347733 519649347 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541609 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(CO)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O8/c1-9-53-39-15-14-31-24-35(39)36(42(53)34-12-10-18-49-40(34)29(4)61-8)25-47(5,6)27-62-45(59)37-13-11-19-54(51-37)44(58)38(22-30-20-32(31)23-33(56)21-30)50-43(57)41(28(2)3)52(7)46(60)48(26-55)16-17-48/h10,12,14-15,18,20-21,23-24,28-29,37-38,41,51,55-56H,9,11,13,16-17,19,22,25-27H2,1-8H3,(H,50,57) WSBKKWJCZDTWIY-UHFFFAOYSA-N 750754 US20250195521, Example A232 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750754&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347775 519649348 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541610 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC(C)(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H71N7O9/c1-12-59-43-18-17-34-27-39(43)40(46(59)38-15-13-20-54-44(38)32(4)67-11)28-53(8,9)30-68-50(65)41-16-14-21-60(56-41)49(64)42(25-33-23-36(34)26-37(61)24-33)55-47(62)45(31(2)3)57(10)48(63)35-19-22-58(29-35)51(66)69-52(5,6)7/h13,15,17-18,20,23-24,26-27,31-32,35,41-42,45,56,61H,12,14,16,19,21-22,25,28-30H2,1-11H3,(H,55,62) RXEAWALVMQHKNK-UHFFFAOYSA-N 750755 US20250195521, Example A233 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750755 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750755&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346983 519649349 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541611 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCC3(CN(S(C)(=O)=O)C3)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O8S2/c1-9-52-36-15-14-29-20-31(36)32(40(52)30-12-10-17-47-38(30)28(4)61-7)22-45(5,6)26-62-43(57)33-13-11-18-54(50-33)42(56)34(21-37-48-35(29)23-63-37)49-41(55)39(27(2)3)53-19-16-46(44(53)58)24-51(25-46)64(8,59)60/h10,12,14-15,17,20,23,27-28,33-34,39,50H,9,11,13,16,18-19,21-22,24-26H2,1-8H3,(H,49,55) SLRAQPCOGOCSJH-UHFFFAOYSA-N 750756 US20250195521, Example A234 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750756&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348196 519649350 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541612 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCC3(CN(C(=O)OC)C3)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N8O8S/c1-9-53-36-15-14-29-20-31(36)32(40(53)30-12-10-17-48-38(30)28(4)61-7)22-46(5,6)26-63-43(58)33-13-11-18-55(51-33)42(57)34(21-37-49-35(29)23-64-37)50-41(56)39(27(2)3)54-19-16-47(44(54)59)24-52(25-47)45(60)62-8/h10,12,14-15,17,20,23,27-28,33-34,39,51H,9,11,13,16,18-19,21-22,24-26H2,1-8H3,(H,50,56) PIEATFFRTIHOKT-UHFFFAOYSA-N 750757 US20250195521, Example A235 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750757&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160212587 519649351 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541613 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C(C)C1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H57N5O7/c1-7-49-39-13-12-31-24-35(39)36(41(49)34-10-8-16-46-40(34)28(3)55-6)25-45(4,5)26-57-44(54)37-11-9-17-50(48-37)43(53)38(22-29-20-32(31)23-33(51)21-29)47-42(52)27(2)30-14-18-56-19-15-30/h8,10,12-13,16,20-21,23-24,27-28,30,37-38,48,51H,7,9,11,14-15,17-19,22,25-26H2,1-6H3,(H,47,52) GXFZPPYFTHXQFQ-UHFFFAOYSA-N 750758 US20250195521, Example A236 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750758&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346481 519649352 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541614 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(S(C)(=O)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O8S2/c1-10-53-37-16-15-29-21-32(37)33(41(53)31-13-11-18-47-39(31)28(4)61-8)23-46(5,6)26-62-45(58)34-14-12-19-54(50-34)44(57)35(22-38-48-36(29)25-63-38)49-42(55)40(27(2)3)51(7)43(56)30-17-20-52(24-30)64(9,59)60/h11,13,15-16,18,21,25,27-28,30,34-35,40,50H,10,12,14,17,19-20,22-24,26H2,1-9H3,(H,49,55) QVNXGUSGJSVZCS-UHFFFAOYSA-N 750759 US20250195521, Example A237 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750759&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160531117 519649353 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541615 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H59N7O7S/c1-9-51-35-17-16-28-21-30(35)31(40(51)29-13-10-18-46-38(29)27(4)57-8)23-45(5,6)25-59-44(56)32-14-11-19-52(49-32)42(54)33(22-37-47-34(28)24-60-37)48-41(53)39(26(2)3)50(7)43(55)36-15-12-20-58-36/h10,13,16-18,21,24,26-27,32-33,36,39,49H,9,11-12,14-15,19-20,22-23,25H2,1-8H3,(H,48,53) DOIMOAPVTNHKFI-UHFFFAOYSA-N 750760 US20250195521, Example A238 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750760&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157867698 519649354 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541616 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H59N7O6S/c1-10-51-36-16-15-28-20-31(36)32(40(51)29-13-11-17-46-38(29)27(5)57-9)22-45(6,7)24-58-44(56)33-14-12-18-52(49-33)43(55)34(21-37-47-35(28)23-59-37)48-41(53)39(25(2)3)50(8)42(54)30-19-26(30)4/h11,13,15-17,20,23,25-27,30,33-34,39,49H,10,12,14,18-19,21-22,24H2,1-9H3,(H,48,53) VAGDVRXHHQZBDB-UHFFFAOYSA-N 750761 US20250195521, Example A239 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750761&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347523 519649355 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541617 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(S(C)(=O)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O9S/c1-9-54-41-13-12-31-23-36(41)37(43(54)38-25-49-16-14-33(38)27-63-7)24-48(4,5)28-64-47(60)39-11-10-17-55(51-39)46(59)40(21-30-19-34(31)22-35(56)20-30)50-44(57)42(29(2)3)52(6)45(58)32-15-18-53(26-32)65(8,61)62/h12-14,16,19-20,22-23,25,29,32,39-40,42,51,56H,9-11,15,17-18,21,24,26-28H2,1-8H3,(H,50,57) VPCMLRNVAGFNDB-UHFFFAOYSA-N 750762 US20250195521, Example A24 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750762&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346989 519649356 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541618 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O8/c1-9-53-39-17-16-31-25-35(39)36(43(53)34-13-10-18-49-41(34)29(4)60-8)26-48(5,6)27-62-47(59)37-14-11-19-54(51-37)45(57)38(23-30-21-32(31)24-33(55)22-30)50-44(56)42(28(2)3)52(7)46(58)40-15-12-20-61-40/h10,13,16-18,21-22,24-25,28-29,37-38,40,42,51,55H,9,11-12,14-15,19-20,23,26-27H2,1-8H3,(H,50,56) HACVIVWYYHQMBM-UHFFFAOYSA-N 750763 US20250195521, Example A240 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750763&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347085 519649357 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541619 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@H](O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O8/c1-9-53-40-15-14-30-24-36(40)37(43(53)35-12-10-16-49-41(35)28(4)61-8)25-48(5,6)26-62-47(60)38-13-11-17-54(51-38)46(59)39(20-29-18-31(30)21-33(55)19-29)50-44(57)42(27(2)3)52(7)45(58)32-22-34(56)23-32/h10,12,14-16,18-19,21,24,27-28,32,34,38-39,42,51,55-56H,9,11,13,17,20,22-23,25-26H2,1-8H3,(H,50,57) LVOOVEJGEUIQEN-UHFFFAOYSA-N 750764 US20250195521, Example A241 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750764&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346522 519649358 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541620 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O7/c1-9-56-42-18-17-33-26-38(42)39(45(56)37-15-12-20-52-43(37)31(4)63-8)27-50(5,6)29-64-49(62)40-16-13-21-57(54-40)48(61)41(24-32-22-35(33)25-36(58)23-32)53-46(59)44(30(2)3)55(7)47(60)34-14-10-11-19-51-28-34/h12,15,17-18,20,22-23,25-26,30-31,34,40-41,44,51,54,58H,9-11,13-14,16,19,21,24,27-29H2,1-8H3,(H,53,59) SFDAAHKUHNIRLS-UHFFFAOYSA-N 750765 US20250195521, Example A242 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750765&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347065 519649359 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541621 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-9-55-41-17-16-32-25-37(41)38(44(55)36-14-11-19-51-42(36)30(4)62-8)26-49(5,6)28-63-48(61)39-15-12-20-56(53-39)47(60)40(23-31-21-34(32)24-35(57)22-31)52-45(58)43(29(2)3)54(7)46(59)33-13-10-18-50-27-33/h11,14,16-17,19,21-22,24-25,29-30,33,39-40,43,50,53,57H,9-10,12-13,15,18,20,23,26-28H2,1-8H3,(H,52,58) DXXGDLQVNLLUAD-UHFFFAOYSA-N 750766 US20250195521, Example A243 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750766&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157950483 519649360 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541622 CCn5c(c1cccnc1[C@H](C)OC)c6CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]3CCN(C(C)=O)C3)Cc4nc(cs4)c7ccc5c6c7 InChI=1S/C47H62N8O7S/c1-10-54-38-16-15-30-21-33(38)34(42(54)32-13-11-18-48-40(32)28(4)61-9)23-47(6,7)26-62-46(60)35-14-12-19-55(51-35)45(59)36(22-39-49-37(30)25-63-39)50-43(57)41(27(2)3)52(8)44(58)31-17-20-53(24-31)29(5)56/h11,13,15-16,18,21,25,27-28,31,35-36,41,51H,10,12,14,17,19-20,22-24,26H2,1-9H3,(H,50,57) MXXSGZJNBLTMPU-UHFFFAOYSA-N 750767 US20250195521, Example A244 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750767&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159703561 519649361 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541623 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H57N7O7S/c1-9-50-35-15-14-27-18-30(35)31(39(50)29-12-10-16-45-37(29)26(4)56-8)20-44(5,6)24-58-43(55)32-13-11-17-51(48-32)42(54)33(19-36-46-34(27)23-59-36)47-40(52)38(25(2)3)49(7)41(53)28-21-57-22-28/h10,12,14-16,18,23,25-26,28,32-33,38,48H,9,11,13,17,19-22,24H2,1-8H3,(H,47,52) VETQNKFZLGZEAN-UHFFFAOYSA-N 750768 US20250195521, Example A245 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750768&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161278582 519649362 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541624 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O7/c1-9-52-39-18-17-32-23-35(39)36(42(52)34-15-11-19-48-40(34)29(4)58-8)24-47(5,6)27-60-46(57)37-16-12-20-53(50-37)45(56)38(22-30-13-10-14-31(32)21-30)49-43(54)41(28(2)3)51(7)44(55)33-25-59-26-33/h10-11,13-15,17-19,21,23,28-29,33,37-38,41,50H,9,12,16,20,22,24-27H2,1-8H3,(H,49,54) SJMABGFXMIAZCV-UHFFFAOYSA-N 750769 US20250195521, Example A246 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750769 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750769&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346565 519649363 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541625 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCc3ncccc3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H65N7O7/c1-9-59-45-19-17-34-28-40(45)41(48(59)39-14-11-21-55-46(39)32(4)66-8)29-53(5,6)30-67-52(65)43-15-12-22-60(57-43)51(64)44(25-33-23-37(34)27-38(61)24-33)56-49(62)47(31(2)3)58(7)50(63)36-16-18-42-35(26-36)13-10-20-54-42/h10-11,13-14,17,19-21,23-24,27-28,31-32,36,43-44,47,57,61H,9,12,15-16,18,22,25-26,29-30H2,1-8H3,(H,56,62) NWEARFSIADLTLY-UHFFFAOYSA-N 750770 US20250195521, Example A247 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750770 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750770&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346584 519649364 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541626 CCN1CC(C(=O)N(C)[C@H](C(=O)N[C@H]2Cc3cc(O)cc(c3)-c3ccc4c(c3)c(c(-c3cccnc3[C@H](C)OC)n4CC)CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C2=O)C(C)C)CC1=O InChI=1S/C50H65N7O8/c1-10-55-27-34(25-42(55)59)47(61)54(8)44(29(3)4)46(60)52-40-22-31-20-33(23-35(58)21-31)32-16-17-41-37(24-32)38(45(56(41)11-2)36-14-12-18-51-43(36)30(5)64-9)26-50(6,7)28-65-49(63)39-15-13-19-57(53-39)48(40)62/h12,14,16-18,20-21,23-24,29-30,34,39-40,44,53,58H,10-11,13,15,19,22,25-28H2,1-9H3,(H,52,60) QUUJRRMGJNDGHU-UHFFFAOYSA-N 750771 US20250195521, Example A248 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750771 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750771&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160525210 519649365 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541627 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1Cc3nccn3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H62N8O7/c1-9-57-41-15-14-32-24-37(41)38(45(57)36-12-10-16-52-43(36)30(4)64-8)26-50(5,6)28-65-49(63)39-13-11-18-58(54-39)48(62)40(22-31-20-33(32)23-35(59)21-31)53-46(60)44(29(2)3)55(7)47(61)34-25-42-51-17-19-56(42)27-34/h10,12,14-17,19-21,23-24,29-30,34,39-40,44,54,59H,9,11,13,18,22,25-28H2,1-8H3,(H,53,60) ZMFPTJGOWSQSJZ-UHFFFAOYSA-N 750772 US20250195521, Example A249 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750772 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750772&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347724 519649366 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541628 CCn1c(-c2cccnc2[C@H](C)OC)cc2cc(-c3cc(O)cc(C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N4CCC[C@@H](C(=O)OCC(C)C)N4)c3)ccc21 InChI=1S/C44H58N6O7/c1-10-49-38-16-15-31(22-33(38)24-39(49)35-13-11-17-45-40(35)28(6)56-9)32-19-30(20-34(52)23-32)21-37(46-42(53)41(27(4)5)48(8)29(7)51)43(54)50-18-12-14-36(47-50)44(55)57-25-26(2)3/h11,13,15-17,19-20,22-24,26-28,36-37,41,47,52H,10,12,14,18,21,25H2,1-9H3,(H,46,53) DEYJZDFLLQSAJU-UHFFFAOYSA-N 750773 US20250195521, Example A25 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750773 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750773&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160778771 519649367 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541629 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1Cc3cccnc3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H63N7O7/c1-9-58-44-17-16-33-26-39(44)40(47(58)38-14-11-19-54-45(38)31(4)65-8)28-52(5,6)29-66-51(64)41-15-12-20-59(56-41)50(63)43(23-32-21-35(33)25-37(60)22-32)55-48(61)46(30(2)3)57(7)49(62)36-24-34-13-10-18-53-42(34)27-36/h10-11,13-14,16-19,21-22,25-26,30-31,36,41,43,46,56,60H,9,12,15,20,23-24,27-29H2,1-8H3,(H,55,61) ZKVLALLEPHZJAI-UHFFFAOYSA-N 750774 US20250195521, Example A250 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750774 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750774&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347457 519649368 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541630 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CNC[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-10-55-41-16-15-32-23-36(41)37(44(55)35-13-11-17-51-42(35)30(5)62-9)24-49(6,7)27-63-48(61)39-14-12-18-56(53-39)47(60)40(21-31-19-33(32)22-34(57)20-31)52-45(58)43(28(2)3)54(8)46(59)38-26-50-25-29(38)4/h11,13,15-17,19-20,22-23,28-30,38-40,43,50,53,57H,10,12,14,18,21,24-27H2,1-9H3,(H,52,58) PYVHHWZKJRKTFD-UHFFFAOYSA-N 750775 US20250195521, Example A251 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750775&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346970 519649369 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541631 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC(=O)N(C3CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H65N7O8/c1-9-56-42-17-14-32-24-38(42)39(46(56)37-12-10-18-52-44(37)30(4)65-8)26-51(5,6)28-66-50(64)40-13-11-19-58(54-40)49(63)41(22-31-20-33(32)23-36(59)21-31)53-47(61)45(29(2)3)55(7)48(62)34-25-43(60)57(27-34)35-15-16-35/h10,12,14,17-18,20-21,23-24,29-30,34-35,40-41,45,54,59H,9,11,13,15-16,19,22,25-28H2,1-8H3,(H,53,61) FWTPKISPLZOJHN-UHFFFAOYSA-N 750776 US20250195521, Example A252 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750776 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750776&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158165316 519649370 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541632 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C1[C@H]3COC[C@@H]13)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H51N5O7/c1-6-47-36-12-11-26-19-30(36)31(39(47)29-9-7-13-44-38(29)24(2)53-5)20-43(3,4)23-55-42(52)34-10-8-14-48(46-34)41(51)35(17-25-15-27(26)18-28(49)16-25)45-40(50)37-32-21-54-22-33(32)37/h7,9,11-13,15-16,18-19,24,32-35,37,46,49H,6,8,10,14,17,20-23H2,1-5H3,(H,45,50) JWYSIMMZQYLROP-UHFFFAOYSA-N 750777 US20250195521, Example A253 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750777&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348203 519649371 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541633 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C1CCCC1C(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H53F2N5O6/c1-6-50-37-15-14-27-22-33(37)34(39(50)32-12-8-16-47-38(32)25(2)56-5)23-44(3,4)24-57-43(55)35-13-9-17-51(49-35)42(54)36(20-26-18-28(27)21-29(52)19-26)48-41(53)31-11-7-10-30(31)40(45)46/h8,12,14-16,18-19,21-22,25,30-31,35-36,40,49,52H,6-7,9-11,13,17,20,23-24H2,1-5H3,(H,48,53) DCMXIQFTFYXUCL-UHFFFAOYSA-N 750778 US20250195521, Example A254 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750778 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750778&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157764800 519649372 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541634 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCNCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O7/c1-8-54-40-12-11-31-24-35(40)36(42(54)37-26-49-14-13-32(37)27-61-7)25-47(4,5)28-62-45(59)38-10-9-17-55(51-38)44(58)39(22-30-20-33(31)23-34(56)21-30)50-43(57)41(29(2)3)52(6)46(60)53-18-15-48-16-19-53/h11-14,20-21,23-24,26,29,38-39,41,48,51,56H,8-10,15-19,22,25,27-28H2,1-7H3,(H,50,57) PTNCTZOCRGCJHF-UHFFFAOYSA-N 750779 US20250195521, Example A255 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750779 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750779&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346676 519649373 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541635 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N6O7/c1-10-50-38-16-15-30-23-34(38)35(41(50)33-13-11-17-46-39(33)27(4)57-9)24-45(6,7)25-58-44(56)36-14-12-18-51(48-36)43(55)37(21-29-19-31(30)22-32(53)20-29)47-42(54)40(26(2)3)49(8)28(5)52/h11,13,15-17,19-20,22-23,26-27,36-37,40,48,53H,10,12,14,18,21,24-25H2,1-9H3,(H,47,54) BTYNCDWJNRHJIM-UHFFFAOYSA-N 750780 US20250195521, Example A256 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750780&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346589 519649374 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541636 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O8/c1-8-53-40-12-11-31-24-35(40)36(42(53)37-26-48-14-13-32(37)27-60-7)25-47(4,5)28-62-45(58)38-10-9-15-54(50-38)44(57)39(22-30-20-33(31)23-34(55)21-30)49-43(56)41(29(2)3)51(6)46(59)52-16-18-61-19-17-52/h11-14,20-21,23-24,26,29,38-39,41,50,55H,8-10,15-19,22,25,27-28H2,1-7H3,(H,49,56) YYVMJVDMCPRZCY-UHFFFAOYSA-N 750781 US20250195521, Example A257 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750781&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346705 519649375 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541637 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C(C)C1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H55N5O7/c1-6-48-39-10-9-30-22-34(39)35(40(48)36-24-45-14-11-31(36)25-54-5)23-44(3,4)26-56-43(53)37-8-7-15-49(47-37)42(52)38(20-28-18-32(30)21-33(50)19-28)46-41(51)27(2)29-12-16-55-17-13-29/h9-11,14,18-19,21-22,24,27,29,37-38,47,50H,6-8,12-13,15-17,20,23,25-26H2,1-5H3,(H,46,51) LFNMCESPIHJBJH-UHFFFAOYSA-N 750782 US20250195521, Example A258 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750782 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750782&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348173 519649376 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541638 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-9-55-42-15-14-32-24-37(42)38(44(55)39-26-50-17-16-34(39)28-62-8)25-49(4,5)29-63-48(61)40-13-11-19-56(52-40)47(60)41(22-31-20-35(32)23-36(57)21-31)51-45(58)43(30(2)3)54(7)46(59)33-12-10-18-53(6)27-33/h14-17,20-21,23-24,26,30,33,40-41,43,52,57H,9-13,18-19,22,25,27-29H2,1-8H3,(H,51,58) VUEIATSHFSCXKS-UHFFFAOYSA-N 750783 US20250195521, Example A259 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750783&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346588 519649377 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541639 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCOC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-8-52-40-12-11-30-22-35(40)36(42(52)37-24-48-15-13-31(37)25-59-7)23-47(4,5)27-61-46(58)38-10-9-16-53(50-38)45(57)39(20-29-18-33(30)21-34(54)19-29)49-43(55)41(28(2)3)51(6)44(56)32-14-17-60-26-32/h11-13,15,18-19,21-22,24,28,32,38-39,41,50,54H,8-10,14,16-17,20,23,25-27H2,1-7H3,(H,49,55) IOWITRRMARPJIP-UHFFFAOYSA-N 750784 US20250195521, Example A26 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750784&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348056 519649378 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541640 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)O[C@H]1CCOC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O9/c1-8-52-40-12-11-30-22-35(40)36(42(52)37-24-48-15-13-31(37)25-59-7)23-47(4,5)27-61-45(57)38-10-9-16-53(50-38)44(56)39(20-29-18-32(30)21-33(54)19-29)49-43(55)41(28(2)3)51(6)46(58)62-34-14-17-60-26-34/h11-13,15,18-19,21-22,24,28,34,38-39,41,50,54H,8-10,14,16-17,20,23,25-27H2,1-7H3,(H,49,55) NUQSLYQMXSXCKQ-UHFFFAOYSA-N 750785 US20250195521, Example A260 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750785&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346578 519649379 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541641 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C1CCCC1C(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H51F2N5O6/c1-5-49-37-12-11-26-20-32(37)33(38(49)34-22-46-14-13-27(34)23-55-4)21-43(2,3)24-56-42(54)35-10-7-15-50(48-35)41(53)36(18-25-16-28(26)19-29(51)17-25)47-40(52)31-9-6-8-30(31)39(44)45/h11-14,16-17,19-20,22,30-31,35-36,39,48,51H,5-10,15,18,21,23-24H2,1-4H3,(H,47,52) RQIKBJMIGOJWDB-UHFFFAOYSA-N 750786 US20250195521, Example A261 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750786 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750786&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347071 519649380 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541642 CCN1C[C@@H](C(=O)N(C)[C@H](C(=O)N[C@H]2Cc3cc(O)cc(c3)-c3ccc4c(c3)c(c(-c3cnccc3COC)n4CC)CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C2=O)C(C)C)CC1=O InChI=1S/C49H63N7O8/c1-9-54-26-34(23-42(54)58)46(60)53(7)43(29(3)4)45(59)51-40-20-30-18-33(21-35(57)19-30)31-13-14-41-36(22-31)37(44(55(41)10-2)38-25-50-16-15-32(38)27-63-8)24-49(5,6)28-64-48(62)39-12-11-17-56(52-39)47(40)61/h13-16,18-19,21-22,25,29,34,39-40,43,52,57H,9-12,17,20,23-24,26-28H2,1-8H3,(H,51,59) JFKRHSFWKCQCTH-UHFFFAOYSA-N 750787 US20250195521, Example A262 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750787&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348179 519649381 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541643 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)N1CC[C@@H]1COC)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C40H51N7O6S/c1-7-45-33-13-12-25-18-28(33)29(36(45)27-10-8-15-41-35(27)24(2)52-6)20-40(3,4)23-53-38(49)30-11-9-16-47(44-30)37(48)31(19-34-42-32(25)22-54-34)43-39(50)46-17-14-26(46)21-51-5/h8,10,12-13,15,18,22,24,26,30-31,44H,7,9,11,14,16-17,19-21,23H2,1-6H3,(H,43,50) XYPQEWDHXGQGIM-UHFFFAOYSA-N 750788 US20250195521, Example A264 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750788&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346969 519649382 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541644 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)N1CCN(C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C40H52N8O5S/c1-7-47-33-13-12-26-20-28(33)29(36(47)27-10-8-14-41-35(27)25(2)52-6)22-40(3,4)24-53-38(50)30-11-9-15-48(44-30)37(49)31(21-34-42-32(26)23-54-34)43-39(51)46-18-16-45(5)17-19-46/h8,10,12-14,20,23,25,30-31,44H,7,9,11,15-19,21-22,24H2,1-6H3,(H,43,51) TVWSDIXAUYSVNK-UHFFFAOYSA-N 750789 US20250195521, Example A265 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750789&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347805 519649383 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541645 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)N1CCC[C@@H]1COC)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H53N7O6S/c1-7-46-34-15-14-26-19-29(34)30(37(46)28-12-8-16-42-36(28)25(2)53-6)21-41(3,4)24-54-39(50)31-13-10-18-48(45-31)38(49)32(20-35-43-33(26)23-55-35)44-40(51)47-17-9-11-27(47)22-52-5/h8,12,14-16,19,23,25,27,31-32,45H,7,9-11,13,17-18,20-22,24H2,1-6H3,(H,44,51) UTXBPYZFQPAXNY-UHFFFAOYSA-N 750790 US20250195521, Example A266 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750790&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346978 519649384 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541646 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)N1CCCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C39H49N7O5S/c1-6-45-32-14-13-25-19-27(32)28(35(45)26-11-9-15-40-34(26)24(2)50-5)21-39(3,4)23-51-37(48)29-12-10-18-46(43-29)36(47)30(20-33-41-31(25)22-52-33)42-38(49)44-16-7-8-17-44/h9,11,13-15,19,22,24,29-30,43H,6-8,10,12,16-18,20-21,23H2,1-5H3,(H,42,49) HJMZUBPJQIRVKT-UHFFFAOYSA-N 750791 US20250195521, Example A267 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750791&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347556 519649385 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541647 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O6S/c1-10-55-37-16-15-30-19-32(37)33(41(55)31-13-11-17-48-39(31)29(4)61-9)21-46(5,6)27-62-44(59)34-14-12-18-56(51-34)43(58)35(20-38-49-36(30)22-63-38)50-42(57)40(28(2)3)53(8)45(60)54-25-47(26-54)23-52(7)24-47/h11,13,15-17,19,22,28-29,34-35,40,51H,10,12,14,18,20-21,23-27H2,1-9H3,(H,50,57) NUWYUTNJYUTVDK-UHFFFAOYSA-N 750792 US20250195521, Example A268 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750792 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750792&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161921865 519649386 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541648 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-9-54-41-13-12-31-23-36(41)37(43(54)38-25-49-16-14-33(38)27-61-8)24-48(4,5)28-62-47(60)39-11-10-17-55(51-39)46(59)40(21-30-19-34(31)22-35(56)20-30)50-44(57)42(29(2)3)53(7)45(58)32-15-18-52(6)26-32/h12-14,16,19-20,22-23,25,29,32,39-40,42,51,56H,9-11,15,17-18,21,24,26-28H2,1-8H3,(H,50,57) PTOYPAREVPJPTM-UHFFFAOYSA-N 750793 US20250195521, Example A27 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750793 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750793&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348406 519649387 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541649 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C39H49N7O6S/c1-6-45-32-12-11-25-19-27(32)28(35(45)26-9-7-13-40-34(26)24(2)50-5)21-39(3,4)23-52-37(48)29-10-8-14-46(43-29)36(47)30(20-33-41-31(25)22-53-33)42-38(49)44-15-17-51-18-16-44/h7,9,11-13,19,22,24,29-30,43H,6,8,10,14-18,20-21,23H2,1-5H3,(H,42,49) UMUOVPOZDUIPQY-UHFFFAOYSA-N 750794 US20250195521, Example A270 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750794 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750794&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347120 519649388 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541650 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC1C(=O)O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N8O8S/c1-9-51-34-15-14-27-20-29(34)30(39(51)28-12-10-17-46-37(28)26(4)60-8)22-45(5,6)24-61-43(58)31-13-11-18-53(49-31)41(55)32(21-36-47-33(27)23-62-36)48-40(54)38(25(2)3)50(7)44(59)52-19-16-35(52)42(56)57/h10,12,14-15,17,20,23,25-26,31-32,35,38,49H,9,11,13,16,18-19,21-22,24H2,1-8H3,(H,48,54)(H,56,57) VTSQBTSSHGEXGH-UHFFFAOYSA-N 750795 US20250195521, Example A271 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750795&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161195127 519649389 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541651 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1[C@H](C)CN(C)C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-55-39-18-17-32-21-34(39)35(43(55)33-15-13-19-49-41(33)31(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-56(52-36)45(59)37(22-40-50-38(32)26-64-40)51-44(58)42(28(2)3)54(10)47(61)57-29(4)24-53(9)25-30(57)5/h13,15,17-19,21,26,28-31,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) SMESADSJBPEYLL-UHFFFAOYSA-N 750796 US20250195521, Example A272 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750796 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750796&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413607 519649390 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541652 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC13CCN(C)CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O6S/c1-10-56-39-16-15-32-25-34(39)35(43(56)33-13-11-20-50-41(33)31(4)63-9)27-48(5,6)29-64-46(61)36-14-12-21-58(53-36)45(60)37(26-40-51-38(32)28-65-40)52-44(59)42(30(2)3)55(8)47(62)57-24-19-49(57)17-22-54(7)23-18-49/h11,13,15-16,20,25,28,30-31,36-37,42,53H,10,12,14,17-19,21-24,26-27,29H2,1-9H3,(H,52,59) RGQYDTQALVTGIL-UHFFFAOYSA-N 750797 US20250195521, Example A273 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750797&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160853720 519649391 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541653 CCn6c(c1cccnc1[C@H](C)OC)c7CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N3CCC34CN(C)C4)Cc5nc(cs5)c8ccc6c7c8 InChI=1S/C47H63N9O6S/c1-10-54-37-16-15-30-21-32(37)33(41(54)31-13-11-18-48-39(31)29(4)61-9)23-46(5,6)27-62-44(59)34-14-12-19-56(51-34)43(58)35(22-38-49-36(30)24-63-38)50-42(57)40(28(2)3)53(8)45(60)55-20-17-47(55)25-52(7)26-47/h11,13,15-16,18,21,24,28-29,34-35,40,51H,10,12,14,17,19-20,22-23,25-27H2,1-9H3,(H,50,57) MRPRHDRTURMPRR-UHFFFAOYSA-N 750798 US20250195521, Example A274 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750798 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750798&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 177372997 519649392 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541654 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1[C@H](C)COC[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-11-53-38-17-16-31-20-33(38)34(42(53)32-14-12-18-48-40(32)30(6)60-10)22-47(7,8)26-62-45(58)35-15-13-19-54(51-35)44(57)36(21-39-49-37(31)25-63-39)50-43(56)41(27(2)3)52(9)46(59)55-28(4)23-61-24-29(55)5/h12,14,16-18,20,25,27-30,35-36,41,51H,11,13,15,19,21-24,26H2,1-10H3,(H,50,56) NFWYNSSUTCSQAM-UHFFFAOYSA-N 750799 US20250195521, Example A275 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750799 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750799&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159769202 519649393 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541655 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1[C@H](C)COC[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-11-53-38-17-16-31-20-33(38)34(42(53)32-14-12-18-48-40(32)30(6)60-10)22-47(7,8)26-62-45(58)35-15-13-19-54(51-35)44(57)36(21-39-49-37(31)25-63-39)50-43(56)41(27(2)3)52(9)46(59)55-28(4)23-61-24-29(55)5/h12,14,16-18,20,25,27-30,35-36,41,51H,11,13,15,19,21-24,26H2,1-10H3,(H,50,56) NFWYNSSUTCSQAM-UHFFFAOYSA-N 750800 US20250195521, Example A276 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750800 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750800&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159769204 519649394 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541656 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H68N10O6S/c1-12-57-39-16-15-31-22-33(39)35(43(57)34-23-32(26-49-41(34)30(4)63-11)56-20-18-54(9)19-21-56)25-48(5,6)28-64-46(61)36-14-13-17-58(52-36)45(60)37(24-40-50-38(31)27-65-40)51-44(59)42(29(2)3)55(10)47(62)53(7)8/h15-16,22-23,26-27,29-30,36-37,42,52H,12-14,17-21,24-25,28H2,1-11H3,(H,51,59) QAIRUZWEDWAIIZ-UHFFFAOYSA-N 750801 US20250195521, Example A277 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750801 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750801&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347994 519649395 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541657 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@@H](C)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-11-54-38-17-16-30-20-33(38)34(42(54)32-14-12-18-48-40(32)29(5)61-10)22-47(6,7)26-62-45(58)35-15-13-19-55(51-35)44(57)36(21-39-49-37(30)25-63-39)50-43(56)41(27(2)3)52(8)46(59)53-23-31(24-53)28(4)60-9/h12,14,16-18,20,25,27-29,31,35-36,41,51H,11,13,15,19,21-24,26H2,1-10H3,(H,50,56) GKXRKCHEHGLYMA-UHFFFAOYSA-N 750802 US20250195521, Example A278 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750802 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750802&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413622 519649396 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541658 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@H](C)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-11-54-38-17-16-30-20-33(38)34(42(54)32-14-12-18-48-40(32)29(5)61-10)22-47(6,7)26-62-45(58)35-15-13-19-55(51-35)44(57)36(21-39-49-37(30)25-63-39)50-43(56)41(27(2)3)52(8)46(59)53-23-31(24-53)28(4)60-9/h12,14,16-18,20,25,27-29,31,35-36,41,51H,11,13,15,19,21-24,26H2,1-10H3,(H,50,56) GKXRKCHEHGLYMA-UHFFFAOYSA-N 750803 US20250195521, Example A279 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750803&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161289491 519649397 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541659 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O8/c1-8-51-39-12-11-29-20-34(39)35(41(51)36-22-47-14-13-30(36)23-58-7)21-46(4,5)26-60-45(57)37-10-9-15-52(49-37)44(56)38(18-28-16-31(29)19-33(53)17-28)48-42(54)40(27(2)3)50(6)43(55)32-24-59-25-32/h11-14,16-17,19-20,22,27,32,37-38,40,49,53H,8-10,15,18,21,23-26H2,1-7H3,(H,48,54) VYDWFQORGZVHQK-UHFFFAOYSA-N 750804 US20250195521, Example A28 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750804&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161740061 519649398 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541660 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(N(C)C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O6S/c1-11-57-39-17-16-31-20-34(39)35(43(57)33-14-12-18-50-41(33)30(4)63-10)24-48(5,6)28-64-46(61)36-15-13-19-58(53-36)45(60)37(21-40-51-38(31)25-65-40)52-44(59)42(29(2)3)55(9)47(62)56-26-49(27-56)22-32(23-49)54(7)8/h12,14,16-18,20,25,29-30,32,36-37,42,53H,11,13,15,19,21-24,26-28H2,1-10H3,(H,52,59) XQZKSMYBFVZXRM-UHFFFAOYSA-N 750805 US20250195521, Example A280 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750805&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157455790 519649399 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541661 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H]1C(=O)NC)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H61N9O7S/c1-10-53-35-16-15-28-21-30(35)31(40(53)29-13-11-18-48-38(29)27(4)61-9)23-46(5,6)25-62-44(59)32-14-12-19-55(51-32)43(58)33(22-37-49-34(28)24-63-37)50-42(57)39(26(2)3)52(8)45(60)54-20-17-36(54)41(56)47-7/h11,13,15-16,18,21,24,26-27,32-33,36,39,51H,10,12,14,17,19-20,22-23,25H2,1-9H3,(H,47,56)(H,50,57) GXPSNVQTNLTULZ-UHFFFAOYSA-N 750806 US20250195521, Example A281 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750806&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413614 519649400 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541662 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@H]1C(=O)NC)C(=O)N1CC(C)C[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O7S/c1-11-54-36-15-14-29-20-31(36)32(41(54)30-13-12-17-49-39(30)28(5)62-10)22-47(6,7)25-63-45(60)34-19-27(4)23-56(52-34)44(59)33(21-38-50-35(29)24-64-38)51-43(58)40(26(2)3)53(9)46(61)55-18-16-37(55)42(57)48-8/h12-15,17,20,24,26-28,33-34,37,40,52H,11,16,18-19,21-23,25H2,1-10H3,(H,48,57)(H,51,58) JSQMIGKJOXZXIE-UHFFFAOYSA-N 750807 US20250195521, Example A282 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750807 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750807&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158497919 519649401 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541663 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H](C)N(C)C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-55-39-18-17-32-21-34(39)35(43(55)33-15-13-19-49-41(33)31(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-57(52-36)45(59)37(22-40-50-38(32)26-64-40)51-44(58)42(28(2)3)54(10)47(61)56-25-29(4)53(9)24-30(56)5/h13,15,17-19,21,26,28-31,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) DKTGAVAZLDSZGF-UHFFFAOYSA-N 750808 US20250195521, Example A283 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750808&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157661770 519649402 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541664 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3CC(C1)N3C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O6S/c1-10-55-38-16-15-29-19-33(38)34(42(55)32-13-11-17-48-40(32)28(4)61-9)22-47(5,6)26-62-45(59)35-14-12-18-56(51-35)44(58)36(21-39-49-37(29)25-63-39)50-43(57)41(27(2)3)53(8)46(60)54-23-30-20-31(24-54)52(30)7/h11,13,15-17,19,25,27-28,30-31,35-36,41,51H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) VQQCGLPWYRCLIP-UHFFFAOYSA-N 750809 US20250195521, Example A284 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750809&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158674259 519649403 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541665 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C3CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-56-39-18-15-30-21-34(39)35(43(56)33-13-11-19-49-41(33)29(4)62-9)23-48(5,6)27-63-46(60)36-14-12-20-57(52-36)45(59)37(22-40-50-38(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)55-24-32(25-55)53(7)31-16-17-31/h11,13,15,18-19,21,26,28-29,31-32,36-37,42,52H,10,12,14,16-17,20,22-25,27H2,1-9H3,(H,51,58) KQAHLUNCORQYMS-UHFFFAOYSA-N 750810 US20250195521, Example A285 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750810&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158423045 519649404 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541666 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H]1C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C39H48N6O5S/c1-7-44-32-13-12-24-17-27(32)28(35(44)25-10-8-14-40-34(25)23(3)49-6)19-39(4,5)21-50-38(48)29-11-9-15-45(43-29)37(47)30(18-33-41-31(24)20-51-33)42-36(46)26-16-22(26)2/h8,10,12-14,17,20,22-23,26,29-30,43H,7,9,11,15-16,18-19,21H2,1-6H3,(H,42,46) NDAVMCQQLNBUMQ-UHFFFAOYSA-N 750811 US20250195521, Example A286 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750811&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347353 519649405 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541667 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H62N6O7/c1-10-53-40-16-15-31-24-36(40)37(43(53)34-13-11-17-49-41(34)29(5)60-9)25-48(6,7)26-61-47(59)38-14-12-18-54(51-38)46(58)39(22-30-20-32(31)23-33(55)21-30)50-44(56)42(27(2)3)52(8)45(57)35-19-28(35)4/h11,13,15-17,20-21,23-24,27-29,35,38-39,42,51,55H,10,12,14,18-19,22,25-26H2,1-9H3,(H,50,56) IUKNWVGAPTWPBU-UHFFFAOYSA-N 750812 US20250195521, Example A287 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750812&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156736467 519649406 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541668 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N3CCN(C)CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H68N10O6S/c1-10-58-40-16-15-32-23-35(40)36(44(58)34-13-11-17-50-42(34)31(4)64-9)25-49(5,6)29-65-47(62)37-14-12-18-59(53-37)46(61)38(24-41-51-39(32)28-66-41)52-45(60)43(30(2)3)55(8)48(63)57-26-33(27-57)56-21-19-54(7)20-22-56/h11,13,15-17,23,28,30-31,33,37-38,43,53H,10,12,14,18-22,24-27,29H2,1-9H3,(H,52,60) KSJMOYYRUDIDIM-UHFFFAOYSA-N 750813 US20250195521, Example A288 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750813&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160294927 519649407 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541669 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C(C)(C)O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-11-54-37-17-16-29-20-32(37)33(41(54)31-14-12-18-48-39(31)28(4)61-10)22-46(5,6)26-62-44(58)34-15-13-19-55(51-34)43(57)35(21-38-49-36(29)25-63-38)50-42(56)40(27(2)3)52(9)45(59)53-23-30(24-53)47(7,8)60/h12,14,16-18,20,25,27-28,30,34-35,40,51,60H,11,13,15,19,21-24,26H2,1-10H3,(H,50,56) DFDSDMUKDKQIEF-UHFFFAOYSA-N 750814 US20250195521, Example A289 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750814&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158810218 519649408 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541670 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O8/c1-10-57-43-14-13-33-24-38(43)39(45(57)40-26-52-17-15-35(40)28-65-9)25-51(6,7)29-66-50(64)41-12-11-18-58(54-41)49(63)42(22-32-20-36(33)23-37(59)21-32)53-46(60)44(30(2)3)55(8)48(62)34-16-19-56(27-34)47(61)31(4)5/h13-15,17,20-21,23-24,26,30-31,34,41-42,44,54,59H,10-12,16,18-19,22,25,27-29H2,1-9H3,(H,53,60) MGJXZZKVTWJYSI-UHFFFAOYSA-N 750815 US20250195521, Example A29 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750815&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161827839 519649409 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541671 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)CN(C)C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H68N10O7S/c1-11-58-39-17-16-32-24-34(39)35(44(58)33-14-12-18-50-42(33)31(4)65-10)26-49(5,6)29-66-47(63)36-15-13-19-59(53-36)46(62)37(25-40-51-38(32)28-67-40)52-45(61)43(30(2)3)55(9)48(64)57-22-20-56(21-23-57)41(60)27-54(7)8/h12,14,16-18,24,28,30-31,36-37,43,53H,11,13,15,19-23,25-27,29H2,1-10H3,(H,52,61) JMRYKWQTKXGNLS-UHFFFAOYSA-N 750816 US20250195521, Example A290 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750816&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161455288 519649410 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541672 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(C)=O)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O7S/c1-10-55-38-16-15-31-23-33(38)34(42(55)32-13-11-17-48-40(32)29(4)62-9)25-47(6,7)27-63-45(60)35-14-12-18-56(51-35)44(59)36(24-39-49-37(31)26-64-39)50-43(58)41(28(2)3)52(8)46(61)54-21-19-53(20-22-54)30(5)57/h11,13,15-17,23,26,28-29,35-36,41,51H,10,12,14,18-22,24-25,27H2,1-9H3,(H,50,58) QZBDPKXESAONRU-UHFFFAOYSA-N 750817 US20250195521, Example A291 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750817&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161809788 519649411 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541673 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H](C)N(C)C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-55-39-18-17-32-21-34(39)35(43(55)33-15-13-19-49-41(33)31(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-57(52-36)45(59)37(22-40-50-38(32)26-64-40)51-44(58)42(28(2)3)54(10)47(61)56-25-29(4)53(9)24-30(56)5/h13,15,17-19,21,26,28-31,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) DKTGAVAZLDSZGF-UHFFFAOYSA-N 750818 US20250195521, Example A292 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750818&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413609 519649412 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541674 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H](C)N(C)C[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-55-39-18-17-32-21-34(39)35(43(55)33-15-13-19-49-41(33)31(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-57(52-36)45(59)37(22-40-50-38(32)26-64-40)51-44(58)42(28(2)3)54(10)47(61)56-25-29(4)53(9)24-30(56)5/h13,15,17-19,21,26,28-31,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) DKTGAVAZLDSZGF-UHFFFAOYSA-N 750819 US20250195521, Example A293 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750819&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413633 519649413 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541675 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOC3(CN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-10-56-38-16-15-31-21-33(38)34(42(56)32-13-11-17-49-40(32)30(4)62-9)23-47(5,6)28-63-45(60)35-14-12-18-57(52-35)44(59)36(22-39-50-37(31)24-65-39)51-43(58)41(29(2)3)54(8)46(61)55-19-20-64-48(27-55)25-53(7)26-48/h11,13,15-17,21,24,29-30,35-36,41,52H,10,12,14,18-20,22-23,25-28H2,1-9H3,(H,51,58) BYGZMFRBVCGZEG-UHFFFAOYSA-N 750820 US20250195521, Example A294 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750820 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750820&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160740094 519649414 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541676 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N3CCC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O6S/c1-9-55-38-16-15-30-21-33(38)34(42(55)32-13-10-17-48-40(32)29(4)61-8)23-47(5,6)27-62-45(59)35-14-11-20-56(51-35)44(58)36(22-39-49-37(30)26-63-39)50-43(57)41(28(2)3)52(7)46(60)54-24-31(25-54)53-18-12-19-53/h10,13,15-17,21,26,28-29,31,35-36,41,51H,9,11-12,14,18-20,22-25,27H2,1-8H3,(H,50,57) UHMSZLRQAGCQQP-UHFFFAOYSA-N 750821 US20250195521, Example A295 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750821&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160473111 519649415 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541677 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN3CCOCC3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-9-56-39-15-14-31-22-34(39)35(43(56)33-12-10-16-49-41(33)30(4)62-8)24-48(5,6)28-64-46(60)36-13-11-17-57(52-36)45(59)37(23-40-50-38(31)27-65-40)51-44(58)42(29(2)3)53(7)47(61)55-19-18-54-20-21-63-26-32(54)25-55/h10,12,14-16,22,27,29-30,32,36-37,42,52H,9,11,13,17-21,23-26,28H2,1-8H3,(H,51,58) XZTWYCPOJRXCCW-UHFFFAOYSA-N 750822 US20250195521, Example A296 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750822&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161669783 519649416 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541678 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(n3nc(C)cc3C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H64N10O6S/c1-11-57-40-17-16-32-21-35(40)36(44(57)34-14-12-18-50-42(34)31(6)64-10)23-49(7,8)27-65-47(62)37-15-13-19-58(54-37)46(61)38(22-41-51-39(32)26-66-41)52-45(60)43(28(2)3)55(9)48(63)56-24-33(25-56)59-30(5)20-29(4)53-59/h12,14,16-18,20-21,26,28,31,33,37-38,43,54H,11,13,15,19,22-25,27H2,1-10H3,(H,52,60) MXAYAPMHSATKJT-UHFFFAOYSA-N 750823 US20250195521, Example A297 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750823&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162135083 519649417 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541679 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C3COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O7S/c1-9-54-38-15-14-29-18-33(38)34(42(54)32-12-10-16-48-40(32)28(4)60-8)20-47(5,6)26-62-45(58)35-13-11-17-55(51-35)44(57)36(19-39-49-37(29)25-63-39)50-43(56)41(27(2)3)52(7)46(59)53-21-30(22-53)31-23-61-24-31/h10,12,14-16,18,25,27-28,30-31,35-36,41,51H,9,11,13,17,19-24,26H2,1-8H3,(H,50,56) YBOHXRXNEPWAKH-UHFFFAOYSA-N 750824 US20250195521, Example A298 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750824&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162085710 519649418 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541680 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C)(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-11-53-36-17-16-29-20-31(36)32(40(53)30-14-12-18-47-38(30)28(4)59-9)22-45(5,6)26-61-43(57)33-15-13-19-54(50-33)42(56)34(21-37-48-35(29)23-62-37)49-41(55)39(27(2)3)51(8)44(58)52-24-46(7,25-52)60-10/h12,14,16-18,20,23,27-28,33-34,39,50H,11,13,15,19,21-22,24-26H2,1-10H3,(H,49,55) MQSZYIHVDCDRAE-UHFFFAOYSA-N 750825 US20250195521, Example A299 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750825 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750825&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161890576 519649419 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541681 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O9/c1-10-56-41-16-15-32-25-37(41)38(44(56)36-13-11-18-51-42(36)30(4)64-8)26-50(5,6)28-66-48(62)39-14-12-19-57(53-39)47(61)40(23-31-21-34(32)24-35(58)22-31)52-45(59)43(29(2)3)54(7)46(60)33-17-20-55(27-33)49(63)65-9/h11,13,15-16,18,21-22,24-25,29-30,33,39-40,43,53,58H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,52,59) XCDKMWGZFSDNKG-UHFFFAOYSA-N 750826 US20250195521, Example A3 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750826&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157242756 519649420 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541682 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O8/c1-9-53-40-13-12-30-21-35(40)36(42(53)37-23-48-15-14-31(37)26-60-7)22-47(4,5)27-62-45(58)38-11-10-16-54(50-38)44(57)39(19-29-17-32(30)20-33(55)18-29)49-43(56)41(28(2)3)51(6)46(59)52-24-34(25-52)61-8/h12-15,17-18,20-21,23,28,34,38-39,41,50,55H,9-11,16,19,22,24-27H2,1-8H3,(H,49,56) OZIHPXJJHWUSDW-UHFFFAOYSA-N 750827 US20250195521, Example A30 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750827&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162051572 519649421 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541683 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H](C)N(C)C[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-55-39-18-17-32-21-34(39)35(43(55)33-15-13-19-49-41(33)31(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-57(52-36)45(59)37(22-40-50-38(32)26-64-40)51-44(58)42(28(2)3)54(10)47(61)56-25-29(4)53(9)24-30(56)5/h13,15,17-19,21,26,28-31,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) DKTGAVAZLDSZGF-UHFFFAOYSA-N 750828 US20250195521, Example A300 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750828&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413639 519649422 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541684 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3CC(C1)O3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O7S/c1-9-53-37-15-14-28-18-32(37)33(41(53)31-12-10-16-47-39(31)27(4)59-8)21-46(5,6)25-60-44(57)34-13-11-17-54(50-34)43(56)35(20-38-48-36(28)24-62-38)49-42(55)40(26(2)3)51(7)45(58)52-22-29-19-30(23-52)61-29/h10,12,14-16,18,24,26-27,29-30,34-35,40,50H,9,11,13,17,19-23,25H2,1-8H3,(H,49,55) DWDXJTPULOVFQT-UHFFFAOYSA-N 750829 US20250195521, Example A301 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750829&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160006696 519649423 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541685 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC(F)F)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58F2N8O7S/c1-9-54-35-15-14-27-18-30(35)31(39(54)29-12-10-16-48-37(29)26(4)60-8)20-45(5,6)24-61-42(58)32-13-11-17-55(51-32)41(57)33(19-36-49-34(27)23-63-36)50-40(56)38(25(2)3)52(7)44(59)53-21-28(22-53)62-43(46)47/h10,12,14-16,18,23,25-26,28,32-33,38,43,51H,9,11,13,17,19-22,24H2,1-8H3,(H,50,56) XEMAFWQJJBMSMW-UHFFFAOYSA-N 750830 US20250195521, Example A302 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750830&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161921136 519649424 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541686 CO[C@@H](C)c1ncccc1-c1c2c3cc(ccc3n1CC(F)(F)F)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60F3N9O6S/c1-26(2)39(55(8)44(62)56-21-29(22-56)54(6)7)41(59)52-34-19-37-51-35(23-65-37)28-14-15-36-31(18-28)32(20-45(4,5)25-64-43(61)33-13-11-17-58(53-33)42(34)60)40(57(36)24-46(47,48)49)30-12-10-16-50-38(30)27(3)63-9/h10,12,14-16,18,23,26-27,29,33-34,39,53H,11,13,17,19-22,24-25H2,1-9H3,(H,52,59) NWYUZVBMTVYAPP-UHFFFAOYSA-N 750831 US20250195521, Example A303 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750831&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157292846 519649425 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541687 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O6S/c1-10-51-36-16-15-29-21-31(36)32(40(51)30-13-11-18-46-38(30)28(5)58-9)23-45(6,7)25-59-43(56)33-14-12-19-53(49-33)42(55)34(22-37-47-35(29)24-60-37)48-41(54)39(26(2)3)50(8)44(57)52-20-17-27(52)4/h11,13,15-16,18,21,24,26-28,33-34,39,49H,10,12,14,17,19-20,22-23,25H2,1-9H3,(H,48,54) XDLDHXYVFSCUEL-UHFFFAOYSA-N 750832 US20250195521, Example A304 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750832&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160081488 519649426 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541688 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H53N7O6S/c1-9-47-33-15-14-26-18-28(33)29(37(47)27-12-10-16-42-35(27)25(4)53-8)20-41(5,6)22-54-40(52)30-13-11-17-48(45-30)39(51)31(19-34-43-32(26)21-55-34)44-38(50)36(24(2)3)46(7)23-49/h10,12,14-16,18,21,23-25,30-31,36,45H,9,11,13,17,19-20,22H2,1-8H3,(H,44,50) YDGURAJKARFELA-UHFFFAOYSA-N 750833 US20250195521, Example A305 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750833&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413624 519649427 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541689 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)CO)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O8S/c1-9-55-37-15-14-30-22-32(37)33(42(55)31-12-10-16-48-40(31)29(4)63-8)24-47(5,6)27-64-45(61)34-13-11-17-56(51-34)44(60)35(23-38-49-36(30)26-65-38)50-43(59)41(28(2)3)52(7)46(62)54-20-18-53(19-21-54)39(58)25-57/h10,12,14-16,22,26,28-29,34-35,41,51,57H,9,11,13,17-21,23-25,27H2,1-8H3,(H,50,59) VDLYNTAOHHQOLF-UHFFFAOYSA-N 750834 US20250195521, Example A306 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750834&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160805175 519649428 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541690 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C)CC13CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-38-16-15-31-23-33(38)34(42(55)32-13-11-19-49-40(32)30(4)62-9)25-47(5,6)28-63-45(60)35-14-12-20-57(52-35)44(59)36(24-39-50-37(31)26-64-39)51-43(58)41(29(2)3)54(8)46(61)56-22-21-53(7)27-48(56)17-18-48/h11,13,15-16,19,23,26,29-30,35-36,41,52H,10,12,14,17-18,20-22,24-25,27-28H2,1-9H3,(H,51,58) CPXYJHAPYROYKW-UHFFFAOYSA-N 750835 US20250195521, Example A307 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750835 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750835&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157874876 519649429 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541691 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3CCC1CN3C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-39-18-15-30-21-34(39)35(43(55)33-13-11-19-49-41(33)29(4)62-9)23-48(5,6)27-63-46(60)36-14-12-20-57(52-36)45(59)37(22-40-50-38(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-25-31-16-17-32(56)24-53(31)7/h11,13,15,18-19,21,26,28-29,31-32,36-37,42,52H,10,12,14,16-17,20,22-25,27H2,1-9H3,(H,51,58) UAGACIKQWGFZRI-UHFFFAOYSA-N 750836 US20250195521, Example A308 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750836&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158009648 519649430 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541692 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@@H](C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-10-53-37-16-15-30-21-32(37)33(41(53)31-13-11-17-47-39(31)29(5)59-9)23-46(6,7)26-61-44(57)34-14-12-18-54(50-34)43(56)35(22-38-48-36(30)25-62-38)49-42(55)40(27(2)3)51(8)45(58)52-19-20-60-28(4)24-52/h11,13,15-17,21,25,27-29,34-35,40,50H,10,12,14,18-20,22-24,26H2,1-9H3,(H,49,55) XDASLSNIXHMYDS-UHFFFAOYSA-N 750837 US20250195521, Example A309 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750837&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158797764 519649431 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541693 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C[C@@H](C)O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O8/c1-9-56-43-13-12-33-23-38(43)39(45(56)40-25-51-16-14-35(40)28-64-8)24-50(5,6)29-65-49(63)41-11-10-17-57(53-41)48(62)42(21-32-19-36(33)22-37(59)20-32)52-46(60)44(30(2)3)54(7)47(61)34-15-18-55(27-34)26-31(4)58/h12-14,16,19-20,22-23,25,30-31,34,41-42,44,53,58-59H,9-11,15,17-18,21,24,26-29H2,1-8H3,(H,52,60) BXFCXWNPVDYJQR-UHFFFAOYSA-N 750838 US20250195521, Example A31 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750838&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413615 519649432 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541694 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@H](C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-10-53-37-16-15-30-21-32(37)33(41(53)31-13-11-17-47-39(31)29(5)59-9)23-46(6,7)26-61-44(57)34-14-12-18-54(50-34)43(56)35(22-38-48-36(30)25-62-38)49-42(55)40(27(2)3)51(8)45(58)52-19-20-60-28(4)24-52/h11,13,15-17,21,25,27-29,34-35,40,50H,10,12,14,18-20,22-24,26H2,1-9H3,(H,49,55) XDASLSNIXHMYDS-UHFFFAOYSA-N 750839 US20250195521, Example A310 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750839 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750839&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413641 519649433 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541695 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C)C3(CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-56-38-16-15-31-23-33(38)34(42(56)32-13-11-19-49-40(32)30(4)62-9)25-47(5,6)28-63-45(60)35-14-12-20-57(52-35)44(59)36(24-39-50-37(31)26-64-39)51-43(58)41(29(2)3)54(8)46(61)55-22-21-53(7)48(27-55)17-18-48/h11,13,15-16,19,23,26,29-30,35-36,41,52H,10,12,14,17-18,20-22,24-25,27-28H2,1-9H3,(H,51,58) GCNWYZBNPAYYOT-UHFFFAOYSA-N 750840 US20250195521, Example A311 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750840&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161705341 519649434 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541696 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H]3COC[C@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O7S/c1-9-54-38-15-14-29-18-33(38)34(42(54)32-12-10-16-48-40(32)28(4)60-8)20-47(5,6)26-62-45(58)35-13-11-17-55(51-35)44(57)36(19-39-49-37(29)25-63-39)50-43(56)41(27(2)3)52(7)46(59)53-21-30-23-61-24-31(30)22-53/h10,12,14-16,18,25,27-28,30-31,35-36,41,51H,9,11,13,17,19-24,26H2,1-8H3,(H,50,56) DTNATLSBVYOQAG-UHFFFAOYSA-N 750841 US20250195521, Example A312 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750841&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413582 519649435 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541697 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H]3CN(C)C[C@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-56-39-16-15-30-19-34(39)35(43(56)33-13-11-17-49-41(33)29(4)62-9)21-48(5,6)27-63-46(60)36-14-12-18-57(52-36)45(59)37(20-40-50-38(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)55-24-31-22-53(7)23-32(31)25-55/h11,13,15-17,19,26,28-29,31-32,36-37,42,52H,10,12,14,18,20-25,27H2,1-9H3,(H,51,58) HPLVVGKBQMIPCK-UHFFFAOYSA-N 750842 US20250195521, Example A313 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750842&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413631 519649436 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541698 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H]3C[C@H]1CN3C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O6S/c1-10-54-38-16-15-29-19-33(38)34(42(54)32-13-11-17-48-40(32)28(4)61-9)22-47(5,6)26-62-45(59)35-14-12-18-56(51-35)44(58)36(21-39-49-37(29)25-63-39)50-43(57)41(27(2)3)53(8)46(60)55-24-30-20-31(55)23-52(30)7/h11,13,15-17,19,25,27-28,30-31,35-36,41,51H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) AMSWROBRZLBTDK-UHFFFAOYSA-N 750843 US20250195521, Example A314 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750843&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159027350 519649437 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541699 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H]1CCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C39H48N6O6S/c1-6-44-31-14-13-24-18-26(31)27(35(44)25-10-7-15-40-34(25)23(2)49-5)20-39(3,4)22-51-38(48)28-11-8-16-45(43-28)37(47)29(19-33-41-30(24)21-52-33)42-36(46)32-12-9-17-50-32/h7,10,13-15,18,21,23,28-29,32,43H,6,8-9,11-12,16-17,19-20,22H2,1-5H3,(H,42,46) NPZVJAYSWAPHRL-UHFFFAOYSA-N 750844 US20250195521, Example A315 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750844&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347154 519649438 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541700 CO[C@@H](C)c1ncccc1-c1c2c3cc(ccc3n1CC(F)F)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H61F2N9O6S/c1-26(2)40(54(8)45(61)55-21-29(22-55)53(6)7)42(58)51-34-19-38-50-35(24-64-38)28-14-15-36-31(18-28)32(20-46(4,5)25-63-44(60)33-13-11-17-57(52-33)43(34)59)41(56(36)23-37(47)48)30-12-10-16-49-39(30)27(3)62-9/h10,12,14-16,18,24,26-27,29,33-34,37,40,52H,11,13,17,19-23,25H2,1-9H3,(H,51,58) ULIZTKJUKFQDKA-UHFFFAOYSA-N 750845 US20250195521, Example A316 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750845 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750845&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158472671 519649439 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541701 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCCN(C)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H58N8O6S/c1-9-50-35-16-15-28-21-30(35)31(39(50)29-13-10-17-45-37(29)27(4)57-8)23-44(5,6)25-58-42(55)32-14-11-20-52(48-32)41(54)33(22-36-46-34(28)24-59-36)47-40(53)38(26(2)3)51-19-12-18-49(7)43(51)56/h10,13,15-17,21,24,26-27,32-33,38,48H,9,11-12,14,18-20,22-23,25H2,1-8H3,(H,47,53) MJXFWLMEAVIICH-UHFFFAOYSA-N 750846 US20250195521, Example A317 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750846&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156736458 519649440 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541702 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-56-39-18-17-31-21-34(39)35(43(56)33-15-13-19-49-41(33)30(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-57(52-36)45(59)37(22-40-50-38(31)26-64-40)51-44(58)42(28(2)3)54(10)47(61)55-24-32(25-55)53(9)29(4)5/h13,15,17-19,21,26,28-30,32,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) SMJNDVNIJYBPCW-UHFFFAOYSA-N 750847 US20250195521, Example A318 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750847&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158065004 519649441 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541703 CCN(CC)C1CN(C(=O)N(C)[C@H](C(=O)N[C@H]2Cc3nc(cs3)-c3ccc4c(c3)c(c(-c3cccnc3[C@H](C)OC)n4CC)CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C2=O)C(C)C)C1 InChI=1S/C48H67N9O6S/c1-11-54(12-2)32-25-55(26-32)47(61)53(9)42(29(4)5)44(58)51-37-23-40-50-38(27-64-40)31-18-19-39-34(22-31)35(43(56(39)13-3)33-16-14-20-49-41(33)30(6)62-10)24-48(7,8)28-63-46(60)36-17-15-21-57(52-36)45(37)59/h14,16,18-20,22,27,29-30,32,36-37,42,52H,11-13,15,17,21,23-26,28H2,1-10H3,(H,51,58) YQLWTVCQWMYYOV-UHFFFAOYSA-N 750848 US20250195521, Example A319 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750848&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160307145 519649442 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541704 CCn1c(-c2cccnc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O7/c1-8-53-40-14-13-30-23-35(40)36(42(53)34-11-9-16-49-39(34)26-60-7)24-47(4,5)27-61-46(59)37-12-10-18-54(51-37)45(58)38(21-29-19-32(30)22-33(55)20-29)50-43(56)41(28(2)3)52(6)44(57)31-15-17-48-25-31/h9,11,13-14,16,19-20,22-23,28,31,37-38,41,48,51,55H,8,10,12,15,17-18,21,24-27H2,1-7H3,(H,50,56) SCLKKOXYZYKYIV-UHFFFAOYSA-N 750849 US20250195521, Example A32 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750849&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159619105 519649443 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541705 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)C1(F)COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C38H45FN6O6S/c1-6-44-30-12-11-23-15-25(30)26(33(44)24-9-7-13-40-32(24)22(2)49-5)17-37(3,4)19-51-35(47)27-10-8-14-45(43-27)34(46)28(16-31-41-29(23)18-52-31)42-36(48)38(39)20-50-21-38/h7,9,11-13,15,18,22,27-28,43H,6,8,10,14,16-17,19-21H2,1-5H3,(H,42,48) NYWKDIQTJPQVLU-UHFFFAOYSA-N 750850 US20250195521, Example A320 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750850&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347804 519649444 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541706 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H54N8O5S/c1-8-48-35-12-11-27-18-29(35)31(38(48)30-19-28(22-42-37(30)25(2)53-7)47-16-14-46(6)15-17-47)21-41(4,5)24-54-40(52)32-10-9-13-49(45-32)39(51)33(43-26(3)50)20-36-44-34(27)23-55-36/h11-12,18-19,22-23,25,32-33,45H,8-10,13-17,20-21,24H2,1-7H3,(H,43,50) QETGPMIOHUOFFA-UHFFFAOYSA-N 750851 US20250195521, Example A321 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750851&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347509 519649445 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541707 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)S(=O)(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H60N8O8S2/c1-10-51-36-16-15-28-19-31(36)32(40(51)30-13-11-17-45-38(30)27(4)58-8)21-44(5,6)25-60-43(55)33-14-12-18-52(48-33)42(54)34(20-37-46-35(28)24-61-37)47-41(53)39(26(2)3)49(7)62(56,57)50-22-29(23-50)59-9/h11,13,15-17,19,24,26-27,29,33-34,39,48H,10,12,14,18,20-23,25H2,1-9H3,(H,47,53) QKZUHPXGCKHFNE-UHFFFAOYSA-N 750852 US20250195521, Example A322 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750852&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347782 519649446 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541708 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@@H]1O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-38-15-14-29-22-33(38)35(42(52)32-12-10-16-48-40(32)27(4)60-8)24-47(5,6)25-61-46(59)36-13-11-17-53(50-36)45(58)37(20-28-18-30(29)21-31(54)19-28)49-43(56)41(26(2)3)51(7)44(57)34-23-39(34)55/h10,12,14-16,18-19,21-22,26-27,34,36-37,39,41,50,54-55H,9,11,13,17,20,23-25H2,1-8H3,(H,49,56) MWDWVKZLUCTMHN-UHFFFAOYSA-N 750853 US20250195521, Example A323 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750853&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346758 519649447 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541709 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H]1[C@@H](C)CCCN1C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O7/c1-8-50-39-16-15-31-24-35(39)36(42(50)34-13-9-17-47-40(34)28(3)58-7)25-46(5,6)26-59-45(57)37-14-11-19-52(49-37)44(56)38(22-30-20-32(31)23-33(54)21-30)48-43(55)41-27(2)12-10-18-51(41)29(4)53/h9,13,15-17,20-21,23-24,27-28,37-38,41,49,54H,8,10-12,14,18-19,22,25-26H2,1-7H3,(H,48,55) SIAQOJHIOHDIMS-UHFFFAOYSA-N 750854 US20250195521, Example A324 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750854&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347158 519649448 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541710 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CN(C(=O)OC)C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O9/c1-11-57-42-17-16-33-24-37(42)38(45(57)36-14-12-18-52-43(36)31(5)65-9)25-51(6,7)28-67-49(63)40-15-13-19-58(54-40)48(62)41(22-32-20-34(33)23-35(59)21-32)53-46(60)44(29(2)3)55(8)47(61)39-27-56(26-30(39)4)50(64)66-10/h12,14,16-18,20-21,23-24,29-31,39-41,44,54,59H,11,13,15,19,22,25-28H2,1-10H3,(H,53,60) AVLHYJPLPGFAQG-UHFFFAOYSA-N 750855 US20250195521, Example A325 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750855&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347845 519649449 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541711 CCn1c(-c2cccnc2C2CCCC2)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CC(Br)C[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H64BrN9O5S/c1-9-57-39-17-16-30-19-34(39)35(43(57)33-15-12-18-50-41(33)29-13-10-11-14-29)22-48(4,5)27-63-46(61)37-20-31(49)23-58(53-37)45(60)36(21-40-51-38(30)26-64-40)52-44(59)42(28(2)3)55(8)47(62)56-24-32(25-56)54(6)7/h12,15-19,26,28-29,31-32,36-37,42,53H,9-11,13-14,20-25,27H2,1-8H3,(H,52,59) UCRYWPMVSGSPPL-UHFFFAOYSA-N 750856 US20250195521, Example A326 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750856&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787080 519649450 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541712 CCn1c(-c2cccnc2C2CCCC2)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O5S/c1-9-56-39-19-18-31-22-34(39)35(43(56)33-16-12-20-49-41(33)30-14-10-11-15-30)24-48(4,5)28-62-46(60)36-17-13-21-57(52-36)45(59)37(23-40-50-38(31)27-63-40)51-44(58)42(29(2)3)54(8)47(61)55-25-32(26-55)53(6)7/h12,16,18-20,22,27,29-30,32,36-37,42,52H,9-11,13-15,17,21,23-26,28H2,1-8H3,(H,51,58) XALISYGRPTUCFS-UHFFFAOYSA-N 750857 US20250195521, Example A327 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750857&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787207 519649451 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541713 CO[C@@H](C)c1ncccc1-c1c2c3cc(ccc3n1CC(F)(F)F)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60F3N9O6S/c1-26(2)39(55(8)44(62)56-21-29(22-56)54(6)7)41(59)52-34-19-37-51-35(23-65-37)28-14-15-36-31(18-28)32(20-45(4,5)25-64-43(61)33-13-11-17-58(53-33)42(34)60)40(57(36)24-46(47,48)49)30-12-10-16-50-38(30)27(3)63-9/h10,12,14-16,18,23,26-27,29,33-34,39,53H,11,13,17,19-22,24-25H2,1-9H3,(H,52,59) NWYUZVBMTVYAPP-UHFFFAOYSA-N 750858 US20250195521, Example A328 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750858&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157292846 519649452 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541714 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N3CCCC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-9-56-39-17-16-31-22-34(39)35(43(56)33-14-12-18-49-41(33)30(4)62-8)24-48(5,6)28-63-46(60)36-15-13-21-57(52-36)45(59)37(23-40-50-38(31)27-64-40)51-44(58)42(29(2)3)53(7)47(61)55-25-32(26-55)54-19-10-11-20-54/h12,14,16-18,22,27,29-30,32,36-37,42,52H,9-11,13,15,19-21,23-26,28H2,1-8H3,(H,51,58) LHDBNQDZAZJZGM-UHFFFAOYSA-N 750859 US20250195521, Example A329 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750859&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158287564 519649453 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541715 CCn1c(-c2ccccc2CCOC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H66N6O8/c1-9-56-44-17-16-35-27-40(44)41(46(56)39-14-11-10-13-34(39)19-22-64-8)28-51(5,6)30-65-50(63)42-15-12-20-57(53-42)49(62)43(25-33-23-37(35)26-38(59)24-33)52-47(60)45(31(2)3)54(7)48(61)36-18-21-55(29-36)32(4)58/h10-11,13-14,16-17,23-24,26-27,31,36,42-43,45,53,59H,9,12,15,18-22,25,28-30H2,1-8H3,(H,52,60) PYGSROBBUSIMIJ-UHFFFAOYSA-N 750860 US20250195521, Example A33 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750860&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159263196 519649454 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541716 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC(F)(F)F)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H57F3N8O7S/c1-9-55-35-15-14-27-18-30(35)31(39(55)29-12-10-16-49-37(29)26(4)61-8)20-44(5,6)24-62-42(59)32-13-11-17-56(52-32)41(58)33(19-36-50-34(27)23-64-36)51-40(57)38(25(2)3)53(7)43(60)54-21-28(22-54)63-45(46,47)48/h10,12,14-16,18,23,25-26,28,32-33,38,52H,9,11,13,17,19-22,24H2,1-8H3,(H,51,57) HLJWFJZJLZLMJV-UHFFFAOYSA-N 750861 US20250195521, Example A330 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750861&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161345688 519649455 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541717 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@@H]1CCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C39H48N6O6S/c1-6-44-31-14-13-24-18-26(31)27(35(44)25-10-7-15-40-34(25)23(2)49-5)20-39(3,4)22-51-38(48)28-11-8-16-45(43-28)37(47)29(19-33-41-30(24)21-52-33)42-36(46)32-12-9-17-50-32/h7,10,13-15,18,21,23,28-29,32,43H,6,8-9,11-12,16-17,19-20,22H2,1-5H3,(H,42,46) NPZVJAYSWAPHRL-UHFFFAOYSA-N 750862 US20250195521, Example A331 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750862&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347816 519649456 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541718 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)CC(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H64N8O6S/c1-12-53-37-18-17-30-21-32(37)33(41(53)31-15-13-19-47-39(31)29(6)59-11)23-46(7,8)26-60-44(57)34-16-14-20-54(50-34)43(56)35(22-38-48-36(30)25-61-38)49-42(55)40(28(4)5)52(10)45(58)51(9)24-27(2)3/h13,15,17-19,21,25,27-29,34-35,40,50H,12,14,16,20,22-24,26H2,1-11H3,(H,49,55) DLPYERYXEYEJAW-UHFFFAOYSA-N 750863 US20250195521, Example A332 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750863&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160970351 519649457 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541719 CCN(C(=O)N(C)[C@H](C(=O)N[C@H]1Cc2nc(cs2)-c2ccc3c(c2)c(c(-c2cccnc2[C@H](C)OC)n3CC)CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C1=O)C(C)C)C(C)C InChI=1S/C46H64N8O6S/c1-12-52(28(5)6)45(58)51(10)40(27(3)4)42(55)49-35-23-38-48-36(25-61-38)30-18-19-37-32(22-30)33(41(53(37)13-2)31-16-14-20-47-39(31)29(7)59-11)24-46(8,9)26-60-44(57)34-17-15-21-54(50-34)43(35)56/h14,16,18-20,22,25,27-29,34-35,40,50H,12-13,15,17,21,23-24,26H2,1-11H3,(H,49,55) WGZNNCRHBYPSAV-UHFFFAOYSA-N 750864 US20250195521, Example A333 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750864&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160336494 519649458 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541720 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C1COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-10-52-36-16-15-28-19-31(36)32(40(52)30-13-11-17-46-38(30)27(4)58-9)21-45(5,6)25-60-43(56)33-14-12-18-53(49-33)42(55)34(20-37-47-35(28)24-61-37)48-41(54)39(26(2)3)51(8)44(57)50(7)29-22-59-23-29/h11,13,15-17,19,24,26-27,29,33-34,39,49H,10,12,14,18,20-23,25H2,1-9H3,(H,48,54) CJRCOTHEQZDCAP-UHFFFAOYSA-N 750865 US20250195521, Example A334 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750865 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750865&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159548154 519649459 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541721 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-9-53-37-16-15-30-23-32(37)33(41(53)31-13-10-17-47-39(31)29(4)59-8)25-46(5,6)27-61-44(57)34-14-11-19-54(50-34)43(56)35(24-38-48-36(30)26-62-38)49-42(55)40(28(2)3)51(7)45(58)52-18-12-21-60-22-20-52/h10,13,15-17,23,26,28-29,34-35,40,50H,9,11-12,14,18-22,24-25,27H2,1-8H3,(H,49,55) ZSKOLEDXRVCYOG-UHFFFAOYSA-N 750866 US20250195521, Example A335 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750866&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157555338 519649460 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541722 CCN(C)C(=O)N(C)[C@H](C(=O)N[C@H]1Cc2nc(cs2)-c2ccc3c(c2)c(c(-c2cccnc2[C@H](C)OC)n3CC)CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C1=O)C(C)C InChI=1S/C44H60N8O6S/c1-11-49(8)43(56)50(9)38(26(3)4)40(53)47-33-22-36-46-34(24-59-36)28-17-18-35-30(21-28)31(39(51(35)12-2)29-15-13-19-45-37(29)27(5)57-10)23-44(6,7)25-58-42(55)32-16-14-20-52(48-32)41(33)54/h13,15,17-19,21,24,26-27,32-33,38,48H,11-12,14,16,20,22-23,25H2,1-10H3,(H,47,53) ZVPITDZXHDNGLQ-UHFFFAOYSA-N 750867 US20250195521, Example A336 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750867&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159700288 519649461 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541723 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(NC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H61N9O6S/c1-10-53-36-16-15-28-19-31(36)32(40(53)30-13-11-17-47-38(30)27(4)59-9)21-45(5,6)25-60-43(57)33-14-12-18-54(50-33)42(56)34(20-37-48-35(28)24-61-37)49-41(55)39(26(2)3)51(8)44(58)52-22-29(23-52)46-7/h11,13,15-17,19,24,26-27,29,33-34,39,46,50H,10,12,14,18,20-23,25H2,1-9H3,(H,49,55) LONWHXGCRHFBOY-UHFFFAOYSA-N 750868 US20250195521, Example A337 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750868&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 172120594 519649462 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541724 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N3CCOCC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-9-56-39-15-14-31-22-34(39)35(43(56)33-12-10-16-49-41(33)30(4)62-8)24-48(5,6)28-64-46(60)36-13-11-17-57(52-36)45(59)37(23-40-50-38(31)27-65-40)51-44(58)42(29(2)3)53(7)47(61)55-25-32(26-55)54-18-20-63-21-19-54/h10,12,14-16,22,27,29-30,32,36-37,42,52H,9,11,13,17-21,23-26,28H2,1-8H3,(H,51,58) OSEQCEJDLWEMEU-UHFFFAOYSA-N 750869 US20250195521, Example A338 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750869&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159976230 519649463 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541725 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H63N9O6S/c1-11-54-37-17-16-29-20-32(37)33(41(54)31-14-12-18-47-39(31)28(4)60-10)22-46(5,6)26-61-44(58)34-15-13-19-55(50-34)43(57)35(21-38-48-36(29)25-62-38)49-42(56)40(27(2)3)52(9)45(59)53-23-30(24-53)51(7)8/h12,14,16-18,20,25,27-28,30,34-35,40,50H,11,13,15,19,21-24,26H2,1-10H3,(H,49,56) ZMKOHZABAKELBG-UHFFFAOYSA-N 750870 US20250195521, Example A339 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750870 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750870&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348131 519649464 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541726 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C41H54N8O5S/c1-8-48-35-12-11-27-18-29(35)31(38(48)30-19-28(22-42-37(30)25(2)53-7)47-16-14-46(6)15-17-47)21-41(4,5)24-54-40(52)32-10-9-13-49(45-32)39(51)33(43-26(3)50)20-36-44-34(27)23-55-36/h11-12,18-19,22-23,25,32-33,45H,8-10,13-17,20-21,24H2,1-7H3,(H,43,50) QETGPMIOHUOFFA-UHFFFAOYSA-N 750871 US20250195521, Example A340 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750871 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750871&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347509 519649465 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541727 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)N(C)CC(C)(C)C2 InChI=1S/C46H63N9O6S/c1-11-54-37-17-16-29-20-32(37)33(41(54)31-14-12-18-47-39(31)28(4)60-9)22-46(5,6)26-51(7)43(57)34-15-13-19-55(50-34)44(58)35(21-38-48-36(29)25-62-38)49-42(56)40(27(2)3)52(8)45(59)53-23-30(24-53)61-10/h12,14,16-18,20,25,27-28,30,34-35,40,50H,11,13,15,19,21-24,26H2,1-10H3,(H,49,56) GLBDMVRIYOXPIG-UHFFFAOYSA-N 750872 US20250195521, Example A341 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750872&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158288355 519649466 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541728 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCN(C(=O)[C@]3(C)CCCN3C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C55H74N8O8/c1-11-62-45-18-17-36-29-41(45)42(48(62)40-15-12-21-56-46(40)34(4)70-10)30-54(5,6)32-71-52(68)43-16-13-23-63(58-43)51(67)44(27-35-25-38(36)28-39(64)26-35)57-49(65)47(33(2)3)60(9)50(66)37-19-24-61(31-37)53(69)55(7)20-14-22-59(55)8/h12,15,17-18,21,25-26,28-29,33-34,37,43-44,47,58,64H,11,13-14,16,19-20,22-24,27,30-32H2,1-10H3,(H,57,65) BXZXNOMZQQLAOD-UHFFFAOYSA-N 750873 US20250195521, Example A342 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750873 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750873&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787130 519649467 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541729 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H59N9O6S/c1-9-52-35-15-14-27-18-30(35)31(39(52)29-12-10-16-46-37(29)26(4)58-8)20-44(5,6)24-59-42(56)32-13-11-17-53(49-32)41(55)33(19-36-47-34(27)23-60-36)48-40(54)38(25(2)3)50(7)43(57)51-21-28(45)22-51/h10,12,14-16,18,23,25-26,28,32-33,38,49H,9,11,13,17,19-22,24,45H2,1-8H3,(H,48,54) OZTRJJJDRFPPRZ-UHFFFAOYSA-N 750874 US20250195521, Example A343 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750874 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750874&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347793 519649468 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541730 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C(=O)O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N8O8S/c1-9-52-35-15-14-27-18-30(35)31(39(52)29-12-10-16-46-37(29)26(4)60-8)20-45(5,6)24-61-43(58)32-13-11-17-53(49-32)41(55)33(19-36-47-34(27)23-62-36)48-40(54)38(25(2)3)50(7)44(59)51-21-28(22-51)42(56)57/h10,12,14-16,18,23,25-26,28,32-33,38,49H,9,11,13,17,19-22,24H2,1-8H3,(H,48,54)(H,56,57) VPWLNKLRKJHYQX-UHFFFAOYSA-N 750875 US20250195521, Example A344 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750875 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750875&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346736 519649469 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541731 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N1CNCC1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H57N7O7/c1-8-50-37-14-13-29-21-33(37)34(41(50)32-11-9-15-47-39(32)27(4)58-7)22-45(5,6)24-59-44(57)35-12-10-16-52(49-35)43(56)36(19-28-17-30(29)20-31(53)18-28)48-42(55)40(26(2)3)51-25-46-23-38(51)54/h9,11,13-15,17-18,20-21,26-27,35-36,40,46,49,53H,8,10,12,16,19,22-25H2,1-7H3,(H,48,55) QBLQDHQGUXLPTA-UHFFFAOYSA-N 750876 US20250195521, Example A345 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750876 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750876&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346772 519649470 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541732 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@@H]1O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-38-15-14-29-22-33(38)35(42(52)32-12-10-16-48-40(32)27(4)60-8)24-47(5,6)25-61-46(59)36-13-11-17-53(50-36)45(58)37(20-28-18-30(29)21-31(54)19-28)49-43(56)41(26(2)3)51(7)44(57)34-23-39(34)55/h10,12,14-16,18-19,21-22,26-27,34,36-37,39,41,50,54-55H,9,11,13,17,20,23-25H2,1-8H3,(H,49,56) MWDWVKZLUCTMHN-UHFFFAOYSA-N 750877 US20250195521, Example A346 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750877 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750877&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346758 519649471 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541733 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1C[C@H]1O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-38-15-14-29-22-33(38)35(42(52)32-12-10-16-48-40(32)27(4)60-8)24-47(5,6)25-61-46(59)36-13-11-17-53(50-36)45(58)37(20-28-18-30(29)21-31(54)19-28)49-43(56)41(26(2)3)51(7)44(57)34-23-39(34)55/h10,12,14-16,18-19,21-22,26-27,34,36-37,39,41,50,54-55H,9,11,13,17,20,23-25H2,1-8H3,(H,49,56) MWDWVKZLUCTMHN-UHFFFAOYSA-N 750878 US20250195521, Example A347 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750878 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750878&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159688938 519649472 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541734 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)OC3CN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H70N8O9/c1-10-60-44-16-15-34-25-40(44)41(47(60)39-13-11-18-54-45(39)32(4)68-9)26-53(5,6)30-69-51(66)42-14-12-19-61(56-42)50(65)43(23-33-21-36(34)24-37(62)22-33)55-48(63)46(31(2)3)58(8)49(64)35-17-20-59(27-35)52(67)70-38-28-57(7)29-38/h11,13,15-16,18,21-22,24-25,31-32,35,38,42-43,46,56,62H,10,12,14,17,19-20,23,26-30H2,1-9H3,(H,55,63) UOPZZDQFIKLGKY-UHFFFAOYSA-N 750879 US20250195521, Example A348 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750879 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750879&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161150633 519649473 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541735 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C1CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O6S/c1-10-53-37-19-18-29-22-32(37)33(41(53)31-16-12-20-47-39(31)28(4)59-9)24-46(5,6)26-60-44(57)34-17-13-21-54(50-34)43(56)35(23-38-48-36(29)25-61-38)49-42(55)40(27(2)3)52(8)45(58)51(7)30-14-11-15-30/h12,16,18-20,22,25,27-28,30,34-35,40,50H,10-11,13-15,17,21,23-24,26H2,1-9H3,(H,49,55) KXRYLLWFKFCACH-UHFFFAOYSA-N 750880 US20250195521, Example A349 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750880 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750880&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159597375 519649474 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541736 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(S(=O)(=O)N3CC(N)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N9O9S/c1-8-58-43-12-11-32-22-38(43)39(45(58)40-24-52-15-13-34(40)28-67-7)23-50(4,5)29-68-49(64)41-10-9-16-59(54-41)48(63)42(20-31-18-35(32)21-37(60)19-31)53-46(61)44(30(2)3)55(6)47(62)33-14-17-56(25-33)69(65,66)57-26-36(51)27-57/h11-13,15,18-19,21-22,24,30,33,36,41-42,44,54,60H,8-10,14,16-17,20,23,25-29,51H2,1-7H3,(H,53,61) FJXRQWSDVHEJTP-UHFFFAOYSA-N 750881 US20250195521, Example A35 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750881&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161647435 519649475 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541737 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H62N8O6S/c1-12-52-36-18-17-29-21-31(36)32(40(52)30-15-13-19-46-38(30)28(6)58-11)23-45(7,8)25-59-43(56)33-16-14-20-53(49-33)42(55)34(22-37-47-35(29)24-60-37)48-41(54)39(26(2)3)51(10)44(57)50(9)27(4)5/h13,15,17-19,21,24,26-28,33-34,39,49H,12,14,16,20,22-23,25H2,1-11H3,(H,48,54) LDFNETITPYIHFO-UHFFFAOYSA-N 750882 US20250195521, Example A350 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750882 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750882&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158781846 519649476 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541738 CCN(CC)C(=O)N(C)[C@H](C(=O)N[C@H]1Cc2nc(cs2)-c2ccc3c(c2)c(c(-c2cccnc2[C@H](C)OC)n3CC)CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C1=O)C(C)C InChI=1S/C45H62N8O6S/c1-11-51(12-2)44(57)50(9)39(27(4)5)41(54)48-34-23-37-47-35(25-60-37)29-18-19-36-31(22-29)32(40(52(36)13-3)30-16-14-20-46-38(30)28(6)58-10)24-45(7,8)26-59-43(56)33-17-15-21-53(49-33)42(34)55/h14,16,18-20,22,25,27-28,33-34,39,49H,11-13,15,17,21,23-24,26H2,1-10H3,(H,48,54) VZAMDYZOFAPELR-UHFFFAOYSA-N 750883 US20250195521, Example A351 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750883 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750883&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159068037 519649477 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541739 CCN(C(=O)N(C)[C@H](C(=O)N[C@H]1Cc2nc(cs2)-c2ccc3c(c2)c(c(-c2cccnc2[C@H](C)OC)n3CC)CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C1=O)C(C)C)C1CC1 InChI=1S/C46H62N8O6S/c1-10-52(30-17-18-30)45(58)51(8)40(27(3)4)42(55)49-35-23-38-48-36(25-61-38)29-16-19-37-32(22-29)33(41(53(37)11-2)31-14-12-20-47-39(31)28(5)59-9)24-46(6,7)26-60-44(57)34-15-13-21-54(50-34)43(35)56/h12,14,16,19-20,22,25,27-28,30,34-35,40,50H,10-11,13,15,17-18,21,23-24,26H2,1-9H3,(H,49,55) FKBDDGZXXAUWFA-UHFFFAOYSA-N 750884 US20250195521, Example A352 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750884 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750884&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158729650 519649478 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541740 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O6S/c1-10-52-36-18-15-28-21-31(36)32(40(52)30-13-11-19-46-38(30)27(4)58-9)23-45(5,6)25-59-43(56)33-14-12-20-53(49-33)42(55)34(22-37-47-35(28)24-60-37)48-41(54)39(26(2)3)51(8)44(57)50(7)29-16-17-29/h11,13,15,18-19,21,24,26-27,29,33-34,39,49H,10,12,14,16-17,20,22-23,25H2,1-9H3,(H,48,54) QQVZGYVSZGGBIJ-UHFFFAOYSA-N 750885 US20250195521, Example A353 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750885 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750885&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161158474 519649479 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541741 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-10-52-36-16-15-28-19-31(36)32(40(52)30-13-11-17-46-38(30)27(4)58-8)21-45(5,6)25-60-43(56)33-14-12-18-53(49-33)42(55)34(20-37-47-35(28)24-61-37)48-41(54)39(26(2)3)50(7)44(57)51-22-29(23-51)59-9/h11,13,15-17,19,24,26-27,29,33-34,39,49H,10,12,14,18,20-23,25H2,1-9H3,(H,48,54) PLMFWNXCVDDSEL-UHFFFAOYSA-N 750886 US20250195521, Example A354 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750886 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750886&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348148 519649480 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541742 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-10-54-40-19-18-33-24-36(40)37(43(54)35-16-12-20-49-41(35)30(4)60-8)25-48(5,6)28-62-46(58)38-17-13-21-55(51-38)45(57)39(23-31-14-11-15-32(33)22-31)50-44(56)42(29(2)3)52(7)47(59)53-26-34(27-53)61-9/h11-12,14-16,18-20,22,24,29-30,34,38-39,42,51H,10,13,17,21,23,25-28H2,1-9H3,(H,50,56) PFERRVCKGYHPIV-UHFFFAOYSA-N 750887 US20250195521, Example A355 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750887 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750887&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347369 519649481 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541743 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(CO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-9-52-36-15-14-29-18-31(36)32(40(52)30-12-10-16-46-38(30)27(4)59-8)20-45(5,6)25-60-43(57)33-13-11-17-53(49-33)42(56)34(19-37-47-35(29)24-61-37)48-41(55)39(26(2)3)50(7)44(58)51-21-28(22-51)23-54/h10,12,14-16,18,24,26-28,33-34,39,49,54H,9,11,13,17,19-23,25H2,1-8H3,(H,48,55) QPHYYUFTTQVQBF-UHFFFAOYSA-N 750888 US20250195521, Example A356 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750888 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750888&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347990 519649482 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541744 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCS(=O)(=O)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O8S2/c1-9-52-36-15-14-29-22-31(36)32(40(52)30-12-10-16-46-38(30)28(4)60-8)24-45(5,6)26-61-43(56)33-13-11-17-53(49-33)42(55)34(23-37-47-35(29)25-62-37)48-41(54)39(27(2)3)50(7)44(57)51-18-20-63(58,59)21-19-51/h10,12,14-16,22,25,27-28,33-34,39,49H,9,11,13,17-21,23-24,26H2,1-8H3,(H,48,54) PAGOPALZSZYNFO-UHFFFAOYSA-N 750889 US20250195521, Example A357 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750889 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750889&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347981 519649483 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541745 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H58N8O7S/c1-9-51-35-15-14-27-18-30(35)31(39(51)29-12-10-16-45-37(29)26(4)58-8)20-44(5,6)24-59-42(56)32-13-11-17-52(48-32)41(55)33(19-36-46-34(27)23-60-36)47-40(54)38(25(2)3)49(7)43(57)50-21-28(53)22-50/h10,12,14-16,18,23,25-26,28,32-33,38,48,53H,9,11,13,17,19-22,24H2,1-8H3,(H,47,54) IGMOUEMVDUTHQP-UHFFFAOYSA-N 750890 US20250195521, Example A358 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750890 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750890&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348305 519649484 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541746 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@@H]1CCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C38H46N6O6S/c1-6-43-30-12-11-23-17-25(30)26(34(43)24-9-7-14-39-33(24)22(2)48-5)19-38(3,4)21-50-37(47)27-10-8-15-44(42-27)36(46)28(18-32-40-29(23)20-51-32)41-35(45)31-13-16-49-31/h7,9,11-12,14,17,20,22,27-28,31,42H,6,8,10,13,15-16,18-19,21H2,1-5H3,(H,41,45) OOZYPWZAMOFIAR-UHFFFAOYSA-N 750891 US20250195521, Example A359 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750891 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750891&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347563 519649485 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541747 CCn1c(-c2ccccc2CCOC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CCCN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C55H75N7O8/c1-10-61-47-20-19-38-31-43(47)44(50(61)42-16-12-11-15-37(42)22-26-69-9)32-55(4,5)34-70-54(68)45-17-13-24-62(57-45)53(67)46(29-36-27-40(38)30-41(63)28-36)56-51(65)49(35(2)3)59(8)52(66)39-21-25-60(33-39)48(64)18-14-23-58(6)7/h11-12,15-16,19-20,27-28,30-31,35,39,45-46,49,57,63H,10,13-14,17-18,21-26,29,32-34H2,1-9H3,(H,56,65) SXFBBKSQIZXJLK-UHFFFAOYSA-N 750892 US20250195521, Example A36 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750892 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750892&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347422 519649486 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541748 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H]1CCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C38H46N6O6S/c1-6-43-30-12-11-23-17-25(30)26(34(43)24-9-7-14-39-33(24)22(2)48-5)19-38(3,4)21-50-37(47)27-10-8-15-44(42-27)36(46)28(18-32-40-29(23)20-51-32)41-35(45)31-13-16-49-31/h7,9,11-12,14,17,20,22,27-28,31,42H,6,8,10,13,15-16,18-19,21H2,1-5H3,(H,41,45) OOZYPWZAMOFIAR-UHFFFAOYSA-N 750893 US20250195521, Example A360 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750893 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750893&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348211 519649487 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541749 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)C1(F)CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C39H47FN6O5S/c1-6-45-31-13-12-24-18-26(31)27(34(45)25-10-7-16-41-33(25)23(2)50-5)20-38(3,4)22-51-36(48)28-11-8-17-46(44-28)35(47)29(19-32-42-30(24)21-52-32)43-37(49)39(40)14-9-15-39/h7,10,12-13,16,18,21,23,28-29,44H,6,8-9,11,14-15,17,19-20,22H2,1-5H3,(H,43,49) OONRTMYQBLOESX-UHFFFAOYSA-N 750894 US20250195521, Example A361 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750894 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750894&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347566 519649488 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541750 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)C1(F)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C38H45FN6O5S/c1-6-44-30-12-11-23-17-25(30)26(33(44)24-9-7-15-40-32(24)22(2)49-5)19-37(3,4)21-50-35(47)27-10-8-16-45(43-27)34(46)28(18-31-41-29(23)20-51-31)42-36(48)38(39)13-14-38/h7,9,11-12,15,17,20,22,27-28,43H,6,8,10,13-14,16,18-19,21H2,1-5H3,(H,42,48) VGBTYXGUMUTAII-UHFFFAOYSA-N 750895 US20250195521, Example A362 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750895 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750895&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346631 519649489 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541751 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O6S/c1-9-53-37-18-17-30-23-32(37)33(41(53)31-15-13-19-47-39(31)29(4)59-8)25-46(5,6)27-60-44(57)34-16-14-22-54(50-34)43(56)35(24-38-48-36(30)26-61-38)49-42(55)40(28(2)3)51(7)45(58)52-20-11-10-12-21-52/h13,15,17-19,23,26,28-29,34-35,40,50H,9-12,14,16,20-22,24-25,27H2,1-8H3,(H,49,55) OBAWXCQSAJWGLZ-UHFFFAOYSA-N 750896 US20250195521, Example A363 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750896 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750896&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347334 519649490 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541752 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O8/c1-10-54-40-16-15-31-23-36(40)37(43(54)35-13-11-17-49-41(35)29(4)61-8)24-48(5,6)27-63-46(59)38-14-12-18-55(51-38)45(58)39(21-30-19-32(31)22-33(56)20-30)50-44(57)42(28(2)3)52(7)47(60)53-25-34(26-53)62-9/h11,13,15-17,19-20,22-23,28-29,34,38-39,42,51,56H,10,12,14,18,21,24-27H2,1-9H3,(H,50,57) SJTUAISTUBBWSH-UHFFFAOYSA-N 750897 US20250195521, Example A364 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750897 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750897&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160755911 519649491 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541753 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCN(C(=O)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O9/c1-10-56-41-16-15-32-25-37(41)38(44(56)36-13-11-18-51-42(36)30(4)64-8)26-50(5,6)28-66-48(62)39-14-12-19-57(53-39)47(61)40(23-31-21-34(32)24-35(58)22-31)52-45(59)43(29(2)3)54(7)46(60)33-17-20-55(27-33)49(63)65-9/h11,13,15-16,18,21-22,24-25,29-30,33,39-40,43,53,58H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,52,59) XCDKMWGZFSDNKG-UHFFFAOYSA-N 750898 US20250195521, Example A365 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750898 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750898&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413585 519649492 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541754 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)c1ccccn1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C40H45N7O5S/c1-6-46-33-15-14-25-19-27(33)28(36(46)26-11-9-17-42-35(26)24(2)51-5)21-40(3,4)23-52-39(50)30-13-10-18-47(45-30)38(49)31(20-34-43-32(25)22-53-34)44-37(48)29-12-7-8-16-41-29/h7-9,11-12,14-17,19,22,24,30-31,45H,6,10,13,18,20-21,23H2,1-5H3,(H,44,48) RZVYMAFFTNIEAY-UHFFFAOYSA-N 750899 US20250195521, Example A366 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750899 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750899&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347015 519649493 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541755 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)C1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C38H46N6O5S/c1-6-43-31-14-13-24-17-26(31)27(34(43)25-9-7-15-39-33(25)22(2)48-5)19-38(3,4)21-49-37(47)28-10-8-16-44(42-28)36(46)29(41-35(45)23-11-12-23)18-32-40-30(24)20-50-32/h7,9,13-15,17,20,22-23,28-29,42H,6,8,10-12,16,18-19,21H2,1-5H3,(H,41,45) TWAFNOCGHNYVDP-UHFFFAOYSA-N 750900 US20250195521, Example A367 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750900 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750900&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347585 519649494 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541756 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)N1CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C38H47N7O5S/c1-6-44-31-13-12-24-18-26(31)27(34(44)25-10-7-14-39-33(25)23(2)49-5)20-38(3,4)22-50-36(47)28-11-8-17-45(42-28)35(46)29(19-32-40-30(24)21-51-32)41-37(48)43-15-9-16-43/h7,10,12-14,18,21,23,28-29,42H,6,8-9,11,15-17,19-20,22H2,1-5H3,(H,41,48) JMQSLKHUSQRXMX-UHFFFAOYSA-N 750901 US20250195521, Example A368 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750901 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750901&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347189 519649495 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541757 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)N1CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C38H47N7O5S/c1-6-44-31-13-12-24-18-26(31)27(34(44)25-10-7-14-39-33(25)23(2)49-5)20-38(3,4)22-50-36(47)28-11-8-17-45(42-28)35(46)29(19-32-40-30(24)21-51-32)41-37(48)43-15-9-16-43/h7,10,12-14,18,21,23,28-29,42H,6,8-9,11,15-17,19-20,22H2,1-5H3,(H,41,48) JMQSLKHUSQRXMX-UHFFFAOYSA-N 750902 US20250195521, Example A369 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750902 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750902&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347189 519649496 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541758 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(S(=O)(=O)N3CC(O)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H66N8O10S/c1-8-57-43-12-11-32-22-38(43)39(45(57)40-24-51-15-13-34(40)28-67-7)23-50(4,5)29-68-49(64)41-10-9-16-58(53-41)48(63)42(20-31-18-35(32)21-36(59)19-31)52-46(61)44(30(2)3)54(6)47(62)33-14-17-55(25-33)69(65,66)56-26-37(60)27-56/h11-13,15,18-19,21-22,24,30,33,37,41-42,44,53,59-60H,8-10,14,16-17,20,23,25-29H2,1-7H3,(H,52,61) JFRHIIYQEGAOGV-UHFFFAOYSA-N 750903 US20250195521, Example A37 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750903 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750903&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161991576 519649497 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541759 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@@H]3CCCN3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H70N8O8/c1-9-60-44-17-16-34-27-39(44)40(47(60)38-13-10-20-55-45(38)32(4)68-8)28-53(5,6)30-69-52(67)42-15-12-21-61(57-42)51(66)43(25-33-23-36(34)26-37(62)24-33)56-48(63)46(31(2)3)58(7)49(64)35-18-22-59(29-35)50(65)41-14-11-19-54-41/h10,13,16-17,20,23-24,26-27,31-32,35,41-43,46,54,57,62H,9,11-12,14-15,18-19,21-22,25,28-30H2,1-8H3,(H,56,63) IVMSNWIMGHYAEI-UHFFFAOYSA-N 750904 US20250195521, Example A370 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750904 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750904&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347358 519649498 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541760 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@H]3CCCN3C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H72N8O8/c1-10-61-44-18-17-35-28-40(44)41(48(61)39-14-11-20-55-46(39)33(4)69-9)29-54(5,6)31-70-53(68)42-15-12-22-62(57-42)51(66)43(26-34-24-37(35)27-38(63)25-34)56-49(64)47(32(2)3)59(8)50(65)36-19-23-60(30-36)52(67)45-16-13-21-58(45)7/h11,14,17-18,20,24-25,27-28,32-33,36,42-43,45,47,57,63H,10,12-13,15-16,19,21-23,26,29-31H2,1-9H3,(H,56,64) ISLICLDMKOZGAE-UHFFFAOYSA-N 750905 US20250195521, Example A371 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750905 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750905&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348384 519649499 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541761 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O6S/c1-9-53-37-18-17-30-23-32(37)33(41(53)31-15-13-19-47-39(31)29(4)59-8)25-46(5,6)27-60-44(57)34-16-14-22-54(50-34)43(56)35(24-38-48-36(30)26-61-38)49-42(55)40(28(2)3)51(7)45(58)52-20-11-10-12-21-52/h13,15,17-19,23,26,28-29,34-35,40,50H,9-12,14,16,20-22,24-25,27H2,1-8H3,(H,49,55) OBAWXCQSAJWGLZ-UHFFFAOYSA-N 750906 US20250195521, Example A372 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750906 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750906&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347334 519649500 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541762 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-9-52-36-15-14-29-22-31(36)32(40(52)30-12-10-16-46-38(30)28(4)58-8)24-45(5,6)26-60-43(56)33-13-11-17-53(49-33)42(55)34(23-37-47-35(29)25-61-37)48-41(54)39(27(2)3)50(7)44(57)51-18-20-59-21-19-51/h10,12,14-16,22,25,27-28,33-34,39,49H,9,11,13,17-21,23-24,26H2,1-8H3,(H,48,54) YCSZVZKXCVDDBV-UHFFFAOYSA-N 750907 US20250195521, Example A373 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750907 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750907&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347752 519649501 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541763 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-9-52-36-15-14-29-22-31(36)32(40(52)30-12-10-16-46-38(30)28(4)58-8)24-45(5,6)26-60-43(56)33-13-11-17-53(49-33)42(55)34(23-37-47-35(29)25-61-37)48-41(54)39(27(2)3)50(7)44(57)51-18-20-59-21-19-51/h10,12,14-16,22,25,27-28,33-34,39,49H,9,11,13,17-21,23-24,26H2,1-8H3,(H,48,54) YCSZVZKXCVDDBV-UHFFFAOYSA-N 750908 US20250195521, Example A374 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750908 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750908&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347752 519649502 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541764 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCNCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H61N9O6S/c1-9-53-36-15-14-29-22-31(36)32(40(53)30-12-10-16-47-38(30)28(4)59-8)24-45(5,6)26-60-43(57)33-13-11-19-54(50-33)42(56)34(23-37-48-35(29)25-61-37)49-41(55)39(27(2)3)51(7)44(58)52-20-17-46-18-21-52/h10,12,14-16,22,25,27-28,33-34,39,46,50H,9,11,13,17-21,23-24,26H2,1-8H3,(H,49,55) BYOJOYNTXATVTR-UHFFFAOYSA-N 750909 US20250195521, Example A375 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750909 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750909&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347757 519649503 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541765 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H](O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-9-52-36-15-14-28-20-31(36)32(40(52)30-12-10-17-46-38(30)27(4)59-8)22-45(5,6)25-60-43(57)33-13-11-18-53(49-33)42(56)34(21-37-47-35(28)24-61-37)48-41(55)39(26(2)3)50(7)44(58)51-19-16-29(54)23-51/h10,12,14-15,17,20,24,26-27,29,33-34,39,49,54H,9,11,13,16,18-19,21-23,25H2,1-8H3,(H,48,55) ILZCWFMEUIKJJK-UHFFFAOYSA-N 750910 US20250195521, Example A376 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750910 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750910&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347780 519649504 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541766 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H64N6O8/c1-10-54-40-16-15-32-25-36(40)37(43(54)35-13-11-18-50-41(35)30(5)61-9)26-49(6,7)27-63-48(60)38-14-12-19-55(52-38)46(58)39(23-31-21-33(32)24-34(56)22-31)51-45(57)42(28(2)3)53(8)47(59)44-29(4)17-20-62-44/h11,13,15-16,18,21-22,24-25,28-30,38-39,42,44,52,56H,10,12,14,17,19-20,23,26-27H2,1-9H3,(H,51,57) PMZCOUADJWGDLT-UHFFFAOYSA-N 750911 US20250195521, Example A377 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750911 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750911&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160251994 519649505 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541767 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@H]3CCCN3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H70N8O8/c1-9-60-44-17-16-34-27-39(44)40(47(60)38-13-10-20-55-45(38)32(4)68-8)28-53(5,6)30-69-52(67)42-15-12-21-61(57-42)51(66)43(25-33-23-36(34)26-37(62)24-33)56-48(63)46(31(2)3)58(7)49(64)35-18-22-59(29-35)50(65)41-14-11-19-54-41/h10,13,16-17,20,23-24,26-27,31-32,35,41-43,46,54,57,62H,9,11-12,14-15,18-19,21-22,25,28-30H2,1-8H3,(H,56,63) IVMSNWIMGHYAEI-UHFFFAOYSA-N 750912 US20250195521, Example A378 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750912 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750912&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347784 519649506 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541768 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@@]3(C)CCCN3C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C55H74N8O8/c1-11-62-45-18-17-36-29-41(45)42(48(62)40-15-12-21-56-46(40)34(4)70-10)30-54(5,6)32-71-52(68)43-16-13-23-63(58-43)51(67)44(27-35-25-38(36)28-39(64)26-35)57-49(65)47(33(2)3)60(9)50(66)37-19-24-61(31-37)53(69)55(7)20-14-22-59(55)8/h12,15,17-18,21,25-26,28-29,33-34,37,43-44,47,58,64H,11,13-14,16,19-20,22-24,27,30-32H2,1-10H3,(H,57,65) BXZXNOMZQQLAOD-UHFFFAOYSA-N 750913 US20250195521, Example A379 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750913 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750913&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346732 519649507 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541769 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)c1ncco1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H55N7O8/c1-8-52-38-12-11-29-22-33(38)34(40(52)35-24-47-14-13-30(35)25-59-7)23-46(4,5)26-61-45(58)36-10-9-16-53(50-36)43(56)37(20-28-18-31(29)21-32(54)19-28)49-41(55)39(27(2)3)51(6)44(57)42-48-15-17-60-42/h11-15,17-19,21-22,24,27,36-37,39,50,54H,8-10,16,20,23,25-26H2,1-7H3,(H,49,55) RAOVYOGYMYKOIO-UHFFFAOYSA-N 750914 US20250195521, Example A38 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750914 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750914&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347680 519649508 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541770 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@]3(C)CCCN3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H72N8O8/c1-10-61-44-17-16-35-28-40(44)41(47(61)39-14-11-20-55-45(39)33(4)69-9)29-53(5,6)31-70-51(67)42-15-12-22-62(58-42)50(66)43(26-34-24-37(35)27-38(63)25-34)57-48(64)46(32(2)3)59(8)49(65)36-18-23-60(30-36)52(68)54(7)19-13-21-56-54/h11,14,16-17,20,24-25,27-28,32-33,36,42-43,46,56,58,63H,10,12-13,15,18-19,21-23,26,29-31H2,1-9H3,(H,57,64) ZJPBMJGTGHYMCE-UHFFFAOYSA-N 750915 US20250195521, Example A380 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750915 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750915&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347340 519649509 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541771 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C(C)(C)NC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H72N8O8/c1-12-60-43-18-17-34-27-39(43)40(46(60)38-15-13-20-55-44(38)32(4)68-11)28-52(5,6)30-69-50(66)41-16-14-21-61(57-41)49(65)42(25-33-23-36(34)26-37(62)24-33)56-47(63)45(31(2)3)58(10)48(64)35-19-22-59(29-35)51(67)53(7,8)54-9/h13,15,17-18,20,23-24,26-27,31-32,35,41-42,45,54,57,62H,12,14,16,19,21-22,25,28-30H2,1-11H3,(H,56,63) KPRSZKYMPCMYMR-UHFFFAOYSA-N 750916 US20250195521, Example A381 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750916 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750916&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346777 519649510 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541772 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C#N)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H57N9O6S/c1-9-53-36-15-14-29-18-31(36)32(40(53)30-12-10-16-47-38(30)27(4)59-8)20-45(5,6)25-60-43(57)33-13-11-17-54(50-33)42(56)34(19-37-48-35(29)24-61-37)49-41(55)39(26(2)3)51(7)44(58)52-22-28(21-46)23-52/h10,12,14-16,18,24,26-28,33-34,39,50H,9,11,13,17,19-20,22-23,25H2,1-8H3,(H,49,55) SZAGPGPWVGYCJF-UHFFFAOYSA-N 750917 US20250195521, Example A382 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750917 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750917&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346746 519649511 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541773 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(S(C)(=O)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O8S2/c1-10-52-36-16-15-28-19-31(36)32(40(52)30-13-11-17-46-38(30)27(4)60-8)21-45(5,6)25-61-43(56)33-14-12-18-53(49-33)42(55)34(20-37-47-35(28)24-62-37)48-41(54)39(26(2)3)50(7)44(57)51-22-29(23-51)63(9,58)59/h11,13,15-17,19,24,26-27,29,33-34,39,49H,10,12,14,18,20-23,25H2,1-9H3,(H,48,54) VRJYQCATZOLIEH-UHFFFAOYSA-N 750918 US20250195521, Example A383 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750918 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750918&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347366 519649512 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541774 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H64N6O7/c1-10-54-41-16-15-32-25-37(41)38(44(54)36-13-11-17-50-42(36)30(5)61-9)26-49(6,7)27-62-48(60)39-14-12-18-55(52-39)47(59)40(23-31-21-33(32)24-35(56)22-31)51-45(57)43(28(2)3)53(8)46(58)34-19-29(4)20-34/h11,13,15-17,21-22,24-25,28-30,34,39-40,43,52,56H,10,12,14,18-20,23,26-27H2,1-9H3,(H,51,57) HVHSIQUWHJPOAP-UHFFFAOYSA-N 750919 US20250195521, Example A384 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750919 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750919&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158598362 519649513 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541775 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@@H]3CCCN3C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H72N8O8/c1-10-61-44-18-17-35-28-40(44)41(48(61)39-14-11-20-55-46(39)33(4)69-9)29-54(5,6)31-70-53(68)42-15-12-22-62(57-42)51(66)43(26-34-24-37(35)27-38(63)25-34)56-49(64)47(32(2)3)59(8)50(65)36-19-23-60(30-36)52(67)45-16-13-21-58(45)7/h11,14,17-18,20,24-25,27-28,32-33,36,42-43,45,47,57,63H,10,12-13,15-16,19,21-23,26,29-31H2,1-9H3,(H,56,64) ISLICLDMKOZGAE-UHFFFAOYSA-N 750920 US20250195521, Example A385 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750920 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750920&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347373 519649514 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541776 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)[C@@H](C)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H72N8O8/c1-12-60-44-18-17-35-27-40(44)41(47(60)39-15-13-20-54-45(39)33(5)68-11)28-53(6,7)30-69-52(67)42-16-14-21-61(56-42)51(66)43(25-34-23-37(35)26-38(62)24-34)55-48(63)46(31(2)3)58(10)50(65)36-19-22-59(29-36)49(64)32(4)57(8)9/h13,15,17-18,20,23-24,26-27,31-33,36,42-43,46,56,62H,12,14,16,19,21-22,25,28-30H2,1-11H3,(H,55,63) PMMMFNPELHPWMX-UHFFFAOYSA-N 750921 US20250195521, Example A386 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750921 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750921&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347755 519649515 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541777 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(COC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-10-53-37-16-15-30-19-32(37)33(41(53)31-13-11-17-47-39(31)28(4)60-9)21-46(5,6)26-61-44(57)34-14-12-18-54(50-34)43(56)35(20-38-48-36(30)25-62-38)49-42(55)40(27(2)3)51(7)45(58)52-22-29(23-52)24-59-8/h11,13,15-17,19,25,27-29,34-35,40,50H,10,12,14,18,20-24,26H2,1-9H3,(H,49,55) CHUYGODZQTYNOM-UHFFFAOYSA-N 750922 US20250195521, Example A387 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750922 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750922&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347360 519649516 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541778 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(c3cn[nH]c3c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N8O6/c1-10-53-39-16-15-29-20-33(39)34(42(53)32-13-11-17-47-40(32)27(4)59-9)23-46(6,7)25-60-45(58)36-14-12-18-54(51-36)44(57)38(49-43(56)41(26(2)3)52(8)28(5)55)22-31-19-30(29)21-37-35(31)24-48-50-37/h11,13,15-17,19-21,24,26-27,36,38,41,51H,10,12,14,18,22-23,25H2,1-9H3,(H,48,50)(H,49,56) VPAGOVKOMFVCOC-UHFFFAOYSA-N 750923 US20250195521, Example A388 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750923 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750923&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347971 519649517 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541779 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCN(C)C1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H56N8O6S/c1-9-49-34-15-14-27-20-29(34)30(38(49)28-12-10-16-44-36(28)26(4)56-8)22-43(5,6)24-57-41(54)31-13-11-17-51(47-31)40(53)32(21-35-45-33(27)23-58-35)46-39(52)37(25(2)3)50-19-18-48(7)42(50)55/h10,12,14-16,20,23,25-26,31-32,37,47H,9,11,13,17-19,21-22,24H2,1-8H3,(H,46,52) TYNCESSAZZTFSL-UHFFFAOYSA-N 750924 US20250195521, Example A389 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750924 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750924&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159533586 519649518 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541780 CCn1c(-c2cccnc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OC1COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O9/c1-8-51-39-14-13-29-21-34(39)35(41(51)33-11-9-15-47-38(33)25-58-7)22-46(4,5)26-60-44(56)36-12-10-16-52(49-36)43(55)37(19-28-17-30(29)20-31(53)18-28)48-42(54)40(27(2)3)50(6)45(57)61-32-23-59-24-32/h9,11,13-15,17-18,20-21,27,32,36-37,40,49,53H,8,10,12,16,19,22-26H2,1-7H3,(H,48,54) NZANKTJDAQXYEE-UHFFFAOYSA-N 750925 US20250195521, Example A39 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750925 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750925&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157823484 519649519 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541781 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CC[C@@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-9-54-40-17-14-30-24-35(40)36(43(54)34-12-10-18-50-41(34)28(4)61-8)25-48(5,6)26-62-47(60)38-13-11-19-55(52-38)46(59)39(22-29-20-31(30)23-32(56)21-29)51-44(57)42(27(2)3)53(7)45(58)33-15-16-37(33)49/h10,12,14,17-18,20-21,23-24,27-28,33,37-39,42,52,56H,9,11,13,15-16,19,22,25-26,49H2,1-8H3,(H,51,57) FCKDDNMEFHNKGZ-UHFFFAOYSA-N 750926 US20250195521, Example A391 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750926&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413636 519649520 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541782 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC[C@@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-9-54-40-17-14-30-24-35(40)36(43(54)34-12-10-18-50-41(34)28(4)61-8)25-48(5,6)26-62-47(60)38-13-11-19-55(52-38)46(59)39(22-29-20-31(30)23-32(56)21-29)51-44(57)42(27(2)3)53(7)45(58)33-15-16-37(33)49/h10,12,14,17-18,20-21,23-24,27-28,33,37-39,42,52,56H,9,11,13,15-16,19,22,25-26,49H2,1-8H3,(H,51,57) FCKDDNMEFHNKGZ-UHFFFAOYSA-N 750927 US20250195521, Example A392 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750927 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750927&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160684443 519649521 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541783 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCNC13CCC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O7/c1-9-57-42-16-15-33-27-37(42)38(45(57)36-13-10-20-52-43(36)31(4)64-8)28-50(5,6)29-65-49(63)40-14-11-22-58(55-40)48(62)41(25-32-23-34(33)26-35(59)24-32)54-46(60)44(30(2)3)56(7)47(61)39-17-21-53-51(39)18-12-19-51/h10,13,15-16,20,23-24,26-27,30-31,39-41,44,53,55,59H,9,11-12,14,17-19,21-22,25,28-29H2,1-8H3,(H,54,60) XAKOZOJRRYPXTR-UHFFFAOYSA-N 750928 US20250195521, Example A393 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750928 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750928&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347009 519649522 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541784 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCC[C@@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O7/c1-9-56-42-19-18-32-26-37(42)38(45(56)36-15-12-20-52-43(36)30(4)63-8)27-50(5,6)28-64-49(62)40-17-13-21-57(54-40)48(61)41(24-31-22-33(32)25-34(58)23-31)53-46(59)44(29(2)3)55(7)47(60)35-14-10-11-16-39(35)51/h12,15,18-20,22-23,25-26,29-30,35,39-41,44,54,58H,9-11,13-14,16-17,21,24,27-28,51H2,1-8H3,(H,53,59) OYBSEUWEWAJTQG-UHFFFAOYSA-N 750929 US20250195521, Example A394 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750929 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750929&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162026968 519649523 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541785 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCCC[C@@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O7/c1-9-56-42-19-18-32-26-37(42)38(45(56)36-15-12-20-52-43(36)30(4)63-8)27-50(5,6)28-64-49(62)40-17-13-21-57(54-40)48(61)41(24-31-22-33(32)25-34(58)23-31)53-46(59)44(29(2)3)55(7)47(60)35-14-10-11-16-39(35)51/h12,15,18-20,22-23,25-26,29-30,35,39-41,44,54,58H,9-11,13-14,16-17,21,24,27-28,51H2,1-8H3,(H,53,59) OYBSEUWEWAJTQG-UHFFFAOYSA-N 750930 US20250195521, Example A395 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750930 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750930&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413603 519649524 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541786 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCC(C3CCCO3)O1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H68N6O9/c1-9-57-41-17-16-33-27-37(41)38(47(57)36-13-10-20-53-45(36)31(4)64-8)28-52(5,6)29-66-51(63)39-14-11-21-58(55-39)49(61)40(25-32-23-34(33)26-35(59)24-32)54-48(60)46(30(2)3)56(7)50(62)44-19-18-43(67-44)42-15-12-22-65-42/h10,13,16-17,20,23-24,26-27,30-31,39-40,42-44,46,55,59H,9,11-12,14-15,18-19,21-22,25,28-29H2,1-8H3,(H,54,60) VIHHIFWMQFDNCX-UHFFFAOYSA-N 750931 US20250195521, Example A396 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750931 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750931&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347541 519649525 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541787 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC[C@@H](CN(C)C)O1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H69N7O8/c1-11-57-42-18-16-33-26-38(42)39(46(57)37-14-12-20-52-44(37)31(4)64-10)27-51(5,6)29-65-50(63)40-15-13-21-58(54-40)48(61)41(24-32-22-34(33)25-35(59)23-32)53-47(60)45(30(2)3)56(9)49(62)43-19-17-36(66-43)28-55(7)8/h12,14,16,18,20,22-23,25-26,30-31,36,40-41,43,45,54,59H,11,13,15,17,19,21,24,27-29H2,1-10H3,(H,53,60) YTULEPBSPQZZFC-UHFFFAOYSA-N 750932 US20250195521, Example A397 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750932 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750932&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413590 519649526 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541788 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)C(C)=C(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H53N5O6/c1-9-47-37-15-14-29-22-33(37)34(39(47)32-12-10-16-44-38(32)27(5)53-8)23-43(6,7)24-54-42(52)35-13-11-17-48(46-35)41(51)36(45-40(50)26(4)25(2)3)20-28-18-30(29)21-31(49)19-28/h10,12,14-16,18-19,21-22,27,35-36,46,49H,9,11,13,17,20,23-24H2,1-8H3,(H,45,50) QCWVNHXHDBACNB-UHFFFAOYSA-N 750933 US20250195521, Example A398 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750933&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346760 519649527 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541789 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H58N8O6S/c1-9-51-35-16-15-28-21-30(35)31(39(51)29-13-10-17-45-37(29)27(4)57-8)23-44(5,6)25-58-42(55)32-14-11-20-52(48-32)41(54)33(22-36-46-34(28)24-59-36)47-40(53)38(26(2)3)49(7)43(56)50-18-12-19-50/h10,13,15-17,21,24,26-27,32-33,38,48H,9,11-12,14,18-20,22-23,25H2,1-8H3,(H,47,53) RELMMSQMWOORDD-UHFFFAOYSA-N 750934 US20250195521, Example A399 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750934&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347293 519649528 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541790 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-9-54-40-15-14-31-24-36(40)37(43(54)35-12-10-17-50-41(35)29(4)61-8)25-48(5,6)27-62-47(60)38-13-11-19-55(52-38)46(59)39(22-30-20-33(31)23-34(56)21-30)51-44(57)42(28(2)3)53(7)45(58)32-16-18-49-26-32/h10,12,14-15,17,20-21,23-24,28-29,32,38-39,42,49,52,56H,9,11,13,16,18-19,22,25-27H2,1-8H3,(H,51,57) WPNIAWVWAWKIGS-UHFFFAOYSA-N 750935 US20250195521, Example A4 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750935&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161102729 519649529 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541791 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N1CCCC1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H56N6O7/c1-7-49-38-13-12-29-22-33(38)34(41(49)35-24-46-15-14-30(35)25-57-6)23-45(4,5)26-58-44(56)36-10-8-17-51(48-36)43(55)37(20-28-18-31(29)21-32(52)19-28)47-42(54)40(27(2)3)50-16-9-11-39(50)53/h12-15,18-19,21-22,24,27,36-37,40,48,52H,7-11,16-17,20,23,25-26H2,1-6H3,(H,47,54) MRKSSRHOLOZSEO-UHFFFAOYSA-N 750936 US20250195521, Example A40 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750936&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162065381 519649530 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541792 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O6S/c1-9-52-36-17-16-29-22-31(36)32(40(52)30-14-12-18-46-38(30)28(4)58-8)24-45(5,6)26-59-43(56)33-15-13-21-53(49-33)42(55)34(23-37-47-35(29)25-60-37)48-41(54)39(27(2)3)50(7)44(57)51-19-10-11-20-51/h12,14,16-18,22,25,27-28,33-34,39,49H,9-11,13,15,19-21,23-24,26H2,1-8H3,(H,48,54) WVNQAATWQZBMKR-UHFFFAOYSA-N 750937 US20250195521, Example A400 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750937&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346611 519649531 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541793 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@H](O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60N8O7S/c1-9-52-36-15-14-28-20-31(36)32(40(52)30-12-10-17-46-38(30)27(4)59-8)22-45(5,6)25-60-43(57)33-13-11-18-53(49-33)42(56)34(21-37-47-35(28)24-61-37)48-41(55)39(26(2)3)50(7)44(58)51-19-16-29(54)23-51/h10,12,14-15,17,20,24,26-27,29,33-34,39,49,54H,9,11,13,16,18-19,21-23,25H2,1-8H3,(H,48,55) ILZCWFMEUIKJJK-UHFFFAOYSA-N 750938 US20250195521, Example A401 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750938&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347336 519649532 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541794 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOC[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-10-52-37-16-15-30-21-32(37)33(41(52)31-13-11-17-47-39(31)29(5)59-9)23-46(6,7)26-61-44(57)34-14-12-18-54(50-34)43(56)35(22-38-48-36(30)25-62-38)49-42(55)40(27(2)3)51(8)45(58)53-19-20-60-24-28(53)4/h11,13,15-17,21,25,27-29,34-35,40,50H,10,12,14,18-20,22-24,26H2,1-9H3,(H,49,55) KSXBQEXUKYZICD-UHFFFAOYSA-N 750939 US20250195521, Example A402 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750939&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347203 519649533 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541795 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOC[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-10-52-37-16-15-30-21-32(37)33(41(52)31-13-11-17-47-39(31)29(5)59-9)23-46(6,7)26-61-44(57)34-14-12-18-54(50-34)43(56)35(22-38-48-36(30)25-62-38)49-42(55)40(27(2)3)51(8)45(58)53-19-20-60-24-28(53)4/h11,13,15-17,21,25,27-29,34-35,40,50H,10,12,14,18-20,22-24,26H2,1-9H3,(H,49,55) KSXBQEXUKYZICD-UHFFFAOYSA-N 750940 US20250195521, Example A403 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750940&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348239 519649534 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541796 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CN3CCCN1CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H68N8O7/c1-9-58-42-16-15-34-27-38(42)39(46(58)37-13-10-17-52-44(37)32(4)65-8)28-51(5,6)30-66-50(64)40-14-11-20-59(54-40)48(62)41(25-33-23-35(34)26-36(60)24-33)53-47(61)45(31(2)3)55(7)49(63)43-29-56-18-12-19-57(43)22-21-56/h10,13,15-17,23-24,26-27,31-32,40-41,43,45,54,60H,9,11-12,14,18-22,25,28-30H2,1-8H3,(H,53,61) KELUHRJEIHKQDX-UHFFFAOYSA-N 750941 US20250195521, Example A404 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750941&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347827 519649535 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541797 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCC(=O)O1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H60N6O9/c1-9-53-38-15-14-30-24-34(38)35(43(53)33-12-10-18-49-41(33)28(4)61-8)25-48(5,6)26-62-47(60)36-13-11-19-54(51-36)45(58)37(22-29-20-31(30)23-32(55)21-29)50-44(57)42(27(2)3)52(7)46(59)39-16-17-40(56)63-39/h10,12,14-15,18,20-21,23-24,27-28,36-37,39,42,51,55H,9,11,13,16-17,19,22,25-26H2,1-8H3,(H,50,57) NPKGPFRAVGQAPU-UHFFFAOYSA-N 750942 US20250195521, Example A405 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750942&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346620 519649536 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541798 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C13CC(CO1)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H62N6O8/c1-9-54-40-15-14-32-22-36(40)37(43(54)35-12-10-16-50-41(35)29(4)61-8)25-48(5,6)27-62-46(59)38-13-11-17-55(52-38)45(58)39(20-30-18-33(32)21-34(56)19-30)51-44(57)42(28(2)3)53(7)47(60)49-23-31(24-49)26-63-49/h10,12,14-16,18-19,21-22,28-29,31,38-39,42,52,56H,9,11,13,17,20,23-27H2,1-8H3,(H,51,57) XQZDDUMCBYQFFN-UHFFFAOYSA-N 750943 US20250195521, Example A406 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750943&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348222 519649537 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541799 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OC[C@@H]3CCC[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H66N6O8/c1-9-56-42-18-17-32-25-38(42)39(45(56)37-15-11-19-52-43(37)30(4)63-8)26-51(5,6)28-65-50(62)40-16-12-20-57(54-40)48(60)41(23-31-21-34(32)24-35(58)22-31)53-47(59)44(29(2)3)55(7)49(61)46-36-14-10-13-33(36)27-64-46/h11,15,17-19,21-22,24-25,29-30,33,36,40-41,44,46,54,58H,9-10,12-14,16,20,23,26-28H2,1-8H3,(H,53,59) GFQRRKVUHLOCPB-UHFFFAOYSA-N 750944 US20250195521, Example A407 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750944&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347853 519649538 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541800 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCC(C(F)(F)F)O1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H61F3N6O8/c1-9-57-38-15-14-30-24-34(38)35(43(57)33-12-10-18-53-41(33)28(4)64-8)25-48(5,6)26-65-47(63)36-13-11-19-58(55-36)45(61)37(22-29-20-31(30)23-32(59)21-29)54-44(60)42(27(2)3)56(7)46(62)39-16-17-40(66-39)49(50,51)52/h10,12,14-15,18,20-21,23-24,27-28,36-37,39-40,42,55,59H,9,11,13,16-17,19,22,25-26H2,1-8H3,(H,54,60) PPGQNQNPHJTWLA-UHFFFAOYSA-N 750945 US20250195521, Example A408 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750945&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347591 519649539 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541801 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCC3(CCOC3)O1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H66N6O9/c1-9-56-41-15-14-33-26-37(41)38(45(56)36-12-10-19-52-43(36)31(4)63-8)27-50(5,6)28-65-49(62)39-13-11-20-57(54-39)47(60)40(24-32-22-34(33)25-35(58)23-32)53-46(59)44(30(2)3)55(7)48(61)42-16-17-51(66-42)18-21-64-29-51/h10,12,14-15,19,22-23,25-26,30-31,39-40,42,44,54,58H,9,11,13,16-18,20-21,24,27-29H2,1-8H3,(H,53,59) JBQPPJBBBNBWFX-UHFFFAOYSA-N 750946 US20250195521, Example A409 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750946&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348249 519649540 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541802 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O7/c1-10-56-43-14-13-33-24-38(43)39(45(56)40-26-51-17-15-35(40)28-63-9)25-50(6,7)29-64-49(62)41-12-11-18-57(53-41)48(61)42(22-32-20-36(33)23-37(58)21-32)52-46(59)44(30(2)3)54(8)47(60)34-16-19-55(27-34)31(4)5/h13-15,17,20-21,23-24,26,30-31,34,41-42,44,53,58H,10-12,16,18-19,22,25,27-29H2,1-9H3,(H,52,59) FYWAOFGOEPBMJV-UHFFFAOYSA-N 750947 US20250195521, Example A41 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750947&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159026002 519649541 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541803 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C13CCC(CO1)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H64N6O8/c1-9-55-41-15-14-33-24-37(41)38(44(55)36-12-10-18-51-42(36)30(4)62-8)26-49(5,6)28-63-47(60)39-13-11-19-56(53-39)46(59)40(22-32-20-34(33)23-35(57)21-32)52-45(58)43(29(2)3)54(7)48(61)50-17-16-31(25-50)27-64-50/h10,12,14-15,18,20-21,23-24,29-31,39-40,43,53,57H,9,11,13,16-17,19,22,25-28H2,1-8H3,(H,52,58) LEKLXECLMXNWDO-UHFFFAOYSA-N 750948 US20250195521, Example A410 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750948&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346647 519649542 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541804 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C13CCC(CO1)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H64N6O8/c1-9-55-41-15-14-33-24-37(41)38(44(55)36-12-10-18-51-42(36)30(4)62-8)26-49(5,6)28-63-47(60)39-13-11-19-56(53-39)46(59)40(22-32-20-34(33)23-35(57)21-32)52-45(58)43(29(2)3)54(7)48(61)50-17-16-31(25-50)27-64-50/h10,12,14-15,18,20-21,23-24,29-31,39-40,43,53,57H,9,11,13,16-17,19,22,25-28H2,1-8H3,(H,52,58) LEKLXECLMXNWDO-UHFFFAOYSA-N 750949 US20250195521, Example A411 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750949&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346647 519649543 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541805 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C13CCC(CC1)O3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H64N6O8/c1-9-55-41-15-14-32-26-37(41)38(44(55)36-12-10-20-51-42(36)30(4)62-8)27-49(5,6)28-63-47(60)39-13-11-21-56(53-39)46(59)40(24-31-22-33(32)25-34(57)23-31)52-45(58)43(29(2)3)54(7)48(61)50-18-16-35(64-50)17-19-50/h10,12,14-15,20,22-23,25-26,29-30,35,39-40,43,53,57H,9,11,13,16-19,21,24,27-28H2,1-8H3,(H,52,58) CTNLCIUJFLUAKJ-UHFFFAOYSA-N 750950 US20250195521, Example A412 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750950&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160026812 519649544 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541806 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CC3(CCOCC3)CO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H68N6O9/c1-9-57-42-15-14-34-26-38(42)39(46(57)37-12-10-18-53-44(37)32(4)64-8)27-51(5,6)29-67-50(63)40-13-11-19-58(55-40)48(61)41(24-33-22-35(34)25-36(59)23-33)54-47(60)45(31(2)3)56(7)49(62)43-28-52(30-66-43)16-20-65-21-17-52/h10,12,14-15,18,22-23,25-26,31-32,40-41,43,45,55,59H,9,11,13,16-17,19-21,24,27-30H2,1-8H3,(H,54,60) AVEGUTIUFMSIED-UHFFFAOYSA-N 750951 US20250195521, Example A413 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750951&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 168856206 519649545 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541807 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC[C@@H](C(N)=O)O1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O9/c1-9-55-38-15-14-30-24-34(38)35(43(55)33-12-10-18-51-41(33)28(4)63-8)25-49(5,6)26-64-48(62)36-13-11-19-56(53-36)46(60)37(22-29-20-31(30)23-32(57)21-29)52-45(59)42(27(2)3)54(7)47(61)40-17-16-39(65-40)44(50)58/h10,12,14-15,18,20-21,23-24,27-28,36-37,39-40,42,53,57H,9,11,13,16-17,19,22,25-26H2,1-8H3,(H2,50,58)(H,52,59) DQHDDVBTBCBRIK-UHFFFAOYSA-N 750952 US20250195521, Example A414 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750952&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346617 519649546 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541808 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H66N6O8/c1-9-59-45-20-19-36-29-41(45)42(48(59)40-17-13-22-55-46(40)33(4)66-8)30-54(5,6)31-68-53(65)43-18-14-23-60(57-43)51(63)44(27-34-25-37(36)28-38(61)26-34)56-50(62)47(32(2)3)58(7)52(64)49-39(21-24-67-49)35-15-11-10-12-16-35/h10-13,15-17,19-20,22,25-26,28-29,32-33,39,43-44,47,49,57,61H,9,14,18,21,23-24,27,30-31H2,1-8H3,(H,56,62) SECNHJFBRDVOQM-UHFFFAOYSA-N 750953 US20250195521, Example A415 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750953&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413601 519649547 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541809 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(C(F)F)CCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H62F2N6O8/c1-9-56-39-16-15-31-25-35(39)36(42(56)34-13-10-18-52-40(34)29(4)63-8)26-48(5,6)27-64-45(61)37-14-11-19-57(54-37)44(60)38(23-30-21-32(31)24-33(58)22-30)53-43(59)41(28(2)3)55(7)47(62)49(46(50)51)17-12-20-65-49/h10,13,15-16,18,21-22,24-25,28-29,37-38,41,46,54,58H,9,11-12,14,17,19-20,23,26-27H2,1-8H3,(H,53,59) NIFPWVRANDEASJ-UHFFFAOYSA-N 750954 US20250195521, Example A416 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750954&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348244 519649548 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541810 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1[C@H]3CC[C@H](C3)[C@@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H67N7O7/c1-9-57-41-17-16-31-25-37(41)38(46(57)36-12-10-18-53-44(36)29(4)64-8)26-51(5,6)27-65-50(63)39-13-11-19-58(55-39)48(61)40(22-30-20-34(31)24-35(59)21-30)54-47(60)45(28(2)3)56(7)49(62)42-32-14-15-33(23-32)43(42)52/h10,12,16-18,20-21,24-25,28-29,32-33,39-40,42-43,45,55,59H,9,11,13-15,19,22-23,26-27,52H2,1-8H3,(H,54,60) UTXKCDHHPUZDHL-UHFFFAOYSA-N 750955 US20250195521, Example A417 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750955&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413586 519649549 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541811 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1COC[C@@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O8/c1-9-54-40-15-14-30-22-34(40)35(43(54)33-12-10-16-50-41(33)28(4)61-8)23-48(5,6)26-63-47(60)38-13-11-17-55(52-38)46(59)39(20-29-18-31(30)21-32(56)19-29)51-44(57)42(27(2)3)53(7)45(58)36-24-62-25-37(36)49/h10,12,14-16,18-19,21-22,27-28,36-39,42,52,56H,9,11,13,17,20,23-26,49H2,1-8H3,(H,51,57) ZHNCTHMRGCGUKF-UHFFFAOYSA-N 750956 US20250195521, Example A418 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750956&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413621 519649550 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541812 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCC[C@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O7/c1-9-56-42-19-18-32-26-37(42)38(45(56)36-15-12-20-52-43(36)30(4)63-8)27-50(5,6)28-64-49(62)40-17-13-21-57(54-40)48(61)41(24-31-22-33(32)25-34(58)23-31)53-46(59)44(29(2)3)55(7)47(60)35-14-10-11-16-39(35)51/h12,15,18-20,22-23,25-26,29-30,35,39-41,44,54,58H,9-11,13-14,16-17,21,24,27-28,51H2,1-8H3,(H,53,59) OYBSEUWEWAJTQG-UHFFFAOYSA-N 750957 US20250195521, Example A419 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750957&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347404 519649551 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541813 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H66N8O8/c1-10-57-42-14-13-32-24-37(42)38(44(57)39-26-51-17-15-34(39)28-65-9)25-50(4,5)29-66-48(63)40-12-11-18-58(53-40)47(62)41(22-31-20-35(32)23-36(59)21-31)52-45(60)43(30(2)3)55(8)46(61)33-16-19-56(27-33)49(64)54(6)7/h13-15,17,20-21,23-24,26,30,33,40-41,43,53,59H,10-12,16,18-19,22,25,27-29H2,1-9H3,(H,52,60) YWOGQSZDLSDZIG-UHFFFAOYSA-N 750958 US20250195521, Example A42 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750958&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348400 519649552 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541814 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1OCC[C@H]1N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O8/c1-9-54-39-15-14-30-24-34(39)35(42(54)33-12-10-17-50-40(33)28(4)61-8)25-48(5,6)26-63-47(60)37-13-11-18-55(52-37)45(58)38(22-29-20-31(30)23-32(56)21-29)51-44(57)41(27(2)3)53(7)46(59)43-36(49)16-19-62-43/h10,12,14-15,17,20-21,23-24,27-28,36-38,41,43,52,56H,9,11,13,16,18-19,22,25-26,49H2,1-8H3,(H,51,57) BNSATHKWFCYXNY-UHFFFAOYSA-N 750959 US20250195521, Example A420 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750959&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413617 519649553 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541815 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1[C@@H](N)[C@@H]3CC[C@H]1O3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O8/c1-9-56-38-15-14-30-24-34(38)35(45(56)33-12-10-18-52-43(33)28(4)63-8)25-50(5,6)26-64-49(62)36-13-11-19-57(54-36)47(60)37(22-29-20-31(30)23-32(58)21-29)53-46(59)44(27(2)3)55(7)48(61)41-39-16-17-40(65-39)42(41)51/h10,12,14-15,18,20-21,23-24,27-28,36-37,39-42,44,54,58H,9,11,13,16-17,19,22,25-26,51H2,1-8H3,(H,53,59) XFQUNZOODWBULA-UHFFFAOYSA-N 750960 US20250195521, Example A421 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750960 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750960&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 168856180 519649554 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541816 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC(C(=O)C(F)(F)F)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H61F3N8O7S/c1-9-58-37-15-14-30-22-32(37)33(41(58)31-12-10-18-52-39(31)28(4)65-8)24-47(5,6)26-66-45(63)34-13-11-19-59(55-34)44(62)35(23-38-53-36(30)25-67-38)54-43(61)40(27(2)3)56(7)46(64)57-20-16-29(17-21-57)42(60)48(49,50)51/h10,12,14-15,18,22,25,27-29,34-35,40,55H,9,11,13,16-17,19-21,23-24,26H2,1-8H3,(H,54,61) ZIQURIZFHRLQRS-UHFFFAOYSA-N 750961 US20250195521, Example A422 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750961&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 168856059 519649555 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541817 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(=O)[C@H]1OCC[C@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C61H78N8O8/c1-8-68-52-21-20-42-33-47(52)49(55(68)48-34-44(36-62-53(48)38(2)75-7)67-26-24-65(5)25-27-67)35-61(3,4)37-77-60(74)50-19-14-23-69(64-50)58(72)51(31-39-29-43(42)32-45(70)30-39)63-57(71)54(41-17-12-13-18-41)66(6)59(73)56-46(22-28-76-56)40-15-10-9-11-16-40/h9-11,15-16,20-21,29-30,32-34,36,38,41,46,50-51,54,56,64,70H,8,12-14,17-19,22-28,31,35,37H2,1-7H3,(H,63,71) YOMRKJMJONGRLZ-UHFFFAOYSA-N 750962 US20250195521, Example A423 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750962&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 168856222 519649556 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541818 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(=O)N1CCS(=N)(=O)CC1)C(=O)N1CCC[C@H](N1)C(=O)CCC(C)(C)C2 InChI=1S/C51H68N8O7S/c1-7-58-43-17-16-35-30-39(43)40(47(58)38-14-10-20-53-45(38)32(2)66-6)31-51(3,4)19-18-44(61)41-15-11-21-59(55-41)49(63)42(28-33-26-36(35)29-37(60)27-33)54-48(62)46(34-12-8-9-13-34)56(5)50(64)57-22-24-67(52,65)25-23-57/h10,14,16-17,20,26-27,29-30,32,34,41-42,46,52,55,60H,7-9,11-13,15,18-19,21-25,28,31H2,1-6H3,(H,54,62) NUWNTRUSVRTPMC-UHFFFAOYSA-N 750963 US20250195521, Example A424 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750963&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787212 519649557 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541819 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1OCC[C@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H66N6O8/c1-9-59-45-20-19-36-29-41(45)42(48(59)40-17-13-22-55-46(40)33(4)66-8)30-54(5,6)31-68-53(65)43-18-14-23-60(57-43)51(63)44(27-34-25-37(36)28-38(61)26-34)56-50(62)47(32(2)3)58(7)52(64)49-39(21-24-67-49)35-15-11-10-12-16-35/h10-13,15-17,19-20,22,25-26,28-29,32-33,39,43-44,47,49,57,61H,9,14,18,21,23-24,27,30-31H2,1-8H3,(H,56,62) SECNHJFBRDVOQM-UHFFFAOYSA-N 750964 US20250195521, Example A425 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750964&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 168856225 519649558 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541820 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(=O)N1CCS(=O)(=NC)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H68N8O8S/c1-8-58-43-18-17-35-29-39(43)40(46(58)38-15-11-19-53-44(38)32(2)66-7)30-51(3,4)31-67-49(63)41-16-12-20-59(55-41)48(62)42(27-33-25-36(35)28-37(60)26-33)54-47(61)45(34-13-9-10-14-34)56(6)50(64)57-21-23-68(65,52-5)24-22-57/h11,15,17-19,25-26,28-29,32,34,41-42,45,55,60H,8-10,12-14,16,20-24,27,30-31H2,1-7H3,(H,54,61) NCAZHWOEDOEUPR-UHFFFAOYSA-N 750965 US20250195521, Example A426 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750965&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347075 519649559 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541821 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC(C(=O)C(F)(F)F)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H64F3N7O8/c1-9-60-41-15-14-33-26-37(41)38(44(60)36-12-10-18-55-42(36)30(4)68-8)27-50(5,6)28-69-48(66)39-13-11-19-61(57-39)47(65)40(24-31-22-34(33)25-35(62)23-31)56-46(64)43(29(2)3)58(7)49(67)59-20-16-32(17-21-59)45(63)51(52,53)54/h10,12,14-15,18,22-23,25-26,29-30,32,39-40,43,57,62H,9,11,13,16-17,19-21,24,27-28H2,1-8H3,(H,56,64) VKVNIEHEAHKTAV-UHFFFAOYSA-N 750966 US20250195521, Example A427 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750966&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347574 519649560 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541822 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1OCC[C@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H63N7O7S/c1-9-57-41-20-19-33-25-36(41)37(45(57)35-17-13-22-52-43(35)31(4)63-8)27-51(5,6)29-65-50(62)38-18-14-23-58(55-38)48(60)39(26-42-53-40(33)28-66-42)54-47(59)44(30(2)3)56(7)49(61)46-34(21-24-64-46)32-15-11-10-12-16-32/h10-13,15-17,19-20,22,25,28,30-31,34,38-39,44,46,55H,9,14,18,21,23-24,26-27,29H2,1-8H3,(H,54,59) AFOLMQZKEJXRDR-UHFFFAOYSA-N 750967 US20250195521, Example A428 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750967&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161455454 519649561 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541823 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1OCC[C@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H66N6O7/c1-9-59-45-23-22-38-30-41(45)42(48(59)40-20-14-25-55-46(40)34(4)65-8)31-54(5,6)32-67-53(64)43-21-15-26-60(57-43)51(62)44(29-35-16-13-19-37(38)28-35)56-50(61)47(33(2)3)58(7)52(63)49-39(24-27-66-49)36-17-11-10-12-18-36/h10-14,16-20,22-23,25,28,30,33-34,39,43-44,47,49,57H,9,15,21,24,26-27,29,31-32H2,1-8H3,(H,56,61) LGMKKBXCXYQNHC-UHFFFAOYSA-N 750968 US20250195521, Example A429 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750968&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347199 519649562 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541824 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CO)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O8/c1-8-49-37-12-11-28-20-32(37)33(40(49)34-22-45-14-13-29(34)24-57-7)21-44(4,5)25-58-43(56)35-10-9-15-50(47-35)42(55)36(18-27-16-30(28)19-31(52)17-27)46-41(54)39(26(2)3)48(6)38(53)23-51/h11-14,16-17,19-20,22,26,35-36,39,47,51-52H,8-10,15,18,21,23-25H2,1-7H3,(H,46,54) JPWBDKCEZPFOKJ-UHFFFAOYSA-N 750969 US20250195521, Example A43 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750969&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347349 519649563 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541825 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(C#N)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H57N7O6/c1-10-52-39-16-15-32-23-35(39)36(42(52)34-13-11-17-48-40(34)28(4)58-9)24-46(6,7)26-59-45(57)37-14-12-18-53(50-37)44(56)38(22-30-19-31(25-47)21-33(32)20-30)49-43(55)41(27(2)3)51(8)29(5)54/h11,13,15-17,19-21,23,27-28,37-38,41,50H,10,12,14,18,22,24,26H2,1-9H3,(H,49,55) MGGVSMNEZCNRPH-UHFFFAOYSA-N 750970 US20250195521, Example A430 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750970&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347581 519649564 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541826 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)NCC(C)(C)C2 InChI=1S/C50H66N8O7/c1-10-57-42-16-15-33-25-38(42)39(45(57)37-13-11-18-51-43(37)30(4)65-9)26-50(6,7)28-52-46(61)40-14-12-19-58(54-40)49(64)41(23-32-21-35(33)24-36(60)22-32)53-47(62)44(29(2)3)55(8)48(63)34-17-20-56(27-34)31(5)59/h11,13,15-16,18,21-22,24-25,29-30,34,40-41,44,54,60H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,52,61)(H,53,62) ZKWNHSCOTVSMHV-UHFFFAOYSA-N 750971 US20250195521, Example A431 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750971&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162122102 519649565 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541827 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CNCCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H66N8O7/c1-9-56-41-15-14-32-24-37(41)38(44(56)36-12-10-16-52-42(36)30(4)63-8)25-49(5,6)28-64-48(62)39-13-11-19-57(54-39)47(61)40(22-31-20-33(32)23-35(58)21-31)53-45(59)43(29(2)3)55(7)46(60)34-26-50-17-18-51-27-34/h10,12,14-16,20-21,23-24,29-30,34,39-40,43,50-51,54,58H,9,11,13,17-19,22,25-28H2,1-8H3,(H,53,59) RPPLKOFNDIQAEE-UHFFFAOYSA-N 750972 US20250195521, Example A432 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750972&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347612 519649566 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541828 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC3(CC1)CN(C)CCO3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H69N9O7S/c1-10-58-40-16-15-33-25-35(40)36(44(58)34-13-11-19-51-42(34)32(4)64-9)27-49(5,6)30-65-47(62)37-14-12-20-59(54-37)46(61)38(26-41-52-39(33)28-67-41)53-45(60)43(31(2)3)56(8)48(63)57-21-17-50(18-22-57)29-55(7)23-24-66-50/h11,13,15-16,19,25,28,31-32,37-38,43,54H,10,12,14,17-18,20-24,26-27,29-30H2,1-9H3,(H,53,60) CRMHWGXGDWUORG-UHFFFAOYSA-N 750973 US20250195521, Example A433 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750973&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346645 519649567 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541829 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@]13CCCNC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-9-55-38-16-15-31-23-33(38)34(42(55)32-13-10-20-50-40(32)30(4)62-8)25-47(5,6)28-63-45(60)35-14-11-21-57(53-35)44(59)36(24-39-51-37(31)26-64-39)52-43(58)41(29(2)3)54(7)46(61)56-22-18-48(56)17-12-19-49-27-48/h10,13,15-16,20,23,26,29-30,35-36,41,49,53H,9,11-12,14,17-19,21-22,24-25,27-28H2,1-8H3,(H,52,58) YMIGAULXXCOESO-UHFFFAOYSA-N 750974 US20250195521, Example A434 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750974&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346648 519649568 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541830 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@]13CCCNC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-9-55-38-16-15-31-23-33(38)34(42(55)32-13-10-20-50-40(32)30(4)62-8)25-47(5,6)28-63-45(60)35-14-11-21-57(53-35)44(59)36(24-39-51-37(31)26-64-39)52-43(58)41(29(2)3)54(7)46(61)56-22-18-48(56)17-12-19-49-27-48/h10,13,15-16,20,23,26,29-30,35-36,41,49,53H,9,11-12,14,17-19,21-22,24-25,27-28H2,1-8H3,(H,52,58) YMIGAULXXCOESO-UHFFFAOYSA-N 750975 US20250195521, Example A435 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750975&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347856 519649569 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541831 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@@]3(CCN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O7S/c1-10-57-39-16-15-32-23-34(39)35(43(57)33-13-11-18-50-41(33)31(4)63-9)25-48(5,6)29-64-46(61)36-14-12-19-58(53-36)45(60)37(24-40-51-38(32)26-66-40)52-44(59)42(30(2)3)55(8)47(62)56-21-22-65-49(28-56)17-20-54(7)27-49/h11,13,15-16,18,23,26,30-31,36-37,42,53H,10,12,14,17,19-22,24-25,27-29H2,1-9H3,(H,52,59) JDNANAZRJDUWNC-UHFFFAOYSA-N 750976 US20250195521, Example A436 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750976&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347550 519649570 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541832 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C)[C@H](c3ccccc3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H67N9O6S/c1-10-60-42-21-20-35-26-37(42)38(47(60)36-18-14-22-53-45(36)33(4)66-9)28-52(5,6)31-67-50(64)39-19-15-23-61(56-39)49(63)40(27-44-54-41(35)30-68-44)55-48(62)46(32(2)3)58(8)51(65)59-25-24-57(7)43(29-59)34-16-12-11-13-17-34/h11-14,16-18,20-22,26,30,32-33,39-40,43,46,56H,10,15,19,23-25,27-29,31H2,1-9H3,(H,55,62) PBVDRUCBSIPDBI-UHFFFAOYSA-N 750977 US20250195521, Example A437 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750977&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348214 519649571 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541833 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC13CCNCC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-9-55-38-15-14-31-24-33(38)34(42(55)32-12-10-19-50-40(32)30(4)62-8)26-47(5,6)28-63-45(60)35-13-11-22-57(53-35)44(59)36(25-39-51-37(31)27-64-39)52-43(58)41(29(2)3)54(7)46(61)56-23-18-48(56)16-20-49-21-17-48/h10,12,14-15,19,24,27,29-30,35-36,41,49,53H,9,11,13,16-18,20-23,25-26,28H2,1-8H3,(H,52,58) UBANZKLFBKBWDB-UHFFFAOYSA-N 750978 US20250195521, Example A438 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750978&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347609 519649572 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541834 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCS1(=O)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H69N9O8S2/c1-10-58-40-16-15-32-23-34(40)36(45(58)35-24-33(27-51-43(35)31(4)66-9)57-20-18-55(7)19-21-57)26-50(5,6)29-67-49(63)37-13-11-17-59(54-37)47(61)38(25-42-52-39(32)28-68-42)53-46(60)44(30(2)3)56(8)48(62)41-14-12-22-69(41,64)65/h15-16,23-24,27-28,30-31,37-38,41,44,54H,10-14,17-22,25-26,29H2,1-9H3,(H,53,60) OYRSRDPDXGRCEF-UHFFFAOYSA-N 750979 US20250195521, Example A439 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750979&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347860 519649573 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541835 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N1CCCCC1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O7/c1-7-50-39-14-13-30-23-34(39)35(42(50)36-25-47-16-15-31(36)26-58-6)24-46(4,5)27-59-45(57)37-11-10-18-52(49-37)44(56)38(21-29-19-32(30)22-33(53)20-29)48-43(55)41(28(2)3)51-17-9-8-12-40(51)54/h13-16,19-20,22-23,25,28,37-38,41,49,53H,7-12,17-18,21,24,26-27H2,1-6H3,(H,48,55) MERJXDJPUCZSGG-UHFFFAOYSA-N 750980 US20250195521, Example A44 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750980&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347402 519649574 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541836 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCCS1(=O)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H69N9O8S2/c1-10-58-40-16-15-32-23-34(40)36(45(58)35-24-33(27-51-43(35)31(4)66-9)57-20-18-55(7)19-21-57)26-50(5,6)29-67-49(63)37-13-11-17-59(54-37)47(61)38(25-42-52-39(32)28-68-42)53-46(60)44(30(2)3)56(8)48(62)41-14-12-22-69(41,64)65/h15-16,23-24,27-28,30-31,37-38,41,44,54H,10-14,17-22,25-26,29H2,1-9H3,(H,53,60) OYRSRDPDXGRCEF-UHFFFAOYSA-N 750981 US20250195521, Example A440 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750981&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160328878 519649575 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541837 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@]3(CCN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O7S/c1-10-57-39-16-15-32-23-34(39)35(43(57)33-13-11-18-50-41(33)31(4)63-9)25-48(5,6)29-64-46(61)36-14-12-19-58(53-36)45(60)37(24-40-51-38(32)26-66-40)52-44(59)42(30(2)3)55(8)47(62)56-21-22-65-49(28-56)17-20-54(7)27-49/h11,13,15-16,18,23,26,30-31,36-37,42,53H,10,12,14,17,19-22,24-25,27-29H2,1-9H3,(H,52,59) JDNANAZRJDUWNC-UHFFFAOYSA-N 750982 pyridinacycloundecaphane-4-yl)-2,3-dimethylcyclopropane-1-carboxamide::US20250195521, Example A441 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750982&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346659 519649576 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541838 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@]13CCCN(C)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O6S/c1-10-56-39-17-16-32-24-34(39)35(43(56)33-14-11-20-50-41(33)31(4)63-9)26-48(5,6)29-64-46(61)36-15-12-22-58(53-36)45(60)37(25-40-51-38(32)27-65-40)52-44(59)42(30(2)3)55(8)47(62)57-23-19-49(57)18-13-21-54(7)28-49/h11,14,16-17,20,24,27,30-31,36-37,42,53H,10,12-13,15,18-19,21-23,25-26,28-29H2,1-9H3,(H,52,59) KATZUAIOYCSBBZ-UHFFFAOYSA-N 750983 US20250195521, Example A442 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750983 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750983&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158461605 519649577 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541839 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)C3(N(C)C)CC3)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H70N10O7S/c1-11-60-40-17-16-33-26-35(40)36(44(60)34-14-12-20-52-42(34)32(4)67-10)28-50(5,6)30-68-47(64)37-15-13-21-61(55-37)46(63)38(27-41-53-39(33)29-69-41)54-45(62)43(31(2)3)57(9)49(66)59-24-22-58(23-25-59)48(65)51(18-19-51)56(7)8/h12,14,16-17,20,26,29,31-32,37-38,43,55H,11,13,15,18-19,21-25,27-28,30H2,1-10H3,(H,54,62) FLYOHGRZRHCULT-UHFFFAOYSA-N 750984 US20250195521, Example A443 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750984&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347226 519649578 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541840 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H]3OCCN(C)[C@@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-10-56-37-16-15-30-21-32(37)33(43(56)31-13-11-17-49-41(31)29(4)62-9)23-48(5,6)27-64-46(60)34-14-12-18-57(52-34)45(59)35(22-40-50-36(30)26-65-40)51-44(58)42(28(2)3)54(8)47(61)55-24-38-39(25-55)63-20-19-53(38)7/h11,13,15-17,21,26,28-29,34-35,38-39,42,52H,10,12,14,18-20,22-25,27H2,1-9H3,(H,51,58) RLMAYLGKWUXOAM-UHFFFAOYSA-N 750985 US20250195521, Example A444 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750985&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348256 519649579 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541841 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H]3OCCN(C)[C@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-10-56-37-16-15-30-21-32(37)33(43(56)31-13-11-17-49-41(31)29(4)62-9)23-48(5,6)27-64-46(60)34-14-12-18-57(52-34)45(59)35(22-40-50-36(30)26-65-40)51-44(58)42(28(2)3)54(8)47(61)55-24-38-39(25-55)63-20-19-53(38)7/h11,13,15-17,21,26,28-29,34-35,38-39,42,52H,10,12,14,18-20,22-25,27H2,1-9H3,(H,51,58) RLMAYLGKWUXOAM-UHFFFAOYSA-N 750986 US20250195521, Example A445 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750986&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158888840 519649580 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541842 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H]3CN(C)C[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O6S/c1-10-54-37-16-15-29-19-32(37)33(42(54)31-13-11-17-48-40(31)28(4)61-9)21-47(5,6)26-62-45(59)34-14-12-18-56(51-34)44(58)35(20-39-49-36(29)25-63-39)50-43(57)41(27(2)3)53(8)46(60)55-23-30-22-52(7)24-38(30)55/h11,13,15-17,19,25,27-28,30,34-35,38,41,51H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) DMPDXWISLHBVMA-UHFFFAOYSA-N 750987 US20250195521, Example A446 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750987&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346655 519649581 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541843 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1[C@@H]3CN(C)C[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O6S/c1-10-54-37-16-15-28-19-30(37)31(42(54)29-13-11-17-48-40(29)27(4)60-9)21-47(5,6)25-61-46(59)34-14-12-18-55(51-34)44(57)35(20-38-49-36(28)24-62-38)50-43(56)41(26(2)3)53(8)45(58)39-32-22-52(7)23-33(32)39/h11,13,15-17,19,24,26-27,32-35,39,41,51H,10,12,14,18,20-23,25H2,1-9H3,(H,50,56) KIWRFGCFLYNSOM-UHFFFAOYSA-N 750988 US20250195521, Example A447 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750988&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347227 519649582 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541844 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1[C@@H]3CNC[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O6S/c1-9-53-36-15-14-27-18-29(36)30(41(53)28-12-10-16-48-39(28)26(4)59-8)20-46(5,6)24-60-45(58)33-13-11-17-54(51-33)43(56)34(19-37-49-35(27)23-61-37)50-42(55)40(25(2)3)52(7)44(57)38-31-21-47-22-32(31)38/h10,12,14-16,18,23,25-26,31-34,38,40,47,51H,9,11,13,17,19-22,24H2,1-8H3,(H,50,55) ACBWNKRDRBPLNP-UHFFFAOYSA-N 750989 US20250195521, Example A448 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750989&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348218 519649583 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541845 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCNC1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H68N10O7S/c1-10-59-40-14-13-31-22-34(40)36(44(59)35-23-32(26-52-42(35)30(4)66-9)58-20-18-56(7)19-21-58)25-50(5,6)28-67-49(65)37-12-11-17-60(55-37)48(64)38(24-41-53-39(31)27-68-41)54-46(62)43(29(2)3)57(8)47(63)33-15-16-51-45(33)61/h13-14,22-23,26-27,29-30,33,37-38,43,55H,10-12,15-21,24-25,28H2,1-9H3,(H,51,61)(H,54,62) PEYIVXJJFREONA-UHFFFAOYSA-N 750990 US20250195521, Example A449 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750990 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750990&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347841 519649584 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541846 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C3CCOCC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H69N7O8/c1-8-58-45-12-11-34-26-40(45)41(47(58)42-28-53-17-13-36(42)30-65-7)27-52(4,5)31-67-51(64)43-10-9-18-59(55-43)50(63)44(24-33-22-37(34)25-39(60)23-33)54-48(61)46(32(2)3)56(6)49(62)35-14-19-57(29-35)38-15-20-66-21-16-38/h11-13,17,22-23,25-26,28,32,35,38,43-44,46,55,60H,8-10,14-16,18-21,24,27,29-31H2,1-7H3,(H,54,61) FQTMIKQWOLXQKT-UHFFFAOYSA-N 750991 US20250195521, Example A45 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750991&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159076144 519649585 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541847 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccncc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C55H72N10O7S/c1-10-64-45-14-13-36-26-39(45)41(49(64)40-27-37(30-57-47(40)34(4)70-9)63-23-21-61(7)22-24-63)29-55(5,6)32-72-54(69)42-12-11-20-65(60-42)52(67)43(28-46-58-44(36)31-73-46)59-51(66)48(33(2)3)62(8)53(68)50-38(17-25-71-50)35-15-18-56-19-16-35/h13-16,18-19,26-27,30-31,33-34,38,42-43,48,50,60H,10-12,17,20-25,28-29,32H2,1-9H3,(H,59,66) YZUKEUQGYUPITE-UHFFFAOYSA-N 750992 US20250195521, Example A450 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750992&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413618 519649586 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541848 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H]3OCCN(C)[C@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-10-56-37-16-15-30-21-32(37)33(43(56)31-13-11-17-49-41(31)29(4)62-9)23-48(5,6)27-64-46(60)34-14-12-18-57(52-34)45(59)35(22-40-50-36(30)26-65-40)51-44(58)42(28(2)3)54(8)47(61)55-24-38-39(25-55)63-20-19-53(38)7/h11,13,15-17,21,26,28-29,34-35,38-39,42,52H,10,12,14,18-20,22-25,27H2,1-9H3,(H,51,58) RLMAYLGKWUXOAM-UHFFFAOYSA-N 750993 US20250195521, Example A451 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750993&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347900 519649587 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541849 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C#N)(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N10O6S/c1-11-56-37-17-16-30-20-32(37)33(41(56)31-14-12-18-49-39(31)29(4)62-10)22-46(5,6)27-63-44(60)34-15-13-19-57(52-34)43(59)35(21-38-50-36(30)23-64-38)51-42(58)40(28(2)3)54(9)45(61)55-25-47(24-48,26-55)53(7)8/h12,14,16-18,20,23,28-29,34-35,40,52H,11,13,15,19,21-22,25-27H2,1-10H3,(H,51,58) OQVBKMIPEOXNLY-UHFFFAOYSA-N 750994 US20250195521, Example A452 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750994&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347239 519649588 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541850 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CCCN(C)C3=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N9O7S/c1-10-57-38-17-16-31-22-33(38)34(42(57)32-14-11-19-50-40(32)30(4)64-9)24-48(5,6)28-65-45(61)35-15-12-21-58(53-35)44(60)36(23-39-51-37(31)25-66-39)52-43(59)41(29(2)3)55(8)47(63)56-26-49(27-56)18-13-20-54(7)46(49)62/h11,14,16-17,19,22,25,29-30,35-36,41,53H,10,12-13,15,18,20-21,23-24,26-28H2,1-9H3,(H,52,59) KCKYEZDBTMOWSG-UHFFFAOYSA-N 750995 US20250195521, Example A453 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750995&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348251 519649589 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541851 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)N(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H61N9O6S/c1-12-52-35-18-17-28-21-30(35)31(39(52)29-15-13-19-45-37(29)27(4)58-11)23-44(5,6)25-59-42(56)32-16-14-20-53(48-32)41(55)33(22-36-46-34(28)24-60-36)47-40(54)38(26(2)3)50(9)43(57)51(10)49(7)8/h13,15,17-19,21,24,26-27,32-33,38,48H,12,14,16,20,22-23,25H2,1-11H3,(H,47,54) YDGZHLBHLZHRLR-UHFFFAOYSA-N 750996 US20250195521, Example A454 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750996&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347608 519649590 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541852 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C1(COC)COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O8S/c1-11-54-37-17-16-30-20-32(37)33(41(54)31-14-12-18-48-39(31)29(4)61-10)22-46(5,6)24-63-44(58)34-15-13-19-55(51-34)43(57)35(21-38-49-36(30)23-64-38)50-42(56)40(28(2)3)52(7)45(59)53(8)47(25-60-9)26-62-27-47/h12,14,16-18,20,23,28-29,34-35,40,51H,11,13,15,19,21-22,24-27H2,1-10H3,(H,50,56) HGLVKOGITTXEAW-UHFFFAOYSA-N 750997 US20250195521, Example A455 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750997&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347850 519649591 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541853 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N)(C#N)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N10O6S/c1-9-54-35-15-14-28-18-30(35)31(39(54)29-12-10-16-48-37(29)27(4)60-8)20-44(5,6)25-61-42(58)32-13-11-17-55(51-32)41(57)33(19-36-49-34(28)21-62-36)50-40(56)38(26(2)3)52(7)43(59)53-23-45(47,22-46)24-53/h10,12,14-16,18,21,26-27,32-33,38,51H,9,11,13,17,19-20,23-25,47H2,1-8H3,(H,50,56) PDFKMNNMTHRUFA-UHFFFAOYSA-N 750998 US20250195521, Example A456 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750998&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348255 519649592 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541854 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(N4CC(F)C4)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H66FN9O6S/c1-9-59-40-15-14-31-18-35(40)36(44(59)34-12-10-16-52-42(34)30(4)65-8)22-49(5,6)28-66-47(63)37-13-11-17-60(55-37)46(62)38(19-41-53-39(31)25-67-41)54-45(61)43(29(2)3)56(7)48(64)58-26-50(27-58)20-33(21-50)57-23-32(51)24-57/h10,12,14-16,18,25,29-30,32-33,37-38,43,55H,9,11,13,17,19-24,26-28H2,1-8H3,(H,54,61) QRUWPCJYODJQHQ-UHFFFAOYSA-N 750999 US20250195521, Example A457 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=750999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=750999&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161175273 519649593 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541855 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@@H](C)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-56-39-18-17-31-21-34(39)35(43(56)33-15-13-19-49-41(33)30(5)62-11)23-48(6,7)27-63-46(60)36-16-14-20-57(52-36)45(59)37(22-40-50-38(31)26-64-40)51-44(58)42(28(2)3)54(10)47(61)55-24-32(25-55)29(4)53(8)9/h13,15,17-19,21,26,28-30,32,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) YCJFBCDPKCPPEX-UHFFFAOYSA-N 751000 US20250195521, Example A458 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751000&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346638 519649594 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541856 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)CCN(C)C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H70N10O7S/c1-11-59-40-17-16-33-26-35(40)36(45(59)34-14-12-19-51-43(34)32(4)66-10)28-50(5,6)30-67-48(64)37-15-13-20-60(54-37)47(63)38(27-41-52-39(33)29-68-41)53-46(62)44(31(2)3)56(9)49(65)58-24-22-57(23-25-58)42(61)18-21-55(7)8/h12,14,16-17,19,26,29,31-32,37-38,44,54H,11,13,15,18,20-25,27-28,30H2,1-10H3,(H,53,62) ICFBAKIBGXOTCL-UHFFFAOYSA-N 751001 US20250195521, Example A459 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751001&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347626 519649595 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541857 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H64N8O7/c1-9-55-41-13-12-32-25-36(41)37(43(55)38-27-49-15-14-33(38)28-62-8)26-48(4,5)29-63-46(60)39-11-10-16-56(51-39)45(59)40(23-31-21-34(32)24-35(57)22-31)50-44(58)42(30(2)3)53(7)47(61)54-19-17-52(6)18-20-54/h12-15,21-22,24-25,27,30,39-40,42,51,57H,9-11,16-20,23,26,28-29H2,1-8H3,(H,50,58) KUIKZPLZGMWGKM-UHFFFAOYSA-N 751002 US20250195521, Example A46 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751002&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346482 519649596 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541858 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C3CCC1CN(C)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-39-18-15-30-21-34(39)35(43(55)33-13-11-19-49-41(33)29(4)62-9)23-48(5,6)27-63-46(60)36-14-12-20-56(52-36)45(59)37(22-40-50-38(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)57-31-16-17-32(57)25-53(7)24-31/h11,13,15,18-19,21,26,28-29,31-32,36-37,42,52H,10,12,14,16-17,20,22-25,27H2,1-9H3,(H,51,58) XBRJHYKVCAQNAQ-UHFFFAOYSA-N 751003 US20250195521, Example A460 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751003&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347905 519649597 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541859 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@]3(CCN(C)C3=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N9O7S/c1-10-57-38-16-15-31-23-33(38)34(42(57)32-13-11-19-50-40(32)30(4)64-9)25-48(5,6)28-65-45(61)35-14-12-20-58(53-35)44(60)36(24-39-51-37(31)26-66-39)52-43(59)41(29(2)3)55(8)47(63)56-22-18-49(27-56)17-21-54(7)46(49)62/h11,13,15-16,19,23,26,29-30,35-36,41,53H,10,12,14,17-18,20-22,24-25,27-28H2,1-9H3,(H,52,59) BNNUCPCNCWUTPP-UHFFFAOYSA-N 751004 US20250195521, Example A461 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751004&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347897 519649598 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541860 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H]3CN(C)CC[C@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-39-16-15-30-21-33(39)34(43(55)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-25-31-24-53(7)20-17-38(31)56/h11,13,15-16,18,21,26,28-29,31,35-36,38,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) JUYVIVLZKJVEGU-UHFFFAOYSA-N 751005 US20250195521, Example A462 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751005&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347904 519649599 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541861 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@H]1CN)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H61N9O6S/c1-9-52-36-15-14-28-20-31(36)32(40(52)30-12-10-17-47-38(30)27(4)59-8)22-45(5,6)25-60-43(57)33-13-11-18-54(50-33)42(56)34(21-37-48-35(28)24-61-37)49-41(55)39(26(2)3)51(7)44(58)53-19-16-29(53)23-46/h10,12,14-15,17,20,24,26-27,29,33-34,39,50H,9,11,13,16,18-19,21-23,25,46H2,1-8H3,(H,49,55) WPCQYDFUZGPPCX-UHFFFAOYSA-N 751006 US20250195521, Example A463 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751006&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347240 519649600 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541862 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(=O)[C@@H]1CCN(C)[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H68N8O6S/c1-8-61-44-23-22-36-28-39(44)40(49(61)37-20-14-25-55-46(37)33(2)67-7)30-54(3,4)32-68-53(66)41-21-15-26-62(58-41)52(65)42(29-45-56-43(36)31-69-45)57-50(63)48(35-18-12-13-19-35)60(6)51(64)38-24-27-59(5)47(38)34-16-10-9-11-17-34/h9-11,14,16-17,20,22-23,25,28,31,33,35,38,41-42,47-48,58H,8,12-13,15,18-19,21,24,26-27,29-30,32H2,1-7H3,(H,57,63) TUIWQDYFLNYYLS-UHFFFAOYSA-N 751007 US20250195521, Example A464 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751007&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787095 519649601 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541863 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C3COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H72N10O7S/c1-10-61-43-14-13-33-20-37(43)39(47(61)38-21-36(24-53-45(38)32(4)67-9)59-18-16-57(7)17-19-59)23-52(5,6)30-69-50(65)40-12-11-15-62(56-40)49(64)41(22-44-54-42(33)29-70-44)55-48(63)46(31(2)3)58(8)51(66)60-25-34(26-60)35-27-68-28-35/h13-14,20-21,24,29,31-32,34-35,40-41,46,56H,10-12,15-19,22-23,25-28,30H2,1-9H3,(H,55,63) SUKLRLSJYCWSCH-UHFFFAOYSA-N 751008 US20250195521, Example A465 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751008&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348220 519649602 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541864 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H70N10O7S/c1-11-59-41-15-14-32-21-35(41)37(45(59)36-22-33(25-51-43(36)31(4)65-9)57-19-17-55(7)18-20-57)24-50(5,6)29-67-48(63)38-13-12-16-60(54-38)47(62)39(23-42-52-40(32)28-68-42)53-46(61)44(30(2)3)56(8)49(64)58-26-34(27-58)66-10/h14-15,21-22,25,28,30-31,34,38-39,44,54H,11-13,16-20,23-24,26-27,29H2,1-10H3,(H,53,61) VYIOPUZYLRJULM-UHFFFAOYSA-N 751009 US20250195521, Example A466 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751009&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348076 519649603 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541865 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(N(C)CCO)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H69N9O7S/c1-10-58-40-16-15-32-21-35(40)36(44(58)34-13-11-17-51-42(34)31(4)65-9)25-49(5,6)29-66-47(63)37-14-12-18-59(54-37)46(62)38(22-41-52-39(32)26-67-41)53-45(61)43(30(2)3)56(8)48(64)57-27-50(28-57)23-33(24-50)55(7)19-20-60/h11,13,15-17,21,26,30-31,33,37-38,43,54,60H,10,12,14,18-20,22-25,27-29H2,1-9H3,(H,53,61) JFJSUEOBEZXKEH-UHFFFAOYSA-N 751010 US20250195521, Example A467 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751010&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158322685 519649604 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541866 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@]13CCCN(C)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O6S/c1-10-56-39-17-16-32-24-34(39)35(43(56)33-14-11-20-50-41(33)31(4)63-9)26-48(5,6)29-64-46(61)36-15-12-22-58(53-36)45(60)37(25-40-51-38(32)27-65-40)52-44(59)42(30(2)3)55(8)47(62)57-23-19-49(57)18-13-21-54(7)28-49/h11,14,16-17,20,24,27,30-31,36-37,42,53H,10,12-13,15,18-19,21-23,25-26,28-29H2,1-9H3,(H,52,59) KATZUAIOYCSBBZ-UHFFFAOYSA-N 751011 US20250195521, Example A468 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751011&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 166144782 519649605 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541867 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C[C@H]1CCN1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-30-22-33(38)34(42(55)32-14-12-19-48-40(32)29(4)61-10)24-47(5,6)27-62-45(59)35-15-13-20-56(51-35)44(58)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)54(9)46(60)53(8)25-31-18-21-52(31)7/h12,14,16-17,19,22,26,28-29,31,35-36,41,51H,11,13,15,18,20-21,23-25,27H2,1-10H3,(H,50,57) YTJGFODXHBUPLB-UHFFFAOYSA-N 751012 US20250195521, Example A469 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751012&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413620 519649606 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541868 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C[C@H](C)O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H67N7O8/c1-9-56-43-13-12-33-23-38(43)39(45(56)40-25-51-16-14-35(40)28-64-8)24-50(5,6)29-65-49(63)41-11-10-17-57(53-41)48(62)42(21-32-19-36(33)22-37(59)20-32)52-46(60)44(30(2)3)54(7)47(61)34-15-18-55(27-34)26-31(4)58/h12-14,16,19-20,22-23,25,30-31,34,41-42,44,53,58-59H,9-11,15,17-18,21,24,26-29H2,1-8H3,(H,52,60) BXFCXWNPVDYJQR-UHFFFAOYSA-N 751013 US20250195521, Example A47 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751013&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160202927 519649607 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541869 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H]3CN(C)C[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-38-16-15-30-21-33(38)34(43(55)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-20-17-31-24-53(7)25-39(31)56/h11,13,15-16,18,21,26,28-29,31,35-36,39,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) UILSLEHRNMDYFZ-UHFFFAOYSA-N 751014 US20250195521, Example A470 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751014&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413645 519649608 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541870 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@H]3CN(C)C[C@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-38-16-15-30-21-33(38)34(43(55)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-20-17-31-24-53(7)25-39(31)56/h11,13,15-16,18,21,26,28-29,31,35-36,39,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) UILSLEHRNMDYFZ-UHFFFAOYSA-N 751015 US20250195521, Example A471 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751015&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160513305 519649609 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541871 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H]3[C@@H](C1)OCCN3C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-10-56-37-16-15-30-21-32(37)33(43(56)31-13-11-17-49-41(31)29(4)62-9)23-48(5,6)27-64-46(60)34-14-12-18-57(52-34)45(59)35(22-40-50-36(30)26-65-40)51-44(58)42(28(2)3)54(8)47(61)55-24-38-39(25-55)63-20-19-53(38)7/h11,13,15-17,21,26,28-29,34-35,38-39,42,52H,10,12,14,18-20,22-25,27H2,1-9H3,(H,51,58) RLMAYLGKWUXOAM-UHFFFAOYSA-N 751016 US20250195521, Example A472 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751016&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413602 519649610 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541872 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C[C@H]1CCCN1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-56-39-19-18-31-23-34(39)35(43(56)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)55(9)47(61)54(8)26-32-15-13-21-53(32)7/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) CPVGIDDVJQJFDI-UHFFFAOYSA-N 751017 US20250195521, Example A473 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751017&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 166145184 519649611 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541873 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOCC13COC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O8S/c1-9-53-37-15-14-30-20-32(37)33(41(53)31-12-10-16-48-39(31)29(4)60-8)22-46(5,6)24-63-44(58)34-13-11-17-55(51-34)43(57)35(21-38-49-36(30)23-64-38)50-42(56)40(28(2)3)52(7)45(59)54-18-19-61-25-47(54)26-62-27-47/h10,12,14-16,20,23,28-29,34-35,40,51H,9,11,13,17-19,21-22,24-27H2,1-8H3,(H,50,56) WJJKIEBBLWRGTL-UHFFFAOYSA-N 751018 US20250195521, Example A474 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751018&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158859896 519649612 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541874 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOC3(COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O8S/c1-9-54-37-15-14-30-20-32(37)33(41(54)31-12-10-16-48-39(31)29(4)60-8)22-46(5,6)25-62-44(58)34-13-11-17-55(51-34)43(57)35(21-38-49-36(30)23-64-38)50-42(56)40(28(2)3)52(7)45(59)53-18-19-63-47(24-53)26-61-27-47/h10,12,14-16,20,23,28-29,34-35,40,51H,9,11,13,17-19,21-22,24-27H2,1-8H3,(H,50,56) YNSVROZJDIDQKQ-UHFFFAOYSA-N 751019 US20250195521, Example A475 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751019&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161581320 519649613 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541875 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H](C)N(C)C[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H77N11O6S/c1-13-62-44-17-16-36-23-38(44)40(48(62)39-24-37(27-54-46(39)35(6)69-12)61-21-19-58(9)20-22-61)26-53(7,8)31-70-51(67)41-15-14-18-64(57-41)50(66)42(25-45-55-43(36)30-71-45)56-49(65)47(32(2)3)60(11)52(68)63-29-33(4)59(10)28-34(63)5/h16-17,23-24,27,30,32-35,41-42,47,57H,13-15,18-22,25-26,28-29,31H2,1-12H3,(H,56,65) IYSZFOZDNLDTOE-UHFFFAOYSA-N 751020 US20250195521, Example A476 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751020&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413643 519649614 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541876 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H73N11O6S/c1-12-61-42-16-15-33-22-36(42)38(46(61)37-23-34(26-52-44(37)32(4)67-11)59-20-18-57(9)19-21-59)25-51(5,6)30-68-49(65)39-14-13-17-62(55-39)48(64)40(24-43-53-41(33)29-69-43)54-47(63)45(31(2)3)58(10)50(66)60-27-35(28-60)56(7)8/h15-16,22-23,26,29,31-32,35,39-40,45,55H,12-14,17-21,24-25,27-28,30H2,1-11H3,(H,54,63) BYFZNHDRYCUNBS-UHFFFAOYSA-N 751021 US20250195521, Example A477 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751021&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159290753 519649615 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541877 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@H](C)CO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-10-54-38-16-15-30-19-33(38)34(42(54)32-13-11-17-48-40(32)29(5)61-9)21-47(6,7)26-62-45(59)35-14-12-18-55(51-35)44(58)36(20-39-49-37(30)25-63-39)50-43(57)41(27(2)3)52(8)46(60)53-22-31(23-53)28(4)24-56/h11,13,15-17,19,25,27-29,31,35-36,41,51,56H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) SLXJONXRSSTRSM-UHFFFAOYSA-N 751022 US20250195521, Example A478 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751022&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160294555 519649616 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541878 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@]3(CCNC3=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N9O7S/c1-9-56-37-15-14-30-22-32(37)33(41(56)31-12-10-18-49-39(31)29(4)63-8)24-47(5,6)27-64-44(60)34-13-11-20-57(53-34)43(59)35(23-38-51-36(30)25-65-38)52-42(58)40(28(2)3)54(7)46(62)55-21-17-48(26-55)16-19-50-45(48)61/h10,12,14-15,18,22,25,28-29,34-35,40,53H,9,11,13,16-17,19-21,23-24,26-27H2,1-8H3,(H,50,61)(H,52,58) OUHVABCXVDTMPM-UHFFFAOYSA-N 751023 US20250195521, Example A479 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751023&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413606 519649617 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541879 CCn1c(-c2cccnc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](N)CCCNC(=N)N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H66N10O7/c1-8-57-40-16-15-30-24-34(40)35(42(57)33-12-9-17-52-39(33)26-64-7)25-48(4,5)27-65-46(63)37-14-11-19-58(55-37)45(62)38(22-29-20-31(30)23-32(59)21-29)54-43(60)41(28(2)3)56(6)44(61)36(49)13-10-18-53-47(50)51/h9,12,15-17,20-21,23-24,28,36-38,41,55,59H,8,10-11,13-14,18-19,22,25-27,49H2,1-7H3,(H,54,60)(H4,50,51,53) BYJZGUIPZBXWMI-UHFFFAOYSA-N 751024 US20250195521, Example A48 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751024&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 177372998 519649618 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541880 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@]3(CCNC3=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N9O7S/c1-9-56-37-15-14-30-22-32(37)33(41(56)31-12-10-18-49-39(31)29(4)63-8)24-47(5,6)27-64-44(60)34-13-11-20-57(53-34)43(59)35(23-38-51-36(30)25-65-38)52-42(58)40(28(2)3)54(7)46(62)55-21-17-48(26-55)16-19-50-45(48)61/h10,12,14-15,18,22,25,28-29,34-35,40,53H,9,11,13,16-17,19-21,23-24,26-27H2,1-8H3,(H,50,61)(H,52,58) OUHVABCXVDTMPM-UHFFFAOYSA-N 751025 US20250195521, Example A480 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751025&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157526310 519649619 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541881 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H]3CN(C)CC[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-39-16-15-30-21-33(39)34(43(55)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-25-31-24-53(7)20-17-38(31)56/h11,13,15-16,18,21,26,28-29,31,35-36,38,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) JUYVIVLZKJVEGU-UHFFFAOYSA-N 751026 US20250195521, Example A481 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751026&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160527225 519649620 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541882 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(C1)CS(=O)(=O)CCN3C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O8S2/c1-10-56-38-16-15-31-21-33(38)34(42(56)32-13-11-17-49-40(32)30(4)64-9)23-47(5,6)27-65-45(60)35-14-12-18-57(52-35)44(59)36(22-39-50-37(31)24-66-39)51-43(58)41(29(2)3)54(8)46(61)55-25-48(26-55)28-67(62,63)20-19-53(48)7/h11,13,15-17,21,24,29-30,35-36,41,52H,10,12,14,18-20,22-23,25-28H2,1-9H3,(H,51,58) HBFPEFAFCNPCGQ-UHFFFAOYSA-N 751027 US20250195521, Example A482 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751027 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751027&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159022131 519649621 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541883 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC13CCN(C)CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H77N11O6S/c1-11-63-44-15-14-36-27-38(44)40(48(63)39-28-37(31-55-46(39)35(4)70-10)62-25-23-60(8)24-26-62)30-53(5,6)33-71-51(68)41-13-12-19-65(58-41)50(67)42(29-45-56-43(36)32-72-45)57-49(66)47(34(2)3)61(9)52(69)64-22-18-54(64)16-20-59(7)21-17-54/h14-15,27-28,31-32,34-35,41-42,47,58H,11-13,16-26,29-30,33H2,1-10H3,(H,57,66) HBQCJHCCIPVNSV-UHFFFAOYSA-N 751028 US20250195521, Example A483 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751028 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751028&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161732448 519649622 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541884 CCn1c(-c2cc(C3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H69N9O6S/c1-12-57-40-16-15-32-22-34(40)36(44(57)35-23-33(26-50-42(35)30(4)63-11)31-17-20-55(9)21-18-31)25-49(5,6)28-64-47(61)37-14-13-19-58(53-37)46(60)38(24-41-51-39(32)27-65-41)52-45(59)43(29(2)3)56(10)48(62)54(7)8/h15-16,22-23,26-27,29-31,37-38,43,53H,12-14,17-21,24-25,28H2,1-11H3,(H,52,59) JYJMYGSZCDMBER-UHFFFAOYSA-N 751029 US20250195521, Example A484 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751029 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751029&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159657662 519649623 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541885 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(N(C)C(C)C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H71N9O6S/c1-12-59-41-18-17-33-21-36(41)37(45(59)35-15-13-19-52-43(35)32(6)65-11)25-50(7,8)29-66-48(63)38-16-14-20-60(55-38)47(62)39(22-42-53-40(33)26-67-42)54-46(61)44(30(2)3)57(10)49(64)58-27-51(28-58)23-34(24-51)56(9)31(4)5/h13,15,17-19,21,26,30-32,34,38-39,44,55H,12,14,16,20,22-25,27-29H2,1-11H3,(H,54,61) XXWVCVAXBKVBQE-UHFFFAOYSA-N 751030 US20250195521, Example A485 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751030 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751030&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158069697 519649624 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541886 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(N4CCOCC4)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H69N9O7S/c1-9-59-41-15-14-33-22-36(41)37(45(59)35-12-10-16-52-43(35)32(4)65-8)26-50(5,6)30-67-48(63)38-13-11-17-60(55-38)47(62)39(23-42-53-40(33)27-68-42)54-46(61)44(31(2)3)56(7)49(64)58-28-51(29-58)24-34(25-51)57-18-20-66-21-19-57/h10,12,14-16,22,27,31-32,34,38-39,44,55H,9,11,13,17-21,23-26,28-30H2,1-8H3,(H,54,61) CCERXMBCDUAZTF-UHFFFAOYSA-N 751031 US20250195521, Example A486 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751031 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751031&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161507485 519649625 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541887 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@@H](C)CO)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O7S/c1-10-54-38-16-15-30-19-33(38)34(42(54)32-13-11-17-48-40(32)29(5)61-9)21-47(6,7)26-62-45(59)35-14-12-18-55(51-35)44(58)36(20-39-49-37(30)25-63-39)50-43(57)41(27(2)3)52(8)46(60)53-22-31(23-53)28(4)24-56/h11,13,15-17,19,25,27-29,31,35-36,41,51,56H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) SLXJONXRSSTRSM-UHFFFAOYSA-N 751032 US20250195521, Example A487 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751032 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751032&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413625 519649626 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541888 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@@H](C)NC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-30-20-33(38)34(42(55)32-14-12-18-49-40(32)29(5)61-10)22-47(6,7)26-62-45(59)35-15-13-19-56(52-35)44(58)36(21-39-50-37(30)25-63-39)51-43(57)41(27(2)3)53(9)46(60)54-23-31(24-54)28(4)48-8/h12,14,16-18,20,25,27-29,31,35-36,41,48,52H,11,13,15,19,21-24,26H2,1-10H3,(H,51,57) ZDNGQTNJWNHSET-UHFFFAOYSA-N 751033 US20250195521, Example A488 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751033 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751033&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 166143987 519649627 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541889 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)[C@@H](O)[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H63N9O7S/c1-11-54-35-17-16-28-20-31(35)32(39(54)30-14-12-18-47-36(30)27(4)61-10)21-46(5,6)25-62-44(59)33-15-13-19-55(50-33)43(58)37(40(56)42-48-34(28)24-63-42)49-41(57)38(26(2)3)52(9)45(60)53-22-29(23-53)51(7)8/h12,14,16-18,20,24,26-27,29,33,37-38,40,50,56H,11,13,15,19,21-23,25H2,1-10H3,(H,49,57) QHAWXXZDIIFJGB-UHFFFAOYSA-N 751034 US20250195521, Example A489 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751034 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751034&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158563753 519649628 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541890 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(C)COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-39-13-12-30-21-34(39)35(41(52)36-23-48-15-14-31(36)24-59-8)22-46(4,5)25-61-44(57)37-11-10-16-53(50-37)43(56)38(19-29-17-32(30)20-33(54)18-29)49-42(55)40(28(2)3)51(7)45(58)47(6)26-60-27-47/h12-15,17-18,20-21,23,28,37-38,40,50,54H,9-11,16,19,22,24-27H2,1-8H3,(H,49,55) BOOLRMDEHLQXFN-UHFFFAOYSA-N 751035 US20250195521, Example A49 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751035 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751035&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158118482 519649629 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541891 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1cccnc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C55H72N10O7S/c1-10-64-45-16-15-35-25-39(45)41(49(64)40-26-37(30-57-47(40)34(4)70-9)63-22-20-61(7)21-23-63)28-55(5,6)32-72-54(69)42-14-12-19-65(60-42)52(67)43(27-46-58-44(35)31-73-46)59-51(66)48(33(2)3)62(8)53(68)50-38(17-24-71-50)36-13-11-18-56-29-36/h11,13,15-16,18,25-26,29-31,33-34,38,42-43,48,50,60H,10,12,14,17,19-24,27-28,32H2,1-9H3,(H,59,66) MHZBQIQXVRAQCH-UHFFFAOYSA-N 751036 US20250195521, Example A490 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751036 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751036&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413635 519649630 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541892 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC[C@H](N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H69N9O6S/c1-11-57-40-20-19-32-24-35(40)36(44(57)34-17-14-21-50-42(34)31(4)63-10)26-49(5,6)29-64-47(61)37-18-15-23-58(53-37)46(60)38(25-41-51-39(32)28-65-41)52-45(59)43(30(2)3)55(9)48(62)56-22-13-12-16-33(27-56)54(7)8/h14,17,19-21,24,28,30-31,33,37-38,43,53H,11-13,15-16,18,22-23,25-27,29H2,1-10H3,(H,52,59) MFAXYUISAVLNEJ-UHFFFAOYSA-N 751037 US20250195521, Example A491 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751037 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751037&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160893980 519649631 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541893 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC[C@@H](N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H69N9O6S/c1-11-57-40-20-19-32-24-35(40)36(44(57)34-17-14-21-50-42(34)31(4)63-10)26-49(5,6)29-64-47(61)37-18-15-23-58(53-37)46(60)38(25-41-51-39(32)28-65-41)52-45(59)43(30(2)3)55(9)48(62)56-22-13-12-16-33(27-56)54(7)8/h14,17,19-21,24,28,30-31,33,37-38,43,53H,11-13,15-16,18,22-23,25-27,29H2,1-10H3,(H,52,59) MFAXYUISAVLNEJ-UHFFFAOYSA-N 751038 US20250195521, Example A492 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751038 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751038&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160893978 519649632 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541894 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@H](N(C)C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H69N9O6S/c1-11-57-40-19-18-32-25-35(40)36(44(57)34-16-12-21-50-42(34)31(4)63-10)27-49(5,6)29-64-47(61)37-17-14-23-58(53-37)46(60)38(26-41-51-39(32)28-65-41)52-45(59)43(30(2)3)55(9)48(62)56-22-13-15-33(20-24-56)54(7)8/h12,16,18-19,21,25,28,30-31,33,37-38,43,53H,11,13-15,17,20,22-24,26-27,29H2,1-10H3,(H,52,59) FDZCYRGRHIOPJJ-UHFFFAOYSA-N 751039 US20250195521, Example A493 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751039 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751039&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158838850 519649633 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541895 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@@H](N(C)C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H69N9O6S/c1-11-57-40-19-18-32-25-35(40)36(44(57)34-16-12-21-50-42(34)31(4)63-10)27-49(5,6)29-64-47(61)37-17-14-23-58(53-37)46(60)38(26-41-51-39(32)28-65-41)52-45(59)43(30(2)3)55(9)48(62)56-22-13-15-33(20-24-56)54(7)8/h12,16,18-19,21,25,28,30-31,33,37-38,43,53H,11,13-15,17,20,22-24,26-27,29H2,1-10H3,(H,52,59) FDZCYRGRHIOPJJ-UHFFFAOYSA-N 751040 US20250195521, Example A494 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751040 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751040&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162763501 519649634 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541896 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@]3(CCN(C)C3=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N9O7S/c1-10-57-38-16-15-31-23-33(38)34(42(57)32-13-11-19-50-40(32)30(4)64-9)25-48(5,6)28-65-45(61)35-14-12-20-58(53-35)44(60)36(24-39-51-37(31)26-66-39)52-43(59)41(29(2)3)55(8)47(63)56-22-18-49(27-56)17-21-54(7)46(49)62/h11,13,15-16,19,23,26,29-30,35-36,41,53H,10,12,14,17-18,20-22,24-25,27-28H2,1-9H3,(H,52,59) BNNUCPCNCWUTPP-UHFFFAOYSA-N 751041 US20250195521, Example A495 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751041 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751041&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161295161 519649635 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541897 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C3CC1CS(=O)(=O)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O8S2/c1-9-52-37-15-14-28-18-32(37)33(41(52)31-12-10-16-47-39(31)27(4)61-8)21-46(5,6)25-62-44(57)34-13-11-17-53(50-34)43(56)35(20-38-48-36(28)22-63-38)49-42(55)40(26(2)3)51(7)45(58)54-29-19-30(54)24-64(59,60)23-29/h10,12,14-16,18,22,26-27,29-30,34-35,40,50H,9,11,13,17,19-21,23-25H2,1-8H3,(H,49,55) TWQONSDYGXSBGH-UHFFFAOYSA-N 751042 US20250195521, Example A496 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751042 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751042&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157212197 519649636 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541898 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H]3CN(C)C[C@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O6S/c1-10-54-37-16-15-29-19-32(37)33(42(54)31-13-11-17-48-40(31)28(4)61-9)21-47(5,6)26-62-45(59)34-14-12-18-56(51-34)44(58)35(20-39-49-36(29)25-63-39)50-43(57)41(27(2)3)53(8)46(60)55-23-30-22-52(7)24-38(30)55/h11,13,15-17,19,25,27-28,30,34-35,38,41,51H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) DMPDXWISLHBVMA-UHFFFAOYSA-N 751043 US20250195521, Example A497 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751043 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751043&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413591 519649637 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541899 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC13CCN(C)CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H69N9O6S/c1-10-57-40-17-16-33-26-35(40)36(44(57)34-14-11-21-51-42(34)32(4)64-9)28-49(5,6)30-65-47(62)37-15-12-23-59(54-37)46(61)38(27-41-52-39(33)29-66-41)53-45(60)43(31(2)3)56(8)48(63)58-22-13-18-50(58)19-24-55(7)25-20-50/h11,14,16-17,21,26,29,31-32,37-38,43,54H,10,12-13,15,18-20,22-25,27-28,30H2,1-9H3,(H,53,60) BBJVDKGPOUKHMY-UHFFFAOYSA-N 751044 US20250195521, Example A498 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751044 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751044&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158363724 519649638 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541900 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CN(C)CCO3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-10-56-38-16-15-31-21-33(38)34(42(56)32-13-11-17-49-40(32)30(4)62-9)23-47(5,6)28-63-45(60)35-14-12-18-57(52-35)44(59)36(22-39-50-37(31)24-65-39)51-43(58)41(29(2)3)54(8)46(61)55-26-48(27-55)25-53(7)19-20-64-48/h11,13,15-17,21,24,29-30,35-36,41,52H,10,12,14,18-20,22-23,25-28H2,1-9H3,(H,51,58) UMIFOPJKBGMPNH-UHFFFAOYSA-N 751045 US20250195521, Example A499 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751045 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751045&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158220091 519649639 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541901 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O8/c1-10-56-42-16-15-33-25-38(42)39(45(56)37-13-11-18-51-43(37)30(4)64-9)26-50(6,7)28-65-49(63)40-14-12-19-57(53-40)48(62)41(23-32-21-35(33)24-36(59)22-32)52-46(60)44(29(2)3)54(8)47(61)34-17-20-55(27-34)31(5)58/h11,13,15-16,18,21-22,24-25,29-30,34,40-41,44,53,59H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,52,60) VKAYBLOEOJIYCW-UHFFFAOYSA-N 751046 US20250195521, Example A5 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751046 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751046&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159205167 519649640 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541902 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OC1CCOC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O9/c1-8-52-40-12-11-30-22-35(40)36(42(52)37-24-48-15-13-31(37)25-59-7)23-47(4,5)27-61-45(57)38-10-9-16-53(50-38)44(56)39(20-29-18-32(30)21-33(54)19-29)49-43(55)41(28(2)3)51(6)46(58)62-34-14-17-60-26-34/h11-13,15,18-19,21-22,24,28,34,38-39,41,50,54H,8-10,14,16-17,20,23,25-27H2,1-7H3,(H,49,55) NUQSLYQMXSXCKQ-UHFFFAOYSA-N 751047 US20250195521, Example A50 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751047 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751047&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347440 519649641 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541903 CCn6c(c1cccnc1[C@H](C)OC)c7CC(C)(C)COC(=O)[C@@H]2CCCN(N2)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N4CC(Cc3cnn(C)c3)C4)Cc5nc(cs5)c8ccc6c7c8 InChI=1S/C49H64N10O6S/c1-10-58-40-16-15-33-20-35(40)36(44(58)34-13-11-17-50-42(34)30(4)64-9)22-49(5,6)28-65-47(62)37-14-12-18-59(54-37)46(61)38(21-41-52-39(33)27-66-41)53-45(60)43(29(2)3)56(8)48(63)57-25-32(26-57)19-31-23-51-55(7)24-31/h11,13,15-17,20,23-24,27,29-30,32,37-38,43,54H,10,12,14,18-19,21-22,25-26,28H2,1-9H3,(H,53,60) IODDBYJQNLRXFB-UHFFFAOYSA-N 751048 US20250195521, Example A500 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751048 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751048&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 177372999 519649642 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541904 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCN(C(=O)OC)[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C56H69N7O9/c1-10-61-46-21-20-37-30-42(46)43(50(61)40-18-14-23-57-47(40)34(4)70-8)31-56(5,6)32-72-54(68)44-19-15-24-63(59-44)53(67)45(28-35-26-38(37)29-39(64)27-35)58-51(65)48(33(2)3)60(7)52(66)41-22-25-62(55(69)71-9)49(41)36-16-12-11-13-17-36/h11-14,16-18,20-21,23,26-27,29-30,33-34,41,44-45,48-49,59,64H,10,15,19,22,24-25,28,31-32H2,1-9H3,(H,58,65) IQSGTJKBLGDEDM-UHFFFAOYSA-N 751049 US20250195521, Example A501 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751049 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751049&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413604 519649643 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541905 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H]1CN(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-54-38-17-16-30-22-33(38)34(42(54)32-14-12-19-48-40(32)29(4)61-10)24-47(5,6)27-62-45(59)35-15-13-20-56(51-35)44(58)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)53(9)46(60)55-21-18-31(55)25-52(7)8/h12,14,16-17,19,22,26,28-29,31,35-36,41,51H,11,13,15,18,20-21,23-25,27H2,1-10H3,(H,50,57) OACXYKVUQDRWNG-UHFFFAOYSA-N 751050 US20250195521, Example A502 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751050 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751050&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413587 519649644 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541906 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC3(CN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-56-38-16-15-31-21-33(38)34(42(56)32-13-11-18-49-40(32)30(4)62-9)23-47(5,6)28-63-45(60)35-14-12-19-57(52-35)44(59)36(22-39-50-37(31)24-64-39)51-43(58)41(29(2)3)54(8)46(61)55-20-17-48(27-55)25-53(7)26-48/h11,13,15-16,18,21,24,29-30,35-36,41,52H,10,12,14,17,19-20,22-23,25-28H2,1-9H3,(H,51,58) VUEFJOPDNPURFR-UHFFFAOYSA-N 751051 US20250195521, Example A503 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751051 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751051&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161053992 519649645 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541907 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C[C@@H]1CCCN1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-56-39-19-18-31-23-34(39)35(43(56)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)55(9)47(61)54(8)26-32-15-13-21-53(32)7/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) CPVGIDDVJQJFDI-UHFFFAOYSA-N 751052 US20250195521, Example A504 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751052 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751052&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158696465 519649646 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541908 CCn1c(-c2cc(C3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H71N9O7S/c1-10-59-42-14-13-34-24-36(42)38(46(59)37-25-35(28-52-44(37)32(4)65-9)33-15-18-56(7)19-16-33)27-51(5,6)30-67-49(63)39-12-11-17-60(55-39)48(62)40(26-43-53-41(34)29-68-43)54-47(61)45(31(2)3)57(8)50(64)58-20-22-66-23-21-58/h13-14,24-25,28-29,31-33,39-40,45,55H,10-12,15-23,26-27,30H2,1-9H3,(H,54,61) XMQGWKFNQWPHGN-UHFFFAOYSA-N 751053 US20250195521, Example A505 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751053 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751053&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160802352 519649647 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541909 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H](F)[C@H](NC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64FN9O6S/c1-10-56-38-16-15-29-21-31(38)32(42(56)30-13-11-18-50-40(30)28(4)62-9)23-47(5,6)26-63-45(60)34-14-12-19-57(53-34)44(59)35(22-39-51-37(29)25-64-39)52-43(58)41(27(2)3)54(8)46(61)55-20-17-33(48)36(24-55)49-7/h11,13,15-16,18,21,25,27-28,33-36,41,49,53H,10,12,14,17,19-20,22-24,26H2,1-9H3,(H,52,58) FUICXOGIPLBJBJ-UHFFFAOYSA-N 751054 cyclopropane-1-carboxamide::US20250195521, Example A506 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751054 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751054&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413637 519649648 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541910 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCN(C(=O)CN(C)C)[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C58H74N8O8/c1-11-64-48-22-21-39-31-44(48)45(53(64)42-19-15-24-59-50(42)36(4)73-10)32-58(5,6)34-74-57(72)46-20-16-25-66(61-46)56(71)47(29-37-27-40(39)30-41(67)28-37)60-54(69)51(35(2)3)63(9)55(70)43-23-26-65(49(68)33-62(7)8)52(43)38-17-13-12-14-18-38/h12-15,17-19,21-22,24,27-28,30-31,35-36,43,46-47,51-52,61,67H,11,16,20,23,25-26,29,32-34H2,1-10H3,(H,60,69) PTTWDFPBIHDVAB-UHFFFAOYSA-N 751055 US20250195521, Example A507 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751055 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751055&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413599 519649649 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541911 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@H]1CN(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-54-38-17-16-30-22-33(38)34(42(54)32-14-12-19-48-40(32)29(4)61-10)24-47(5,6)27-62-45(59)35-15-13-20-56(51-35)44(58)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)53(9)46(60)55-21-18-31(55)25-52(7)8/h12,14,16-17,19,22,26,28-29,31,35-36,41,51H,11,13,15,18,20-21,23-25,27H2,1-10H3,(H,50,57) OACXYKVUQDRWNG-UHFFFAOYSA-N 751056 US20250195521, Example A508 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751056 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751056&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161775429 519649650 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541912 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(CF)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C55H67FN6O7/c1-9-61-46-20-19-38-29-42(46)43(49(61)41-17-13-22-57-47(41)34(4)67-8)30-55(5,6)32-69-54(66)44-18-14-23-62(59-44)52(64)45(28-35-25-36(31-56)27-39(38)26-35)58-51(63)48(33(2)3)60(7)53(65)50-40(21-24-68-50)37-15-11-10-12-16-37/h10-13,15-17,19-20,22,25-27,29,33-34,40,44-45,48,50,59H,9,14,18,21,23-24,28,30-32H2,1-8H3,(H,58,63) ZNONISUBCAVPPJ-UHFFFAOYSA-N 751057 US20250195521, Example A509 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751057 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751057&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413592 519649651 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541913 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C3COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O8/c1-8-56-43-12-11-32-22-38(43)39(45(56)40-24-51-15-13-34(40)26-63-7)23-50(4,5)29-65-49(62)41-10-9-16-57(53-41)48(61)42(20-31-18-35(32)21-37(58)19-31)52-46(59)44(30(2)3)54(6)47(60)33-14-17-55(25-33)36-27-64-28-36/h11-13,15,18-19,21-22,24,30,33,36,41-42,44,53,58H,8-10,14,16-17,20,23,25-29H2,1-7H3,(H,52,59) GGURXHJSBGUFSG-UHFFFAOYSA-N 751058 US20250195521, Example A51 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751058 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751058&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157053663 519649652 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541914 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(O)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O7S/c1-9-54-37-15-14-29-18-32(37)33(41(54)31-12-10-16-48-39(31)28(4)61-8)22-46(5,6)26-62-44(59)34-13-11-17-55(51-34)43(58)35(19-38-49-36(29)23-63-38)50-42(57)40(27(2)3)52(7)45(60)53-24-47(25-53)20-30(56)21-47/h10,12,14-16,18,23,27-28,30,34-35,40,51,56H,9,11,13,17,19-22,24-26H2,1-8H3,(H,50,57) YWDSVLJPEQBFIE-UHFFFAOYSA-N 751059 US20250195521, Example A510 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751059 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751059&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158378426 519649653 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541915 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(N(C)C4COC4)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H69N9O7S/c1-10-59-41-16-15-32-19-36(41)37(45(59)35-13-11-17-52-43(35)31(4)65-9)23-50(5,6)29-67-48(63)38-14-12-18-60(55-38)47(62)39(20-42-53-40(32)26-68-42)54-46(61)44(30(2)3)57(8)49(64)58-27-51(28-58)21-33(22-51)56(7)34-24-66-25-34/h11,13,15-17,19,26,30-31,33-34,38-39,44,55H,10,12,14,18,20-25,27-29H2,1-9H3,(H,54,61) IFWZQXYBHCQYSN-UHFFFAOYSA-N 751060 US20250195521, Example A511 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751060 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751060&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161744965 519649654 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541916 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(NCCOC)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H69N9O7S/c1-10-58-40-16-15-32-21-35(40)36(44(58)34-13-11-17-52-42(34)31(4)65-9)25-49(5,6)29-66-47(62)37-14-12-19-59(55-37)46(61)38(22-41-53-39(32)26-67-41)54-45(60)43(30(2)3)56(7)48(63)57-27-50(28-57)23-33(24-50)51-18-20-64-8/h11,13,15-17,21,26,30-31,33,37-38,43,51,55H,10,12,14,18-20,22-25,27-29H2,1-9H3,(H,54,60) JGWFQCCAGKLIJE-UHFFFAOYSA-N 751061 US20250195521, Example A512 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751061&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 177373000 519649655 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541917 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CCN(C)CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O6S/c1-10-57-39-16-15-32-23-34(39)35(43(57)33-13-11-19-50-41(33)31(4)63-9)25-48(5,6)29-64-46(61)36-14-12-20-58(53-36)45(60)37(24-40-51-38(32)26-65-40)52-44(59)42(30(2)3)55(8)47(62)56-27-49(28-56)17-21-54(7)22-18-49/h11,13,15-16,19,23,26,30-31,36-37,42,53H,10,12,14,17-18,20-22,24-25,27-29H2,1-9H3,(H,52,59) KMYCCRKGPLPXGE-UHFFFAOYSA-N 751062 US20250195521, Example A513 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751062 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751062&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160296155 519649656 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541918 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@@H](CO)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O8S/c1-10-54-37-16-15-29-19-32(37)33(42(54)31-13-11-17-48-40(31)28(4)61-8)21-47(5,6)26-63-45(59)34-14-12-18-55(51-34)44(58)35(20-39-49-36(29)25-64-39)50-43(57)41(27(2)3)52(7)46(60)53-22-30(23-53)38(24-56)62-9/h11,13,15-17,19,25,27-28,30,34-35,38,41,51,56H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) XGCZKHDZZYJBSZ-UHFFFAOYSA-N 751063 US20250195521, Example A514 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751063 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751063&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159218980 519649657 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541919 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@H](CO)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H64N8O8S/c1-10-54-37-16-15-29-19-32(37)33(42(54)31-13-11-17-48-40(31)28(4)61-8)21-47(5,6)26-63-45(59)34-14-12-18-55(51-34)44(58)35(20-39-49-36(29)25-64-39)50-43(57)41(27(2)3)52(7)46(60)53-22-30(23-53)38(24-56)62-9/h11,13,15-17,19,25,27-28,30,34-35,38,41,51,56H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) XGCZKHDZZYJBSZ-UHFFFAOYSA-N 751064 US20250195521, Example A515 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751064 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751064&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413600 519649658 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541920 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@@H]3CCN(C)C[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-38-16-15-30-21-33(38)34(43(55)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-24-31-17-20-53(7)25-39(31)56/h11,13,15-16,18,21,26,28-29,31,35-36,39,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) XRNWJHVRSPVTDP-UHFFFAOYSA-N 751065 US20250195521, Example A516 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751065 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751065&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413610 519649659 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541921 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H]3CCN(C)C[C@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-38-16-15-30-21-33(38)34(43(55)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-24-31-17-20-53(7)25-39(31)56/h11,13,15-16,18,21,26,28-29,31,35-36,39,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) XRNWJHVRSPVTDP-UHFFFAOYSA-N 751066 US20250195521, Example A517 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751066&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413594 519649660 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541922 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@@H]1CN(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-55-39-19-18-31-23-34(39)35(43(55)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)54(9)47(61)56-21-13-15-32(56)26-53(7)8/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) VZLBGGNSENSDPA-UHFFFAOYSA-N 751067 US20250195521, Example A518 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751067&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413613 519649661 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541923 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@H]1CN(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-55-39-19-18-31-23-34(39)35(43(55)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)54(9)47(61)56-21-13-15-32(56)26-53(7)8/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) VZLBGGNSENSDPA-UHFFFAOYSA-N 751068 US20250195521, Example A519 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751068 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751068&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158385344 519649662 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541924 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)c1ncco1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H55N7O7/c1-8-51-38-12-11-29-22-33(38)34(40(51)35-24-46-14-13-30(35)25-57-7)23-45(4,5)26-59-43(56)36-10-9-16-52(49-36)42(55)37(20-28-18-31(29)21-32(53)19-28)48-41(54)39(27(2)3)50(6)44-47-15-17-58-44/h11-15,17-19,21-22,24,27,36-37,39,49,53H,8-10,16,20,23,25-26H2,1-7H3,(H,48,54) VPWUWUGEMCDLDB-UHFFFAOYSA-N 751069 US20250195521, Example A52 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751069&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159767479 519649663 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541925 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC13CCOCC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H66N8O7S/c1-9-55-39-16-15-32-25-34(39)35(43(55)33-13-10-20-50-41(33)31(4)62-8)27-48(5,6)29-64-46(60)36-14-11-22-57(53-36)45(59)37(26-40-51-38(32)28-65-40)52-44(58)42(30(2)3)54(7)47(61)56-21-12-17-49(56)18-23-63-24-19-49/h10,13,15-16,20,25,28,30-31,36-37,42,53H,9,11-12,14,17-19,21-24,26-27,29H2,1-8H3,(H,52,58) VWCRTXSCWCOGRS-UHFFFAOYSA-N 751070 US20250195521, Example A520 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751070 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751070&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159808774 519649664 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541926 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CCOCC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H64N8O7S/c1-9-55-38-15-14-31-22-33(38)34(42(55)32-12-10-18-49-40(32)30(4)61-8)24-47(5,6)28-63-45(59)35-13-11-19-56(52-35)44(58)36(23-39-50-37(31)25-64-39)51-43(57)41(29(2)3)53(7)46(60)54-26-48(27-54)16-20-62-21-17-48/h10,12,14-15,18,22,25,29-30,35-36,41,52H,9,11,13,16-17,19-21,23-24,26-28H2,1-8H3,(H,51,57) NFSQZMJWLYNFDQ-UHFFFAOYSA-N 751071 US20250195521, Example A521 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751071&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161976091 519649665 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541927 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CCCO3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O7S/c1-9-54-37-16-15-30-21-32(37)33(41(54)31-13-10-18-48-39(31)29(4)60-8)23-46(5,6)27-61-44(58)34-14-11-19-55(51-34)43(57)35(22-38-49-36(30)24-63-38)50-42(56)40(28(2)3)52(7)45(59)53-25-47(26-53)17-12-20-62-47/h10,13,15-16,18,21,24,28-29,34-35,40,51H,9,11-12,14,17,19-20,22-23,25-27H2,1-8H3,(H,50,56) WNORUKBAUNDKED-UHFFFAOYSA-N 751072 US20250195521, Example A522 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751072 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751072&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157132710 519649666 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541928 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O6S/c1-9-53-36-15-14-29-20-31(36)32(40(53)30-12-10-18-47-38(30)28(4)59-8)22-45(5,6)26-60-43(57)33-13-11-19-54(50-33)42(56)34(21-37-48-35(29)23-61-37)49-41(55)39(27(2)3)51(7)44(58)52-24-46(25-52)16-17-46/h10,12,14-15,18,20,23,27-28,33-34,39,50H,9,11,13,16-17,19,21-22,24-26H2,1-8H3,(H,49,55) VQVPMZLTEGLWKV-UHFFFAOYSA-N 751073 US20250195521, Example A523 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751073 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751073&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158844641 519649667 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541929 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C)[C@@H](c3ccccc3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H67N9O6S/c1-10-60-42-21-20-35-26-37(42)38(47(60)36-18-14-22-53-45(36)33(4)66-9)28-52(5,6)31-67-50(64)39-19-15-23-61(56-39)49(63)40(27-44-54-41(35)30-68-44)55-48(62)46(32(2)3)58(8)51(65)59-25-24-57(7)43(29-59)34-16-12-11-13-17-34/h11-14,16-18,20-22,26,30,32-33,39-40,43,46,56H,10,15,19,23-25,27-29,31H2,1-9H3,(H,55,62) PBVDRUCBSIPDBI-UHFFFAOYSA-N 751074 US20250195521, Example A524 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751074&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161930705 519649668 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541930 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(=O)N1CCN(C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-8-56-39-18-17-32-25-34(39)35(43(56)33-15-11-19-49-41(33)30(2)62-7)27-48(3,4)29-63-46(60)36-16-12-20-57(52-36)45(59)37(26-40-50-38(32)28-64-40)51-44(58)42(31-13-9-10-14-31)54(6)47(61)55-23-21-53(5)22-24-55/h11,15,17-19,25,28,30-31,36-37,42,52H,8-10,12-14,16,20-24,26-27,29H2,1-7H3,(H,51,58) YQKCDUBVUJAGEI-UHFFFAOYSA-N 751075 US20250195521, Example A525 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751075&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162090139 519649669 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541931 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(=O)N(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H70N10O6S/c1-10-59-41-18-17-33-24-35(41)37(45(59)36-25-34(28-51-43(36)31(2)65-9)58-22-20-56(7)21-23-58)27-50(3,4)30-66-48(63)38-16-13-19-60(54-38)47(62)39(26-42-52-40(33)29-67-42)53-46(61)44(32-14-11-12-15-32)57(8)49(64)55(5)6/h17-18,24-25,28-29,31-32,38-39,44,54H,10-16,19-23,26-27,30H2,1-9H3,(H,53,61) CDZQCZJVAIWDGF-UHFFFAOYSA-N 751076 US20250195521, Example A526 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751076&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161298868 519649670 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541932 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C1(C)COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-11-53-36-17-16-29-20-31(36)32(40(53)30-14-12-18-47-38(30)28(4)59-10)22-45(5,6)24-61-43(57)33-15-13-19-54(50-33)42(56)34(21-37-48-35(29)23-62-37)49-41(55)39(27(2)3)51(8)44(58)52(9)46(7)25-60-26-46/h12,14,16-18,20,23,27-28,33-34,39,50H,11,13,15,19,21-22,24-26H2,1-10H3,(H,49,55) ATIAJDZUGIAMIC-UHFFFAOYSA-N 751077 US20250195521, Example A527 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751077&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158745532 519649671 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541933 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC13COC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O7S/c1-9-53-37-16-15-30-21-32(37)33(41(53)31-13-10-18-48-39(31)29(4)60-8)23-46(5,6)25-62-44(58)34-14-11-20-55(51-34)43(57)35(22-38-49-36(30)24-63-38)50-42(56)40(28(2)3)52(7)45(59)54-19-12-17-47(54)26-61-27-47/h10,13,15-16,18,21,24,28-29,34-35,40,51H,9,11-12,14,17,19-20,22-23,25-27H2,1-8H3,(H,50,56) CUEXKKSSNBQNMH-UHFFFAOYSA-N 751078 US20250195521, Example A528 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751078&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160245097 519649672 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541934 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C1CCCC1)N(C)C(=O)N1CCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H70N10O6S/c1-8-60-42-17-16-34-25-36(42)38(46(60)37-26-35(29-52-44(37)32(2)66-7)58-23-21-56(5)22-24-58)28-51(3,4)31-67-49(64)39-15-11-20-61(55-39)48(63)40(27-43-53-41(34)30-68-43)54-47(62)45(33-13-9-10-14-33)57(6)50(65)59-18-12-19-59/h16-17,25-26,29-30,32-33,39-40,45,55H,8-15,18-24,27-28,31H2,1-7H3,(H,54,62) RZTZSCLYJBPMNQ-UHFFFAOYSA-N 751079 US20250195521, Example A529 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751079&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161501539 519649673 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541935 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H](OC(=O)N(C)C)C(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O8/c1-9-49-37-13-12-28-21-32(37)33(38(49)34-23-45-15-14-29(34)24-56-8)22-44(4,5)25-57-42(54)35-11-10-16-50(47-35)41(53)36(19-27-17-30(28)20-31(51)18-27)46-40(52)39(26(2)3)58-43(55)48(6)7/h12-15,17-18,20-21,23,26,35-36,39,47,51H,9-11,16,19,22,24-25H2,1-8H3,(H,46,52) XPOFCEVQOWJRPB-UHFFFAOYSA-N 751080 US20250195521, Example A53 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751080&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158561653 519649674 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541936 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC13CCS(=O)(=O)CC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H64N8O8S2/c1-9-54-38-15-14-31-24-33(38)34(42(54)32-12-10-19-49-40(32)30(4)63-8)26-47(5,6)28-64-45(59)35-13-11-20-56(52-35)44(58)36(25-39-50-37(31)27-65-39)51-43(57)41(29(2)3)53(7)46(60)55-21-16-48(55)17-22-66(61,62)23-18-48/h10,12,14-15,19,24,27,29-30,35-36,41,52H,9,11,13,16-18,20-23,25-26,28H2,1-8H3,(H,51,57) ZSMLKSQPUJHQMH-UHFFFAOYSA-N 751081 US20250195521, Example A530 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751081&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159961278 519649675 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541937 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@@H](N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-56-39-19-18-31-23-34(39)35(43(56)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)54(9)47(61)55-21-13-15-32(26-55)53(7)8/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) JMJMPKKSIZBADV-UHFFFAOYSA-N 751082 US20250195521, Example A531 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751082&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413616 519649676 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541938 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CC(N(C)CCOC)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H71N9O7S/c1-11-59-41-17-16-33-22-36(41)37(45(59)35-14-12-18-52-43(35)32(4)66-10)26-50(5,6)30-67-48(63)38-15-13-19-60(55-38)47(62)39(23-42-53-40(33)27-68-42)54-46(61)44(31(2)3)57(8)49(64)58-28-51(29-58)24-34(25-51)56(7)20-21-65-9/h12,14,16-18,22,27,31-32,34,38-39,44,55H,11,13,15,19-21,23-26,28-30H2,1-10H3,(H,54,61) OCTGVBYNGIKYFM-UHFFFAOYSA-N 751083 US20250195521, Example A532 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751083&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158245513 519649677 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541939 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@H](C)COC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H66N8O7S/c1-11-55-39-17-16-31-20-34(39)35(43(55)33-14-12-18-49-41(33)30(5)62-10)22-48(6,7)27-63-46(59)36-15-13-19-56(52-36)45(58)37(21-40-50-38(31)26-64-40)51-44(57)42(28(2)3)53(8)47(60)54-23-32(24-54)29(4)25-61-9/h12,14,16-18,20,26,28-30,32,36-37,42,52H,11,13,15,19,21-25,27H2,1-10H3,(H,51,57) NCWMJMYZCHAXOC-UHFFFAOYSA-N 751084 US20250195521, Example A533 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751084&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159775913 519649678 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541940 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@@H](C)COC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H66N8O7S/c1-11-55-39-17-16-31-20-34(39)35(43(55)33-14-12-18-49-41(33)30(5)62-10)22-48(6,7)27-63-46(59)36-15-13-19-56(52-36)45(58)37(21-40-50-38(31)26-64-40)51-44(57)42(28(2)3)53(8)47(60)54-23-32(24-54)29(4)25-61-9/h12,14,16-18,20,26,28-30,32,36-37,42,52H,11,13,15,19,21-25,27H2,1-10H3,(H,51,57) NCWMJMYZCHAXOC-UHFFFAOYSA-N 751085 US20250195521, Example A534 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751085&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413628 519649679 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541941 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@H](C)NC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-30-20-33(38)34(42(55)32-14-12-18-49-40(32)29(5)61-10)22-47(6,7)26-62-45(59)35-15-13-19-56(52-35)44(58)36(21-39-50-37(30)25-63-39)51-43(57)41(27(2)3)53(9)46(60)54-23-31(24-54)28(4)48-8/h12,14,16-18,20,25,27-29,31,35-36,41,48,52H,11,13,15,19,21-24,26H2,1-10H3,(H,51,57) ZDNGQTNJWNHSET-UHFFFAOYSA-N 751086 US20250195521, Example A535 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751086&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157928840 519649680 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541942 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN3C(=O)CN(C)C[C@@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H66N10O7S/c1-10-57-39-16-15-31-21-34(39)35(44(57)33-13-11-17-50-42(33)30(4)65-9)23-49(5,6)28-66-47(63)36-14-12-18-59(53-36)46(62)37(22-40-51-38(31)27-67-40)52-45(61)43(29(2)3)55(8)48(64)56-19-20-58-32(25-56)24-54(7)26-41(58)60/h11,13,15-17,21,27,29-30,32,36-37,43,53H,10,12,14,18-20,22-26,28H2,1-9H3,(H,52,61) ZBUFPPGBUDNENN-UHFFFAOYSA-N 751087 US20250195521, Example A536 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751087&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413584 519649681 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541943 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN3C(=O)CN(C)C[C@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H66N10O7S/c1-10-57-39-16-15-31-21-34(39)35(44(57)33-13-11-17-50-42(33)30(4)65-9)23-49(5,6)28-66-47(63)36-14-12-18-59(53-36)46(62)37(22-40-51-38(31)27-67-40)52-45(61)43(29(2)3)55(8)48(64)56-19-20-58-32(25-56)24-54(7)26-41(58)60/h11,13,15-17,21,27,29-30,32,36-37,43,53H,10,12,14,18-20,22-26,28H2,1-9H3,(H,52,61) ZBUFPPGBUDNENN-UHFFFAOYSA-N 751088 US20250195521, Example A537 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751088&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160490680 519649682 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541944 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC([C@H](C)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-56-39-18-17-31-21-34(39)35(43(56)33-15-13-19-49-41(33)30(5)62-11)23-48(6,7)27-63-46(60)36-16-14-20-57(52-36)45(59)37(22-40-50-38(31)26-64-40)51-44(58)42(28(2)3)54(10)47(61)55-24-32(25-55)29(4)53(8)9/h13,15,17-19,21,26,28-30,32,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) YCJFBCDPKCPPEX-UHFFFAOYSA-N 751089 US20250195521, Example A538 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751089&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160709175 519649683 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541945 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3CCN(C)CC31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-38-16-15-30-21-33(38)34(43(55)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)56-24-31-17-20-53(7)25-39(31)56/h11,13,15-16,18,21,26,28-29,31,35-36,39,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) XRNWJHVRSPVTDP-UHFFFAOYSA-N 751090 US20250195521, Example A539 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751090&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161824151 519649684 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541946 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C42H55N7O6S/c1-10-48-34-16-15-27-19-29(34)30(38(48)28-13-11-17-43-36(28)25(4)54-9)21-42(6,7)23-55-41(53)31-14-12-18-49(46-31)40(52)32(20-35-44-33(27)22-56-35)45-39(51)37(24(2)3)47(8)26(5)50/h11,13,15-17,19,22,24-25,31-32,37,46H,10,12,14,18,20-21,23H2,1-9H3,(H,45,51) VYOHGUPLOVGJNF-UHFFFAOYSA-N 751091 US20250195521, Example A54 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751091&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158085703 519649685 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541947 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C3COCC1C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O7S/c1-9-52-37-15-14-28-18-32(37)33(41(52)31-12-10-16-47-39(31)27(4)59-8)21-46(5,6)25-61-44(57)34-13-11-17-53(50-34)43(56)35(20-38-48-36(28)24-62-38)49-42(55)40(26(2)3)51(7)45(58)54-29-19-30(54)23-60-22-29/h10,12,14-16,18,24,26-27,29-30,34-35,40,50H,9,11,13,17,19-23,25H2,1-8H3,(H,49,55) NJTBYXMXOOVEMY-UHFFFAOYSA-N 751092 US20250195521, Example A540 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751092&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161364130 519649686 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541948 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C3CC1CN(C)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N9O6S/c1-10-54-38-16-15-29-19-33(38)34(42(54)32-13-11-17-48-40(32)28(4)61-9)22-47(5,6)26-62-45(59)35-14-12-18-55(51-35)44(58)36(21-39-49-37(29)25-63-39)50-43(57)41(27(2)3)53(8)46(60)56-30-20-31(56)24-52(7)23-30/h11,13,15-17,19,25,27-28,30-31,35-36,41,51H,10,12,14,18,20-24,26H2,1-9H3,(H,50,57) OYUAIIKODWMGRE-UHFFFAOYSA-N 751093 US20250195521, Example A541 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751093&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160789607 519649687 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541949 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCN(C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-10-55-38-17-16-31-24-33(38)34(42(55)32-14-11-18-48-40(32)30(4)61-9)26-47(5,6)28-62-45(59)35-15-12-21-56(51-35)44(58)36(25-39-49-37(31)27-63-39)50-43(57)41(29(2)3)53(8)46(60)54-20-13-19-52(7)22-23-54/h11,14,16-18,24,27,29-30,35-36,41,51H,10,12-13,15,19-23,25-26,28H2,1-9H3,(H,50,57) MJMGSIVZTFMZPD-UHFFFAOYSA-N 751094 US20250195521, Example A542 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751094&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161387197 519649688 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541950 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C(=O)N3CCOCC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N9O8S/c1-9-57-39-15-14-31-22-34(39)35(43(57)33-12-10-16-50-41(33)30(4)64-8)24-49(5,6)28-66-47(62)36-13-11-17-58(53-36)46(61)37(23-40-51-38(31)27-67-40)52-44(59)42(29(2)3)54(7)48(63)56-25-32(26-56)45(60)55-18-20-65-21-19-55/h10,12,14-16,22,27,29-30,32,36-37,42,53H,9,11,13,17-21,23-26,28H2,1-8H3,(H,52,59) FKBVUGFEFRMGTF-UHFFFAOYSA-N 751095 US20250195521, Example A543 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751095&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158776548 519649689 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541951 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1C[C@@H](c3ccccc3)CC1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H59N7O6S/c1-8-54-40-19-18-32-22-35(40)36(45(54)34-16-12-20-50-43(34)30(4)61-7)25-49(5,6)28-62-48(60)37-17-13-21-56(53-37)47(59)38(24-41-51-39(32)27-63-41)52-46(58)44(29(2)3)55-26-33(23-42(55)57)31-14-10-9-11-15-31/h9-12,14-16,18-20,22,27,29-30,33,37-38,44,53H,8,13,17,21,23-26,28H2,1-7H3,(H,52,58) VVGCARDAIIFLAY-UHFFFAOYSA-N 751096 US20250195521, Example A544 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751096&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413632 519649690 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541952 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC13CN(C)C3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-55-38-17-16-31-22-33(38)34(42(55)32-14-11-19-49-40(32)30(4)62-9)24-47(5,6)28-63-45(60)35-15-12-21-57(52-35)44(59)36(23-39-50-37(31)25-64-39)51-43(58)41(29(2)3)54(8)46(61)56-20-13-18-48(56)26-53(7)27-48/h11,14,16-17,19,22,25,29-30,35-36,41,52H,10,12-13,15,18,20-21,23-24,26-28H2,1-9H3,(H,51,58) VEBYTLMPWNLHHG-UHFFFAOYSA-N 751097 US20250195521, Example A545 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751097&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159978509 519649691 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541953 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1cccnc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H65N7O8/c1-9-59-44-17-16-34-27-40(44)41(47(59)39-14-11-20-55-45(39)32(4)66-8)28-53(5,6)30-68-52(65)42-15-12-21-60(57-42)50(63)43(25-33-23-36(34)26-37(61)24-33)56-49(62)46(31(2)3)58(7)51(64)48-38(18-22-67-48)35-13-10-19-54-29-35/h10-11,13-14,16-17,19-20,23-24,26-27,29,31-32,38,42-43,46,48,57,61H,9,12,15,18,21-22,25,28,30H2,1-8H3,(H,56,62) YFAYBAGAIGWKDY-UHFFFAOYSA-N 751098 US20250195521, Example A546 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751098&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162763293 519649692 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541954 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN3CCOC[C@@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-9-56-39-15-14-31-22-34(39)35(43(56)33-12-10-16-49-41(33)30(4)62-8)24-48(5,6)28-64-46(60)36-13-11-17-57(52-36)45(59)37(23-40-50-38(31)27-65-40)51-44(58)42(29(2)3)53(7)47(61)55-19-18-54-20-21-63-26-32(54)25-55/h10,12,14-16,22,27,29-30,32,36-37,42,52H,9,11,13,17-21,23-26,28H2,1-8H3,(H,51,58) XZTWYCPOJRXCCW-UHFFFAOYSA-N 751099 US20250195521, Example A547 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751099&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160926613 519649693 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541955 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN3CCOC[C@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-9-56-39-15-14-31-22-34(39)35(43(56)33-12-10-16-49-41(33)30(4)62-8)24-48(5,6)28-64-46(60)36-13-11-17-57(52-36)45(59)37(23-40-50-38(31)27-65-40)51-44(58)42(29(2)3)53(7)47(61)55-19-18-54-20-21-63-26-32(54)25-55/h10,12,14-16,22,27,29-30,32,36-37,42,52H,9,11,13,17-21,23-26,28H2,1-8H3,(H,51,58) XZTWYCPOJRXCCW-UHFFFAOYSA-N 751100 US20250195521, Example A548 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751100&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413608 519649694 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541956 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(S(=O)(=O)NC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H61N9O8S2/c1-10-53-36-16-15-28-19-31(36)32(40(53)30-13-11-17-47-38(30)27(4)61-9)21-45(5,6)25-62-43(57)33-14-12-18-54(50-33)42(56)34(20-37-48-35(28)24-63-37)49-41(55)39(26(2)3)51(8)44(58)52-22-29(23-52)64(59,60)46-7/h11,13,15-17,19,24,26-27,29,33-34,39,46,50H,10,12,14,18,20-23,25H2,1-9H3,(H,49,55) KEGWFQBMSNLHKR-UHFFFAOYSA-N 751101 US20250195521, Example A549 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751101&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160083825 519649695 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541957 CCn1c(-c2cccnc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O7/c1-9-49-38-15-14-29-22-33(38)34(40(49)32-12-10-16-45-37(32)24-56-8)23-44(5,6)25-57-43(55)35-13-11-17-50(47-35)42(54)36(20-28-18-30(29)21-31(52)19-28)46-41(53)39(26(2)3)48(7)27(4)51/h10,12,14-16,18-19,21-22,26,35-36,39,47,52H,9,11,13,17,20,23-25H2,1-8H3,(H,46,53) QBPCCGGHDVECKE-UHFFFAOYSA-N 751102 US20250195521, Example A55 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751102&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159929753 519649696 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541958 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(N(C)S(C)(=O)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H63N9O8S2/c1-11-54-37-17-16-29-20-32(37)33(41(54)31-14-12-18-47-39(31)28(4)62-9)22-46(5,6)26-63-44(58)34-15-13-19-55(50-34)43(57)35(21-38-48-36(29)25-64-38)49-42(56)40(27(2)3)51(7)45(59)53-23-30(24-53)52(8)65(10,60)61/h12,14,16-18,20,25,27-28,30,34-35,40,50H,11,13,15,19,21-24,26H2,1-10H3,(H,49,56) HJPKHYINRTUKDF-UHFFFAOYSA-N 751103 US20250195521, Example A550 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751103&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160991522 519649697 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541959 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(S(=O)(=O)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H63N9O8S2/c1-11-54-37-17-16-29-20-32(37)33(41(54)31-14-12-18-47-39(31)28(4)62-10)22-46(5,6)26-63-44(58)34-15-13-19-55(50-34)43(57)35(21-38-48-36(29)25-64-38)49-42(56)40(27(2)3)52(9)45(59)53-23-30(24-53)65(60,61)51(7)8/h12,14,16-18,20,25,27-28,30,34-35,40,50H,11,13,15,19,21-24,26H2,1-10H3,(H,49,56) RIXMUUUHWJURQA-UHFFFAOYSA-N 751104 US20250195521, Example A551 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751104&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160584612 519649698 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541960 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(NS(C)(=O)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H61N9O8S2/c1-10-53-36-16-15-28-19-31(36)32(40(53)30-13-11-17-46-38(30)27(4)61-8)21-45(5,6)25-62-43(57)33-14-12-18-54(49-33)42(56)34(20-37-47-35(28)24-63-37)48-41(55)39(26(2)3)51(7)44(58)52-22-29(23-52)50-64(9,59)60/h11,13,15-17,19,24,26-27,29,33-34,39,49-50H,10,12,14,18,20-23,25H2,1-9H3,(H,48,55) RNDKKEHTNZGZGE-UHFFFAOYSA-N 751105 US20250195521, Example A552 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751105&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 171517050 519649699 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541961 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(O)(COC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O8S/c1-10-53-36-16-15-29-19-31(36)32(40(53)30-13-11-17-47-38(30)28(4)61-9)21-45(5,6)25-62-43(57)33-14-12-18-54(50-33)42(56)34(20-37-48-35(29)22-63-37)49-41(55)39(27(2)3)51(7)44(58)52-23-46(59,24-52)26-60-8/h11,13,15-17,19,22,27-28,33-34,39,50,59H,10,12,14,18,20-21,23-26H2,1-9H3,(H,49,55) RWFZZXXANVFNHV-UHFFFAOYSA-N 751106 US20250195521, Example A553 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751106&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160992852 519649700 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541962 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1C[C@H]1O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-9-52-38-15-14-29-22-33(38)35(42(52)32-12-10-16-48-40(32)27(4)60-8)24-47(5,6)25-61-46(59)36-13-11-17-53(50-36)45(58)37(20-28-18-30(29)21-31(54)19-28)49-43(56)41(26(2)3)51(7)44(57)34-23-39(34)55/h10,12,14-16,18-19,21-22,26-27,34,36-37,39,41,50,54-55H,9,11,13,17,20,23-25H2,1-8H3,(H,49,56) MWDWVKZLUCTMHN-UHFFFAOYSA-N 751107 US20250195521, Example A554 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751107&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347350 519649701 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541963 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H70N10O7S/c1-10-59-41-14-13-33-24-35(41)37(45(59)36-25-34(28-51-43(36)32(4)65-9)57-18-16-55(7)17-19-57)27-50(5,6)30-67-48(63)38-12-11-15-60(54-38)47(62)39(26-42-52-40(33)29-68-42)53-46(61)44(31(2)3)56(8)49(64)58-20-22-66-23-21-58/h13-14,24-25,28-29,31-32,38-39,44,54H,10-12,15-23,26-27,30H2,1-9H3,(H,53,61) MXBSSOFPCWCDAF-UHFFFAOYSA-N 751108 US20250195521, Example A555 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751108&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160448397 519649702 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541964 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(CCc1ccncc1)C1CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H62N8O5S/c1-8-55-41-16-13-33-25-36(41)37(45(55)35-11-9-20-51-43(35)31(4)61-7)27-49(5,6)29-62-48(60)38-12-10-23-57(54-38)47(59)39(26-42-52-40(33)28-63-42)53-46(58)44(30(2)3)56(34-14-15-34)24-19-32-17-21-50-22-18-32/h9,11,13,16-18,20-22,25,28,30-31,34,38-39,44,54H,8,10,12,14-15,19,23-24,26-27,29H2,1-7H3,(H,53,58) MQYPBBFGYLBEMC-UHFFFAOYSA-N 751109 US20250195521, Example A556 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751109&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787132 519649703 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541965 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)CCc1ccncc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N9O6S/c1-10-57-40-16-15-33-25-35(40)36(44(57)34-13-11-20-51-42(34)31(4)63-9)27-49(5,6)29-64-47(61)37-14-12-23-58(54-37)46(60)38(26-41-52-39(33)28-65-41)53-45(59)43(30(2)3)56(8)48(62)55(7)24-19-32-17-21-50-22-18-32/h11,13,15-18,20-22,25,28,30-31,37-38,43,54H,10,12,14,19,23-24,26-27,29H2,1-9H3,(H,53,59) LYDTXOLKEYQRBK-UHFFFAOYSA-N 751110 US20250195521, Example A557 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751110&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160940761 519649704 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541966 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H]1CN)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H61N9O6S/c1-9-52-36-15-14-28-20-31(36)32(40(52)30-12-10-17-47-38(30)27(4)59-8)22-45(5,6)25-60-43(57)33-13-11-18-54(50-33)42(56)34(21-37-48-35(28)24-61-37)49-41(55)39(26(2)3)51(7)44(58)53-19-16-29(53)23-46/h10,12,14-15,17,20,24,26-27,29,33-34,39,50H,9,11,13,16,18-19,21-23,25,46H2,1-8H3,(H,49,55) WPCQYDFUZGPPCX-UHFFFAOYSA-N 751111 US20250195521, Example A558 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751111&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413612 519649705 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541967 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H](F)[C@H](N)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62FN9O6S/c1-9-55-37-15-14-28-20-30(37)31(41(55)29-12-10-17-49-39(29)27(4)61-8)22-46(5,6)25-62-44(59)34-13-11-18-56(52-34)43(58)35(21-38-50-36(28)24-63-38)51-42(57)40(26(2)3)53(7)45(60)54-19-16-32(47)33(48)23-54/h10,12,14-15,17,20,24,26-27,32-35,40,52H,9,11,13,16,18-19,21-23,25,48H2,1-8H3,(H,51,57) YSTOOQZXCMTYKH-UHFFFAOYSA-N 751112 US20250195521, Example A559 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751112&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413638 519649706 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541968 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H](NC(=O)c1ncco1)C(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H53N7O8/c1-7-51-37-11-10-28-21-32(37)33(39(51)34-23-46-13-12-29(34)24-58-6)22-45(4,5)25-60-44(57)35-9-8-15-52(50-35)43(56)36(19-27-17-30(28)20-31(53)18-27)48-40(54)38(26(2)3)49-41(55)42-47-14-16-59-42/h10-14,16-18,20-21,23,26,35-36,38,50,53H,7-9,15,19,22,24-25H2,1-6H3,(H,48,54)(H,49,55) GYAYZRVWSSNAHM-UHFFFAOYSA-N 751113 US20250195521, Example A56 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751113&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162762989 519649707 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541969 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC13COC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O7S/c1-9-52-36-15-14-29-20-31(36)32(40(52)30-12-10-17-47-38(30)28(4)59-8)22-45(5,6)24-61-43(57)33-13-11-18-54(50-33)42(56)34(21-37-48-35(29)23-62-37)49-41(55)39(27(2)3)51(7)44(58)53-19-16-46(53)25-60-26-46/h10,12,14-15,17,20,23,27-28,33-34,39,50H,9,11,13,16,18-19,21-22,24-26H2,1-8H3,(H,49,55) KIPONNCNGYOOAZ-UHFFFAOYSA-N 751114 US20250195521, Example A560 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751114&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160522036 519649708 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541970 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N1CCC3(COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H59N7O6S/c1-8-51-36-14-13-29-19-31(36)32(40(51)30-11-9-16-46-38(30)28(4)56-7)21-44(5,6)24-58-43(55)33-12-10-17-52(49-33)42(54)34(20-37-47-35(29)22-59-37)48-41(53)39(27(2)3)50-18-15-45(23-50)25-57-26-45/h9,11,13-14,16,19,22,27-28,33-34,39,49H,8,10,12,15,17-18,20-21,23-26H2,1-7H3,(H,48,53) LFUNAJGUPLLSAC-UHFFFAOYSA-N 751115 US20250195521, Example A561 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751115&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787170 519649709 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541971 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C59H76N8O7/c1-10-66-50-22-21-42-32-45(50)47(53(66)46-33-43(35-60-51(46)38(4)72-9)65-27-25-63(7)26-28-65)34-59(5,6)36-74-58(71)48-20-15-24-67(62-48)56(69)49(31-39-16-14-19-41(42)30-39)61-55(68)52(37(2)3)64(8)57(70)54-44(23-29-73-54)40-17-12-11-13-18-40/h11-14,16-19,21-22,30,32-33,35,37-38,44,48-49,52,54,62H,10,15,20,23-29,31,34,36H2,1-9H3,(H,61,68) TWVPZPXINONYPL-UHFFFAOYSA-N 751116 US20250195521, Example A562 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751116&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413619 519649710 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541972 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)[C@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-30-22-33(38)34(42(55)32-14-12-19-48-40(32)29(4)61-10)24-47(5,6)27-62-45(59)35-15-13-20-56(51-35)44(58)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)54(9)46(60)53(8)31-18-21-52(7)25-31/h12,14,16-17,19,22,26,28-29,31,35-36,41,51H,11,13,15,18,20-21,23-25,27H2,1-10H3,(H,50,57) SNGPQXBJGHZWRZ-UHFFFAOYSA-N 751117 US20250195521, Example A563 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751117&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159794636 519649711 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541973 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)[C@@H]1CCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-30-22-33(38)34(42(55)32-14-12-19-48-40(32)29(4)61-10)24-47(5,6)27-62-45(59)35-15-13-20-56(51-35)44(58)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)54(9)46(60)53(8)31-18-21-52(7)25-31/h12,14,16-17,19,22,26,28-29,31,35-36,41,51H,11,13,15,18,20-21,23-25,27H2,1-10H3,(H,50,57) SNGPQXBJGHZWRZ-UHFFFAOYSA-N 751118 US20250195521, Example A564 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751118&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413595 519649712 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541974 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC3(CCN(C)CC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H69N9O6S/c1-10-58-40-16-15-33-25-35(40)36(44(58)34-13-11-20-51-42(34)32(4)64-9)27-49(5,6)30-65-47(62)37-14-12-21-59(54-37)46(61)38(26-41-52-39(33)28-66-41)53-45(60)43(31(2)3)56(8)48(63)57-24-19-50(29-57)17-22-55(7)23-18-50/h11,13,15-16,20,25,28,31-32,37-38,43,54H,10,12,14,17-19,21-24,26-27,29-30H2,1-9H3,(H,53,60) JDUFXOQCMGVZCP-UHFFFAOYSA-N 751119 US20250195521, Example A565 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751119&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161063799 519649713 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541975 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@@H](N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-30-22-33(38)34(42(55)32-14-12-19-48-40(32)29(4)61-10)24-47(5,6)27-62-45(59)35-15-13-20-56(51-35)44(58)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)53(9)46(60)54-21-18-31(25-54)52(7)8/h12,14,16-17,19,22,26,28-29,31,35-36,41,51H,11,13,15,18,20-21,23-25,27H2,1-10H3,(H,50,57) IEAYBGPDOUHNCJ-UHFFFAOYSA-N 751120 US20250195521, Example A566 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751120&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413605 519649714 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541976 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H](N)[C@@H](F)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H60FN9O6S/c1-9-54-36-15-14-27-18-29(36)30(40(54)28-12-10-16-48-38(28)26(4)60-8)20-45(5,6)24-61-43(58)33-13-11-17-55(51-33)42(57)34(19-37-49-35(27)23-62-37)50-41(56)39(25(2)3)52(7)44(59)53-21-31(46)32(47)22-53/h10,12,14-16,18,23,25-26,31-34,39,51H,9,11,13,17,19-22,24,47H2,1-8H3,(H,50,56) ISNOBGXBBTZHJL-UHFFFAOYSA-N 751121 US20250195521, Example A567 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751121&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160041491 519649715 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541977 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H]3CCN(C)[C@H]3C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-56-38-16-15-30-21-33(38)34(43(56)32-13-11-18-49-41(32)29(4)62-9)23-48(5,6)27-63-46(60)35-14-12-19-57(52-35)45(59)36(22-40-50-37(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)55-24-31-17-20-53(7)39(31)25-55/h11,13,15-16,18,21,26,28-29,31,35-36,39,42,52H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,51,58) DJWMRVJIQLNBMC-UHFFFAOYSA-N 751122 US20250195521, Example A568 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751122&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413640 519649716 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541978 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@H](N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-56-39-19-18-31-23-34(39)35(43(56)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)54(9)47(61)55-21-13-15-32(26-55)53(7)8/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) JMJMPKKSIZBADV-UHFFFAOYSA-N 751123 US20250195521, Example A569 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751123&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158112509 519649717 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541979 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)S(C)(=O)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H56N6O8S/c1-9-48-37-13-12-28-21-32(37)33(39(48)34-23-44-15-14-29(34)24-56-7)22-43(4,5)25-57-42(53)35-11-10-16-49(46-35)41(52)36(19-27-17-30(28)20-31(50)18-27)45-40(51)38(26(2)3)47(6)58(8,54)55/h12-15,17-18,20-21,23,26,35-36,38,46,50H,9-11,16,19,22,24-25H2,1-8H3,(H,45,51) NWMCWZPFNPFDKA-UHFFFAOYSA-N 751124 US20250195521, Example A57 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751124&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347430 519649718 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541980 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H63N9O6S/c1-10-54-37-16-15-30-23-32(37)33(41(54)31-13-11-17-47-39(31)29(4)60-9)25-46(5,6)27-61-44(58)34-14-12-18-55(50-34)43(57)35(24-38-48-36(30)26-62-38)49-42(56)40(28(2)3)52(8)45(59)53-21-19-51(7)20-22-53/h11,13,15-17,23,26,28-29,34-35,40,50H,10,12,14,18-22,24-25,27H2,1-9H3,(H,49,56) WYYAODAFAXDCTM-UHFFFAOYSA-N 751125 US20250195521, Example A570 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751125&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160267136 519649719 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541981 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC(N(C)C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-56-39-17-16-31-24-34(39)35(43(56)33-14-12-20-49-41(33)30(4)62-10)26-48(5,6)28-63-46(60)36-15-13-21-57(52-36)45(59)37(25-40-50-38(31)27-64-40)51-44(58)42(29(2)3)54(9)47(61)55-22-18-32(19-23-55)53(7)8/h12,14,16-17,20,24,27,29-30,32,36-37,42,52H,11,13,15,18-19,21-23,25-26,28H2,1-10H3,(H,51,58) IICRPLUPLHCJKS-UHFFFAOYSA-N 751126 US20250195521, Example A571 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751126&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160067012 519649720 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541982 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOC[C@@H]1CN(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O7S/c1-11-55-39-17-16-31-22-34(39)35(43(55)33-14-12-18-49-41(33)30(4)62-10)24-48(5,6)28-64-46(60)36-15-13-19-57(52-36)45(59)37(23-40-50-38(31)27-65-40)51-44(58)42(29(2)3)54(9)47(61)56-20-21-63-26-32(56)25-53(7)8/h12,14,16-18,22,27,29-30,32,36-37,42,52H,11,13,15,19-21,23-26,28H2,1-10H3,(H,51,58) VEKJJZLEZHIHPY-UHFFFAOYSA-N 751127 US20250195521, Example A572 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751127&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157923590 519649721 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541983 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@H](CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H69N9O6S/c1-11-57-40-19-18-33-23-35(40)36(44(57)34-16-12-20-50-42(34)31(4)63-10)25-49(5,6)29-64-47(61)37-17-14-22-58(53-37)46(60)38(24-41-51-39(33)28-65-41)52-45(59)43(30(2)3)55(9)48(62)56-21-13-15-32(27-56)26-54(7)8/h12,16,18-20,23,28,30-32,37-38,43,53H,11,13-15,17,21-22,24-27,29H2,1-10H3,(H,52,59) JQZWAOIUJYERFI-UHFFFAOYSA-N 751128 US20250195521, Example A573 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751128&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 166144789 519649722 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541984 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@@H](CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H69N9O6S/c1-11-57-40-19-18-33-23-35(40)36(44(57)34-16-12-20-50-42(34)31(4)63-10)25-49(5,6)29-64-47(61)37-17-14-22-58(53-37)46(60)38(24-41-51-39(33)28-65-41)52-45(59)43(30(2)3)55(9)48(62)56-21-13-15-32(27-56)26-54(7)8/h12,16,18-20,23,28,30-32,37-38,43,53H,11,13-15,17,21-22,24-27,29H2,1-10H3,(H,52,59) JQZWAOIUJYERFI-UHFFFAOYSA-N 751129 US20250195521, Example A574 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751129 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751129&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157342797 519649723 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541985 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(CN(C)C)(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O7S/c1-12-56-38-18-17-31-21-33(38)34(42(56)32-15-13-19-49-40(32)30(4)62-10)23-47(5,6)28-64-45(60)35-16-14-20-57(52-35)44(59)36(22-39-50-37(31)24-65-39)51-43(58)41(29(2)3)54(9)46(61)55-26-48(27-55,63-11)25-53(7)8/h13,15,17-19,21,24,29-30,35-36,41,52H,12,14,16,20,22-23,25-28H2,1-11H3,(H,51,58) CBZRTMNHJSYHDN-UHFFFAOYSA-N 751130 US20250195521, Example A575 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751130&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159492704 519649724 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541986 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-31-20-33(38)34(42(55)32-14-12-18-48-40(32)29(4)61-10)22-47(5,6)27-62-45(59)35-15-13-19-56(51-35)44(58)36(21-39-49-37(31)26-63-39)50-43(57)41(28(2)3)53(9)46(60)54-24-30(25-54)23-52(7)8/h12,14,16-18,20,26,28-30,35-36,41,51H,11,13,15,19,21-25,27H2,1-10H3,(H,50,57) KFTDZWBFAFLQDH-UHFFFAOYSA-N 751131 US20250195521, Example A576 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751131&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157488168 519649725 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541987 CCn1c(-c2cc(C3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C60H77N7O8/c1-10-66-51-19-18-41-31-46(51)48(54(66)47-32-43(34-61-52(47)37(4)73-9)39-20-24-64(7)25-21-39)33-60(5,6)35-75-59(72)49-17-14-23-67(63-49)57(70)50(29-38-27-42(41)30-44(68)28-38)62-56(69)53(36(2)3)65(8)58(71)55-45(22-26-74-55)40-15-12-11-13-16-40/h11-13,15-16,18-19,27-28,30-32,34,36-37,39,45,49-50,53,55,63,68H,10,14,17,20-26,29,33,35H2,1-9H3,(H,62,69) HTZVIKZWMWMAPD-UHFFFAOYSA-N 751132 US20250195521, Example A577 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751132&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413642 519649726 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541988 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](CC1CC1)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H60N8O7S/c1-8-53-37-16-15-29-20-32(37)33(41(53)31-11-9-17-47-40(31)27(2)59-6)22-46(3,4)26-61-44(57)34-12-10-18-54(50-34)43(56)35(21-39-48-36(29)25-62-39)49-42(55)38(19-28-13-14-28)51(5)45(58)52-23-30(24-52)60-7/h9,11,15-17,20,25,27-28,30,34-35,38,50H,8,10,12-14,18-19,21-24,26H2,1-7H3,(H,49,55) UDPOWSZOSHORNX-UHFFFAOYSA-N 751133 US20250195521, Example A578 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751133&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347172 519649727 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541989 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CC[C@H](C)[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H62N8O7S/c1-11-53-36-15-14-29-19-32(36)33(41(53)31-13-12-17-47-39(31)28(5)59-9)21-46(6,7)25-61-44(57)38-27(4)16-18-54(50-38)43(56)34(20-37-48-35(29)24-62-37)49-42(55)40(26(2)3)51(8)45(58)52-22-30(23-52)60-10/h12-15,17,19,24,26-28,30,34,38,40,50H,11,16,18,20-23,25H2,1-10H3,(H,49,55) QJDXKGVJNCPPCU-UHFFFAOYSA-N 751134 US20250195521, Example A579 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751134&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347823 519649728 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541990 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C43H54N6O7/c1-8-48-37-12-11-28-20-32(37)33(39(48)34-22-44-14-13-29(34)23-55-7)21-43(5,6)24-56-42(54)35-10-9-15-49(47-35)41(53)36(18-27-16-30(28)19-31(51)17-27)46-40(52)38(25(2)3)45-26(4)50/h11-14,16-17,19-20,22,25,35-36,38,47,51H,8-10,15,18,21,23-24H2,1-7H3,(H,45,50)(H,46,52) GNLNPUSPXKKPBV-UHFFFAOYSA-N 751135 US20250195521, Example A58 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751135&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156736411 519649729 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541991 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H](OC)[C@@H](N)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H63N9O7S/c1-10-54-36-16-15-28-19-30(36)31(41(54)29-13-11-17-48-39(29)27(4)60-8)21-46(5,6)25-62-44(58)33-14-12-18-55(51-33)43(57)34(20-38-49-35(28)24-63-38)50-42(56)40(26(2)3)52(7)45(59)53-22-32(47)37(23-53)61-9/h11,13,15-17,19,24,26-27,32-34,37,40,51H,10,12,14,18,20-23,25,47H2,1-9H3,(H,50,56) HMTOFGIOOPZTPB-UHFFFAOYSA-N 751136 US20250195521, Example A580 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751136&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157971415 519649730 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541992 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1C[C@H](N)[C@@H](O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H61N9O7S/c1-9-53-35-15-14-27-18-29(35)30(40(53)28-12-10-16-47-38(28)26(4)60-8)20-45(5,6)24-61-43(58)32-13-11-17-54(50-32)42(57)33(19-37-48-34(27)23-62-37)49-41(56)39(25(2)3)51(7)44(59)52-21-31(46)36(55)22-52/h10,12,14-16,18,23,25-26,31-33,36,39,50,55H,9,11,13,17,19-22,24,46H2,1-8H3,(H,49,56) JEGXAGCWIBJODM-UHFFFAOYSA-N 751137 US20250195521, Example A581 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751137&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161605318 519649731 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541993 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@H](c3ccccc3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H64N8O7S/c1-9-58-41-20-19-34-25-36(41)37(46(58)35-17-13-21-52-44(35)32(4)64-8)27-51(5,6)30-66-49(62)38-18-14-22-59(55-38)48(61)39(26-43-53-40(34)29-67-43)54-47(60)45(31(2)3)56(7)50(63)57-23-24-65-42(28-57)33-15-11-10-12-16-33/h10-13,15-17,19-21,25,29,31-32,38-39,42,45,55H,9,14,18,22-24,26-28,30H2,1-8H3,(H,54,60) XXLFIVFZQQVEDE-UHFFFAOYSA-N 751138 US20250195521, Example A582 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751138&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413593 519649732 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541994 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C56H73N9O7S/c1-10-64-46-19-18-37-27-40(46)42(50(64)41-28-38(31-57-48(41)35(4)70-9)63-24-22-61(7)23-25-63)30-56(5,6)33-72-55(69)43-17-14-21-65(60-43)53(67)44(29-47-58-45(37)32-73-47)59-52(66)49(34(2)3)62(8)54(68)51-39(20-26-71-51)36-15-12-11-13-16-36/h11-13,15-16,18-19,27-28,31-32,34-35,39,43-44,49,51,60H,10,14,17,20-26,29-30,33H2,1-9H3,(H,59,66) YZMGQVBZZTXCCV-UHFFFAOYSA-N 751139 US20250195521, Example A583 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751139&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 176787097 519649733 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541995 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H66N6O8/c1-9-59-45-20-19-36-29-41(45)42(48(59)40-17-13-22-55-46(40)33(4)66-8)30-54(5,6)31-68-53(65)43-18-14-23-60(57-43)51(63)44(27-34-25-37(36)28-38(61)26-34)56-50(62)47(32(2)3)58(7)52(64)49-39(21-24-67-49)35-15-11-10-12-16-35/h10-13,15-17,19-20,22,25-26,28-29,32-33,39,43-44,47,49,57,61H,9,14,18,21,23-24,27,30-31H2,1-8H3,(H,56,62) SECNHJFBRDVOQM-UHFFFAOYSA-N 751140 US20250195521, Example A584 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751140&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413626 519649734 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541996 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H63N7O7S/c1-9-57-41-20-19-33-25-36(41)37(45(57)35-17-13-22-52-43(35)31(4)63-8)27-51(5,6)29-65-50(62)38-18-14-23-58(55-38)48(60)39(26-42-53-40(33)28-66-42)54-47(59)44(30(2)3)56(7)49(61)46-34(21-24-64-46)32-15-11-10-12-16-32/h10-13,15-17,19-20,22,25,28,30-31,34,38-39,44,46,55H,9,14,18,21,23-24,26-27,29H2,1-8H3,(H,54,59) AFOLMQZKEJXRDR-UHFFFAOYSA-N 751141 US20250195521, Example A585 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751141&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413630 519649735 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541997 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H66N6O7/c1-9-59-45-23-22-38-30-41(45)42(48(59)40-20-14-25-55-46(40)34(4)65-8)31-54(5,6)32-67-53(64)43-21-15-26-60(57-43)51(62)44(29-35-16-13-19-37(38)28-35)56-50(61)47(33(2)3)58(7)52(63)49-39(24-27-66-49)36-17-11-10-12-18-36/h10-14,16-20,22-23,25,28,30,33-34,39,43-44,47,49,57H,9,15,21,24,26-27,29,31-32H2,1-8H3,(H,56,61) LGMKKBXCXYQNHC-UHFFFAOYSA-N 751142 US20250195521, Example A586 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751142&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413589 519649736 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541998 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)[C@@H]1CCCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-56-39-19-18-31-23-34(39)35(43(56)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)55(9)47(61)54(8)32-15-13-21-53(7)26-32/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) ITQLCYYCJUDPIF-UHFFFAOYSA-N 751143 US20250195521, Example A587 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751143&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 166144617 519649737 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1541999 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)[C@H]1CCCN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-11-56-39-19-18-31-23-34(39)35(43(56)33-16-12-20-49-41(33)30(4)62-10)25-48(5,6)28-63-46(60)36-17-14-22-57(52-36)45(59)37(24-40-50-38(31)27-64-40)51-44(58)42(29(2)3)55(9)47(61)54(8)32-15-13-21-53(7)26-32/h12,16,18-20,23,27,29-30,32,36-37,42,52H,11,13-15,17,21-22,24-26,28H2,1-10H3,(H,51,58) ITQLCYYCJUDPIF-UHFFFAOYSA-N 751144 US20250195521, Example A588 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751144&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157602185 519649738 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542000 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCCC3(CN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O6S/c1-10-57-39-17-16-32-22-34(39)35(43(57)33-14-11-19-50-41(33)31(4)63-9)24-48(5,6)29-64-46(61)36-15-12-21-58(53-36)45(60)37(23-40-51-38(32)25-65-40)52-44(59)42(30(2)3)55(8)47(62)56-20-13-18-49(28-56)26-54(7)27-49/h11,14,16-17,19,22,25,30-31,36-37,42,53H,10,12-13,15,18,20-21,23-24,26-29H2,1-9H3,(H,52,59) NAVXEVHYHWVUHS-UHFFFAOYSA-N 751145 US20250195521, Example A589 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751145&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161232012 519649739 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542001 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@@H](OC(=O)N1CCCC1)C(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O8/c1-7-51-39-13-12-30-23-34(39)35(40(51)36-25-47-15-14-31(36)26-58-6)24-46(4,5)27-59-44(56)37-11-10-18-52(49-37)43(55)38(21-29-19-32(30)22-33(53)20-29)48-42(54)41(28(2)3)60-45(57)50-16-8-9-17-50/h12-15,19-20,22-23,25,28,37-38,41,49,53H,7-11,16-18,21,24,26-27H2,1-6H3,(H,48,54) ZIWNTASQRIYITG-UHFFFAOYSA-N 751146 US20250195521, Example A59 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751146&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347658 519649740 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542002 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@H](CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O7S/c1-11-56-39-17-16-31-22-34(39)35(43(56)33-14-12-18-49-41(33)30(4)62-10)24-48(5,6)28-64-46(60)36-15-13-19-57(52-36)45(59)37(23-40-50-38(31)27-65-40)51-44(58)42(29(2)3)54(9)47(61)55-20-21-63-32(26-55)25-53(7)8/h12,14,16-18,22,27,29-30,32,36-37,42,52H,11,13,15,19-21,23-26,28H2,1-10H3,(H,51,58) YDPHPXXIIGIMHK-UHFFFAOYSA-N 751147 US20250195521, Example A590 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751147&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 166144405 519649741 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542003 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@@H](CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O7S/c1-11-56-39-17-16-31-22-34(39)35(43(56)33-14-12-18-49-41(33)30(4)62-10)24-48(5,6)28-64-46(60)36-15-13-19-57(52-36)45(59)37(23-40-50-38(31)27-65-40)51-44(58)42(29(2)3)54(9)47(61)55-20-21-63-32(26-55)25-53(7)8/h12,14,16-18,22,27,29-30,32,36-37,42,52H,11,13,15,19-21,23-26,28H2,1-10H3,(H,51,58) YDPHPXXIIGIMHK-UHFFFAOYSA-N 751148 US20250195521, Example A591 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751148&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159375396 519649742 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542004 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(cc(C(F)F)c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C55H66F2N6O7/c1-9-62-45-20-19-36-29-41(45)42(48(62)40-17-13-22-58-46(40)33(4)68-8)30-55(5,6)31-70-54(67)43-18-14-23-63(60-43)52(65)44(27-34-25-37(36)28-38(26-34)50(56)57)59-51(64)47(32(2)3)61(7)53(66)49-39(21-24-69-49)35-15-11-10-12-16-35/h10-13,15-17,19-20,22,25-26,28-29,32-33,39,43-44,47,49-50,60H,9,14,18,21,23-24,27,30-31H2,1-8H3,(H,59,64) POHMISVOSLUVON-UHFFFAOYSA-N 751149 US20250195521, Example A592 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751149&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413634 519649743 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542005 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C56H73N9O7S/c1-10-64-46-19-18-37-27-40(46)42(50(64)41-28-38(31-57-48(41)35(4)70-9)63-24-22-61(7)23-25-63)30-56(5,6)33-72-55(69)43-17-14-21-65(60-43)53(67)44(29-47-58-45(37)32-73-47)59-52(66)49(34(2)3)62(8)54(68)51-39(20-26-71-51)36-15-12-11-13-16-36/h11-13,15-16,18-19,27-28,31-32,34-35,39,43-44,49,51,60H,10,14,17,20-26,29-30,33H2,1-9H3,(H,59,66) YZMGQVBZZTXCCV-UHFFFAOYSA-N 751150 US20250195521, Example A593 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751150&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413596 519649744 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542006 CCn1c(-c2cc(N3CCN(C)CC3)cnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1OCC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C59H76N8O8/c1-10-66-50-19-18-40-31-45(50)47(53(66)46-32-42(34-60-51(46)37(4)73-9)65-24-22-63(7)23-25-65)33-59(5,6)35-75-58(72)48-17-14-21-67(62-48)56(70)49(29-38-27-41(40)30-43(68)28-38)61-55(69)52(36(2)3)64(8)57(71)54-44(20-26-74-54)39-15-12-11-13-16-39/h11-13,15-16,18-19,27-28,30-32,34,36-37,44,48-49,52,54,62,68H,10,14,17,20-26,29,33,35H2,1-9H3,(H,61,69) GFNDELQKEXXURO-UHFFFAOYSA-N 751151 US20250195521, Example A594 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751151&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413623 519649745 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542007 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)[C@H]3CCCN3C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H70N10O7S/c1-10-60-40-18-17-33-26-35(40)36(45(60)34-14-11-19-52-43(34)32(4)67-9)28-51(5,6)30-68-49(65)37-15-12-21-61(55-37)47(63)38(27-42-53-39(33)29-69-42)54-46(62)44(31(2)3)57(8)50(66)59-24-22-58(23-25-59)48(64)41-16-13-20-56(41)7/h11,14,17-19,26,29,31-32,37-38,41,44,55H,10,12-13,15-16,20-25,27-28,30H2,1-9H3,(H,54,62) DKCRXRVATBAFEQ-UHFFFAOYSA-N 751152 US20250195521, Example A595 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751152&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413629 519649746 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542008 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)[C@@H]3CCCN3C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H70N10O7S/c1-10-60-40-18-17-33-26-35(40)36(45(60)34-14-11-19-52-43(34)32(4)67-9)28-51(5,6)30-68-49(65)37-15-12-21-61(55-37)47(63)38(27-42-53-39(33)29-69-42)54-46(62)44(31(2)3)57(8)50(66)59-24-22-58(23-25-59)48(64)41-16-13-20-56(41)7/h11,14,17-19,26,29,31-32,37-38,41,44,55H,10,12-13,15-16,20-25,27-28,30H2,1-9H3,(H,54,62) DKCRXRVATBAFEQ-UHFFFAOYSA-N 751153 US20250195521, Example A596 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751153&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158862138 519649747 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542009 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(O)(CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O7S/c1-11-55-37-17-16-30-20-32(37)33(41(55)31-14-12-18-48-39(31)29(4)62-10)22-46(5,6)27-63-44(59)34-15-13-19-56(51-34)43(58)35(21-38-49-36(30)23-64-38)50-42(57)40(28(2)3)53(9)45(60)54-25-47(61,26-54)24-52(7)8/h12,14,16-18,20,23,28-29,34-35,40,51,61H,11,13,15,19,21-22,24-27H2,1-10H3,(H,50,57) MAAWYBYVVMEVGL-UHFFFAOYSA-N 751154 US20250195521, Example A597 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751154&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158322773 519649748 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542010 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)[C@@H](OC)[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H60N8O7S/c1-12-51-33-18-17-27-21-29(33)30(37(51)28-15-13-19-45-34(28)26(4)57-10)22-44(5,6)24-59-42(55)31-16-14-20-52(48-31)41(54)35(38(58-11)40-46-32(27)23-60-40)47-39(53)36(25(2)3)50(9)43(56)49(7)8/h13,15,17-19,21,23,25-26,31,35-36,38,48H,12,14,16,20,22,24H2,1-11H3,(H,47,53) ZTWNLXXZWCKULG-UHFFFAOYSA-N 751155 US20250195521, Example A598 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751155&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346781 519649749 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542011 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC[C@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H64N8O6S/c1-9-57-42-22-21-34-26-36(42)37(46(57)35-18-13-23-52-44(35)32(4)64-8)28-51(5,6)30-65-49(62)38-19-14-25-59(55-38)48(61)39(27-43-53-40(34)29-66-43)54-47(60)45(31(2)3)56(7)50(63)58-24-15-20-41(58)33-16-11-10-12-17-33/h10-13,16-18,21-23,26,29,31-32,38-39,41,45,55H,9,14-15,19-20,24-25,27-28,30H2,1-8H3,(H,54,60) RWZJYIBBYMAPQM-UHFFFAOYSA-N 751156 US20250195521, Example A599 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751156&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162086967 519649750 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542012 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN3CC[C@@H](O)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H70N8O9/c1-8-60-45-12-11-34-24-40(45)41(48(60)42-26-54-16-13-36(42)30-69-7)25-53(4,5)31-70-52(68)43-10-9-17-61(56-43)51(67)44(22-33-20-37(34)23-39(63)21-33)55-49(65)47(32(2)3)57(6)50(66)35-14-19-59(27-35)46(64)29-58-18-15-38(62)28-58/h11-13,16,20-21,23-24,26,32,35,38,43-44,47,56,62-63H,8-10,14-15,17-19,22,25,27-31H2,1-7H3,(H,55,65) PUKNUUDOUPJXRX-UHFFFAOYSA-N 751157 US20250195521, Example A6 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751157&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156736450 519649751 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542013 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H65N7O7/c1-10-56-42-19-18-35-26-38(42)39(45(56)37-16-12-21-51-43(37)31(4)63-9)27-50(6,7)29-64-49(62)40-17-13-22-57(53-40)48(61)41(25-33-14-11-15-34(35)24-33)52-46(59)44(30(2)3)54(8)47(60)36-20-23-55(28-36)32(5)58/h11-12,14-16,18-19,21,24,26,30-31,36,40-41,44,53H,10,13,17,20,22-23,25,27-29H2,1-9H3,(H,52,59) ZSQTWIYZMUPGOC-UHFFFAOYSA-N 751158 US20250195521, Example A60 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751158&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157302464 519649752 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542014 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCO[C@@H](c3ccccc3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H64N8O7S/c1-9-58-41-20-19-34-25-36(41)37(46(58)35-17-13-21-52-44(35)32(4)64-8)27-51(5,6)30-66-49(62)38-18-14-22-59(55-38)48(61)39(26-43-53-40(34)29-67-43)54-47(60)45(31(2)3)56(7)50(63)57-23-24-65-42(28-57)33-15-11-10-12-16-33/h10-13,15-17,19-21,25,29,31-32,38-39,42,45,55H,9,14,18,22-24,26-28,30H2,1-8H3,(H,54,60) XXLFIVFZQQVEDE-UHFFFAOYSA-N 751159 US20250195521, Example A600 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751159&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160139201 519649753 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542015 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCC13CCOCC3)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H64N8O7S/c1-9-54-38-15-14-31-24-33(38)34(42(54)32-12-10-19-49-40(32)30(4)61-8)26-47(5,6)28-63-45(59)35-13-11-20-56(52-35)44(58)36(25-39-50-37(31)27-64-39)51-43(57)41(29(2)3)53(7)46(60)55-21-16-48(55)17-22-62-23-18-48/h10,12,14-15,19,24,27,29-30,35-36,41,52H,9,11,13,16-18,20-23,25-26,28H2,1-8H3,(H,51,57) AQNISUSIABWVJO-UHFFFAOYSA-N 751160 US20250195521, Example A601 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751160&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157972537 519649754 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542016 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC3(CCN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-56-38-16-15-31-21-33(38)34(42(56)32-13-11-18-49-40(32)30(4)62-9)23-47(5,6)28-63-45(60)35-14-12-19-57(52-35)44(59)36(22-39-50-37(31)24-64-39)51-43(58)41(29(2)3)54(8)46(61)55-26-48(27-55)17-20-53(7)25-48/h11,13,15-16,18,21,24,29-30,35-36,41,52H,10,12,14,17,19-20,22-23,25-28H2,1-9H3,(H,51,58) XKJNLIOQGLQWNH-UHFFFAOYSA-N 751161 US20250195521, Example A602 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751161&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160265775 519649755 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542017 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC[C@H](N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H65N9O6S/c1-11-55-38-17-16-30-22-33(38)34(42(55)32-14-12-19-48-40(32)29(4)61-10)24-47(5,6)27-62-45(59)35-15-13-20-56(51-35)44(58)36(23-39-49-37(30)26-63-39)50-43(57)41(28(2)3)53(9)46(60)54-21-18-31(25-54)52(7)8/h12,14,16-17,19,22,26,28-29,31,35-36,41,51H,11,13,15,18,20-21,23-25,27H2,1-10H3,(H,50,57) IEAYBGPDOUHNCJ-UHFFFAOYSA-N 751162 US20250195521, Example A603 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751162&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157501486 519649756 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542018 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCOC[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H64N8O7S/c1-9-57-41-20-19-34-25-36(41)37(46(57)35-17-13-21-52-44(35)32(4)64-8)27-51(5,6)30-66-49(62)38-18-14-22-59(55-38)48(61)39(26-43-53-40(34)29-67-43)54-47(60)45(31(2)3)56(7)50(63)58-23-24-65-28-42(58)33-15-11-10-12-16-33/h10-13,15-17,19-21,25,29,31-32,38-39,42,45,55H,9,14,18,22-24,26-28,30H2,1-8H3,(H,54,60) UJJYYIUFXDHYSF-UHFFFAOYSA-N 751163 US20250195521, Example A604 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751163&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158093542 519649757 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542019 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCN[C@@H]1c1ccccc1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C54H67N7O7/c1-9-60-45-20-19-36-29-41(45)42(49(60)39-17-13-22-55-46(39)33(4)67-8)30-54(5,6)31-68-53(66)43-18-14-24-61(58-43)52(65)44(27-34-25-37(36)28-38(62)26-34)57-50(63)48(32(2)3)59(7)51(64)40-21-23-56-47(40)35-15-11-10-12-16-35/h10-13,15-17,19-20,22,25-26,28-29,32-33,40,43-44,47-48,56,58,62H,9,14,18,21,23-24,27,30-31H2,1-8H3,(H,57,63) HTWFUKOIUSASHH-UHFFFAOYSA-N 751164 US20250195521, Example A605 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751164&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413597 519649758 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542020 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)C3COC3)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N9O8S/c1-9-57-39-15-14-31-22-34(39)35(43(57)33-12-10-16-50-41(33)30(4)64-8)24-49(5,6)28-66-47(62)36-13-11-17-58(53-36)46(61)37(23-40-51-38(31)27-67-40)52-44(59)42(29(2)3)54(7)48(63)56-20-18-55(19-21-56)45(60)32-25-65-26-32/h10,12,14-16,22,27,29-30,32,36-37,42,53H,9,11,13,17-21,23-26,28H2,1-8H3,(H,52,59) NYCUOYCNOLYMLQ-UHFFFAOYSA-N 751165 US20250195521, Example A606 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751165&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158851497 519649759 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542021 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CCN(C(=O)C3CC3)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N9O7S/c1-9-57-39-17-16-32-24-34(39)35(43(57)33-12-10-18-50-41(33)30(4)64-8)26-49(5,6)28-65-47(62)36-13-11-19-58(53-36)46(61)37(25-40-51-38(32)27-66-40)52-44(59)42(29(2)3)54(7)48(63)56-22-20-55(21-23-56)45(60)31-14-15-31/h10,12,16-18,24,27,29-31,36-37,42,53H,9,11,13-15,19-23,25-26,28H2,1-8H3,(H,52,59) VBFFYEXTUWPNTC-UHFFFAOYSA-N 751166 US20250195521, Example A607 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751166&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160128912 519649760 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542022 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C3CN(C)C3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O6S/c1-10-56-39-16-15-30-19-34(39)35(43(56)33-13-11-17-49-41(33)29(4)62-9)21-48(5,6)27-63-46(60)36-14-12-18-57(52-36)45(59)37(20-40-50-38(30)26-64-40)51-44(58)42(28(2)3)54(8)47(61)55-24-32(25-55)31-22-53(7)23-31/h11,13,15-17,19,26,28-29,31-32,36-37,42,52H,10,12,14,18,20-25,27H2,1-9H3,(H,51,58) YVHAFRZCJMYCKJ-UHFFFAOYSA-N 751167 US20250195521, Example A608 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751167&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 162124984 519649761 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542023 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1[C@@H](C)CN(C)C[C@@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-55-39-18-17-32-21-34(39)35(43(55)33-15-13-19-49-41(33)31(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-56(52-36)45(59)37(22-40-50-38(32)26-64-40)51-44(58)42(28(2)3)54(10)47(61)57-29(4)24-53(9)25-30(57)5/h13,15,17-19,21,26,28-31,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) SMESADSJBPEYLL-UHFFFAOYSA-N 751168 US20250195521, Example A609 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751168&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161379488 519649762 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542024 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N6O6/c1-10-50-38-19-18-32-24-34(38)35(41(50)33-16-12-20-46-39(33)28(4)56-9)25-45(6,7)26-57-44(55)36-17-13-21-51(48-36)43(54)37(23-30-14-11-15-31(32)22-30)47-42(53)40(27(2)3)49(8)29(5)52/h11-12,14-16,18-20,22,24,27-28,36-37,40,48H,10,13,17,21,23,25-26H2,1-9H3,(H,47,53) BXVRDWXKSQDUAB-UHFFFAOYSA-N 751169 US20250195521, Example A61 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751169&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161107437 519649763 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542025 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1[C@H](C)CN(C)C[C@H]1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H67N9O6S/c1-12-55-39-18-17-32-21-34(39)35(43(55)33-15-13-19-49-41(33)31(6)62-11)23-48(7,8)27-63-46(60)36-16-14-20-56(52-36)45(59)37(22-40-50-38(32)26-64-40)51-44(58)42(28(2)3)54(10)47(61)57-29(4)24-53(9)25-30(57)5/h13,15,17-19,21,26,28-31,36-37,42,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,58) SMESADSJBPEYLL-UHFFFAOYSA-N 751170 US20250195521, Example A610 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751170&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413598 519649764 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542026 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N(C)C1CN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H63N9O6S/c1-11-54-37-17-16-29-20-32(37)33(41(54)31-14-12-18-47-39(31)28(4)60-10)22-46(5,6)26-61-44(58)34-15-13-19-55(50-34)43(57)35(21-38-48-36(29)25-62-38)49-42(56)40(27(2)3)53(9)45(59)52(8)30-23-51(7)24-30/h12,14,16-18,20,25,27-28,30,34-35,40,50H,11,13,15,19,21-24,26H2,1-10H3,(H,49,56) ZYLLRRIGFFYDSX-UHFFFAOYSA-N 751171 US20250195521, Example A611 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751171 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751171&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161450617 519649765 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542027 CCn1c(-c2cccnc2C(C)C)c2c3cc(cnc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H59N9O6S/c1-10-52-38(29-13-11-15-45-36(29)25(2)3)31-19-44(6,7)24-59-42(56)32-14-12-16-53(49-32)41(55)33(18-35-47-34(23-60-35)27-17-30(31)39(52)46-20-27)48-40(54)37(26(4)5)50(8)43(57)51-21-28(22-51)58-9/h11,13,15,17,20,23,25-26,28,32-33,37,49H,10,12,14,16,18-19,21-22,24H2,1-9H3,(H,48,54) UTOGAYPOXISZBA-UHFFFAOYSA-N 751172 US20250195521, Example A612 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751172&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160326106 519649766 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542028 CCn1c(-c2cccnc2C(C)C)c2c3nc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H59N9O6S/c1-10-52-34-16-15-30-33-23-60-35(46-33)19-32(48-40(54)38(26(4)5)50(8)43(57)51-21-27(22-51)58-9)41(55)53-18-12-14-31(49-53)42(56)59-24-44(6,7)20-29(37(34)47-30)39(52)28-13-11-17-45-36(28)25(2)3/h11,13,15-17,23,25-27,31-32,38,49H,10,12,14,18-22,24H2,1-9H3,(H,48,54) QUNHZJJERFUCCA-UHFFFAOYSA-N 751173 US20250195521, Example A613 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751173&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161175007 519649767 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542029 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)N1CC(C(C)(C)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H66N8O7S/c1-12-55-38-18-17-30-21-33(38)34(42(55)32-15-13-19-49-40(32)29(4)61-10)23-47(5,6)27-63-45(59)35-16-14-20-56(52-35)44(58)36(22-39-50-37(30)26-64-39)51-43(57)41(28(2)3)53(9)46(60)54-24-31(25-54)48(7,8)62-11/h13,15,17-19,21,26,28-29,31,35-36,41,52H,12,14,16,20,22-25,27H2,1-11H3,(H,51,57) QXWDVSPWGGDMBN-UHFFFAOYSA-N 751174 US20250195521, Example A614 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751174&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161728107 519649768 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542030 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@]1(F)CCN(C(=O)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H64FN7O9/c1-10-57-40-16-15-32-25-36(40)37(43(57)35-13-11-18-52-41(35)30(4)65-8)26-49(5,6)28-67-46(62)38-14-12-19-58(54-38)45(61)39(23-31-21-33(32)24-34(59)22-31)53-44(60)42(29(2)3)55(7)47(63)50(51)17-20-56(27-50)48(64)66-9/h11,13,15-16,18,21-22,24-25,29-30,38-39,42,54,59H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,53,60) VONNIBJJSLKEOG-UHFFFAOYSA-N 751175 US20250195521, Example A615 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751175 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751175&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 167413583 519649769 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542031 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@]1(F)CCN(C(=O)OC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H64FN7O9/c1-10-57-40-16-15-32-25-36(40)37(43(57)35-13-11-18-52-41(35)30(4)65-8)26-49(5,6)28-67-46(62)38-14-12-19-58(54-38)45(61)39(23-31-21-33(32)24-34(59)22-31)53-44(60)42(29(2)3)55(7)47(63)50(51)17-20-56(27-50)48(64)66-9/h11,13,15-16,18,21-22,24-25,29-30,38-39,42,54,59H,10,12,14,17,19-20,23,26-28H2,1-9H3,(H,53,60) VONNIBJJSLKEOG-UHFFFAOYSA-N 751176 US20250195521, Example A616 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751176&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157471792 519649770 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542032 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CN/C(N)=N/C#N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N10O7/c1-8-55-38-12-11-29-20-33(38)34(41(55)35-22-49-14-13-30(35)24-62-7)21-46(4,5)25-63-44(61)36-10-9-15-56(53-36)43(60)37(18-28-16-31(29)19-32(57)17-28)52-42(59)40(27(2)3)54(6)39(58)23-50-45(48)51-26-47/h11-14,16-17,19-20,22,27,36-37,40,53,57H,8-10,15,18,21,23-25H2,1-7H3,(H,52,59)(H3,48,50,51) HHNCHDCNGXDORF-UHFFFAOYSA-N 751177 US20250195521, Example A62 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751177&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159469635 519649771 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542033 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)c1cnc(N)[nH]c1=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H57N9O7/c1-8-54-37-12-11-28-20-32(37)33(40(54)34-22-48-14-13-29(34)24-61-7)21-46(4,5)25-62-44(60)35-10-9-15-55(52-35)43(59)36(18-27-16-30(28)19-31(56)17-27)50-42(58)39(26(2)3)53(6)38-23-49-45(47)51-41(38)57/h11-14,16-17,19-20,22-23,26,35-36,39,52,56H,8-10,15,18,21,24-25H2,1-7H3,(H,50,58)(H3,47,49,51,57) OQEDYFLYXLUDQV-UHFFFAOYSA-N 751178 US20250195521, Example A63 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751178&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347672 519649772 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542034 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)c1ncc[nH]1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H56N8O7/c1-8-53-38-12-11-29-22-33(38)34(40(53)35-24-47-14-13-30(35)25-60-7)23-46(4,5)26-61-45(59)36-10-9-17-54(51-36)43(57)37(20-28-18-31(29)21-32(55)19-28)50-42(56)39(27(2)3)52(6)44(58)41-48-15-16-49-41/h11-16,18-19,21-22,24,27,36-37,39,51,55H,8-10,17,20,23,25-26H2,1-7H3,(H,48,49)(H,50,56) ARVSODLOZGRMAM-UHFFFAOYSA-N 751179 US20250195521, Example A64 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751179&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159350508 519649773 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542035 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CN1CCOCC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O8/c1-8-54-41-12-11-32-24-36(41)37(44(54)38-26-49-14-13-33(38)28-61-7)25-48(4,5)29-63-47(60)39-10-9-15-55(51-39)46(59)40(22-31-20-34(32)23-35(56)21-31)50-45(58)43(30(2)3)52(6)42(57)27-53-16-18-62-19-17-53/h11-14,20-21,23-24,26,30,39-40,43,51,56H,8-10,15-19,22,25,27-29H2,1-7H3,(H,50,58) STOQLEXLUVAAPW-UHFFFAOYSA-N 751180 US20250195521, Example A65 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751180&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156736480 519649774 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542036 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCCCN)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H63N7O7/c1-8-53-40-15-14-31-24-35(40)36(43(53)37-26-49-18-16-32(37)27-60-7)25-47(4,5)28-61-46(59)38-12-11-19-54(51-38)45(58)39(22-30-20-33(31)23-34(55)21-30)50-44(57)42(29(2)3)52(6)41(56)13-9-10-17-48/h14-16,18,20-21,23-24,26,29,38-39,42,51,55H,8-13,17,19,22,25,27-28,48H2,1-7H3,(H,50,57) VWBSTJPKOQLEFV-UHFFFAOYSA-N 751181 US20250195521, Example A66 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751181&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156736469 519649775 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542037 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCN)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H59N7O7/c1-8-51-38-12-11-29-22-33(38)34(41(51)35-24-47-16-14-30(35)25-58-7)23-45(4,5)26-59-44(57)36-10-9-17-52(49-36)43(56)37(20-28-18-31(29)21-32(53)19-28)48-42(55)40(27(2)3)50(6)39(54)13-15-46/h11-12,14,16,18-19,21-22,24,27,36-37,40,49,53H,8-10,13,15,17,20,23,25-26,46H2,1-7H3,(H,48,55) PHJSDNNCGKHXQM-UHFFFAOYSA-N 751182 US20250195521, Example A67 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751182&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160758868 519649776 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542038 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CNC(=N)N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H59N9O7/c1-8-53-37-12-11-28-20-32(37)33(40(53)34-22-48-14-13-29(34)24-60-7)21-45(4,5)25-61-43(59)35-10-9-15-54(51-35)42(58)36(18-27-16-30(28)19-31(55)17-27)50-41(57)39(26(2)3)52(6)38(56)23-49-44(46)47/h11-14,16-17,19-20,22,26,35-36,39,51,55H,8-10,15,18,21,23-25H2,1-7H3,(H,50,57)(H4,46,47,49) YFNPCQHIALZYNT-UHFFFAOYSA-N 751183 US20250195521, Example A68 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751183&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 157728108 519649777 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542039 CCn1c(-c2ccccc2CCOC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CNC(=N)N)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N8O7/c1-8-54-39-16-15-31-24-35(39)36(42(54)34-13-10-9-12-30(34)17-19-61-7)25-47(4,5)27-62-45(60)37-14-11-18-55(52-37)44(59)38(22-29-20-32(31)23-33(56)21-29)51-43(58)41(28(2)3)53(6)40(57)26-50-46(48)49/h9-10,12-13,15-16,20-21,23-24,28,37-38,41,52,56H,8,11,14,17-19,22,25-27H2,1-7H3,(H,51,58)(H4,48,49,50) VCSYIXPKHLFRLN-UHFFFAOYSA-N 751184 US20250195521, Example A69 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751184&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158307575 519649778 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542040 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H63N7O8/c1-9-55-42-13-12-32-23-37(42)38(44(55)39-25-50-16-14-34(39)27-63-8)24-49(5,6)28-64-48(62)40-11-10-17-56(52-40)47(61)41(21-31-19-35(32)22-36(58)20-31)51-45(59)43(29(2)3)53(7)46(60)33-15-18-54(26-33)30(4)57/h12-14,16,19-20,22-23,25,29,33,40-41,43,52,58H,9-11,15,17-18,21,24,26-28H2,1-8H3,(H,51,59) LLABUPIZWWIFKX-UHFFFAOYSA-N 751185 US20250195521, Example A7 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751185&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161215250 519649779 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542041 CCn1c(-c2ccccc2CCOC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)CCN)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H62N6O7/c1-8-52-40-16-15-32-26-36(40)37(43(52)35-13-10-9-12-31(35)18-21-59-7)27-47(4,5)28-60-46(58)38-14-11-20-53(50-38)45(57)39(24-30-22-33(32)25-34(54)23-30)49-44(56)42(29(2)3)51(6)41(55)17-19-48/h9-10,12-13,15-16,22-23,25-26,29,38-39,42,50,54H,8,11,14,17-21,24,27-28,48H2,1-7H3,(H,49,56) JAOWURVSSHTPNH-UHFFFAOYSA-N 751186 US20250195521, Example A70 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751186&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160856295 519649780 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542042 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H]([C@H](C)OC)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O8/c1-9-49-38-13-12-29-21-33(38)34(40(49)35-23-45-15-14-30(35)24-56-7)22-44(4,5)25-58-43(55)36-11-10-16-50(47-36)42(54)37(19-28-17-31(29)20-32(52)18-28)46-41(53)39(26(2)57-8)48(6)27(3)51/h12-15,17-18,20-21,23,26,36-37,39,47,52H,9-11,16,19,22,24-25H2,1-8H3,(H,46,53) RJTAGAYCSSLYLK-UHFFFAOYSA-N 751187 US20250195521, Example A75 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751187&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346899 519649781 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542043 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H]([C@@H](C)OC)N(C)C(C)=O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H56N6O8/c1-9-49-38-13-12-29-21-33(38)34(40(49)35-23-45-15-14-30(35)24-56-7)22-44(4,5)25-58-43(55)36-11-10-16-50(47-36)42(54)37(19-28-17-31(29)20-32(52)18-28)46-41(53)39(26(2)57-8)48(6)27(3)51/h12-15,17-18,20-21,23,26,36-37,39,47,52H,9-11,16,19,22,24-25H2,1-8H3,(H,46,53) RJTAGAYCSSLYLK-UHFFFAOYSA-N 751188 US20250195521, Example A76 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751188&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346902 519649782 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542044 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)CC(F)(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C44H55F3N6O6/c1-8-52-37-12-11-28-20-32(37)33(39(52)34-22-48-14-13-29(34)23-58-7)21-43(4,5)25-59-42(57)35-10-9-15-53(50-35)41(56)36(18-27-16-30(28)19-31(54)17-27)49-40(55)38(26(2)3)51(6)24-44(45,46)47/h11-14,16-17,19-20,22,26,35-36,38,50,54H,8-10,15,18,21,23-25H2,1-7H3,(H,49,55) ZFNARQPMTWGPGD-UHFFFAOYSA-N 751189 US20250195521, Example A77 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751189&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346519 519649783 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542045 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1NC[C@@H]3C[C@@H]31)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H61N7O7/c1-8-54-40-12-11-29-20-35(40)36(43(54)37-24-49-14-13-30(37)25-61-7)22-48(4,5)26-62-47(60)38-10-9-15-55(52-38)45(58)39(18-28-16-31(29)19-33(56)17-28)51-44(57)42(27(2)3)53(6)46(59)41-34-21-32(34)23-50-41/h11-14,16-17,19-20,24,27,32,34,38-39,41-42,50,52,56H,8-10,15,18,21-23,25-26H2,1-7H3,(H,51,57) BGVYZMWKSVBFAA-UHFFFAOYSA-N 751190 US20250195521, Example A78 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751190&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347029 519649784 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542046 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CNC[C@@H]1C(F)(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H60F3N7O7/c1-8-57-40-12-11-29-20-33(40)34(42(57)35-22-52-14-13-30(35)25-64-7)21-47(4,5)26-65-46(63)38-10-9-15-58(55-38)45(62)39(18-28-16-31(29)19-32(59)17-28)54-43(60)41(27(2)3)56(6)44(61)36-23-53-24-37(36)48(49,50)51/h11-14,16-17,19-20,22,27,36-39,41,53,55,59H,8-10,15,18,21,23-26H2,1-7H3,(H,54,60) ZOXRDJSVTKFBBH-UHFFFAOYSA-N 751191 US20250195521, Example A79 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751191&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347425 519649785 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542047 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C(C)(C)N(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C53H72N8O8/c1-12-60-44-16-15-34-26-39(44)40(46(60)41-28-54-19-17-36(41)30-68-11)27-52(4,5)31-69-50(66)42-14-13-20-61(56-42)49(65)43(24-33-22-37(34)25-38(62)23-33)55-47(63)45(32(2)3)58(10)48(64)35-18-21-59(29-35)51(67)53(6,7)57(8)9/h15-17,19,22-23,25-26,28,32,35,42-43,45,56,62H,12-14,18,20-21,24,27,29-31H2,1-11H3,(H,55,63) ULTGDPPCWIXNDW-UHFFFAOYSA-N 751192 US20250195521, Example A8 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751192&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160555315 519649786 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542048 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CN(C(C)=O)C[C@@H]1C(F)(F)F)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C50H62F3N7O8/c1-9-59-42-13-12-31-21-35(42)36(44(59)37-23-54-15-14-32(37)26-67-8)22-49(5,6)27-68-48(66)40-11-10-16-60(56-40)47(65)41(19-30-17-33(31)20-34(62)18-30)55-45(63)43(28(2)3)57(7)46(64)38-24-58(29(4)61)25-39(38)50(51,52)53/h12-15,17-18,20-21,23,28,38-41,43,56,62H,9-11,16,19,22,24-27H2,1-8H3,(H,55,63) OFDJFZQWPOITRU-UHFFFAOYSA-N 751193 US20250195521, Example A80 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751193&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159975819 519649787 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542049 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OC1CNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H59N7O8/c1-8-52-39-12-11-29-20-34(39)35(41(52)36-24-47-14-13-30(36)25-59-7)21-46(4,5)26-60-44(57)37-10-9-15-53(50-37)43(56)38(18-28-16-31(29)19-32(54)17-28)49-42(55)40(27(2)3)51(6)45(58)61-33-22-48-23-33/h11-14,16-17,19-20,24,27,33,37-38,40,48,50,54H,8-10,15,18,21-23,25-26H2,1-7H3,(H,49,55) DNCCTABTBOQWID-UHFFFAOYSA-N 751194 US20250195521, Example A81 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751194&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347438 519649788 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542050 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)O[C@@H]1CCOC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O9/c1-8-52-40-12-11-30-22-35(40)36(42(52)37-24-48-15-13-31(37)25-59-7)23-47(4,5)27-61-45(57)38-10-9-16-53(50-38)44(56)39(20-29-18-32(30)21-33(54)19-29)49-43(55)41(28(2)3)51(6)46(58)62-34-14-17-60-26-34/h11-13,15,18-19,21-22,24,28,34,38-39,41,50,54H,8-10,14,16-17,20,23,25-27H2,1-7H3,(H,49,55) NUQSLYQMXSXCKQ-UHFFFAOYSA-N 751195 US20250195521, Example A82 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751195&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347434 519649789 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542051 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCN1C)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-9-54-40-15-14-31-24-35(40)36(43(54)37-26-49-17-16-32(37)27-61-8)25-48(4,5)28-62-47(60)38-12-10-19-55(51-38)45(58)39(22-30-20-33(31)23-34(56)21-30)50-44(57)42(29(2)3)53(7)46(59)41-13-11-18-52(41)6/h14-17,20-21,23-24,26,29,38-39,41-42,51,56H,9-13,18-19,22,25,27-28H2,1-8H3,(H,50,57) VIQOATDSPPTPJV-UHFFFAOYSA-N 751196 US20250195521, Example A83 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751196&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161309138 519649790 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542052 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CCN(C)CC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H65N7O7/c1-9-55-42-13-12-33-25-37(42)38(44(55)39-27-50-17-14-34(39)28-62-8)26-49(4,5)29-63-48(61)40-11-10-18-56(52-40)47(60)41(23-31-21-35(33)24-36(57)22-31)51-45(58)43(30(2)3)54(7)46(59)32-15-19-53(6)20-16-32/h12-14,17,21-22,24-25,27,30,32,40-41,43,52,57H,9-11,15-16,18-20,23,26,28-29H2,1-8H3,(H,51,58) KDHGBLPXONBXRR-UHFFFAOYSA-N 751197 US20250195521, Example A84 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751197 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751197&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348129 519649791 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542053 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H63N7O7/c1-8-54-41-14-13-31-23-36(41)37(43(54)38-26-50-17-15-33(38)27-61-7)24-48(4,5)28-62-47(60)39-12-10-18-55(52-39)46(59)40(21-30-19-34(31)22-35(56)20-30)51-44(57)42(29(2)3)53(6)45(58)32-11-9-16-49-25-32/h13-15,17,19-20,22-23,26,29,32,39-40,42,49,52,56H,8-12,16,18,21,24-25,27-28H2,1-7H3,(H,51,57) VIWJKSRFFLINLW-UHFFFAOYSA-N 751198 US20250195521, Example A85 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751198&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161310886 519649792 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542054 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)c1nccs1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H55N7O6S/c1-8-51-38-12-11-29-22-33(38)34(40(51)35-24-46-14-13-30(35)25-57-7)23-45(4,5)26-58-43(56)36-10-9-16-52(49-36)42(55)37(20-28-18-31(29)21-32(53)19-28)48-41(54)39(27(2)3)50(6)44-47-15-17-59-44/h11-15,17-19,21-22,24,27,36-37,39,49,53H,8-10,16,20,23,25-26H2,1-7H3,(H,48,54) IKSUILJJUYGEMN-UHFFFAOYSA-N 751199 US20250195521, Example A86 GTPase KRas [G12D] Homo sapiens >10000 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751199 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751199&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346894 519649793 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542055 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CNC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H59N7O7/c1-8-52-39-12-11-29-20-34(39)35(41(52)36-24-47-14-13-30(36)25-59-7)21-46(4,5)26-60-45(58)37-10-9-15-53(50-37)44(57)38(18-28-16-31(29)19-33(54)17-28)49-42(55)40(27(2)3)51(6)43(56)32-22-48-23-32/h11-14,16-17,19-20,24,27,32,37-38,40,48,50,54H,8-10,15,18,21-23,25-26H2,1-7H3,(H,49,55) LDSLPKKSIZLTDQ-UHFFFAOYSA-N 751200 US20250195521, Example A87 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751200&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156348121 519649794 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542056 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1CN(C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H61N7O7/c1-9-53-40-13-12-30-21-35(40)36(42(53)37-23-48-15-14-31(37)26-60-8)22-47(4,5)27-61-46(59)38-11-10-16-54(50-38)45(58)39(19-29-17-32(30)20-34(55)18-29)49-43(56)41(28(2)3)52(7)44(57)33-24-51(6)25-33/h12-15,17-18,20-21,23,28,33,38-39,41,50,55H,9-11,16,19,22,24-27H2,1-8H3,(H,49,56) RFJBUDTWXMUMIU-UHFFFAOYSA-N 751201 US20250195521, Example A88 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751201&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160609807 519649795 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542057 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(O)COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O9/c1-8-51-38-12-11-29-20-33(38)34(40(51)35-22-47-14-13-30(35)23-59-7)21-45(4,5)24-61-43(56)36-10-9-15-52(49-36)42(55)37(18-28-16-31(29)19-32(53)17-28)48-41(54)39(27(2)3)50(6)44(57)46(58)25-60-26-46/h11-14,16-17,19-20,22,27,36-37,39,49,53,58H,8-10,15,18,21,23-26H2,1-7H3,(H,48,54) WQBMFCZGZHXHCL-UHFFFAOYSA-N 751202 US20250195521, Example A89 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751202&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 161574468 519649796 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542058 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)C3COC3)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H65N7O9/c1-8-57-43-12-11-32-22-38(43)39(45(57)40-24-52-15-13-34(40)26-65-7)23-51(4,5)29-67-50(64)41-10-9-16-58(54-41)49(63)42(20-31-18-35(32)21-37(59)19-31)53-46(60)44(30(2)3)55(6)47(61)33-14-17-56(25-33)48(62)36-27-66-28-36/h11-13,15,18-19,21-22,24,30,33,36,41-42,44,54,59H,8-10,14,16-17,20,23,25-29H2,1-7H3,(H,53,60) ZGPOGVIPNSZOIS-UHFFFAOYSA-N 751203 US20250195521, Example A9 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751203&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158523242 519649797 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542059 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-8-52-39-14-13-30-23-34(39)35(42(52)36-25-48-16-15-31(36)26-59-7)24-47(4,5)27-61-46(58)37-11-9-17-53(50-37)44(56)38(21-29-19-32(30)22-33(54)20-29)49-43(55)41(28(2)3)51(6)45(57)40-12-10-18-60-40/h13-16,19-20,22-23,25,28,37-38,40-41,50,54H,8-12,17-18,21,24,26-27H2,1-7H3,(H,49,55) BIIJZFDFKWBFHM-UHFFFAOYSA-N 751204 US20250195521, Example A90 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751204&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347702 519649798 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542060 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCCO1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-8-52-39-14-13-30-23-34(39)35(42(52)36-25-48-16-15-31(36)26-59-7)24-47(4,5)27-61-46(58)37-11-9-17-53(50-37)44(56)38(21-29-19-32(30)22-33(54)20-29)49-43(55)41(28(2)3)51(6)45(57)40-12-10-18-60-40/h13-16,19-20,22-23,25,28,37-38,40-41,50,54H,8-12,17-18,21,24,26-27H2,1-7H3,(H,49,55) BIIJZFDFKWBFHM-UHFFFAOYSA-N 751205 US20250195521, Example A91 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751205&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347379 519649799 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542061 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H](C)O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N6O8/c1-9-50-38-13-12-29-21-33(38)34(40(50)35-23-46-15-14-30(35)24-58-8)22-45(5,6)25-59-44(57)36-11-10-16-51(48-36)43(56)37(19-28-17-31(29)20-32(53)18-28)47-41(54)39(26(2)3)49(7)42(55)27(4)52/h12-15,17-18,20-21,23,26-27,36-37,39,48,52-53H,9-11,16,19,22,24-25H2,1-8H3,(H,47,54) HUOVKZBKBKLDFR-UHFFFAOYSA-N 751206 US20250195521, Example A92 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751206 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751206&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346926 519649800 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542062 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H](C)O)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C45H58N6O8/c1-9-50-38-13-12-29-21-33(38)34(40(50)35-23-46-15-14-30(35)24-58-8)22-45(5,6)25-59-44(57)36-11-10-16-51(48-36)43(56)37(19-28-17-31(29)20-32(53)18-28)47-41(54)39(26(2)3)49(7)42(55)27(4)52/h12-15,17-18,20-21,23,26-27,36-37,39,48,52-53H,9-11,16,19,22,24-25H2,1-8H3,(H,47,54) HUOVKZBKBKLDFR-UHFFFAOYSA-N 751207 US20250195521, Example A93 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751207 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751207&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158592188 519649801 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542063 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@@H]1CCOC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C47H60N6O8/c1-8-52-40-12-11-30-22-35(40)36(42(52)37-24-48-15-13-31(37)25-59-7)23-47(4,5)27-61-46(58)38-10-9-16-53(50-38)45(57)39(20-29-18-33(30)21-34(54)19-29)49-43(55)41(28(2)3)51(6)44(56)32-14-17-60-26-32/h11-13,15,18-19,21-22,24,28,32,38-39,41,50,54H,8-10,14,16-17,20,23,25-27H2,1-7H3,(H,49,55) IOWITRRMARPJIP-UHFFFAOYSA-N 751208 US20250195521, Example A94 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751208&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 158762673 519649802 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542064 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H70N8O8/c1-11-59-43-17-16-34-26-39(43)40(47(59)38-14-12-19-53-45(38)32(4)67-10)27-52(5,6)30-68-51(66)41-15-13-20-60(55-41)50(65)42(24-33-22-36(34)25-37(61)23-33)54-48(63)46(31(2)3)57(9)49(64)35-18-21-58(28-35)44(62)29-56(7)8/h12,14,16-17,19,22-23,25-26,31-32,35,41-42,46,55,61H,11,13,15,18,20-21,24,27-30H2,1-10H3,(H,54,63) WMCSECRLFJWCLH-UHFFFAOYSA-N 751209 US20250195521, Example A95 GTPase KRas [G12D] Homo sapiens 55.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751209 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751209&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156346931 519649803 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542065 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C52H70N8O7/c1-11-59-43-20-19-36-27-39(43)40(47(59)38-17-13-22-53-45(38)33(4)66-10)28-52(5,6)31-67-51(65)41-18-14-23-60(55-41)50(64)42(26-34-15-12-16-35(36)25-34)54-48(62)46(32(2)3)57(9)49(63)37-21-24-58(29-37)44(61)30-56(7)8/h12-13,15-17,19-20,22,25,27,32-33,37,41-42,46,55H,11,14,18,21,23-24,26,28-31H2,1-10H3,(H,54,62) UGSCBVPFIYFSOQ-UHFFFAOYSA-N 751210 US20250195521, Example A96 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751210 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751210&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347397 519649804 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542066 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CN(C)C)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C49H67N9O7S/c1-11-57-39-17-16-31-22-34(39)35(44(57)33-14-12-19-50-42(33)30(4)64-10)24-49(5,6)28-65-48(63)36-15-13-20-58(53-36)47(62)37(23-40-51-38(31)27-66-40)52-45(60)43(29(2)3)55(9)46(61)32-18-21-56(25-32)41(59)26-54(7)8/h12,14,16-17,19,22,27,29-30,32,36-37,43,53H,11,13,15,18,20-21,23-26,28H2,1-10H3,(H,52,60) MRQKLWAOZMIPEA-UHFFFAOYSA-N 751211 US20250195521, Example A97 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751211&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 159651638 519649805 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542067 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CNC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C51H68N8O7/c1-10-58-42-19-18-35-26-38(42)39(46(58)37-16-12-21-53-44(37)32(4)65-9)27-51(5,6)30-66-50(64)40-17-13-22-59(55-40)49(63)41(25-33-14-11-15-34(35)24-33)54-47(61)45(31(2)3)56(8)48(62)36-20-23-57(29-36)43(60)28-52-7/h11-12,14-16,18-19,21,24,26,31-32,36,40-41,45,52,55H,10,13,17,20,22-23,25,27-30H2,1-9H3,(H,54,61) AWLQSNOSMGATIU-UHFFFAOYSA-N 751212 US20250195521, Example A98 GTPase KRas [G12D] Homo sapiens 5500 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751212 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751212&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 156347412 519649806 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542068 CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1csc(n1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(=O)CNC)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C48H65N9O7S/c1-10-56-38-16-15-30-21-33(38)34(43(56)32-13-11-18-50-41(32)29(4)63-9)23-48(5,6)27-64-47(62)35-14-12-19-57(53-35)46(61)36(22-39-51-37(30)26-65-39)52-44(59)42(28(2)3)54(8)45(60)31-17-20-55(25-31)40(58)24-49-7/h11,13,15-16,18,21,26,28-29,31,35-36,42,49,53H,10,12,14,17,19-20,22-25,27H2,1-9H3,(H,52,59) ROMIHKNXTFGWQE-UHFFFAOYSA-N 751213 US20250195521, Example A99 GTPase KRas [G12D] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1006&target=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751213&enzyme=GTPase+KRas+%5BG12D%5D&column=ki&startPg=0&Increment=50&submit=Search 160683753 519649807 1 MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JHL,7NY8,6YXW,6MQN,7W5R,7C41,7C40,6YR8,9PVF,5UK9,5UFE,7RSE,7RSC,6W4E,9KFL,4TQ9,5OCG,4DSU,4DST,4DSO,4DSN,6W4F,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,8QVU,5WPM,5WLB,6P0Z,5VQ0,5VPZ,5VPY,5VPI,5VP7,5V9O,5V9L,5V71,5KYK,6M9W,5WHB,5WHA,9BG5,6GOE,8EPW,8EBZ,7KFZ,6XGV,6OB3,7RP3,8AFC GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1542334 CCC(=O)N1CC[C@H](C(=O)N(C)[C@H](C(=O)N[C@H]2Cc3cc(O)cc(c3)-c3ccc4c(c3)c(c(-c3ccccc3CCOC)n4CC)CC(C)(C)COC(=O)[C@@H]3CCCN(N3)C2=O)C(C)C)C1 InChI=1S/C52H68N6O8/c1-9-45(60)56-22-19-36(30-56)49(62)55(7)46(32(3)4)48(61)53-43-26-33-24-37(27-38(59)25-33)35-17-18-44-40(28-35)41(47(57(44)10-2)39-15-12-11-14-34(39)20-23-65-8)29-52(5,6)31-66-51(64)42-16-13-21-58(54-42)50(43)63/h11-12,14-15,17-18,24-25,27-28,32,36,42-43,46,54,59H,9-10,13,16,19-23,26,29-31H2,1-8H3,(H,53,61) WSKJWPKYVOMLEY-UHFFFAOYSA-N 751214 US20250195521, Example A34 GTPase KRas [G12C] Homo sapiens 550 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751214&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search 161526084 519649808 1 MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90 GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1547589 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(O)COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O9/c1-8-51-38-12-11-29-20-33(38)34(40(51)35-22-47-14-13-30(35)23-59-7)21-45(4,5)24-61-43(56)36-10-9-15-52(49-36)42(55)37(18-28-16-31(29)19-32(53)17-28)48-41(54)39(27(2)3)50(6)44(57)46(58)25-60-26-46/h11-14,16-17,19-20,22,27,36-37,39,49,53,58H,8-10,15,18,21,23-26H2,1-7H3,(H,48,54) WQBMFCZGZHXHCL-UHFFFAOYSA-N 751215 US20250195521, Example A89a GTPase KRas [G12C] Homo sapiens 9.00 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751215&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search 161574468 519649809 1 MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90 GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10 1547591 CCn1c(-c2cnccc2COC)c2c3cc(ccc31)-c1cc(O)cc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)C1(O)COC1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2 InChI=1S/C46H58N6O9/c1-8-51-38-12-11-29-20-33(38)34(40(51)35-22-47-14-13-30(35)23-59-7)21-45(4,5)24-61-43(56)36-10-9-15-52(49-36)42(55)37(18-28-16-31(29)19-32(53)17-28)48-41(54)39(27(2)3)50(6)44(57)46(58)25-60-26-46/h11-14,16-17,19-20,22,27,36-37,39,49,53,58H,8-10,15,18,21,23-26H2,1-7H3,(H,48,54) WQBMFCZGZHXHCL-UHFFFAOYSA-N 751216 US20250195521, Example A89b GTPase KRas [G12C] Homo sapiens 34.0 US Patent 10.7270/Q2MG7V3C US20250195521 AHLER, E; STAHLHUT ESPINOSA, CE; MONTGOMERY, DC; QUINTANA, E; WILDES, DE; LEE, GJ; TOVBIS SHIFRIN, N 6/19/2025 10/14/2025 Revolution Medicines http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=751216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=864&target=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=751216&enzyme=GTPase+KRas+%5BG12C%5D&column=ki&startPg=0&Increment=50&submit=Search 161574468 519649810 1 MTEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM 8JGD,7W5R,7C41,7C40,9KFL,4TQ9,5WPM,5WLB,7NY8,6YXW,6MQN,8G4F,6H47,6H46,5O2T,5O2S,5MLB,5MLA,5VQ0,5VPZ,5VPY,5VPI,5VP7,6YR8,6GJ8,9PVF,5UK9,5UFE,5WHB,5WHA,6GOE,5UFQ,6WS4,9C41,9C3Q,6P0Z,7ROV,9C43,7F0W,7EYX,6M9W,9RKC,9P45,9P44,9GBJ,8AZY,6ZL5,6GJ5,4EPR,8STN,7XKJ,8FMK,8FMJ,9BG5,9C40,8EPW,8EBZ,7KFZ,6XGV,6OB3,9C3R,9U99,9U90 GTPase KRas RASK_HUMAN P01116 A8K8Z5 B0LPF9 P01118 Q96D10