BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 524563 CCS(=O)(=O)N1CC[C@H](NC2=c3nc(-c4cc(C)n(-c5ccc(N6CCOCC6)cc5)c4C)[nH]c3=NCC2Br)C1 InChI=1S/C28H36BrN7O3S/c1-4-40(37,38)35-10-9-20(17-35)31-25-24(29)16-30-28-26(25)32-27(33-28)23-15-18(2)36(19(23)3)22-7-5-21(6-8-22)34-11-13-39-14-12-34/h5-8,15,20,24,31H,4,9-14,16-17H2,1-3H3,(H,30,32,33) YQVAQNWJTMEGMA-UHFFFAOYSA-N 791933 (S)-6-bromo-2-(2,5-dimethyl-1-(4-morpholinophenyl)-1H-pyrrol-3-yl)-N-(1-(ethylsulfonyl) pyrrolidine-3-yl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 1 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 4.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791933 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791933&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524564 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(N6CCOCC6)c5)c4C)nc23)C1 InChI=1S/C28H34BrN7O3S/c1-4-40(37,38)35-9-8-20(17-35)31-25-24(29)16-30-28-26(25)32-27(33-28)23-14-18(2)36(19(23)3)22-7-5-6-21(15-22)34-10-12-39-13-11-34/h5-7,14-16,20H,4,8-13,17H2,1-3H3,(H2,30,31,32,33) RCHAUQLVXFRUCL-UHFFFAOYSA-N 791934 US12545673, Example 2 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 4.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791934 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791934&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524565 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(OCCN6CCOCC6)c5)c4C)[nH]c23)C1 InChI=1S/C30H38BrN7O4S/c1-4-43(39,40)37-9-8-22(19-37)33-27-26(31)18-32-30-28(27)34-29(35-30)25-16-20(2)38(21(25)3)23-6-5-7-24(17-23)42-15-12-36-10-13-41-14-11-36/h5-7,16-18,22H,4,8-15,19H2,1-3H3,(H2,32,33,34,35) QCTIXSGOPHWDBE-UHFFFAOYSA-N 791935 US12545673, Example 3 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 5.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791935 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791935&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524566 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(OCCN6CCOCC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H38BrN7O4S/c1-4-43(39,40)37-10-9-22(19-37)33-27-26(31)18-32-30-28(27)34-29(35-30)25-17-20(2)38(21(25)3)23-5-7-24(8-6-23)42-16-13-36-11-14-41-15-12-36/h5-8,17-18,22H,4,9-16,19H2,1-3H3,(H2,32,33,34,35) FTXWSEWSYRYNNG-UHFFFAOYSA-N 791936 US12545673, Example 4 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 13.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791936&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524567 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(OCCN6CCOCC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H38BrN7O4S/c1-4-43(39,40)37-10-9-22(19-37)33-27-26(31)18-32-30-28(27)34-29(35-30)25-17-20(2)38(21(25)3)23-5-7-24(8-6-23)42-16-13-36-11-14-41-15-12-36/h5-8,17-18,22H,4,9-16,19H2,1-3H3,(H2,32,33,34,35) FTXWSEWSYRYNNG-UHFFFAOYSA-N 791936 US12545673, Example 4 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 56.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791936&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524568 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)N6CCOCC6)cc5)c4C)nc23)C1 InChI=1S/C29H34BrN7O4S/c1-4-42(39,40)36-10-9-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-15-18(2)37(19(23)3)22-7-5-20(6-8-22)29(38)35-11-13-41-14-12-35/h5-8,15-16,21H,4,9-14,17H2,1-3H3,(H2,31,32,33,34) DEMLPSYWHXUJGZ-UHFFFAOYSA-N 791937 US12545673, Example 5 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 6.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791937&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524569 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)N6CCOCC6)cc5)c4C)nc23)C1 InChI=1S/C29H34BrN7O4S/c1-4-42(39,40)36-10-9-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-15-18(2)37(19(23)3)22-7-5-20(6-8-22)29(38)35-11-13-41-14-12-35/h5-8,15-16,21H,4,9-14,17H2,1-3H3,(H2,31,32,33,34) DEMLPSYWHXUJGZ-UHFFFAOYSA-N 791937 US12545673, Example 5 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 92.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791937&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524570 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)N6CCOCC6)cc5)c4C)nc23)C1 InChI=1S/C29H34BrN7O4S/c1-4-42(39,40)36-10-9-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-15-18(2)37(19(23)3)22-7-5-20(6-8-22)29(38)35-11-13-41-14-12-35/h5-8,15-16,21H,4,9-14,17H2,1-3H3,(H2,31,32,33,34) DEMLPSYWHXUJGZ-UHFFFAOYSA-N 791937 US12545673, Example 5 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 47.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791937 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791937&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524571 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)N6CCOCC6)c5)c4C)nc23)C1 InChI=1S/C29H34BrN7O4S/c1-4-42(39,40)36-9-8-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-14-18(2)37(19(23)3)22-7-5-6-20(15-22)29(38)35-10-12-41-13-11-35/h5-7,14-16,21H,4,8-13,17H2,1-3H3,(H2,31,32,33,34) KRRAGOABOIDARO-UHFFFAOYSA-N 791938 US12545673, Example 6 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 6.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791938&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524572 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)N6CCOCC6)c5)c4C)nc23)C1 InChI=1S/C29H34BrN7O4S/c1-4-42(39,40)36-9-8-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-14-18(2)37(19(23)3)22-7-5-6-20(15-22)29(38)35-10-12-41-13-11-35/h5-7,14-16,21H,4,8-13,17H2,1-3H3,(H2,31,32,33,34) KRRAGOABOIDARO-UHFFFAOYSA-N 791938 US12545673, Example 6 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 181 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791938&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524573 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)N6CCOCC6)c5)c4C)nc23)C1 InChI=1S/C29H34BrN7O4S/c1-4-42(39,40)36-9-8-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-14-18(2)37(19(23)3)22-7-5-6-20(15-22)29(38)35-10-12-41-13-11-35/h5-7,14-16,21H,4,8-13,17H2,1-3H3,(H2,31,32,33,34) KRRAGOABOIDARO-UHFFFAOYSA-N 791938 US12545673, Example 6 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791938 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791938&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524574 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cc(NS(C)(=O)=O)ccc5C)c4C)nc23)C1 InChI=1S/C26H32BrN7O4S2/c1-6-40(37,38)33-10-9-19(14-33)29-23-21(27)13-28-26-24(23)30-25(31-26)20-11-16(3)34(17(20)4)22-12-18(8-7-15(22)2)32-39(5,35)36/h7-8,11-13,19,32H,6,9-10,14H2,1-5H3,(H2,28,29,30,31) RJXOAPIKVLVXBR-UHFFFAOYSA-N 791939 US12545673, Example 7 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 6.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791939&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524575 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cc(NS(C)(=O)=O)ccc5C)c4C)nc23)C1 InChI=1S/C26H32BrN7O4S2/c1-6-40(37,38)33-10-9-19(14-33)29-23-21(27)13-28-26-24(23)30-25(31-26)20-11-16(3)34(17(20)4)22-12-18(8-7-15(22)2)32-39(5,35)36/h7-8,11-13,19,32H,6,9-10,14H2,1-5H3,(H2,28,29,30,31) RJXOAPIKVLVXBR-UHFFFAOYSA-N 791939 US12545673, Example 7 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 44.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791939 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791939&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524576 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(NS(C)(=O)=O)cc5C)c4C)nc23)C1 InChI=1S/C26H32BrN7O4S2/c1-6-40(37,38)33-10-9-19(14-33)29-23-21(27)13-28-26-24(23)30-25(31-26)20-12-16(3)34(17(20)4)22-8-7-18(11-15(22)2)32-39(5,35)36/h7-8,11-13,19,32H,6,9-10,14H2,1-5H3,(H2,28,29,30,31) JOTKXEFDFJWXGI-UHFFFAOYSA-N 791940 US12545673, Example 8 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791940 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791940&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524577 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(NS(C)(=O)=O)c5C)c4C)nc23)C1 InChI=1S/C26H32BrN7O4S2/c1-6-40(37,38)33-11-10-18(14-33)29-23-20(27)13-28-26-24(23)30-25(31-26)19-12-15(2)34(17(19)4)22-9-7-8-21(16(22)3)32-39(5,35)36/h7-9,12-13,18,32H,6,10-11,14H2,1-5H3,(H2,28,29,30,31) DOOCRVNTHCACMN-UHFFFAOYSA-N 791941 US12545673, Example 9 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 10.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791941 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791941&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524578 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(S(=O)(=O)N6CCOCC6)cc5)c4C)nc23)C1 InChI=1S/C28H34BrN7O5S2/c1-4-42(37,38)35-10-9-20(17-35)31-25-24(29)16-30-28-26(25)32-27(33-28)23-15-18(2)36(19(23)3)21-5-7-22(8-6-21)43(39,40)34-11-13-41-14-12-34/h5-8,15-16,20H,4,9-14,17H2,1-3H3,(H2,30,31,32,33) OZIXJVWBQBDYOP-UHFFFAOYSA-N 791942 US12545673, Example 10 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791942 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791942&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524579 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(S(=O)(=O)N6CCOCC6)c5)c4C)nc23)C1 InChI=1S/C28H34BrN7O5S2/c1-4-42(37,38)35-9-8-20(17-35)31-25-24(29)16-30-28-26(25)32-27(33-28)23-14-18(2)36(19(23)3)21-6-5-7-22(15-21)43(39,40)34-10-12-41-13-11-34/h5-7,14-16,20H,4,8-13,17H2,1-3H3,(H2,30,31,32,33) AWHQXQVJQQVHAJ-UHFFFAOYSA-N 791943 US12545673, Example 11 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791943 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791943&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524580 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NS(C)(=O)=O)c5)c4C)[nH]c23)C1 InChI=1S/C25H30BrN7O4S2/c1-5-39(36,37)32-10-9-18(14-32)28-22-21(26)13-27-25-23(22)29-24(30-25)20-11-15(2)33(16(20)3)19-8-6-7-17(12-19)31-38(4,34)35/h6-8,11-13,18,31H,5,9-10,14H2,1-4H3,(H2,27,28,29,30) MUOVPMNIYGMOOH-UHFFFAOYSA-N 791944 US12545673, Example 12 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791944&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524581 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NS(C)(=O)=O)c5)c4C)[nH]c23)C1 InChI=1S/C25H30BrN7O4S2/c1-5-39(36,37)32-10-9-18(14-32)28-22-21(26)13-27-25-23(22)29-24(30-25)20-11-15(2)33(16(20)3)19-8-6-7-17(12-19)31-38(4,34)35/h6-8,11-13,18,31H,5,9-10,14H2,1-4H3,(H2,27,28,29,30) MUOVPMNIYGMOOH-UHFFFAOYSA-N 791944 US12545673, Example 12 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 65.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791944&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524582 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NS(C)(=O)=O)c5)c4C)[nH]c23)C1 InChI=1S/C25H30BrN7O4S2/c1-5-39(36,37)32-10-9-18(14-32)28-22-21(26)13-27-25-23(22)29-24(30-25)20-11-15(2)33(16(20)3)19-8-6-7-17(12-19)31-38(4,34)35/h6-8,11-13,18,31H,5,9-10,14H2,1-4H3,(H2,27,28,29,30) MUOVPMNIYGMOOH-UHFFFAOYSA-N 791944 US12545673, Example 12 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791944 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791944&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524583 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5c(Cl)cccc5Cl)c4C)nc23)C1 InChI=1S/C24H25BrCl2N6O2S/c1-4-36(34,35)32-9-8-15(12-32)29-20-17(25)11-28-24-21(20)30-23(31-24)16-10-13(2)33(14(16)3)22-18(26)6-5-7-19(22)27/h5-7,10-11,15H,4,8-9,12H2,1-3H3,(H2,28,29,30,31) HIMSYTBPFAZQPL-UHFFFAOYSA-N 791945 US12545673, Example 13 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791945 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791945&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524584 CCS(=O)(=O)N1CC[C@H](NC2=c3nc(-c4cc(C)n(-c5cc(Cl)ccc5Cl)c4C)[nH]c3=NCC2Br)C1 InChI=1S/C24H27BrCl2N6O2S/c1-4-36(34,35)32-8-7-16(12-32)29-21-18(25)11-28-24-22(21)30-23(31-24)17-9-13(2)33(14(17)3)20-10-15(26)5-6-19(20)27/h5-6,9-10,16,18,29H,4,7-8,11-12H2,1-3H3,(H,28,30,31) MDBSCWBBRLXGLX-UHFFFAOYSA-N 791946 6-bromo-2-(1-(2,5-dichlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-N—((S)-1-(ethylsulfonyl) pyrrolidine-3-yl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 14 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 17.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791946 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791946&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524585 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(Cl)c(Cl)c5)c4C)nc23)C1 InChI=1S/C24H25BrCl2N6O2S/c1-4-36(34,35)32-8-7-15(12-32)29-21-18(25)11-28-24-22(21)30-23(31-24)17-9-13(2)33(14(17)3)16-5-6-19(26)20(27)10-16/h5-6,9-11,15H,4,7-8,12H2,1-3H3,(H2,28,29,30,31) XFIMGCQQRYZXOA-UHFFFAOYSA-N 791947 US12545673, Example 15 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 34.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791947 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791947&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524586 CCS(=O)(=O)N1CC[C@H](NC2=c3nc(-c4cc(C)n(-c5ccccc5Cl)c4C)[nH]c3=NCC2Br)C1 InChI=1S/C24H28BrClN6O2S/c1-4-35(33,34)31-10-9-16(13-31)28-21-18(25)12-27-24-22(21)29-23(30-24)17-11-14(2)32(15(17)3)20-8-6-5-7-19(20)26/h5-8,11,16,18,28H,4,9-10,12-13H2,1-3H3,(H,27,29,30) KXILJPYWIFKMFS-UHFFFAOYSA-N 791948 6-bromo-2-(1-(2-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-N—((S)-1-(ethylsulfonyl) pyrrolidine-3-yl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 16 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 11.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791948 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791948&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524587 CCS(=O)(=O)N1CC[C@H](NC2=c3nc(-c4cc(C)n(C5C=C(S(N)(=O)=O)C=CC5Cl)c4C)[nH]c3=NCC2Br)C1 InChI=1S/C24H31BrClN7O4S2/c1-4-38(34,35)32-8-7-15(12-32)29-21-18(25)11-28-24-22(21)30-23(31-24)17-9-13(2)33(14(17)3)20-10-16(39(27,36)37)5-6-19(20)26/h5-6,9-10,15,18-20,29H,4,7-8,11-12H2,1-3H3,(H2,27,36,37)(H,28,30,31) ANVGQGSAOSBBRV-UHFFFAOYSA-N 791949 3-(3-(6-bromo-7-(((S)-1-(ethylsulfonyl) pyrrolidine-3-yl)amino)-3H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)-4-chlorobenzenesulfonamide::US12545673, Example 17 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 12.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791949 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791949&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524588 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(S(=O)(=O)NC)c5)c4C)[nH]c23)C1 InChI=1S/C25H30BrN7O4S2/c1-5-38(34,35)32-10-9-17(14-32)29-22-21(26)13-28-25-23(22)30-24(31-25)20-11-15(2)33(16(20)3)18-7-6-8-19(12-18)39(36,37)27-4/h6-8,11-13,17,27H,5,9-10,14H2,1-4H3,(H2,28,29,30,31) VTAGDUDUIJKBOY-UHFFFAOYSA-N 791950 US12545673, Example 18 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 13.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791950&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524589 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(S(=O)(=O)NC)c5)c4C)[nH]c23)C1 InChI=1S/C25H30BrN7O4S2/c1-5-38(34,35)32-10-9-17(14-32)29-22-21(26)13-28-25-23(22)30-24(31-25)20-11-15(2)33(16(20)3)18-7-6-8-19(12-18)39(36,37)27-4/h6-8,11-13,17,27H,5,9-10,14H2,1-4H3,(H2,28,29,30,31) VTAGDUDUIJKBOY-UHFFFAOYSA-N 791950 US12545673, Example 18 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 109 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791950&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524590 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(S(=O)(=O)NC)c5)c4C)[nH]c23)C1 InChI=1S/C25H30BrN7O4S2/c1-5-38(34,35)32-10-9-17(14-32)29-22-21(26)13-28-25-23(22)30-24(31-25)20-11-15(2)33(16(20)3)18-7-6-8-19(12-18)39(36,37)27-4/h6-8,11-13,17,27H,5,9-10,14H2,1-4H3,(H2,28,29,30,31) VTAGDUDUIJKBOY-UHFFFAOYSA-N 791950 US12545673, Example 18 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791950 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791950&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524591 CCNS(=O)(=O)c1cccc(-n2c(C)cc(-c3nc4ncc(Br)c(NC5CCN(S(=O)(=O)CC)C5)c4[nH]3)c2C)c1 InChI=1S/C26H32BrN7O4S2/c1-5-29-40(37,38)20-9-7-8-19(13-20)34-16(3)12-21(17(34)4)25-31-24-23(22(27)14-28-26(24)32-25)30-18-10-11-33(15-18)39(35,36)6-2/h7-9,12-14,18,29H,5-6,10-11,15H2,1-4H3,(H2,28,30,31,32) PLGIZJLMXSZNJO-UHFFFAOYSA-N 791951 US12545673, Example 19 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791951&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524592 CCNS(=O)(=O)c1cccc(-n2c(C)cc(-c3nc4ncc(Br)c(NC5CCN(S(=O)(=O)CC)C5)c4[nH]3)c2C)c1 InChI=1S/C26H32BrN7O4S2/c1-5-29-40(37,38)20-9-7-8-19(13-20)34-16(3)12-21(17(34)4)25-31-24-23(22(27)14-28-26(24)32-25)30-18-10-11-33(15-18)39(35,36)6-2/h7-9,12-14,18,29H,5-6,10-11,15H2,1-4H3,(H2,28,30,31,32) PLGIZJLMXSZNJO-UHFFFAOYSA-N 791951 US12545673, Example 19 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 90.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791951&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524593 CCNS(=O)(=O)c1cccc(-n2c(C)cc(-c3nc4ncc(Br)c(NC5CCN(S(=O)(=O)CC)C5)c4[nH]3)c2C)c1 InChI=1S/C26H32BrN7O4S2/c1-5-29-40(37,38)20-9-7-8-19(13-20)34-16(3)12-21(17(34)4)25-31-24-23(22(27)14-28-26(24)32-25)30-18-10-11-33(15-18)39(35,36)6-2/h7-9,12-14,18,29H,5-6,10-11,15H2,1-4H3,(H2,28,30,31,32) PLGIZJLMXSZNJO-UHFFFAOYSA-N 791951 US12545673, Example 19 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791951 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791951&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524594 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(N)=O)c5)c4C)[nH]c23)C1 InChI=1S/C25H28BrN7O3S/c1-4-37(35,36)32-9-8-17(13-32)29-21-20(26)12-28-25-22(21)30-24(31-25)19-10-14(2)33(15(19)3)18-7-5-6-16(11-18)23(27)34/h5-7,10-12,17H,4,8-9,13H2,1-3H3,(H2,27,34)(H2,28,29,30,31) KNTPPWFJAREMRJ-UHFFFAOYSA-N 791952 US12545673, Example 20 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791952&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524595 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(N)=O)c5)c4C)[nH]c23)C1 InChI=1S/C25H28BrN7O3S/c1-4-37(35,36)32-9-8-17(13-32)29-21-20(26)12-28-25-22(21)30-24(31-25)19-10-14(2)33(15(19)3)18-7-5-6-16(11-18)23(27)34/h5-7,10-12,17H,4,8-9,13H2,1-3H3,(H2,27,34)(H2,28,29,30,31) KNTPPWFJAREMRJ-UHFFFAOYSA-N 791952 US12545673, Example 20 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 217 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791952&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524596 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(N)=O)c5)c4C)[nH]c23)C1 InChI=1S/C25H28BrN7O3S/c1-4-37(35,36)32-9-8-17(13-32)29-21-20(26)12-28-25-22(21)30-24(31-25)19-10-14(2)33(15(19)3)18-7-5-6-16(11-18)23(27)34/h5-7,10-12,17H,4,8-9,13H2,1-3H3,(H2,27,34)(H2,28,29,30,31) KNTPPWFJAREMRJ-UHFFFAOYSA-N 791952 US12545673, Example 20 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 31.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791952 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791952&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524597 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(OCCOC)c5)c4C)[nH]c23)C1 InChI=1S/C27H33BrN6O4S/c1-5-39(35,36)33-10-9-19(16-33)30-24-23(28)15-29-27-25(24)31-26(32-27)22-13-17(2)34(18(22)3)20-7-6-8-21(14-20)38-12-11-37-4/h6-8,13-15,19H,5,9-12,16H2,1-4H3,(H2,29,30,31,32) SFUYSVJDHUGTRF-UHFFFAOYSA-N 791953 US12545673, Example 21 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 15.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791953&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524598 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(OCCOC)c5)c4C)[nH]c23)C1 InChI=1S/C27H33BrN6O4S/c1-5-39(35,36)33-10-9-19(16-33)30-24-23(28)15-29-27-25(24)31-26(32-27)22-13-17(2)34(18(22)3)20-7-6-8-21(14-20)38-12-11-37-4/h6-8,13-15,19H,5,9-12,16H2,1-4H3,(H2,29,30,31,32) SFUYSVJDHUGTRF-UHFFFAOYSA-N 791953 US12545673, Example 21 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 243 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791953&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524599 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(OCCOC)c5)c4C)[nH]c23)C1 InChI=1S/C27H33BrN6O4S/c1-5-39(35,36)33-10-9-19(16-33)30-24-23(28)15-29-27-25(24)31-26(32-27)22-13-17(2)34(18(22)3)20-7-6-8-21(14-20)38-12-11-37-4/h6-8,13-15,19H,5,9-12,16H2,1-4H3,(H2,29,30,31,32) SFUYSVJDHUGTRF-UHFFFAOYSA-N 791953 US12545673, Example 21 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 75.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791953 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791953&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524600 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(OCCOC)cc5)c4C)[nH]c23)C1 InChI=1S/C27H33BrN6O4S/c1-5-39(35,36)33-11-10-19(16-33)30-24-23(28)15-29-27-25(24)31-26(32-27)22-14-17(2)34(18(22)3)20-6-8-21(9-7-20)38-13-12-37-4/h6-9,14-15,19H,5,10-13,16H2,1-4H3,(H2,29,30,31,32) ONLVFGISTSYZPH-UHFFFAOYSA-N 791954 US12545673, Example 22 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 17.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791954&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524601 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(OCCOC)cc5)c4C)[nH]c23)C1 InChI=1S/C27H33BrN6O4S/c1-5-39(35,36)33-11-10-19(16-33)30-24-23(28)15-29-27-25(24)31-26(32-27)22-14-17(2)34(18(22)3)20-6-8-21(9-7-20)38-13-12-37-4/h6-9,14-15,19H,5,10-13,16H2,1-4H3,(H2,29,30,31,32) ONLVFGISTSYZPH-UHFFFAOYSA-N 791954 US12545673, Example 22 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 186 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791954&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524602 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(OCCOC)cc5)c4C)[nH]c23)C1 InChI=1S/C27H33BrN6O4S/c1-5-39(35,36)33-11-10-19(16-33)30-24-23(28)15-29-27-25(24)31-26(32-27)22-14-17(2)34(18(22)3)20-6-8-21(9-7-20)38-13-12-37-4/h6-9,14-15,19H,5,10-13,16H2,1-4H3,(H2,29,30,31,32) ONLVFGISTSYZPH-UHFFFAOYSA-N 791954 US12545673, Example 22 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 38.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791954 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791954&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524603 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(S(N)(=O)=O)c5)c4C)[nH]c23)C1 InChI=1S/C24H28BrN7O4S2/c1-4-37(33,34)31-9-8-16(13-31)28-21-20(25)12-27-24-22(21)29-23(30-24)19-10-14(2)32(15(19)3)17-6-5-7-18(11-17)38(26,35)36/h5-7,10-12,16H,4,8-9,13H2,1-3H3,(H2,26,35,36)(H2,27,28,29,30) FPFOJAXMYPLIFT-UHFFFAOYSA-N 791955 US12545673, Example 23 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 17.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791955&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524604 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(S(N)(=O)=O)c5)c4C)[nH]c23)C1 InChI=1S/C24H28BrN7O4S2/c1-4-37(33,34)31-9-8-16(13-31)28-21-20(25)12-27-24-22(21)29-23(30-24)19-10-14(2)32(15(19)3)17-6-5-7-18(11-17)38(26,35)36/h5-7,10-12,16H,4,8-9,13H2,1-3H3,(H2,26,35,36)(H2,27,28,29,30) FPFOJAXMYPLIFT-UHFFFAOYSA-N 791955 US12545673, Example 23 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 56.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791955&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524605 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(S(N)(=O)=O)c5)c4C)[nH]c23)C1 InChI=1S/C24H28BrN7O4S2/c1-4-37(33,34)31-9-8-16(13-31)28-21-20(25)12-27-24-22(21)29-23(30-24)19-10-14(2)32(15(19)3)17-6-5-7-18(11-17)38(26,35)36/h5-7,10-12,16H,4,8-9,13H2,1-3H3,(H2,26,35,36)(H2,27,28,29,30) FPFOJAXMYPLIFT-UHFFFAOYSA-N 791955 US12545673, Example 23 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791955 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791955&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524606 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(S(N)(=O)=O)cc5)c4C)[nH]c23)C1 InChI=1S/C24H28BrN7O4S2/c1-4-37(33,34)31-10-9-16(13-31)28-21-20(25)12-27-24-22(21)29-23(30-24)19-11-14(2)32(15(19)3)17-5-7-18(8-6-17)38(26,35)36/h5-8,11-12,16H,4,9-10,13H2,1-3H3,(H2,26,35,36)(H2,27,28,29,30) ICJLTSAGNPBPJU-UHFFFAOYSA-N 791956 US12545673, Example 24 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 20.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791956&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524607 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(S(N)(=O)=O)cc5)c4C)[nH]c23)C1 InChI=1S/C24H28BrN7O4S2/c1-4-37(33,34)31-10-9-16(13-31)28-21-20(25)12-27-24-22(21)29-23(30-24)19-11-14(2)32(15(19)3)17-5-7-18(8-6-17)38(26,35)36/h5-8,11-12,16H,4,9-10,13H2,1-3H3,(H2,26,35,36)(H2,27,28,29,30) ICJLTSAGNPBPJU-UHFFFAOYSA-N 791956 US12545673, Example 24 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 95.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791956&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524608 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(S(N)(=O)=O)cc5)c4C)[nH]c23)C1 InChI=1S/C24H28BrN7O4S2/c1-4-37(33,34)31-10-9-16(13-31)28-21-20(25)12-27-24-22(21)29-23(30-24)19-11-14(2)32(15(19)3)17-5-7-18(8-6-17)38(26,35)36/h5-8,11-12,16H,4,9-10,13H2,1-3H3,(H2,26,35,36)(H2,27,28,29,30) ICJLTSAGNPBPJU-UHFFFAOYSA-N 791956 US12545673, Example 24 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 29.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791956 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791956&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524609 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccccc5)c4C)nc23)C1 InChI=1S/C24H27BrN6O2S/c1-4-34(32,33)30-11-10-17(14-30)27-21-20(25)13-26-24-22(21)28-23(29-24)19-12-15(2)31(16(19)3)18-8-6-5-7-9-18/h5-9,12-13,17H,4,10-11,14H2,1-3H3,(H2,26,27,28,29) RWKDUVXGPYCACK-UHFFFAOYSA-N 791957 (S)-6-bromo-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-N-(1-(ethylsulfonyl) pyrrolidine-3-yl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 25 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 26.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791957&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524610 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccccc5)c4C)nc23)C1 InChI=1S/C24H27BrN6O2S/c1-4-34(32,33)30-11-10-17(14-30)27-21-20(25)13-26-24-22(21)28-23(29-24)19-12-15(2)31(16(19)3)18-8-6-5-7-9-18/h5-9,12-13,17H,4,10-11,14H2,1-3H3,(H2,26,27,28,29) RWKDUVXGPYCACK-UHFFFAOYSA-N 791957 (S)-6-bromo-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-N-(1-(ethylsulfonyl) pyrrolidine-3-yl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 25 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 250 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791957&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524611 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccccc5)c4C)nc23)C1 InChI=1S/C24H27BrN6O2S/c1-4-34(32,33)30-11-10-17(14-30)27-21-20(25)13-26-24-22(21)28-23(29-24)19-12-15(2)31(16(19)3)18-8-6-5-7-9-18/h5-9,12-13,17H,4,10-11,14H2,1-3H3,(H2,26,27,28,29) RWKDUVXGPYCACK-UHFFFAOYSA-N 791957 (S)-6-bromo-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-N-(1-(ethylsulfonyl) pyrrolidine-3-yl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 25 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 71.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791957 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791957&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524612 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1c(Cl)cccc1Cl InChI=1S/C24H19BrCl2N6O2S/c1-12-9-16(13(2)33(12)22-18(26)7-4-8-19(22)27)23-31-21-20(17(25)11-29-24(21)32-23)30-14-5-3-6-15(10-14)36(28,34)35/h3-11H,1-2H3,(H2,28,34,35)(H2,29,30,31,32) FVEDUJLDWZUBPI-UHFFFAOYSA-N 791958 3-((6-bromo-2-(1-(2,6-dichlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 26 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 19.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791958 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791958&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524613 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1ccc(C(=O)N2CCOCC2)cc1 InChI=1S/C29H28BrN7O4S/c1-17-14-23(18(2)37(17)21-8-6-19(7-9-21)29(38)36-10-12-41-13-11-36)27-34-26-25(24(30)16-32-28(26)35-27)33-20-4-3-5-22(15-20)42(31,39)40/h3-9,14-16H,10-13H2,1-2H3,(H2,31,39,40)(H2,32,33,34,35) CQYKDYHDMBORSI-UHFFFAOYSA-N 791959 3-((6-bromo-2-(2,5-dimethyl-1-(4-(morpholine-4-carbonyl)phenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 27 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 20.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791959&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524614 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1ccc(C(=O)N2CCOCC2)cc1 InChI=1S/C29H28BrN7O4S/c1-17-14-23(18(2)37(17)21-8-6-19(7-9-21)29(38)36-10-12-41-13-11-36)27-34-26-25(24(30)16-32-28(26)35-27)33-20-4-3-5-22(15-20)42(31,39)40/h3-9,14-16H,10-13H2,1-2H3,(H2,31,39,40)(H2,32,33,34,35) CQYKDYHDMBORSI-UHFFFAOYSA-N 791959 3-((6-bromo-2-(2,5-dimethyl-1-(4-(morpholine-4-carbonyl)phenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 27 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 178 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791959&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524615 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1ccc(C(=O)N2CCOCC2)cc1 InChI=1S/C29H28BrN7O4S/c1-17-14-23(18(2)37(17)21-8-6-19(7-9-21)29(38)36-10-12-41-13-11-36)27-34-26-25(24(30)16-32-28(26)35-27)33-20-4-3-5-22(15-20)42(31,39)40/h3-9,14-16H,10-13H2,1-2H3,(H2,31,39,40)(H2,32,33,34,35) CQYKDYHDMBORSI-UHFFFAOYSA-N 791959 3-((6-bromo-2-(2,5-dimethyl-1-(4-(morpholine-4-carbonyl)phenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 27 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 176 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791959 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791959&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524616 Cc1cc(c(C)n1-c1cccc(c1)C(=O)N1CCOCC1)-c1nc2c(Nc3cccc(c3)S(N)(=O)=O)c(Br)cnc2[nH]1 InChI=1S/C29H28BrN7O4S/c1-17-13-23(18(2)37(17)21-7-3-5-19(14-21)29(38)36-9-11-41-12-10-36)27-34-26-25(24(30)16-32-28(26)35-27)33-20-6-4-8-22(15-20)42(31,39)40/h3-8,13-16H,9-12H2,1-2H3,(H2,31,39,40)(H2,32,33,34,35) LADDIBHPOZPBQV-UHFFFAOYSA-N 50620993 CHEMBL5410283::US12545673, Example 28 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 57.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620993&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524617 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1ccc(S(=O)(=O)N2CCOCC2)cc1 InChI=1S/C28H28BrN7O5S2/c1-17-14-23(18(2)36(17)20-6-8-21(9-7-20)43(39,40)35-10-12-41-13-11-35)27-33-26-25(24(29)16-31-28(26)34-27)32-19-4-3-5-22(15-19)42(30,37)38/h3-9,14-16H,10-13H2,1-2H3,(H2,30,37,38)(H2,31,32,33,34) XOVIURLRAAUXDG-UHFFFAOYSA-N 791961 3-((6-bromo-2-(2,5-dimethyl-1-(4-(morpholinosulfonyl)phenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 29 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791961 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791961&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524618 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1ccccc1Cl InChI=1S/C24H20BrClN6O2S/c1-13-10-17(14(2)32(13)20-9-4-3-8-19(20)26)23-30-22-21(18(25)12-28-24(22)31-23)29-15-6-5-7-16(11-15)35(27,33)34/h3-12H,1-2H3,(H2,27,33,34)(H2,28,29,30,31) YPZXYQLZUNXUCP-UHFFFAOYSA-N 791962 3-((6-bromo-2-(1-(2-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 31 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 35.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791962 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791962&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524619 Cc1cc(NS(C)(=O)=O)ccc1-n1c(C)cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c1C InChI=1S/C26H26BrN7O4S2/c1-14-10-18(33-39(4,35)36)8-9-22(14)34-15(2)11-20(16(34)3)25-31-24-23(21(27)13-29-26(24)32-25)30-17-6-5-7-19(12-17)40(28,37)38/h5-13,33H,1-4H3,(H2,28,37,38)(H2,29,30,31,32) GUOUOKWKXNNUPK-UHFFFAOYSA-N 791963 3-((6-bromo-2-(2,5-dimethyl-1-(2-methyl-4-(methylsulfonamido)phenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 32 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 32.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791963 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791963&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524620 Cc1ccc(NS(C)(=O)=O)cc1-n1c(C)cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c1C InChI=1S/C26H26BrN7O4S2/c1-14-8-9-18(33-39(4,35)36)12-22(14)34-15(2)10-20(16(34)3)25-31-24-23(21(27)13-29-26(24)32-25)30-17-6-5-7-19(11-17)40(28,37)38/h5-13,33H,1-4H3,(H2,28,37,38)(H2,29,30,31,32) SDKMICWAVBWTFY-UHFFFAOYSA-N 791964 3-((6-bromo-2-(2,5-dimethyl-1-(2-methyl-5-(methylsulfonamido)phenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 33 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 38.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791964 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791964&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524621 Cc1c(NS(C)(=O)=O)cccc1-n1c(C)cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c1C InChI=1S/C26H26BrN7O4S2/c1-14-11-19(16(3)34(14)22-10-6-9-21(15(22)2)33-39(4,35)36)25-31-24-23(20(27)13-29-26(24)32-25)30-17-7-5-8-18(12-17)40(28,37)38/h5-13,33H,1-4H3,(H2,28,37,38)(H2,29,30,31,32) JUCWYXUZTSQPRJ-UHFFFAOYSA-N 791965 3-((6-bromo-2-(2,5-dimethyl-1-(2-methyl-3-(methylsulfonamido)phenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 34 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 41.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791965 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791965&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524622 Cc1cc(-c2nc3c([nH]2)=NCC(Br)C=3NC2C=C(S(N)(=O)=O)C=CC2)c(C)n1-c1cc(Cl)ccc1Cl InChI=1S/C24H23BrCl2N6O2S/c1-12-8-17(13(2)33(12)20-9-14(26)6-7-19(20)27)23-31-22-21(18(25)11-29-24(22)32-23)30-15-4-3-5-16(10-15)36(28,34)35/h3,5-10,15,18,30H,4,11H2,1-2H3,(H2,28,34,35)(H,29,31,32) FTJZHVBHMRGWSE-UHFFFAOYSA-N 791966 3-((6-bromo-2-(1-(2,5-dichlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 35 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 46.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791966 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791966&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524623 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1cc(S(N)(=O)=O)ccc1Cl InChI=1S/C24H21BrClN7O4S2/c1-12-8-17(13(2)33(12)20-10-16(39(28,36)37)6-7-19(20)26)23-31-22-21(18(25)11-29-24(22)32-23)30-14-4-3-5-15(9-14)38(27,34)35/h3-11H,1-2H3,(H2,27,34,35)(H2,28,36,37)(H2,29,30,31,32) WEDVKXNACWSICM-UHFFFAOYSA-N 791967 3-(3-(6-bromo-7-((3-sulfamoylphenyl)amino)-3H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrole-1-yl)-4-chlorobenzenesulfonamide::US12545673, Example 36 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 46.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791967 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791967&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524624 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1cccc(N2CCOCC2)c1 InChI=1S/C28H28BrN7O3S/c1-17-13-23(18(2)36(17)21-7-4-6-20(15-21)35-9-11-39-12-10-35)27-33-26-25(24(29)16-31-28(26)34-27)32-19-5-3-8-22(14-19)40(30,37)38/h3-8,13-16H,9-12H2,1-2H3,(H2,30,37,38)(H2,31,32,33,34) ZDROOLJMCNLAKT-UHFFFAOYSA-N 791968 3-((6-bromo-2-(2,5-dimethyl-1-(3-morpholinophenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 37 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 47.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791968 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791968&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524625 Cc1cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c(C)n1-c1cccc(OCCN2CCOCC2)c1 InChI=1S/C30H32BrN7O4S/c1-19-15-25(20(2)38(19)22-6-4-7-23(17-22)42-14-11-37-9-12-41-13-10-37)29-35-28-27(26(31)18-33-30(28)36-29)34-21-5-3-8-24(16-21)43(32,39)40/h3-8,15-18H,9-14H2,1-2H3,(H2,32,39,40)(H2,33,34,35,36) CCNCRQWVZXHLKE-UHFFFAOYSA-N 791969 3-((6-bromo-2-(2,5-dimethyl-1-(3-(2-morpholinoethoxy)phenyl)-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 38 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 52.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791969 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791969&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524626 Cc1cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c(C)n1-c1ccc(OCCN2CCOCC2)cc1 InChI=1S/C30H32BrN7O4S/c1-19-16-25(20(2)38(19)22-6-8-23(9-7-22)42-15-12-37-10-13-41-14-11-37)29-35-28-27(26(31)18-33-30(28)36-29)34-21-4-3-5-24(17-21)43(32,39)40/h3-9,16-18H,10-15H2,1-2H3,(H2,32,39,40)(H2,33,34,35,36) ARPCAUQDUDMNCR-UHFFFAOYSA-N 791970 3-((6-bromo-2-(2,5-dimethyl-1-(4-(2-morpholinoethoxy)phenyl)-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 39 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 72.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791970 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791970&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524627 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1ccc(N2CCOCC2)cc1 InChI=1S/C28H28BrN7O3S/c1-17-14-23(18(2)36(17)21-8-6-20(7-9-21)35-10-12-39-13-11-35)27-33-26-25(24(29)16-31-28(26)34-27)32-19-4-3-5-22(15-19)40(30,37)38/h3-9,14-16H,10-13H2,1-2H3,(H2,30,37,38)(H2,31,32,33,34) JPTYXVKYGFFTMF-UHFFFAOYSA-N 791971 3-((6-bromo-2-(2,5-dimethyl-1-(4-morpholinophenyl)-1H-pyrrol-3-yl)-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 40 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 68.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791971 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791971&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524628 Cc1cc(-c2nc3c(Nc4cccc(S(N)(=O)=O)c4)c(Br)cnc3[nH]2)c(C)n1-c1ccc2c(c1)OCO2 InChI=1S/C25H21BrN6O4S/c1-13-8-18(14(2)32(13)16-6-7-20-21(10-16)36-12-35-20)24-30-23-22(19(26)11-28-25(23)31-24)29-15-4-3-5-17(9-15)37(27,33)34/h3-11H,12H2,1-2H3,(H2,27,33,34)(H2,28,29,30,31) HPUUWFFHPBPQFZ-UHFFFAOYSA-N 791972 3-((2-(1-(benzo[d][1,3]dioxole-5-yl)-2,5-dimethyl-1H-pyrrol-3-yl)-6-bromo-3H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 41 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 70.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791972 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791972&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524629 COCCOc1cccc(-n2c(C)cc(-c3nc4ncc(Br)c(Nc5cccc(S(N)(=O)=O)c5)c4[nH]3)c2C)c1 InChI=1S/C27H27BrN6O4S/c1-16-12-22(17(2)34(16)19-7-5-8-20(14-19)38-11-10-37-3)26-32-25-24(23(28)15-30-27(25)33-26)31-18-6-4-9-21(13-18)39(29,35)36/h4-9,12-15H,10-11H2,1-3H3,(H2,29,35,36)(H2,30,31,32,33) FGAJJLRRLJGMBW-UHFFFAOYSA-N 791973 3-((6-bromo-2-(1-(3-(2-methoxyethoxy)phenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 42 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 83.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791973 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791973&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524630 Cc1cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c(C)n1-c1ccccc1 InChI=1S/C24H21BrN6O2S/c1-14-11-19(15(2)31(14)17-8-4-3-5-9-17)23-29-22-21(20(25)13-27-24(22)30-23)28-16-7-6-10-18(12-16)34(26,32)33/h3-13H,1-2H3,(H2,26,32,33)(H2,27,28,29,30) KSTAFUGECYSKAI-UHFFFAOYSA-N 791974 3-((6-bromo-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 43 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 85.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791974 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791974&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524631 Cc1cc(-c2nc3c(Nc4ccc5c(c4)OCO5)c(Br)cnc3[nH]2)c(C)n1-c1cccc(S(N)(=O)=O)c1 InChI=1S/C25H21BrN6O4S/c1-13-8-18(14(2)32(13)16-4-3-5-17(10-16)37(27,33)34)24-30-23-22(19(26)11-28-25(23)31-24)29-15-6-7-20-21(9-15)36-12-35-20/h3-11H,12H2,1-2H3,(H2,27,33,34)(H2,28,29,30,31) UJRFHPURILXTNM-UHFFFAOYSA-N 791975 3-(3-(7-(benzo[d][1,3]dioxole-5-yl-amino)-6-bromo-3H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)benzenesulfonamide::US12545673, Example 44 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 27.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791975&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524632 Cc1cc(-c2nc3c(Nc4ccc5c(c4)OCO5)c(Br)cnc3[nH]2)c(C)n1-c1cccc(S(N)(=O)=O)c1 InChI=1S/C25H21BrN6O4S/c1-13-8-18(14(2)32(13)16-4-3-5-17(10-16)37(27,33)34)24-30-23-22(19(26)11-28-25(23)31-24)29-15-6-7-20-21(9-15)36-12-35-20/h3-11H,12H2,1-2H3,(H2,27,33,34)(H2,28,29,30,31) UJRFHPURILXTNM-UHFFFAOYSA-N 791975 3-(3-(7-(benzo[d][1,3]dioxole-5-yl-amino)-6-bromo-3H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)benzenesulfonamide::US12545673, Example 44 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 211 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791975&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524633 Cc1cc(-c2nc3c(Nc4ccc5c(c4)OCO5)c(Br)cnc3[nH]2)c(C)n1-c1cccc(S(N)(=O)=O)c1 InChI=1S/C25H21BrN6O4S/c1-13-8-18(14(2)32(13)16-4-3-5-17(10-16)37(27,33)34)24-30-23-22(19(26)11-28-25(23)31-24)29-15-6-7-20-21(9-15)36-12-35-20/h3-11H,12H2,1-2H3,(H2,27,33,34)(H2,28,29,30,31) UJRFHPURILXTNM-UHFFFAOYSA-N 791975 3-(3-(7-(benzo[d][1,3]dioxole-5-yl-amino)-6-bromo-3H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)benzenesulfonamide::US12545673, Example 44 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 109 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791975 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791975&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524634 COCCOc1ccc(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc6c(c5)OCO6)c4C)nc23)cc1 InChI=1S/C28H26BrN5O4/c1-16-12-21(17(2)34(16)19-6-9-23-24(13-19)38-15-37-23)27-32-26-25(22(29)14-30-28(26)33-27)31-18-4-7-20(8-5-18)36-11-10-35-3/h4-9,12-14H,10-11,15H2,1-3H3,(H2,30,31,32,33) HJIHGTWRSJGVGM-UHFFFAOYSA-N 791976 2-(1-(benzo[d][1,3]dioxole-5-yl)-2,5-dimethyl-1H-pyrrol-3-yl)-6-bromo-N-(4-(2-methoxyethoxy)phenyl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 45 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 32.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791976&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524635 COCCOc1ccc(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc6c(c5)OCO6)c4C)nc23)cc1 InChI=1S/C28H26BrN5O4/c1-16-12-21(17(2)34(16)19-6-9-23-24(13-19)38-15-37-23)27-32-26-25(22(29)14-30-28(26)33-27)31-18-4-7-20(8-5-18)36-11-10-35-3/h4-9,12-14H,10-11,15H2,1-3H3,(H2,30,31,32,33) HJIHGTWRSJGVGM-UHFFFAOYSA-N 791976 2-(1-(benzo[d][1,3]dioxole-5-yl)-2,5-dimethyl-1H-pyrrol-3-yl)-6-bromo-N-(4-(2-methoxyethoxy)phenyl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 45 Mitogen-activated protein kinase kinase kinase 10 Homo sapiens 524 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001798&target=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791976&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+10&column=ki&startPg=0&Increment=50&submit=Search 1 MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH 2RF0 Mitogen-activated protein kinase kinase kinase 10 M3K10_HUMAN Q02779 Q12761 Q14871 524636 COCCOc1ccc(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc6c(c5)OCO6)c4C)nc23)cc1 InChI=1S/C28H26BrN5O4/c1-16-12-21(17(2)34(16)19-6-9-23-24(13-19)38-15-37-23)27-32-26-25(22(29)14-30-28(26)33-27)31-18-4-7-20(8-5-18)36-11-10-35-3/h4-9,12-14H,10-11,15H2,1-3H3,(H2,30,31,32,33) HJIHGTWRSJGVGM-UHFFFAOYSA-N 791976 2-(1-(benzo[d][1,3]dioxole-5-yl)-2,5-dimethyl-1H-pyrrol-3-yl)-6-bromo-N-(4-(2-methoxyethoxy)phenyl)-3H-imidazo[4,5-b]pyridine-7-amine::US12545673, Example 45 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 85.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791976 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791976&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524637 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc6c(c5)OCO6)c4C)nc23)C1 InChI=1S/C25H27BrN6O4S/c1-4-37(33,34)31-8-7-16(12-31)28-22-19(26)11-27-25-23(22)29-24(30-25)18-9-14(2)32(15(18)3)17-5-6-20-21(10-17)36-13-35-20/h5-6,9-11,16H,4,7-8,12-13H2,1-3H3,(H2,27,28,29,30) SFFBFTYNUAZHMK-UHFFFAOYSA-N 791977 US12545673, Example 49 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 15.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791977&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524638 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc6c(c5)OCO6)c4C)nc23)C1 InChI=1S/C25H27BrN6O4S/c1-4-37(33,34)31-8-7-16(12-31)28-22-19(26)11-27-25-23(22)29-24(30-25)18-9-14(2)32(15(18)3)17-5-6-20-21(10-17)36-13-35-20/h5-6,9-11,16H,4,7-8,12-13H2,1-3H3,(H2,27,28,29,30) SFFBFTYNUAZHMK-UHFFFAOYSA-N 791977 US12545673, Example 49 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 50.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791977 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791977&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524639 CCS(=O)(=O)N1CC[C@H](Nc2ccnc3[nH]c(-c4cc(C)n(-c5cc(NS(C)(=O)=O)ccc5C)c4C)nc23)C1 InChI=1S/C26H33N7O4S2/c1-6-39(36,37)32-12-10-20(15-32)28-22-9-11-27-26-24(22)29-25(30-26)21-13-17(3)33(18(21)4)23-14-19(8-7-16(23)2)31-38(5,34)35/h7-9,11,13-14,20,31H,6,10,12,15H2,1-5H3,(H2,27,28,29,30) FRULESDDJURMNJ-UHFFFAOYSA-N 791978 US12545673, Example 50 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens >30000 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791978&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524640 CCS(=O)(=O)N1CC[C@H](Nc2ccnc3[nH]c(-c4cc(C)n(-c5cc(NS(C)(=O)=O)ccc5C)c4C)nc23)C1 InChI=1S/C26H33N7O4S2/c1-6-39(36,37)32-12-10-20(15-32)28-22-9-11-27-26-24(22)29-25(30-26)21-13-17(3)33(18(21)4)23-14-19(8-7-16(23)2)31-38(5,34)35/h7-9,11,13-14,20,31H,6,10,12,15H2,1-5H3,(H2,27,28,29,30) FRULESDDJURMNJ-UHFFFAOYSA-N 791978 US12545673, Example 50 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens >30000 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791978 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791978&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524641 CCS(=O)(=O)N1CC[C@H](Nc2c(Cl)cnc3[nH]c(-c4cc(C)n(-c5cc(NS(C)(=O)=O)ccc5C)c4C)nc23)C1 InChI=1S/C26H32ClN7O4S2/c1-6-40(37,38)33-10-9-19(14-33)29-23-21(27)13-28-26-24(23)30-25(31-26)20-11-16(3)34(17(20)4)22-12-18(8-7-15(22)2)32-39(5,35)36/h7-8,11-13,19,32H,6,9-10,14H2,1-5H3,(H2,28,29,30,31) LMQAMZBATZYFKH-UHFFFAOYSA-N 791979 US12545673, Example 51 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 330 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791979&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524642 CCS(=O)(=O)N1CC[C@H](Nc2c(Cl)cnc3[nH]c(-c4cc(C)n(-c5cc(NS(C)(=O)=O)ccc5C)c4C)nc23)C1 InChI=1S/C26H32ClN7O4S2/c1-6-40(37,38)33-10-9-19(14-33)29-23-21(27)13-28-26-24(23)30-25(31-26)20-11-16(3)34(17(20)4)22-12-18(8-7-15(22)2)32-39(5,35)36/h7-8,11-13,19,32H,6,9-10,14H2,1-5H3,(H2,28,29,30,31) LMQAMZBATZYFKH-UHFFFAOYSA-N 791979 US12545673, Example 51 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 53.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791979 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791979&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524643 CCS(=O)(=O)N1CC[C@H](Nc2c(Cl)cnc3nc(-c4cc(C)n(-c5ccc(OCCN6CCOCC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H38ClN7O4S/c1-4-43(39,40)37-10-9-22(19-37)33-27-26(31)18-32-30-28(27)34-29(35-30)25-17-20(2)38(21(25)3)23-5-7-24(8-6-23)42-16-13-36-11-14-41-15-12-36/h5-8,17-18,22H,4,9-16,19H2,1-3H3,(H2,32,33,34,35) ULXHCKOEIXLUFY-UHFFFAOYSA-N 791980 US12545673, Example 52 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 324 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791980&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524644 CCS(=O)(=O)N1CC[C@H](Nc2c(Cl)cnc3nc(-c4cc(C)n(-c5ccc(OCCN6CCOCC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H38ClN7O4S/c1-4-43(39,40)37-10-9-22(19-37)33-27-26(31)18-32-30-28(27)34-29(35-30)25-17-20(2)38(21(25)3)23-5-7-24(8-6-23)42-16-13-36-11-14-41-15-12-36/h5-8,17-18,22H,4,9-16,19H2,1-3H3,(H2,32,33,34,35) ULXHCKOEIXLUFY-UHFFFAOYSA-N 791980 US12545673, Example 52 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 87.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791980 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791980&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524645 CCS(=O)(=O)N1CC[C@H](Nc2ccnc3nc(-c4cc(C)n(-c5ccc(OCCN6CCOCC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H39N7O4S/c1-4-42(38,39)36-12-10-23(20-36)32-27-9-11-31-30-28(27)33-29(34-30)26-19-21(2)37(22(26)3)24-5-7-25(8-6-24)41-18-15-35-13-16-40-17-14-35/h5-9,11,19,23H,4,10,12-18,20H2,1-3H3,(H2,31,32,33,34) CLACMJXNGZJBNR-UHFFFAOYSA-N 791981 US12545673, Example 53 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 23181 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791981&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524646 CCS(=O)(=O)N1CC[C@H](Nc2ccnc3nc(-c4cc(C)n(-c5ccc(OCCN6CCOCC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H39N7O4S/c1-4-42(38,39)36-12-10-23(20-36)32-27-9-11-31-30-28(27)33-29(34-30)26-19-21(2)37(22(26)3)24-5-7-25(8-6-24)41-18-15-35-13-16-40-17-14-35/h5-9,11,19,23H,4,10,12-18,20H2,1-3H3,(H2,31,32,33,34) CLACMJXNGZJBNR-UHFFFAOYSA-N 791981 US12545673, Example 53 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 10561 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791981 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791981&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524647 CCS(=O)(=O)N1CC[C@H](Nc2c(Cl)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCOCC6)c5)c4C)[nH]c23)C1 InChI=1S/C29H34ClN7O4S/c1-4-42(39,40)36-9-8-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-14-18(2)37(19(23)3)22-7-5-6-20(15-22)29(38)35-10-12-41-13-11-35/h5-7,14-16,21H,4,8-13,17H2,1-3H3,(H2,31,32,33,34) VKVODUVMGQDQHC-UHFFFAOYSA-N 791982 US12545673, Example 54 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 136 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791982&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524648 CCS(=O)(=O)N1CC[C@H](Nc2c(Cl)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCOCC6)c5)c4C)[nH]c23)C1 InChI=1S/C29H34ClN7O4S/c1-4-42(39,40)36-9-8-21(17-36)32-25-24(30)16-31-28-26(25)33-27(34-28)23-14-18(2)37(19(23)3)22-7-5-6-20(15-22)29(38)35-10-12-41-13-11-35/h5-7,14-16,21H,4,8-13,17H2,1-3H3,(H2,31,32,33,34) VKVODUVMGQDQHC-UHFFFAOYSA-N 791982 US12545673, Example 54 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 84.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791982 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791982&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524649 CCS(=O)(=O)N1CC[C@@H](C1)Nc1ccnc2[nH]c(nc12)-c1cc(C)n(c1C)-c1cccc(c1)C(=O)N1CCOCC1 |r| InChI=1S/C29H35N7O4S/c1-4-41(38,39)35-11-9-22(18-35)31-25-8-10-30-28-26(25)32-27(33-28)24-16-19(2)36(20(24)3)23-7-5-6-21(17-23)29(37)34-12-14-40-15-13-34/h5-8,10,16-17,22H,4,9,11-15,18H2,1-3H3,(H2,30,31,32,33) MNUONHZJRPCMFI-UHFFFAOYSA-N 50620991 CHEMBL5401171::US12545673, Example 55 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 5922 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620991&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524650 CCS(=O)(=O)N1CC[C@@H](C1)Nc1ccnc2[nH]c(nc12)-c1cc(C)n(c1C)-c1cccc(c1)C(=O)N1CCOCC1 |r| InChI=1S/C29H35N7O4S/c1-4-41(38,39)35-11-9-22(18-35)31-25-8-10-30-28-26(25)32-27(33-28)24-16-19(2)36(20(24)3)23-7-5-6-21(17-23)29(37)34-12-14-40-15-13-34/h5-8,10,16-17,22H,4,9,11-15,18H2,1-3H3,(H2,30,31,32,33) MNUONHZJRPCMFI-UHFFFAOYSA-N 50620991 CHEMBL5401171::US12545673, Example 55 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 4655 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50620991 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50620991&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524651 CCN(CC)CCNC(=O)c1cccc(-n2c(C)cc(-c3nc4ncc(Br)c(NC5CCN(S(=O)(=O)CC)C5)c4[nH]3)c2C)c1 InChI=1S/C31H41BrN8O3S/c1-6-38(7-2)15-13-33-31(41)22-10-9-11-24(17-22)40-20(4)16-25(21(40)5)29-36-28-27(26(32)18-34-30(28)37-29)35-23-12-14-39(19-23)44(42,43)8-3/h9-11,16-18,23H,6-8,12-15,19H2,1-5H3,(H,33,41)(H2,34,35,36,37) KZUOUOMEBDSEQB-UHFFFAOYSA-N 791984 US12545673, Example 56 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 122 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791984 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791984&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524652 CCN(CC)CCNC(=O)c1ccc(-n2c(C)cc(-c3nc4ncc(Br)c(NC5CCN(S(=O)(=O)CC)C5)c4[nH]3)c2C)cc1 InChI=1S/C31H41BrN8O3S/c1-6-38(7-2)16-14-33-31(41)22-9-11-24(12-10-22)40-20(4)17-25(21(40)5)29-36-28-27(26(32)18-34-30(28)37-29)35-23-13-15-39(19-23)44(42,43)8-3/h9-12,17-18,23H,6-8,13-16,19H2,1-5H3,(H,33,41)(H2,34,35,36,37) BXFBHQFIHTYCIH-UHFFFAOYSA-N 791985 US12545673, Example 57 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 97.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791985&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524653 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)O)c5)c4C)nc23)C1 InChI=1S/C25H27BrN6O4S/c1-4-37(35,36)31-9-8-17(13-31)28-21-20(26)12-27-24-22(21)29-23(30-24)19-10-14(2)32(15(19)3)18-7-5-6-16(11-18)25(33)34/h5-7,10-12,17H,4,8-9,13H2,1-3H3,(H,33,34)(H2,27,28,29,30) XSTPWOGVWQRXQA-UHFFFAOYSA-N 791986 US12545673, Example 58 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 53.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791986 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791986&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524654 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)O)cc5)c4C)nc23)C1 InChI=1S/C25H27BrN6O4S/c1-4-37(35,36)31-10-9-17(13-31)28-21-20(26)12-27-24-22(21)29-23(30-24)19-11-14(2)32(15(19)3)18-7-5-16(6-8-18)25(33)34/h5-8,11-12,17H,4,9-10,13H2,1-3H3,(H,33,34)(H2,27,28,29,30) OVDPPYWTOMBMFG-UHFFFAOYSA-N 791987 US12545673, Example 59 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 19.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791987 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791987&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524655 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)NCN(C)C)c5)c4C)nc23)C1 InChI=1S/C28H35BrN8O3S/c1-6-41(39,40)36-11-10-20(15-36)32-24-23(29)14-30-27-25(24)33-26(34-27)22-12-17(2)37(18(22)3)21-9-7-8-19(13-21)28(38)31-16-35(4)5/h7-9,12-14,20H,6,10-11,15-16H2,1-5H3,(H,31,38)(H2,30,32,33,34) NRJHZGVYOHNQIP-UHFFFAOYSA-N 791988 US12545673, Example 60 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 27.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791988&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524656 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)NCN(C)C)c5)c4C)nc23)C1 InChI=1S/C28H35BrN8O3S/c1-6-41(39,40)36-11-10-20(15-36)32-24-23(29)14-30-27-25(24)33-26(34-27)22-12-17(2)37(18(22)3)21-9-7-8-19(13-21)28(38)31-16-35(4)5/h7-9,12-14,20H,6,10-11,15-16H2,1-5H3,(H,31,38)(H2,30,32,33,34) NRJHZGVYOHNQIP-UHFFFAOYSA-N 791988 US12545673, Example 60 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791988 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791988&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524657 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)N(C)CCN(C)C)c5)c4C)nc23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-12-11-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-15-19(2)39(20(24)3)23-10-8-9-21(16-23)30(40)37(6)14-13-36(4)5/h8-10,15-17,22H,7,11-14,18H2,1-6H3,(H2,32,33,34,35) SMHCXPVBKCHAHT-UHFFFAOYSA-N 791989 US12545673, Example 61 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 30.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791989&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524658 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)N(C)CCN(C)C)c5)c4C)nc23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-12-11-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-15-19(2)39(20(24)3)23-10-8-9-21(16-23)30(40)37(6)14-13-36(4)5/h8-10,15-17,22H,7,11-14,18H2,1-6H3,(H2,32,33,34,35) SMHCXPVBKCHAHT-UHFFFAOYSA-N 791989 US12545673, Example 61 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791989 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791989&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524659 CCS(=O)(=O)N1CC[C@@H](C1)Nc1c(Br)cnc2[nH]c(nc12)-c1cc(C)n(c1C)-c1ccc(cc1)C(=O)NCCN(C)C |r| InChI=1S/C29H37BrN8O3S/c1-6-42(40,41)37-13-11-21(17-37)33-25-24(30)16-32-28-26(25)34-27(35-28)23-15-18(2)38(19(23)3)22-9-7-20(8-10-22)29(39)31-12-14-36(4)5/h7-10,15-16,21H,6,11-14,17H2,1-5H3,(H,31,39)(H2,32,33,34,35) TYJDSXORSRPUSN-UHFFFAOYSA-N 50621003 CHEMBL5435826::US12545673, Example 62 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 17.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621003&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524660 CCS(=O)(=O)N1CC[C@@H](C1)Nc1c(Br)cnc2[nH]c(nc12)-c1cc(C)n(c1C)-c1ccc(cc1)C(=O)NCCN(C)C |r| InChI=1S/C29H37BrN8O3S/c1-6-42(40,41)37-13-11-21(17-37)33-25-24(30)16-32-28-26(25)34-27(35-28)23-15-18(2)38(19(23)3)22-9-7-20(8-10-22)29(39)31-12-14-36(4)5/h7-10,15-16,21H,6,11-14,17H2,1-5H3,(H,31,39)(H2,32,33,34,35) TYJDSXORSRPUSN-UHFFFAOYSA-N 50621003 CHEMBL5435826::US12545673, Example 62 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621003&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524661 CCS(=O)(=O)N1CC[C@@H](C1)Nc1c(Br)cnc2[nH]c(nc12)-c1cc(C)n(c1C)-c1ccc(cc1)C(=O)N(C)CCN(C)C |r| InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-13-12-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-16-19(2)39(20(24)3)23-10-8-21(9-11-23)30(40)37(6)15-14-36(4)5/h8-11,16-17,22H,7,12-15,18H2,1-6H3,(H2,32,33,34,35) VRAVNWIBZWSUBR-UHFFFAOYSA-N 50621004 CHEMBL5416972::US12545673, Example 63 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621004&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524662 CCS(=O)(=O)N1CC[C@@H](C1)Nc1c(Br)cnc2[nH]c(nc12)-c1cc(C)n(c1C)-c1ccc(cc1)C(=O)N(C)CCN(C)C |r| InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-13-12-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-16-19(2)39(20(24)3)23-10-8-21(9-11-23)30(40)37(6)15-14-36(4)5/h8-11,16-17,22H,7,12-15,18H2,1-6H3,(H2,32,33,34,35) VRAVNWIBZWSUBR-UHFFFAOYSA-N 50621004 CHEMBL5416972::US12545673, Example 63 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50621004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50621004&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524663 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN(C)C)c5)c4C)[nH]c23)C1 InChI=1S/C28H35BrN8O3S/c1-6-41(39,40)36-11-10-20(15-36)32-25-23(29)14-30-28-26(25)33-27(34-28)22-12-17(2)37(18(22)3)21-9-7-8-19(13-21)31-24(38)16-35(4)5/h7-9,12-14,20H,6,10-11,15-16H2,1-5H3,(H,31,38)(H2,30,32,33,34) OYBANAXRUFZOAY-UHFFFAOYSA-N 791992 US12545673, Example 64 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791992&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524664 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN(C)C)c5)c4C)[nH]c23)C1 InChI=1S/C28H35BrN8O3S/c1-6-41(39,40)36-11-10-20(15-36)32-25-23(29)14-30-28-26(25)33-27(34-28)22-12-17(2)37(18(22)3)21-9-7-8-19(13-21)31-24(38)16-35(4)5/h7-9,12-14,20H,6,10-11,15-16H2,1-5H3,(H,31,38)(H2,30,32,33,34) OYBANAXRUFZOAY-UHFFFAOYSA-N 791992 US12545673, Example 64 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791992 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791992&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524665 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCN(C)CC6)c5)c4C)[nH]c23)C1 InChI=1S/C31H40BrN9O3S/c1-5-45(43,44)40-10-9-23(18-40)35-28-26(32)17-33-31-29(28)36-30(37-31)25-15-20(2)41(21(25)3)24-8-6-7-22(16-24)34-27(42)19-39-13-11-38(4)12-14-39/h6-8,15-17,23H,5,9-14,18-19H2,1-4H3,(H,34,42)(H2,33,35,36,37) RHKNSPGTLFJIRH-UHFFFAOYSA-N 791993 US12545673, Example 65 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 26.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791993&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524666 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCN(C)CC6)c5)c4C)[nH]c23)C1 InChI=1S/C31H40BrN9O3S/c1-5-45(43,44)40-10-9-23(18-40)35-28-26(32)17-33-31-29(28)36-30(37-31)25-15-20(2)41(21(25)3)24-8-6-7-22(16-24)34-27(42)19-39-13-11-38(4)12-14-39/h6-8,15-17,23H,5,9-14,18-19H2,1-4H3,(H,34,42)(H2,33,35,36,37) RHKNSPGTLFJIRH-UHFFFAOYSA-N 791993 US12545673, Example 65 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 42.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791993 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791993&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524667 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCOCC6)c5)c4C)[nH]c23)C1 InChI=1S/C30H37BrN8O4S/c1-4-44(41,42)38-9-8-22(17-38)34-27-25(31)16-32-30-28(27)35-29(36-30)24-14-19(2)39(20(24)3)23-7-5-6-21(15-23)33-26(40)18-37-10-12-43-13-11-37/h5-7,14-16,22H,4,8-13,17-18H2,1-3H3,(H,33,40)(H2,32,34,35,36) OJJWCMYQUPFQHH-UHFFFAOYSA-N 791994 US12545673, Example 66 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 17.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791994&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524668 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCOCC6)c5)c4C)[nH]c23)C1 InChI=1S/C30H37BrN8O4S/c1-4-44(41,42)38-9-8-22(17-38)34-27-25(31)16-32-30-28(27)35-29(36-30)24-14-19(2)39(20(24)3)23-7-5-6-21(15-23)33-26(40)18-37-10-12-43-13-11-37/h5-7,14-16,22H,4,8-13,17-18H2,1-3H3,(H,33,40)(H2,32,34,35,36) OJJWCMYQUPFQHH-UHFFFAOYSA-N 791994 US12545673, Example 66 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791994 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791994&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524669 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(C(=O)N6CCN(C)CC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H37BrN8O3S/c1-5-43(41,42)38-11-10-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-16-19(2)39(20(24)3)23-8-6-21(7-9-23)30(40)37-14-12-36(4)13-15-37/h6-9,16-17,22H,5,10-15,18H2,1-4H3,(H2,32,33,34,35) KIUNFEZMVKCPAZ-UHFFFAOYSA-N 791995 US12545673, Example 67 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 19.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791995&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524670 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(C(=O)N6CCN(C)CC6)cc5)c4C)[nH]c23)C1 InChI=1S/C30H37BrN8O3S/c1-5-43(41,42)38-11-10-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-16-19(2)39(20(24)3)23-8-6-21(7-9-23)30(40)37-14-12-36(4)13-15-37/h6-9,16-17,22H,5,10-15,18H2,1-4H3,(H2,32,33,34,35) KIUNFEZMVKCPAZ-UHFFFAOYSA-N 791995 US12545673, Example 67 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 32.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791995 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791995&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524671 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCN(C)CC6)c5)c4C)[nH]c23)C1 InChI=1S/C30H37BrN8O3S/c1-5-43(41,42)38-10-9-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-15-19(2)39(20(24)3)23-8-6-7-21(16-23)30(40)37-13-11-36(4)12-14-37/h6-8,15-17,22H,5,9-14,18H2,1-4H3,(H2,32,33,34,35) CCDINAZZDDKPRI-UHFFFAOYSA-N 791996 US12545673, Example 68 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 16.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791996&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524672 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCN(C)CC6)c5)c4C)[nH]c23)C1 InChI=1S/C30H37BrN8O3S/c1-5-43(41,42)38-10-9-22(18-38)33-26-25(31)17-32-29-27(26)34-28(35-29)24-15-19(2)39(20(24)3)23-8-6-7-21(16-23)30(40)37-13-11-36(4)12-14-37/h6-8,15-17,22H,5,9-14,18H2,1-4H3,(H2,32,33,34,35) CCDINAZZDDKPRI-UHFFFAOYSA-N 791996 US12545673, Example 68 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791996 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791996&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524673 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)NCCN6CCOCC6)c5)c4C)nc23)C1 InChI=1S/C31H39BrN8O4S/c1-4-45(42,43)39-10-8-23(19-39)35-27-26(32)18-34-30-28(27)36-29(37-30)25-16-20(2)40(21(25)3)24-7-5-6-22(17-24)31(41)33-9-11-38-12-14-44-15-13-38/h5-7,16-18,23H,4,8-15,19H2,1-3H3,(H,33,41)(H2,34,35,36,37) LLLHADFTAJAISP-UHFFFAOYSA-N 791997 US12545673, Example 69 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 13.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791997&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524674 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)NCCN6CCOCC6)c5)c4C)nc23)C1 InChI=1S/C31H39BrN8O4S/c1-4-45(42,43)39-10-8-23(19-39)35-27-26(32)18-34-30-28(27)36-29(37-30)25-16-20(2)40(21(25)3)24-7-5-6-22(17-24)31(41)33-9-11-38-12-14-44-15-13-38/h5-7,16-18,23H,4,8-15,19H2,1-3H3,(H,33,41)(H2,34,35,36,37) LLLHADFTAJAISP-UHFFFAOYSA-N 791997 US12545673, Example 69 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791997 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791997&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524675 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)NCCN6CCOCC6)cc5)c4C)nc23)C1 InChI=1S/C31H39BrN8O4S/c1-4-45(42,43)39-11-9-23(19-39)35-27-26(32)18-34-30-28(27)36-29(37-30)25-17-20(2)40(21(25)3)24-7-5-22(6-8-24)31(41)33-10-12-38-13-15-44-16-14-38/h5-8,17-18,23H,4,9-16,19H2,1-3H3,(H,33,41)(H2,34,35,36,37) FZIDQNJTWDXISK-UHFFFAOYSA-N 791998 US12545673, Example 70 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 18.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791998&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524676 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)NCCN6CCOCC6)cc5)c4C)nc23)C1 InChI=1S/C31H39BrN8O4S/c1-4-45(42,43)39-11-9-23(19-39)35-27-26(32)18-34-30-28(27)36-29(37-30)25-17-20(2)40(21(25)3)24-7-5-22(6-8-24)31(41)33-10-12-38-13-15-44-16-14-38/h5-8,17-18,23H,4,9-16,19H2,1-3H3,(H,33,41)(H2,34,35,36,37) FZIDQNJTWDXISK-UHFFFAOYSA-N 791998 US12545673, Example 70 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791998 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791998&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524677 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)NCCN6CCN(C)CC6)c5)c4C)nc23)C1 InChI=1S/C32H42BrN9O3S/c1-5-46(44,45)41-11-9-24(20-41)36-28-27(33)19-35-31-29(28)37-30(38-31)26-17-21(2)42(22(26)3)25-8-6-7-23(18-25)32(43)34-10-12-40-15-13-39(4)14-16-40/h6-8,17-19,24H,5,9-16,20H2,1-4H3,(H,34,43)(H2,35,36,37,38) SGKLHEGIHGNHJH-UHFFFAOYSA-N 791999 US12545673, Example 71 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 26.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791999&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524678 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5cccc(C(=O)NCCN6CCN(C)CC6)c5)c4C)nc23)C1 InChI=1S/C32H42BrN9O3S/c1-5-46(44,45)41-11-9-24(20-41)36-28-27(33)19-35-31-29(28)37-30(38-31)26-17-21(2)42(22(26)3)25-8-6-7-23(18-25)32(43)34-10-12-40-15-13-39(4)14-16-40/h6-8,17-19,24H,5,9-16,20H2,1-4H3,(H,34,43)(H2,35,36,37,38) SGKLHEGIHGNHJH-UHFFFAOYSA-N 791999 US12545673, Example 71 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 36.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=791999 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=791999&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524679 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)NCCN6CCN(C)CC6)cc5)c4C)nc23)C1 InChI=1S/C32H42BrN9O3S/c1-5-46(44,45)41-12-10-24(20-41)36-28-27(33)19-35-31-29(28)37-30(38-31)26-18-21(2)42(22(26)3)25-8-6-23(7-9-25)32(43)34-11-13-40-16-14-39(4)15-17-40/h6-9,18-19,24H,5,10-17,20H2,1-4H3,(H,34,43)(H2,35,36,37,38) CRUCCIOYMRZMTB-UHFFFAOYSA-N 792000 US12545673, Example 72 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 15.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792000&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524680 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)NCCN6CCN(C)CC6)cc5)c4C)nc23)C1 InChI=1S/C32H42BrN9O3S/c1-5-46(44,45)41-12-10-24(20-41)36-28-27(33)19-35-31-29(28)37-30(38-31)26-18-21(2)42(22(26)3)25-8-6-23(7-9-25)32(43)34-11-13-40-16-14-39(4)15-17-40/h6-9,18-19,24H,5,10-17,20H2,1-4H3,(H,34,43)(H2,35,36,37,38) CRUCCIOYMRZMTB-UHFFFAOYSA-N 792000 US12545673, Example 72 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792000 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792000&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524681 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(NC(=O)CN(C)C)cc5C)c4C)[nH]c23)C1 InChI=1S/C29H37BrN8O3S/c1-7-42(40,41)37-11-10-21(15-37)33-26-23(30)14-31-29-27(26)34-28(35-29)22-13-18(3)38(19(22)4)24-9-8-20(12-17(24)2)32-25(39)16-36(5)6/h8-9,12-14,21H,7,10-11,15-16H2,1-6H3,(H,32,39)(H2,31,33,34,35) AWRINZIYPCALKP-UHFFFAOYSA-N 792001 US12545673, Example 73 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792001&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524682 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(NC(=O)CN(C)C)cc5C)c4C)[nH]c23)C1 InChI=1S/C29H37BrN8O3S/c1-7-42(40,41)37-11-10-21(15-37)33-26-23(30)14-31-29-27(26)34-28(35-29)22-13-18(3)38(19(22)4)24-9-8-20(12-17(24)2)32-25(39)16-36(5)6/h8-9,12-14,21H,7,10-11,15-16H2,1-6H3,(H,32,39)(H2,31,33,34,35) AWRINZIYPCALKP-UHFFFAOYSA-N 792001 US12545673, Example 73 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792001&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524683 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CN(C)C)ccc5C)c4C)[nH]c23)C1 InChI=1S/C29H37BrN8O3S/c1-7-42(40,41)37-11-10-21(15-37)33-26-23(30)14-31-29-27(26)34-28(35-29)22-12-18(3)38(19(22)4)24-13-20(9-8-17(24)2)32-25(39)16-36(5)6/h8-9,12-14,21H,7,10-11,15-16H2,1-6H3,(H,32,39)(H2,31,33,34,35) VCLOAGHLXNAYNZ-UHFFFAOYSA-N 792002 US12545673, Example 74 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 46.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792002&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524684 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CN(C)C)ccc5C)c4C)[nH]c23)C1 InChI=1S/C29H37BrN8O3S/c1-7-42(40,41)37-11-10-21(15-37)33-26-23(30)14-31-29-27(26)34-28(35-29)22-12-18(3)38(19(22)4)24-13-20(9-8-17(24)2)32-25(39)16-36(5)6/h8-9,12-14,21H,7,10-11,15-16H2,1-6H3,(H,32,39)(H2,31,33,34,35) VCLOAGHLXNAYNZ-UHFFFAOYSA-N 792002 US12545673, Example 74 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 43.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792002 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792002&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524685 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(NC(=O)CN6CCN(C)CC6)cc5C)c4C)[nH]c23)C1 InChI=1S/C32H42BrN9O3S/c1-6-46(44,45)41-10-9-24(18-41)36-29-26(33)17-34-32-30(29)37-31(38-32)25-16-21(3)42(22(25)4)27-8-7-23(15-20(27)2)35-28(43)19-40-13-11-39(5)12-14-40/h7-8,15-17,24H,6,9-14,18-19H2,1-5H3,(H,35,43)(H2,34,36,37,38) MKDKJNKDLSZSLV-UHFFFAOYSA-N 792003 US12545673, Example 75 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 16.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792003&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524686 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(NC(=O)CN6CCN(C)CC6)cc5C)c4C)[nH]c23)C1 InChI=1S/C32H42BrN9O3S/c1-6-46(44,45)41-10-9-24(18-41)36-29-26(33)17-34-32-30(29)37-31(38-32)25-16-21(3)42(22(25)4)27-8-7-23(15-20(27)2)35-28(43)19-40-13-11-39(5)12-14-40/h7-8,15-17,24H,6,9-14,18-19H2,1-5H3,(H,35,43)(H2,34,36,37,38) MKDKJNKDLSZSLV-UHFFFAOYSA-N 792003 US12545673, Example 75 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 30.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792003 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792003&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524687 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CN6CCN(C)CC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C32H42BrN9O3S/c1-6-46(44,45)41-10-9-24(18-41)36-29-26(33)17-34-32-30(29)37-31(38-32)25-15-21(3)42(22(25)4)27-16-23(8-7-20(27)2)35-28(43)19-40-13-11-39(5)12-14-40/h7-8,15-17,24H,6,9-14,18-19H2,1-5H3,(H,35,43)(H2,34,36,37,38) RPQRWSGQGCFXBM-UHFFFAOYSA-N 792004 US12545673, Example 76 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 63.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792004&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524688 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CN6CCN(C)CC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C32H42BrN9O3S/c1-6-46(44,45)41-10-9-24(18-41)36-29-26(33)17-34-32-30(29)37-31(38-32)25-15-21(3)42(22(25)4)27-16-23(8-7-20(27)2)35-28(43)19-40-13-11-39(5)12-14-40/h7-8,15-17,24H,6,9-14,18-19H2,1-5H3,(H,35,43)(H2,34,36,37,38) RPQRWSGQGCFXBM-UHFFFAOYSA-N 792004 US12545673, Example 76 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 64.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792004 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792004&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524689 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(NC(=O)CN6CCOCC6)cc5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O4S/c1-5-45(42,43)39-9-8-23(17-39)35-28-25(32)16-33-31-29(28)36-30(37-31)24-15-20(3)40(21(24)4)26-7-6-22(14-19(26)2)34-27(41)18-38-10-12-44-13-11-38/h6-7,14-16,23H,5,8-13,17-18H2,1-4H3,(H,34,41)(H2,33,35,36,37) IMHKJJMSYWVINE-UHFFFAOYSA-N 792005 US12545673, Example 77 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792005&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524690 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5ccc(NC(=O)CN6CCOCC6)cc5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O4S/c1-5-45(42,43)39-9-8-23(17-39)35-28-25(32)16-33-31-29(28)36-30(37-31)24-15-20(3)40(21(24)4)26-7-6-22(14-19(26)2)34-27(41)18-38-10-12-44-13-11-38/h6-7,14-16,23H,5,8-13,17-18H2,1-4H3,(H,34,41)(H2,33,35,36,37) IMHKJJMSYWVINE-UHFFFAOYSA-N 792005 US12545673, Example 77 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792005 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792005&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524691 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CN6CCOCC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O4S/c1-5-45(42,43)39-9-8-23(17-39)35-28-25(32)16-33-31-29(28)36-30(37-31)24-14-20(3)40(21(24)4)26-15-22(7-6-19(26)2)34-27(41)18-38-10-12-44-13-11-38/h6-7,14-16,23H,5,8-13,17-18H2,1-4H3,(H,34,41)(H2,33,35,36,37) JTJGLNYBQXXBQF-UHFFFAOYSA-N 792006 US12545673, Example 78 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 47.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792006&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524692 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CN6CCOCC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O4S/c1-5-45(42,43)39-9-8-23(17-39)35-28-25(32)16-33-31-29(28)36-30(37-31)24-14-20(3)40(21(24)4)26-15-22(7-6-19(26)2)34-27(41)18-38-10-12-44-13-11-38/h6-7,14-16,23H,5,8-13,17-18H2,1-4H3,(H,34,41)(H2,33,35,36,37) JTJGLNYBQXXBQF-UHFFFAOYSA-N 792006 US12545673, Example 78 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792006 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792006&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524693 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CCN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-14-11-21(17-38)33-27-23(31)16-32-30-28(27)35-29(36-30)22-15-18(2)39(20(22)4)25-10-8-9-24(19(25)3)34-26(40)12-13-37(5)6/h8-10,15-16,21H,7,11-14,17H2,1-6H3,(H,34,40)(H2,32,33,35,36) SPWYNSNVCGOUGP-UHFFFAOYSA-N 792007 US12545673, Example 79 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792007&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524694 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CCN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-14-11-21(17-38)33-27-23(31)16-32-30-28(27)35-29(36-30)22-15-18(2)39(20(22)4)25-10-8-9-24(19(25)3)34-26(40)12-13-37(5)6/h8-10,15-16,21H,7,11-14,17H2,1-6H3,(H,34,40)(H2,32,33,35,36) SPWYNSNVCGOUGP-UHFFFAOYSA-N 792007 US12545673, Example 79 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 35.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792007 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792007&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524695 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CCN(C)C)ccc5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-13-10-22(17-38)34-27-24(31)16-32-30-28(27)35-29(36-30)23-14-19(3)39(20(23)4)25-15-21(9-8-18(25)2)33-26(40)11-12-37(5)6/h8-9,14-16,22H,7,10-13,17H2,1-6H3,(H,33,40)(H2,32,34,35,36) HXRKEKIQYPAZAI-UHFFFAOYSA-N 792008 US12545673, Example 80 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 33.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792008&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524696 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(NC(=O)CCN(C)C)ccc5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-13-10-22(17-38)34-27-24(31)16-32-30-28(27)35-29(36-30)23-14-19(3)39(20(23)4)25-15-21(9-8-18(25)2)33-26(40)11-12-37(5)6/h8-9,14-16,22H,7,10-13,17H2,1-6H3,(H,33,40)(H2,32,34,35,36) HXRKEKIQYPAZAI-UHFFFAOYSA-N 792008 US12545673, Example 80 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792008 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792008&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524697 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCN(C)CC6)c5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O3S/c1-6-44(42,43)39-11-10-22(18-39)34-27-25(32)17-33-30-28(27)35-29(36-30)24-16-19(2)40(21(24)4)26-9-7-8-23(20(26)3)31(41)38-14-12-37(5)13-15-38/h7-9,16-17,22H,6,10-15,18H2,1-5H3,(H2,33,34,35,36) QKFILIJRYKNWJT-UHFFFAOYSA-N 792009 US12545673, Example 81 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 9.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792009&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524698 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCN(C)CC6)c5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O3S/c1-6-44(42,43)39-11-10-22(18-39)34-27-25(32)17-33-30-28(27)35-29(36-30)24-16-19(2)40(21(24)4)26-9-7-8-23(20(26)3)31(41)38-14-12-37(5)13-15-38/h7-9,16-17,22H,6,10-15,18H2,1-5H3,(H2,33,34,35,36) QKFILIJRYKNWJT-UHFFFAOYSA-N 792009 US12545673, Example 81 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792009 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792009&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524699 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)NCCN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-13-11-21(17-38)34-26-24(31)16-33-29-27(26)35-28(36-29)23-15-18(2)39(20(23)4)25-10-8-9-22(19(25)3)30(40)32-12-14-37(5)6/h8-10,15-16,21H,7,11-14,17H2,1-6H3,(H,32,40)(H2,33,34,35,36) OYYJQSDINALFRV-UHFFFAOYSA-N 792010 3-(3-(6-bromo-7-(((S)-1-(ethylsulfonyl)pyrrolidine-3-yl)amino)-1H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)-N-(2-(dimethylamino)ethyl)-2-methylbenzamide::US12545673, Example 82 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792010&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524700 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)NCCN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-13-11-21(17-38)34-26-24(31)16-33-29-27(26)35-28(36-29)23-15-18(2)39(20(23)4)25-10-8-9-22(19(25)3)30(40)32-12-14-37(5)6/h8-10,15-16,21H,7,11-14,17H2,1-6H3,(H,32,40)(H2,33,34,35,36) OYYJQSDINALFRV-UHFFFAOYSA-N 792010 3-(3-(6-bromo-7-(((S)-1-(ethylsulfonyl)pyrrolidine-3-yl)amino)-1H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)-N-(2-(dimethylamino)ethyl)-2-methylbenzamide::US12545673, Example 82 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 34.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792010 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792010&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524701 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCOCC6)c5C)c4C)[nH]c23)C1 InChI=1S/C30H36BrN7O4S/c1-5-43(40,41)37-10-9-21(17-37)33-26-24(31)16-32-29-27(26)34-28(35-29)23-15-18(2)38(20(23)4)25-8-6-7-22(19(25)3)30(39)36-11-13-42-14-12-36/h6-8,15-16,21H,5,9-14,17H2,1-4H3,(H2,32,33,34,35) IHBPKPSYCGRFKY-UHFFFAOYSA-N 792011 US12545673, Example 83 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 12.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792011&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524702 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(C(=O)N6CCOCC6)c5C)c4C)[nH]c23)C1 InChI=1S/C30H36BrN7O4S/c1-5-43(40,41)37-10-9-21(17-37)33-26-24(31)16-32-29-27(26)34-28(35-29)23-15-18(2)38(20(23)4)25-8-6-7-22(19(25)3)30(39)36-11-13-42-14-12-36/h6-8,15-16,21H,5,9-14,17H2,1-4H3,(H2,32,33,34,35) IHBPKPSYCGRFKY-UHFFFAOYSA-N 792011 US12545673, Example 83 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 22.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792011 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792011&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524703 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C29H37BrN8O3S/c1-7-42(40,41)37-12-11-20(15-37)32-26-22(30)14-31-29-27(26)34-28(35-29)21-13-17(2)38(19(21)4)24-10-8-9-23(18(24)3)33-25(39)16-36(5)6/h8-10,13-14,20H,7,11-12,15-16H2,1-6H3,(H,33,39)(H2,31,32,34,35) XELACDNSJHLMHB-UHFFFAOYSA-N 792012 US12545673, Example 84 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 8.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792012&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524704 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C29H37BrN8O3S/c1-7-42(40,41)37-12-11-20(15-37)32-26-22(30)14-31-29-27(26)34-28(35-29)21-13-17(2)38(19(21)4)24-10-8-9-23(18(24)3)33-25(39)16-36(5)6/h8-10,13-14,20H,7,11-12,15-16H2,1-6H3,(H,33,39)(H2,31,32,34,35) XELACDNSJHLMHB-UHFFFAOYSA-N 792012 US12545673, Example 84 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 16.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792012 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792012&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524705 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCOCC6)c5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O4S/c1-5-45(42,43)39-10-9-22(17-39)34-28-24(32)16-33-31-29(28)36-30(37-31)23-15-19(2)40(21(23)4)26-8-6-7-25(20(26)3)35-27(41)18-38-11-13-44-14-12-38/h6-8,15-16,22H,5,9-14,17-18H2,1-4H3,(H,35,41)(H2,33,34,36,37) DGCJRTJNRKOKQT-UHFFFAOYSA-N 792013 US12545673, Example 85 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 11.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792013&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524706 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCOCC6)c5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O4S/c1-5-45(42,43)39-10-9-22(17-39)34-28-24(32)16-33-31-29(28)36-30(37-31)23-15-19(2)40(21(23)4)26-8-6-7-25(20(26)3)35-27(41)18-38-11-13-44-14-12-38/h6-8,15-16,22H,5,9-14,17-18H2,1-4H3,(H,35,41)(H2,33,34,36,37) DGCJRTJNRKOKQT-UHFFFAOYSA-N 792013 US12545673, Example 85 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792013 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792013&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524707 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CCN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-14-11-21(17-38)33-27-23(31)16-32-30-28(27)35-29(36-30)22-15-18(2)39(20(22)4)25-10-8-9-24(19(25)3)34-26(40)12-13-37(5)6/h8-10,15-16,21H,7,11-14,17H2,1-6H3,(H,34,40)(H2,32,33,35,36) SPWYNSNVCGOUGP-UHFFFAOYSA-N 792014 US12545673, Example 86 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 7.00 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792014&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524708 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CCN(C)C)c5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-14-11-21(17-38)33-27-23(31)16-32-30-28(27)35-29(36-30)22-15-18(2)39(20(22)4)25-10-8-9-24(19(25)3)34-26(40)12-13-37(5)6/h8-10,15-16,21H,7,11-14,17H2,1-6H3,(H,34,40)(H2,32,33,35,36) SPWYNSNVCGOUGP-UHFFFAOYSA-N 792014 US12545673, Example 86 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792014 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792014&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524709 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCN(C)CC6)c5C)c4C)[nH]c23)C1 InChI=1S/C32H42BrN9O3S/c1-6-46(44,45)41-11-10-23(18-41)35-29-25(33)17-34-32-30(29)37-31(38-32)24-16-20(2)42(22(24)4)27-9-7-8-26(21(27)3)36-28(43)19-40-14-12-39(5)13-15-40/h7-9,16-17,23H,6,10-15,18-19H2,1-5H3,(H,36,43)(H2,34,35,37,38) IEQOXHFQHHVZPT-UHFFFAOYSA-N 792015 US12545673, Example 87 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 13.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792015&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524710 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cccc(NC(=O)CN6CCN(C)CC6)c5C)c4C)[nH]c23)C1 InChI=1S/C32H42BrN9O3S/c1-6-46(44,45)41-11-10-23(18-41)35-29-25(33)17-34-32-30(29)37-31(38-32)24-16-20(2)42(22(24)4)27-9-7-8-26(21(27)3)36-28(43)19-40-14-12-39(5)13-15-40/h7-9,16-17,23H,6,10-15,18-19H2,1-5H3,(H,36,43)(H2,34,35,37,38) IEQOXHFQHHVZPT-UHFFFAOYSA-N 792015 US12545673, Example 87 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 24.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792015 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792015&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524711 Cc1ccc(NC(=O)CN2CCOCC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C31H33BrN8O4S/c1-18-7-8-22(35-27(41)17-39-9-11-44-12-10-39)15-26(18)40-19(2)13-24(20(40)3)30-37-29-28(25(32)16-34-31(29)38-30)36-21-5-4-6-23(14-21)45(33,42)43/h4-8,13-16H,9-12,17H2,1-3H3,(H,35,41)(H2,33,42,43)(H2,34,36,37,38) MZJOGKNMJLVGHV-UHFFFAOYSA-N 792016 US12545673, Example 88 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 52.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792016&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524712 Cc1ccc(NC(=O)CN2CCOCC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C31H33BrN8O4S/c1-18-7-8-22(35-27(41)17-39-9-11-44-12-10-39)15-26(18)40-19(2)13-24(20(40)3)30-37-29-28(25(32)16-34-31(29)38-30)36-21-5-4-6-23(14-21)45(33,42)43/h4-8,13-16H,9-12,17H2,1-3H3,(H,35,41)(H2,33,42,43)(H2,34,36,37,38) MZJOGKNMJLVGHV-UHFFFAOYSA-N 792016 US12545673, Example 88 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 82.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792016 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792016&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524713 Cc1ccc(NC(=O)CN2CCN(C)CC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C32H36BrN9O3S/c1-19-8-9-23(36-28(43)18-41-12-10-40(4)11-13-41)16-27(19)42-20(2)14-25(21(42)3)31-38-30-29(26(33)17-35-32(30)39-31)37-22-6-5-7-24(15-22)46(34,44)45/h5-9,14-17H,10-13,18H2,1-4H3,(H,36,43)(H2,34,44,45)(H2,35,37,38,39) MXMCHRZKCBXDRI-UHFFFAOYSA-N 792017 US12545673, Example 89 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 81.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792017&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524714 Cc1ccc(NC(=O)CN2CCN(C)CC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C32H36BrN9O3S/c1-19-8-9-23(36-28(43)18-41-12-10-40(4)11-13-41)16-27(19)42-20(2)14-25(21(42)3)31-38-30-29(26(33)17-35-32(30)39-31)37-22-6-5-7-24(15-22)46(34,44)45/h5-9,14-17H,10-13,18H2,1-4H3,(H,36,43)(H2,34,44,45)(H2,35,37,38,39) MXMCHRZKCBXDRI-UHFFFAOYSA-N 792017 US12545673, Example 89 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 169 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792017&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524715 Cc1ccc(NC(=O)CN(C)C)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C29H31BrN8O3S/c1-16-9-10-20(33-25(39)15-37(4)5)13-24(16)38-17(2)11-22(18(38)3)28-35-27-26(23(30)14-32-29(27)36-28)34-19-7-6-8-21(12-19)42(31,40)41/h6-14H,15H2,1-5H3,(H,33,39)(H2,31,40,41)(H2,32,34,35,36) JUAIMTVDQSLDLY-UHFFFAOYSA-N 792018 US12545673, Example 90 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 92.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792018&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524716 Cc1ccc(NC(=O)CN(C)C)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C29H31BrN8O3S/c1-16-9-10-20(33-25(39)15-37(4)5)13-24(16)38-17(2)11-22(18(38)3)28-35-27-26(23(30)14-32-29(27)36-28)34-19-7-6-8-21(12-19)42(31,40)41/h6-14H,15H2,1-5H3,(H,33,39)(H2,31,40,41)(H2,32,34,35,36) JUAIMTVDQSLDLY-UHFFFAOYSA-N 792018 US12545673, Example 90 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 160 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792018 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792018&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524717 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(C(=O)N6CCOCC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C30H36BrN7O4S/c1-5-43(40,41)37-9-8-22(17-37)33-26-24(31)16-32-29-27(26)34-28(35-29)23-14-19(3)38(20(23)4)25-15-21(7-6-18(25)2)30(39)36-10-12-42-13-11-36/h6-7,14-16,22H,5,8-13,17H2,1-4H3,(H2,32,33,34,35) QGTRVDDGBAFPNJ-UHFFFAOYSA-N 792019 US12545673, Example 91 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 25.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792019&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524718 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(C(=O)N6CCOCC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C30H36BrN7O4S/c1-5-43(40,41)37-9-8-22(17-37)33-26-24(31)16-32-29-27(26)34-28(35-29)23-14-19(3)38(20(23)4)25-15-21(7-6-18(25)2)30(39)36-10-12-42-13-11-36/h6-7,14-16,22H,5,8-13,17H2,1-4H3,(H2,32,33,34,35) QGTRVDDGBAFPNJ-UHFFFAOYSA-N 792019 US12545673, Example 91 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 19.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792019 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792019&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524719 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(C(=O)N6CCN(C)CC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O3S/c1-6-44(42,43)39-10-9-23(18-39)34-27-25(32)17-33-30-28(27)35-29(36-30)24-15-20(3)40(21(24)4)26-16-22(8-7-19(26)2)31(41)38-13-11-37(5)12-14-38/h7-8,15-17,23H,6,9-14,18H2,1-5H3,(H2,33,34,35,36) KETOSJPFBNIOCP-UHFFFAOYSA-N 792020 US12545673, Example 92 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 26.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792020&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524720 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(C(=O)N6CCN(C)CC6)ccc5C)c4C)[nH]c23)C1 InChI=1S/C31H39BrN8O3S/c1-6-44(42,43)39-10-9-23(18-39)34-27-25(32)17-33-30-28(27)35-29(36-30)24-15-20(3)40(21(24)4)26-16-22(8-7-19(26)2)31(41)38-13-11-37(5)12-14-38/h7-8,15-17,23H,6,9-14,18H2,1-5H3,(H2,33,34,35,36) KETOSJPFBNIOCP-UHFFFAOYSA-N 792020 US12545673, Example 92 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 15.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792020 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792020&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524721 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(C(=O)NCCN(C)C)ccc5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-12-10-22(17-38)34-26-24(31)16-33-29-27(26)35-28(36-29)23-14-19(3)39(20(23)4)25-15-21(9-8-18(25)2)30(40)32-11-13-37(5)6/h8-9,14-16,22H,7,10-13,17H2,1-6H3,(H,32,40)(H2,33,34,35,36) JFDZJDCCXLJSNK-UHFFFAOYSA-N 792021 3-(3-(6-bromo-7-(((S)-1-(ethylsulfonyl)pyrrolidine-3-yl)amino)-1H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)-N-(2-(dimethylamino)ethyl)-4-methylbenzamide::US12545673, Example 93 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 54.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792021&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524722 CCS(=O)(=O)N1CC[C@H](Nc2c(Br)cnc3nc(-c4cc(C)n(-c5cc(C(=O)NCCN(C)C)ccc5C)c4C)[nH]c23)C1 InChI=1S/C30H39BrN8O3S/c1-7-43(41,42)38-12-10-22(17-38)34-26-24(31)16-33-29-27(26)35-28(36-29)23-14-19(3)39(20(23)4)25-15-21(9-8-18(25)2)30(40)32-11-13-37(5)6/h8-9,14-16,22H,7,10-13,17H2,1-6H3,(H,32,40)(H2,33,34,35,36) JFDZJDCCXLJSNK-UHFFFAOYSA-N 792021 3-(3-(6-bromo-7-(((S)-1-(ethylsulfonyl)pyrrolidine-3-yl)amino)-1H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)-N-(2-(dimethylamino)ethyl)-4-methylbenzamide::US12545673, Example 93 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 33.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792021 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792021&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524723 Cc1ccc(C(=O)N2CCOCC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C30H30BrN7O4S/c1-17-7-8-20(30(39)37-9-11-42-12-10-37)14-25(17)38-18(2)13-23(19(38)3)28-35-27-26(24(31)16-33-29(27)36-28)34-21-5-4-6-22(15-21)43(32,40)41/h4-8,13-16H,9-12H2,1-3H3,(H2,32,40,41)(H2,33,34,35,36) LGDMURPOHQWWPA-UHFFFAOYSA-N 792022 3-((6-bromo-2-(2,5-dimethyl-1-(2-methyl-5-(morpholine-4-carbonyl)phenyl)-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 94 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 73.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792022&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524724 Cc1ccc(C(=O)N2CCOCC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C30H30BrN7O4S/c1-17-7-8-20(30(39)37-9-11-42-12-10-37)14-25(17)38-18(2)13-23(19(38)3)28-35-27-26(24(31)16-33-29(27)36-28)34-21-5-4-6-22(15-21)43(32,40)41/h4-8,13-16H,9-12H2,1-3H3,(H2,32,40,41)(H2,33,34,35,36) LGDMURPOHQWWPA-UHFFFAOYSA-N 792022 3-((6-bromo-2-(2,5-dimethyl-1-(2-methyl-5-(morpholine-4-carbonyl)phenyl)-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 94 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 52.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792022 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792022&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524725 Cc1ccc(C(=O)N2CCN(C)CC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C31H33BrN8O3S/c1-18-8-9-21(31(41)39-12-10-38(4)11-13-39)15-26(18)40-19(2)14-24(20(40)3)29-36-28-27(25(32)17-34-30(28)37-29)35-22-6-5-7-23(16-22)44(33,42)43/h5-9,14-17H,10-13H2,1-4H3,(H2,33,42,43)(H2,34,35,36,37) JBGLFWKCDPUPKK-UHFFFAOYSA-N 792023 3-((6-bromo-2-(2,5-dimethyl-1-(2-methyl-5-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 95 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 60.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792023&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524726 Cc1ccc(C(=O)N2CCN(C)CC2)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C31H33BrN8O3S/c1-18-8-9-21(31(41)39-12-10-38(4)11-13-39)15-26(18)40-19(2)14-24(20(40)3)29-36-28-27(25(32)17-34-30(28)37-29)35-22-6-5-7-23(16-22)44(33,42)43/h5-9,14-17H,10-13H2,1-4H3,(H2,33,42,43)(H2,34,35,36,37) JBGLFWKCDPUPKK-UHFFFAOYSA-N 792023 3-((6-bromo-2-(2,5-dimethyl-1-(2-methyl-5-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrrol-3-yl)-1H-imidazo[4,5-b]pyridine-7-yl)amino)benzenesulfonamide::US12545673, Example 95 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 37.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792023 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792023&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524727 Cc1ccc(C(=O)NCCN(C)C)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C30H33BrN8O3S/c1-17-9-10-20(30(40)33-11-12-38(4)5)14-25(17)39-18(2)13-23(19(39)3)28-36-27-26(24(31)16-34-29(27)37-28)35-21-7-6-8-22(15-21)43(32,41)42/h6-10,13-16H,11-12H2,1-5H3,(H,33,40)(H2,32,41,42)(H2,34,35,36,37) QSPOEZGAJAKHGG-UHFFFAOYSA-N 792024 3-(3-(6-bromo-7-((3-sulfamoylphenyl)amino)-1H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)-N-(2-(dimethylamino)ethyl)-4-methylbenzamide::US12545673, Example 96 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 137 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792024&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524728 Cc1ccc(C(=O)NCCN(C)C)cc1-n1c(C)cc(-c2nc3ncc(Br)c(Nc4cccc(S(N)(=O)=O)c4)c3[nH]2)c1C InChI=1S/C30H33BrN8O3S/c1-17-9-10-20(30(40)33-11-12-38(4)5)14-25(17)39-18(2)13-23(19(39)3)28-36-27-26(24(31)16-34-29(27)37-28)35-21-7-6-8-22(15-21)43(32,41)42/h6-10,13-16H,11-12H2,1-5H3,(H,33,40)(H2,32,41,42)(H2,34,35,36,37) QSPOEZGAJAKHGG-UHFFFAOYSA-N 792024 3-(3-(6-bromo-7-((3-sulfamoylphenyl)amino)-1H-imidazo[4,5-b]pyridine-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl)-N-(2-(dimethylamino)ethyl)-4-methylbenzamide::US12545673, Example 96 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 145 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792024&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524729 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)N6CCN(C)CC6)cc5C)c4C)nc23)C1 InChI=1S/C31H39BrN8O3S/c1-6-44(42,43)39-10-9-23(18-39)34-27-25(32)17-33-30-28(27)35-29(36-30)24-16-20(3)40(21(24)4)26-8-7-22(15-19(26)2)31(41)38-13-11-37(5)12-14-38/h7-8,15-17,23H,6,9-14,18H2,1-5H3,(H2,33,34,35,36) DEEQCBLBWWDQGB-UHFFFAOYSA-N 792025 US12545673, Example 97 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 20.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792025&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524730 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)N6CCN(C)CC6)cc5C)c4C)nc23)C1 InChI=1S/C31H39BrN8O3S/c1-6-44(42,43)39-10-9-23(18-39)34-27-25(32)17-33-30-28(27)35-29(36-30)24-16-20(3)40(21(24)4)26-8-7-22(15-19(26)2)31(41)38-13-11-37(5)12-14-38/h7-8,15-17,23H,6,9-14,18H2,1-5H3,(H2,33,34,35,36) DEEQCBLBWWDQGB-UHFFFAOYSA-N 792025 US12545673, Example 97 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792025 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792025&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5 524731 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)N6CCOCC6)cc5C)c4C)nc23)C1 InChI=1S/C30H36BrN7O4S/c1-5-43(40,41)37-9-8-22(17-37)33-26-24(31)16-32-29-27(26)34-28(35-29)23-15-19(3)38(20(23)4)25-7-6-21(14-18(25)2)30(39)36-10-12-42-13-11-36/h6-7,14-16,22H,5,8-13,17H2,1-4H3,(H2,32,33,34,35) PGOIAVDZWKUUTN-UHFFFAOYSA-N 792026 US12545673, Example 98 Mitogen-activated protein kinase kinase kinase 11 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001795&target=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792026&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+11&column=ki&startPg=0&Increment=50&submit=Search 1 MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEPGQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPVGQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAPWVPEAGP 6CQ7,5K26,5K28 Mitogen-activated protein kinase kinase kinase 11 M3K11_HUMAN Q16584 B4DS76 Q53H00 Q59F06 Q6P2G4 524732 CCS(=O)(=O)N1CCC(Nc2c(Br)cnc3[nH]c(-c4cc(C)n(-c5ccc(C(=O)N6CCOCC6)cc5C)c4C)nc23)C1 InChI=1S/C30H36BrN7O4S/c1-5-43(40,41)37-9-8-22(17-37)33-26-24(31)16-32-29-27(26)34-28(35-29)23-15-19(3)38(20(23)4)25-7-6-21(14-18(25)2)30(39)36-10-12-42-13-11-36/h6-7,14-16,22H,5,8-13,17H2,1-4H3,(H2,32,33,34,35) PGOIAVDZWKUUTN-UHFFFAOYSA-N 792026 US12545673, Example 98 Mitogen-activated protein kinase kinase kinase 9 Homo sapiens 14.0 US Patent 10.7270/Q20006X6 aid1795523 US12545673 Lee, JW; Son, DH; Kang, NS; Choi, SW 2/10/2026 6/22/2026 TSD Life Sciences Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=792026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6817&target=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=792026&enzyme=Mitogen-activated+protein+kinase+kinase+kinase+9&column=ki&startPg=0&Increment=50&submit=Search 1 MEPSRALLGCLASAAAAAPPGEDGAGAGAEEEEEEEEEAAAAVGPGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQLLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAEREIDILERELNIIIHQLCQEKPRVKKRKGKFRKSRLKLKDGNRISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQLTPGESSKTWGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANGLSTPSESPHFHLGLKSLVDGYKQWSSSAPNLVKGPRSSPALPGFTSLMEMEDEDSEGPGSGESRLQHSPSQSYLCIPFPRGEDGDGPSSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRRCEVALLGCGAVLAATGLGFDLLEAGKCQLLPLEEPEPPAREEKKRREGLFQRSSRPRRSTSPPSRKLFKKEEPMLLLGDPSASLTLLSLSSISECNSTRSLLRSDSDEIVVYEMPVSPVEAPPLSPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPRPRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFASSSSTVEERPGLPALLPFQAGPLPPTERTLLDLDAEGQSQDSTVPLCRAELNTHRPAPYEIQQEFWS 4UY9 Mitogen-activated protein kinase kinase kinase 9 M3K9_HUMAN P80192 A3KN85 Q0D2G7 Q6EH31 Q9H2N5